Hepatic steatosis mice obese. Medical search. Frequent questions

Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. (ulaval.ca)
In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
Twelve newborn C57BL/6 J male mice were subcutaneously injected with monosodium glutamate (MSG) to induce obesity on a conventional diet. (biomedcentral.com)
A scientific team from the University of Barcelona and the CIBERobn has designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy which consists of implanting cells that have been manipulated and transformed in order to treat a disease. (drramon.com)
In conclusion, the implantation of adipocytes expressing the mitochondrial enzyme CPT1AM helps to reduce obesity and glucose intolerance in mice. (drramon.com)
Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice. (drramon.com)
Effect of barley supplementation on the fecal microbiota, caecal biochemistry, and key biomarkers of obesity and inflammation in obese db/db mice. (sustainableseedsystems.org)
Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. (molecularmetabolism.com)
Our findings show that BMP4 prevents, but does not reverse, established obesity in adult mice, while it improves insulin sensitivity independent of weight reduction. (molecularmetabolism.com)
Specifically reducing dietary levels of histidine by 67% reduces the weight gain of young, lean male mice, reducing both adipose and lean mass without altering glucose metabolism, and rapidly reverses diet-induced obesity and hepatic steatosis in diet-induced obese male mice, increasing insulin sensitivity. (niagads.org)
Overall, our findings demonstrate that dietary histidine is a key regulator of weight and body composition in male mice and in humans, and suggest that reducing dietary histidine may be a translatable option for the treatment of obesity. (niagads.org)
In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total cholesterol, adipocyte size, crown-like structures, proinflammatory cytokine secretion (IL-6 and tumor necrosis factor α) in adipose tissue, liver injury, hepatic steatosis, and inflammation foci, while treatment with IL-10 or PSL alone did not. (elsevierpure.com)
lion adults are obese and 2.1 bil ion attributed to obesity. (who.int)
[ 1 , 5 ] Hispanic children are disproportionately affected by the obesity epidemic with 38.1% of Hispanic children and adolescents 12 to 19 years of age found to be overweight/obese according to the 2011-2012 National Health and Nutrition Examination data. (medscape.com)

Thirty male healthy C57BL/6J mice (5 weeks old, each weighing 18-22 g) were obtained from Shanghai Sippr-BK Laboratory Animal Co., Ltd. (Certification No. SCXK (Hu) 2013-0016) and housed in standard laboratory conditions. (hindawi.com)
In our study, 8-week-old C57BL/6 mice were fed on a normal diet or a high-fat diet for 16 weeks. (diabetesjournals.org)
gigasNakai alleviates hyperglycemia and hepatic steatosis in C57BL/KsJ-mice [12]. (euromedh2020.com)
Apigenin served as a potent therapy against UC in C57BL/6 mice through the inhibition of inflammatory cytokines,and COX-2, and through the reduction in immune cell infiltration in colon tissues [ 11 ] . (encyclopedia.pub)
The male, 6C7 weeks outdated, C57BL/6 mice (weighing 18C20?g) were purchased through the Beijing Essential River Lab Pet Technology Co., Ltd. (Beijing, China). (geogise.com)
Here, we find that dietary histidine plays a key role in the response to an LP diet in male C57BL/6J mice. (niagads.org)

Aloxe3 and Alox12b mRNA was detected in the tongue, forestomach, trachea, brain, testis, and adipose tissue of mice and in the spinal cord of rats. (wikipedia.org)
Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
The NAFLD group had higher hepatic fat ( P ±0.001) lower skeletal muscle IS ( P = 0.01), hepatic IS ( P = 0.01), and adipose tissue IS ( P = 0.04). (medscape.com)
Hepatic IS ( r = -0.42, P = 0.01) and adipose IS ( r = -.54, P = 0.001) correlated with arterial stiffness (AIx). (medscape.com)
Vascular stiffness was related to hepatic and adipose tissue insulin resistance. (medscape.com)

According to disease severity, NAFLD could progress from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and finally develop to hepatocellular carcinoma (HCC) [ 4 ]. (hindawi.com)
2015. Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway. . (oregonstate.edu)
2012. Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. . (oregonstate.edu)
Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. (colorado.edu)
Within the spectrum of NAFLD, non-alcoholic steatohepatitis (NASH) in combination with hepatic inflammation and fibrosis can lead to liver cirrhosis and hepatocellular carcinoma. (biomedcentral.com)
Among the various forms of NAFLD, non-alcoholic steatohepatitis (NASH) involves hepatic inflammation and fibrosis, which can lead to cirrhosis, and the reported five-year cumulative incidence of liver cancer among patients with cirrhosis is 20% in Japan [ 2 ]. (biomedcentral.com)

Here, we investigated the effects of MitoTEMPO on NAFLD using high fat diet- (HFD-) induced obese mice as animal models. (hindawi.com)
Our results suggest that MitoTEMPO appears to be a potential chemical compound affecting certain immune cells and further ameliorates inflammation in obese-associated NAFLD. (hindawi.com)
Besides, the pathogenesis is different between humans and the MCD-induced mouse NAFLD model. (hindawi.com)
Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. (hindawi.com)
This review discusses the role of adipokines and PPARs with regard to hepatic energy metabolism and progression of NAFLD. (wjgnet.com)
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. (biomedcentral.com)
Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM's holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. (biomedcentral.com)
Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases including NAFLD for centuries in Asia, and TCM's holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease [ 8 ]. (biomedcentral.com)
In the scholarly study, we explored the consequences of RDV on NAFLD activated by HFD in mice. (geogise.com)
Orlistat (ORL) can be used like a weight-loss agent since it induces fats malabsorption, and a randomized handled trial reported that ORL improved hepatic steatosis in obese NAFLD individuals. (geogise.com)
TAK-448 protected insulin resistant, obese mice against the development of hepatic steatosis: H& E showing fatty liver.Invention Summary:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide that can progress to steatohepatitis (NASH), the leading reason for liver transplants. (testtechnologypublisher.com)
Nonalcoholic fatty liver disease (NAFLD), comprising a spectrum of conditions ranging from steatosis to steatohepatitis and cirrhosis, represents the most common cause of chronic liver disease. (medscape.com)
c-IMT was not found to be higher in individuals with T2DM with vs without NAFLD, but hepatic steatosis was not associated with c-IMT. (medscape.com)
[ 18 ] Children with biopsyproven NAFLD have significantly higher fasting insulin, triglycerides, cholesterol, blood pressure, and lower high-density lipoprotein (HDL) compared with obese peers with no NAFLD. (medscape.com)
The role of NAFLD as an added risk for subclinical atherosclerosis in obese youth with altered glucose metabolism, beyond the effect of hyperglycemia is not clear. (medscape.com)

ALOX12B and ALOXE3 in humans, Alox12b and Aloxe3 in mice, and comparable orthologs in other in other species are proposed to act sequentially in a multistep metabolic pathway that forms products that are structurally critical for creating and maintaining the skin's water barrier function. (wikipedia.org)
Notably, recent experimental studies have strongly implicated ceramides in the development of numerous metabolic diseases such as insulin resistance, diabetes, cardiomyopathy, hepatic-steatosis, and atherosclerosis. (frontiersin.org)
Our aim was to generate adipocytes that could express a constitutively active form of CPT1A - CPT1AM - capable of burning excess fat and improving the obese metabolic phenotype of mice after implantation. (drramon.com)
We discovered that RDV supplementation could ameliorate HFD-induced metabolic disorder and insulin level of resistance in mice effectively. (geogise.com)

A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. (colorado.edu)

The results showed that the hepatic steatosis in liver tissues of HFD mice injected with MitoTEMPO was significantly ameliorated. (hindawi.com)
In conclusion, empagliflozin could significantly reduce the body weight and liver weight, and improve fasting blood glucose and hepatic steatosis. (diabetesjournals.org)
Inhibition of triacylglycerol (TAG) synthesis via diacylglycerol acyltransferase 2 (DGAT2) antisense oligonucleotides improves liver steatosis (Yamaguchi et al. (webmedcentral.com)
Hepatic steatosis, inflammatory cell infiltration, and hepatocyte ballooning in the liver and increased hepatic mRNA expression of fatty acid synthase and glycerol-3-phosphate acyltransferase were observed in the MSG-treated mice. (biomedcentral.com)
thus, the mechanism underlying the effect of FOS on lipid metabolism in the liver or visceral fat levels cannot be examined, whereas the monosodium glutamate (MSG)-treated mouse is an appropriate animal model of NASH. (biomedcentral.com)
As a result, in obese mice, it has been possible to reduce weight, fatty liver (hepatic steatosis), cholesterol and glucose levels. (drramon.com)
BMP4 also decreased hepatic glucose production and reduced gluconeogenic enzymes in the liver, but not in the kidney, in addition to enhancing insulin action in the liver. (molecularmetabolism.com)

PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid metabolism remains unclear. (edu.au)
In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
Hepatic mRNA expression of lipid metabolism enzymes and SCFA in feces and sera were measured. (biomedcentral.com)
Chronic treatment of E6 significantly decreased body weight and fasting blood glucose, improved lipid metabolism, and also reduced hepatic steatosis in diet-induced obese mice. (innopep.com)

Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice. (ulaval.ca)

Senescence-accelerated prone mice exhibit higher expression of FAS, hepatic steatosis with increased hepatic cholesterol (CH) content, plasma TAG, and aspartate aminotransferase levels (Kuhla et al. (webmedcentral.com)
Here, we examine whether intervening with a selective PPARδ agonist corrects hepatic steatosis induced by a high-fat, cholesterol-containing ( HFHC ) diet. (edu.au)
Ldlr−/− mice were fed a chow or HFHC diet ( 42% fat, 0.2% cholesterol ) for 4 weeks. (edu.au)

However, limited data in patients with cirrhosis suggest that zidovudine may accumulate in patients with hepatic impairment because of decreased glucuronidation. (who.int)

These processes to severe lipodystrophy and induces insulin resistance in mice (He et al. (deepdyve.com)

Here we report that a selective high-affinity, orally available, small-molecule Gpr120 agonist (cpdA) exerts potent anti-inflammatory effects on macrophages in vitro and in obese mice in vivo. (elsevierpure.com)
One of the lead peptides, peptide 10, exhibited intestinotrophic and anti-inflammatory effects in DSS-induced intestinal inflammation in mice. (innopep.com)
RDV enhances disease outcomes and attenuates viral loads in severe acute respiratory syndrome CoV (SARS-CoV)-infected mice with crucial inflammatory response. (geogise.com)
Hepatic lipid deposition and inflammatory response in HFD-fed mice were markedly alleviated by RDV also. (geogise.com)

HFHC-fed animals were hyperinsulinemic and exhibited selective hepatic insulin resistance, which contributed to elevated fasting FA synthesis and hyperglycemia. (edu.au)
GW1516 intervention normalized fasting hyperinsulinemia and selective hepatic insulin resistance and attenuated fasting FA synthesis and hyperglycemia. (edu.au)

Thus, PPARδ agonist treatment inhibits the progression of preestablished hepatic steatosis. (edu.au)
Gpr120 agonist treatment of high-fat diet-fed obese mice causes improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity and decreased hepatic steatosis. (elsevierpure.com)

This study aimed to determine the effects of fructo-oligosaccharides (FOS) on steatohepatitis and visceral adiposity in an obese mouse model of NASH. (biomedcentral.com)

In mice, blocking ceramide production improves insulin sensitivity, prevents β-cell failure, resolves hepatic steatosis, hypertriglyceridemia, and prevents atherosclerosis, and heart failure ( 6 - 22 ). (frontiersin.org)
[ 12 ] Another study concluded that hepatic fat may be protective against atherosclerosis in 60-year-old adults with T2DM. (medscape.com)

Dietary-induced obese C57BL6/N mice received AAV8 BMP4 gene therapy at 17-18 weeks of age. (molecularmetabolism.com)

Following termination, the mice underwent additional characterization in vitro. (molecularmetabolism.com)

Senp2 knockout mice exhibited a lipodystrophy-like phenotype. (deepdyve.com)

Surprisingly, we observed no effect on body weight, browning of WAT, or energy expenditure in these obese mice, but whole-body insulin sensitivity and glucose tolerance were robustly improved. (molecularmetabolism.com)
Reduced histidine promotes leanness and increased energy expenditure in male mice. (niagads.org)

2007). Suppression of the genes, which are involved in lipogenesis (ATP-citrate lyase (ACL), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA-desaturase 1 or sterol regulatory element-binding protein 1(SREBP-1)), reduced proliferation and survival of hepatic carcinoma cells (Calvisi et al. (webmedcentral.com)

While weight loss is ideal, the overwhelming majority of the obese population - either due to chronic entrainment of metabolism or behavior, increased age or accumulation of injuries - retain or regain excess weight. (augusta.edu)
When compared to teduglutide (GLP2-2G) in the DSS-induced chronic colitis models in mice, peptide 10 had improved efficacy with better intestinotrophic effects. (innopep.com)

Around 70% of American adults are obese or obese having a BMI 25 [3]. (euromedh2020.com)
unshiuMarkovich, YY-312, reduces surplus fat in obese adults [13] and saponin-rich small fraction ofA. (euromedh2020.com)

sessiliflorusinhibits bodyweight gain in high-fat diet plan- (HFD-) induced mice without Olumacostat glasaretil symptoms of diarrhea [14]. (euromedh2020.com)

adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)

moschataDuchesne, known as pumpkin also, assists improve lipid profile, insulin level of resistance, and additional related complications in obese rats [11]. (euromedh2020.com)

Data from patients with moderate to severe hepatic impairment show that hepatic dysfunction does not affect lamivudine pharmacokinetics significantly. (who.int)
As zidovudine doses may need to be adjusted, it is recommended that separate preparations of lamivudine and zidovudine are used in patients with severe hepatic impairment. (who.int)

LIF protects mice from Ionizing radiation: survival is measured in control group without treatment (WT) vs. those treated with LIF (WT + LIF). (testtechnologypublisher.com)

they co-localize at the surface of keratinocytes in the stratum granulosum of mouse skin and during mouse embryogenesis appear concurrently at the onset of skin development at day 15.5. (wikipedia.org)

The physical bodyweight of mice and total energy intake had been measured, and the later on one was regarded towards the energy of different feeds following the pet test. (geogise.com)

RHI and AIx were related to hepatic fat content. (medscape.com)

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. (colorado.edu)

In primary mouse hepatocytes, GW1516 treatment stimulated AMP-activated protein kinase ( AMPK ) and acetyl-CoA carboxylase ( ACC ) phosphorylation in WT hepatocytes, but not AMPKβ1−/− hepatocytes. (edu.au)
We found that SET domain bifurcated 1 Since no difference in food intake was observed between adqcKO f/f (Setdb1) was a SUMOylated protein and that Senp2 de-SUMOylated Senp2 and Senp2 mice fedeitherwithNCD or HFD and regulated Setdb1 action in trimethylation at histone 3 lysine 9 (Supplementary Figure S2A). (deepdyve.com)

Anatomy11

Organisms10

Diseases27

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology1

Phenomena and Processes23

Technology, Industry, Agriculture2

Health Care2

Geographicals1

Obesity14

C57BL6

Adipose6

Fibrosis6

NAFLD15

Metabolic4

Nonalcoholic steatohepatitis1

Liver7

Lipid metabolism4

Blood glucose1

Cholesterol3

Cirrhosis1

Induces1

Inflammatory4

Hyperglycemia2

Agonist treatment2

Steatohepatitis1

Atherosclerosis2

Dietary1

Vitro1

Phenotype1

Energy expenditure2

Suppression1

Chronic2

Adults2

High fat1

Exhibit1

Rats1

Severe2

Survival1

Development1

Bodyweight1

Content1

Characterization1

Protein2