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  • platelet- deriv
  • Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium: Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. (nii.ac.jp)
  • Sorafenib is a multitargeted tyrosine kinase inhibitor that blocks the Ser/Thr kinase Raf and several receptor tyrosine kinases including vascular endothelial growth factor receptor- (VEGFR-) 2 and -3 and platelet-derived growth factor receptor- (PDGFR-) to inhibit tumor cell proliferation and tumor angiogenesis. (hindawi.com)
  • methods
  • METHODS: Rat HSC-T6 cells were cultured in separate dishes and treated with various concentration of transforming growth factor (TGF)-β1, IGFBP-7 or anti-IGFBP-7 antibody for 24 h. (ebscohost.com)
  • caused steatosis
  • We found that while albumin and urea secretions were relatively similar in MPTCs and MPCCs (suggesting well-differentiated PHHs), increasing HSC numbers within MPTCs downregulated hepatic cytochrome-P450 (2A6, 3A4) and transporter activities, and caused steatosis over 2 weeks. (rsc.org)
  • regeneration
  • Regeneration is a process in which tissue parenchymal cells play a major role in reconstructing the lost part of the tissue, resulting in both structural and functional restoration. (thefreelibrary.com)
  • tumor
  • Tumor microenvironment confers drug resistance to kinase inhibitors by increasing RKT ligand levels that result in the activation of cell-survival signaling including PI3K and MAPK signals. (hindawi.com)
  • human HSC cell
  • In our study, ROS in human HSC cell line LX-2 was induced by ferric nitrilotriacetate (Fe-NTA) and assessed by superoxide dismutase (SOD) activity and methane dicarboxylic aldehyde (MDA) level. (sigmaaldrich.com)
  • decrease
  • Finally, we confirm the decrease in hepatic retinoid content that occurs in alcoholic liver disease in humans, even at the early stages of the disease. (ovid.com)
  • effects
  • In addition to modulating insulin-like growth factors action, it is now clear that insulin-like growth factor-binding protein-3 also has intrinsic effects on cell growth and survival. (ebscohost.com)
  • pancreas
  • Vitamin A-storing cells exist in extrahepatic organs such as the pancreas, lungs, kidneys and intestines. (nih.gov)