• The most common malignant tumor, hepatocellular carcinoma (HCC), arises from well-differentiated hepatocytes [ 1 ]. (biomedcentral.com)
  • It is the most common type of malignant tumor observed worldwide, and it usually results in death within 6-20 months [ 2 , 3 ]. (biomedcentral.com)
  • An analysis of extensive cancer datasets confirmed fundamental differences of tumor mutational burden in HCC and malignant melanoma, challenging the notion that exome-derived mutations contribute relevantly to the expectable neoepitope pool in malignancies with only few mutations. (biomedcentral.com)
  • Normal oral keratinocytes are transformed into precancerous lesions through various signaling pathways, which further deteriorate into malignant tumors. (biomedcentral.com)
  • Local invasion and distant metastasis are the cause of death in most malignant tumors. (biomedcentral.com)
  • Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)
  • Different levels of viable cell inoculum density produced contrasting effects between 255 solid tumors as compared to 72 malignant. (shengsci.com)
  • Researchers from the Georg-Speyer-Haus in Frankfurt am Main and the University Hospital and Goethe University Frankfurt, identified a new combination therapy to boost anti-tumor immune therapy in liver cancer and liver metastasis. (georg-speyer-haus.de)
  • Our data on preclinical models are encouraging for the improvement of immune therapy options for hepatocellular carcinoma and liver metastasis. (georg-speyer-haus.de)
  • Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
  • One of the first molecules implicated in enhancement of distant metastasis after irradiation of the primary tumor was angiostatin, produced by the primary tumor and keeping metastasis dormant. (biomedcentral.com)
  • Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
  • Zurück zum Zitat Gay LJ, Felding-Habermann B. Contribution of platelets to tumour metastasis. (springermedizin.at)
  • Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. (biomedcentral.com)
  • The objective of this retrospective study was to clarify the potential prognostic significance of pre-therapeutic fibrinogen levels in head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by primary radiotherapy (RT) or with postoperative radiotherapy (PORT). (springermedizin.at)
  • Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. (springermedizin.at)
  • The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)
  • Prof. Florian Greten, director of Georg-Speyer-Haus and spokesperson of the LOEWE Centre Frankfurt Cancer Institute explains: "The study highlights the crucial role of the tumor microenvironment in cancer therapy. (georg-speyer-haus.de)
  • It focuses on the immune compartment of the tumor microenvironment and how to modulate the immune system toward a potent anti-tumor response. (georg-speyer-haus.de)
  • These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
  • Secondly, the locally hypermethylation of the tumor suppressor gene promoter, and thirdly, 5mC-containing-DNA sequences or direct mutations exposed to ultraviolet light or other carcinogens [ 9 ]. (biomedcentral.com)
  • Dano, K. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. (nature.com)
  • However, tumor-fighting T cells are in turn inactivated in ferroptotic tumors by two independent mechanisms. (georg-speyer-haus.de)
  • Review the mechanisms of predisposition to Wilms tumor. (nih.gov)
  • The prevalence of bilateral involvement is higher in individuals with a predisposition to Wilms tumor than in those without a genetic predisposition (see Mechanisms of Predisposition to Wilms Tumor ), but unilateral, unifocal Wilms tumor does not preclude an underlying germline or epigenetic cause. (nih.gov)
  • Currently, the term "Magic Bullet", coined by Paul Ehrlich, should be revisited and applied to new, more selective and effective cancer treatments. (eurekaselect.com)
  • They found that in cancer cells, ferroptosis - an iron-dependent form of cell death - triggers activation of tumor-fighting T cells in preclinical models. (georg-speyer-haus.de)
  • With the concomitant increase in liquid biopsy analyses for cancer screening, for detection of minimal residual disease after surgery, and for monitoring cancer patients, the need for high-precision analyses of circulating tumor-derived nucleic acid molecules is obvious, but not necessarily implemented. (biomedcentral.com)
  • The cytotoxic potential of 4NC was tested towards MCF-7 and MDA-MD-231 breast cancer cells, with a lower impact in the non-tumor lineage HB4a. (bvsalud.org)
  • Here, we examined the role of CRV in breast cancer cell adhesion, migration and invasion in vitro and how this component could suppress the growth of Ehrlich carcinoma-bearing mice. (bvsalud.org)
  • Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). (biomedcentral.com)
  • Purpose: The current investigation was conducted with the aim to elucidate and determine the anti-cancer efficacy in vitro on colon carcinoma human cell lines and to determine its probable mode of action. (ac.ir)
  • There are 10 biological capabilities involved as the hallmarks of cancer, during the multistep of human tumors development. (inabj.org)
  • Smyth MJ, Dunn GP, Schreiber RD. Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. (inabj.org)
  • It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. (biomedcentral.com)
  • Metastatic cancer cells are released from the primary tumor or from other metastases, at an undefined moment of its development, to arrive in the circulation and home at distant sites, where the ecosystem permits them to survive and either remain dormant as micro-metastases or grow to form macro-metastases (Mareel et al. (biomedcentral.com)
  • There is good evidence that cancer cells disseminate from the primary site early during tumor development (Hosseini et al. (biomedcentral.com)
  • In addition, the novel cancer stem cell paradigm raises the prospect of cell-targeted therapies instead of treatment directed against the whole tumour. (nature.com)
  • Since then, chemotherapy has been one of the main therapeutic strategies in cancer treatment, but, to paraphrase Paul Ehrlich, resistance has followed as a faithful shadow. (nature.com)
  • Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g. (shengsci.com)
  • In animal studies, pathological lesions associated with aflatoxin B1 intoxication include reduction in weight of liver, vacuolation of hepatocytes, and hepatic carcinoma. (wikipedia.org)
  • Eligible patients were ≥ 18 years with histologically confirmed colorectal adenocarcinoma with liver-only or liver-dominant metastases, and treatment with LP-irinotecan TACE (LifePearl™ microspheres, Terumo Europe N.V., Leuven, Belgium) decided in a multi-disciplinary tumour board. (springer.com)
  • The chemopreventive solid tumor protocol did not modify CYP levels in the liver or intestine or N-acetylglucosaminidase and myeloperoxidase activity in the liver. (bvsalud.org)
  • Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique? (oaepublish.com)
  • NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma. (ac.ir)
  • These antagonists inhibit tumour cell proliferation (tumour cells die by apoptosis), angiogenesis, and tumour cell migration. (eurekaselect.com)
  • Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. (shengsci.com)
  • Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
  • Zhang J, Wang WL, Li Q, Qiao Q. Expression of transforming growth factor-alpha and hepatitis B surface antigen in human hepatocellular carcinoma tissues and its significance. (ac.ir)
  • Tumor antigens and tumor antigen discovery. (inabj.org)
  • Then we remove the obstacles the tumor-fighting T cells face, the suppression cells and the shielding by PD-L1. (georg-speyer-haus.de)
  • Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. (inabj.org)
  • Recently, HCC -a tumor renowned to be refractory to systemic chemotherapy- has attracted wide interest as a result of improved understanding of its molecular biology and pathogenesis. (eurekaselect.com)
  • Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine. (nih.gov)
  • However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. (mdpi.com)
  • In vivo, treatment with CRV significantly decreased tumor growth, increased tumor necrosis area, and reduced the expression of VEGF and HIF-1α in Ehrlich carcinoma-bearing mice. (bvsalud.org)
  • Until no far past, advanced hepatocellular carcinoma (HCC) was considered as an "orphan" disease in terms of effective molecules when compared with other highly prevalent cancers worldwide. (eurekaselect.com)
  • Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment? (oaepublish.com)
  • The SFP reduced solid tumor growth in both solid tumor protocols but did not inhibit liquid tumor development. (bvsalud.org)
  • Tumors with anaplastic histology usually have somatic mutation of TP53 and inferior prognosis compared to tumors with favorable histology [ Ooms et al 2016 , Daw et al 2020 ]. (nih.gov)
  • The impact of plasma Epstein-Barr virus DNA and fibrinogen on nasopharyngeal carcinoma prognosis: an observational study. (springermedizin.at)
  • After the binding of SP to the tachykinin neurokinin-1 receptor (NK-1 receptor), the peptide exerts a mitogenic action on tumour and endothelial cells (inducing angiogenesis). (eurekaselect.com)
  • It also regulates the migration of tumour cells and exerts an antiapoptotic effect on them. (eurekaselect.com)
  • On the one hand, cells called myeloid-derived suppressive cells suppress tumor-fighting T cells. (georg-speyer-haus.de)
  • On the other hand, the tumor cells shield themselves from the T cells with the immune checkpoint receptor PD-L1. (georg-speyer-haus.de)
  • Thus, the team succeeded in showing that in a preclinical model, a triple therapy consisting of a substance that induces ferroptosis combined with the simultaneous administration of an immune checkpoint blocker as well as an inhibitor that prevents the recruitment of myeloid suppressive cells significantly reduces the growth of hepatocellular carcinoma. (georg-speyer-haus.de)
  • First, we make the tumor-fighting T cells reactive toward the tumor cells. (georg-speyer-haus.de)
  • The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. (bvsalud.org)
  • The SFP reduced total CYP levels in the solid and liquid tumor protocols and reduced the gene expression of Cyp1a1 and Cyp2e1 in rats and CYP1A2 in HepG2 cells. (bvsalud.org)
  • Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. (inabj.org)
  • Nephrogenic rests, benign foci of embryonal kidney cells that persist abnormally into postnatal life, are considered to be Wilms tumor precursors. (nih.gov)
  • Such cells are described as disseminated tumor cells (DTC) (Sosa et al. (biomedcentral.com)
  • The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. (shengsci.com)
  • Successful, non-invasive delivery of biodegradable and non-toxic combination therapies that can target existing cancerous cells and prevent the development of new tumors all in one dose is ideal for clinical treatment. (ntno.org)
  • Wilms tumor (nephroblastoma), an embryonal malignancy of the kidney, is the most common renal tumor of childhood [ Fernandez et al 2021 ]. (nih.gov)
  • A definitive diagnosis of Wilms tumor can be made only on histologic assessment of the tumor. (nih.gov)
  • HCC is a well-vascularized tumor in which angiogenesis is strongly implicated for aggressiveness and dissemination and targeted drugs (mainly angiogenesis inhibitors) have been tested to block neovessels and various signaling pathways involved in this disease. (eurekaselect.com)
  • Daily oral administration of 4NC (25 mgâ ¯kg-1) for 21 days led to a consistent reduction in tumor growth compared to the vehicle group. (bvsalud.org)
  • 1975. Tumor growth inhibition by ammonium chloride-induced acidosis. (cdc.gov)
  • Here, we found that endogenous IL-4 promotes tumor growth because neutralizing IL-4 by 11B1. (shengsci.com)
  • Effects of tumor cell viability and inoculum density on growth parameters in the human tumor, soft-agar clonogenic assay. (shengsci.com)
  • For some tumors, immune checkpoint blockades are by now part of first-line treatment. (georg-speyer-haus.de)
  • Since these mutated HLA ligands were unacquainted to the immune system before carcinogenesis, they have been proposed as ideal tumor-specific targets [ 10 , 11 ]. (biomedcentral.com)
  • Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. (inabj.org)
  • Yet, far less attention is paid to the effects of these treatments on tumor progression as reflected by the metastatic process. (biomedcentral.com)
  • We hypothesized that a preneoplastic field of inflammation, telomere shortening, and senescence underlies tumor progression in UC progressors. (shengsci.com)
  • For in vivo studies, solid Ehrlich carcinoma (SEC) was used, a syngeneic mouse model with non-nuclear estrogen and progesterone positivity, characterized by immunohistochemistry. (bvsalud.org)
  • Briefly describe the clinical characteristics of Wilms tumor. (nih.gov)
  • Clinical features of Wilms tumor predisposition syndromes (See Table 1 and Table 2 . (nih.gov)
  • Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. (shengsci.com)
  • Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System. (nih.gov)
  • Additional pathogenic variants transform nephrogenic rests into a Wilms tumor [ Fernandez et al 2021 ]. (nih.gov)
  • Provide an evaluation strategy to determine if a proband with Wilms tumor has a predisposition to Wilms tumor, identify the genetic or epigenetic mechanism for Wilms tumor, and determine risks for additional medical complications. (nih.gov)
  • Our findings argue that senescence acts as a tumor suppressor mechanism that is abrogated during the transition from LGD to HGD in UC. (shengsci.com)
  • These results open new possibilities for the use of 4NC as a tumor cell metabolism modulating agent. (bvsalud.org)
  • One probable mode of action for ICP inhibitors is the induction and/or restoration of T cell effector functions against individual somatic tumor mutations presented by HLA molecules (i.e., mutated neoepitopes) [ 9 ]. (biomedcentral.com)
  • 2001 ). Molecular communication between ecosystems is also witnessed by the vasculogenic and pro-metastatic tumor bed effect as discussed by Kuonen et al. (biomedcentral.com)
  • Biological occurrences connected to tumor development are among HCC's distinguishing characteristics [ 4 ]. (biomedcentral.com)
  • However, their significance for tumor development has not been investigated. (shengsci.com)
  • In 10%-15% of individuals with Wilms tumor, the cause is considered to be a germline pathogenic variant or an epigenetic alteration occurring early during embryogenesis [ Mahamdallie et al 2019 ]. (nih.gov)
  • An increase of N-acetylglucosaminidase activity was observed in all SFP-treated rats, and TNF-α levels increased in the solid tumor protocol in the vehicle, SFP, and vincristine (positive control) groups. (bvsalud.org)
  • The first group includes pharmacological and physiological factors such as drug metabolism and excretion, inadequate access of the drug to the tumour, inadequate infusion rate and inadequate route of delivery. (nature.com)
  • Although Anthony van Leeuwenhoek, who discovered microbial attachment to his own tooth surface, is credited with the discovery of biofilm nearly 40 years ago, one of the major breakthroughs happened when Dr. G.D. Ehrlich confirmed the hypothesis in 2006, that indeed chronic middle-ear disorders are 'chronic' biofilm related and don't recur due to new infections. (blogspot.com)
  • Four hundred and forty-seven human tumor specimens were accessioned and processed for clonogenic assay, yielding 374 specimens, representing 23 different histiotypes, adequate for culture. (shengsci.com)
  • Aflatoxin B1 is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma (HCC) in humans. (wikipedia.org)
  • In total, 50 patients ≥ 18 years diagnosed with CRLM and decided to be treated with irinotecan-eluting LifePearl™ microspheres TACE (LP-irinotecan TACE) by a multidisciplinary tumour board. (springer.com)
  • The SFP was used in the following protocols: (i) solid tumor, (ii) liquid tumor, and (iii) chemopreventive solid tumor. (bvsalud.org)