• Sarkar and his colleagues isolated oligoadenylate synthetases-like (OASL), a protein that appears quite often in people suffering from liver cancer caused by the hepatitis C virus. (medicaldaily.com)
  • We report a child who died of FVH upon infection with hepatitis A virus (HAV) at age 11 yr and who was homozygous for a private 40-nucleotide deletion in IL18BP , which encodes the IL-18 binding protein (IL-18BP). (nih.gov)
  • Naturally occurring protein could serve as effective treatment for viral infections. (medicaldaily.com)
  • A laboratory-based investigation led by the University of Pittsburgh Cancer Institute (UPCI) and UPMC Cancer Center has discovered a naturally occurring protein in human cells that may improve our ability to identify and treat viral infection such as influenza and hepatitis C. (medicaldaily.com)
  • Further testing found mice without OASL were significantly more susceptible to viral infection compared to those with the protein. (medicaldaily.com)
  • Interferon , a similar natural occurring protein that is produced and released by cells to combat viruses, is currently used in hepatitis C treatment, but it is unsuccessful in treating influenza. (medicaldaily.com)
  • Some viruses (e.g. influenza and many animal viruses) have viral envelopes covering their protective protein capsids. (wikipedia.org)
  • We show that human IL-18 and IL-18BP are both secreted mostly by hepatocytes and macrophages in the liver. (nih.gov)
  • Moreover, in the absence of IL-18BP, excessive NK cell activation by IL-18 results in uncontrolled killing of human hepatocytes in vitro. (nih.gov)
  • Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies. (semanticscholar.org)
  • It is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside inhibitor. (wikipedia.org)
  • Although liver diseases transmissible among human populations were identified early in the history of medicine, the first known hepatitis with a viral etiological agent was Hepatitis A, in the picornaviridae family. (wikipedia.org)
  • There are six treatment options approved by the U.S. Food and Drug Administration (FDA) available for persons with a chronic hepatitis B infection: alpha-interferon, pegylated interferon, adefovir, entecavir, telbivudine, and lamivudine. (wikipedia.org)
  • Conclusion: Using in vitro cell culture and human liver-chimeric mouse models, we show that a human mAb targeting the HCV coreceptor SR-BI completely prevents infection and intrahepatic spread of multiple HCV genotypes. (ugent.be)
  • Clinically, it is comparable to hepatitis A, but in pregnant women, the disease is more often severe and is associated with a clinical syndrome called fulminant liver failure. (wikipedia.org)