Hepatic steatosis metabolic syndrome is central obesity. Medical search. Frequent questions

2 NAFLD is associated with obesity and features of metabolic syndrome, including hypertension, dyslipidemia, central adiposity, insulin resistance, or diabetes. (xiahepublishing.com)
Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. (biomedcentral.com)
The burden for hepatocellular carcinoma (HCC) attributed to nonalcoholic fatty liver disease (NAFLD) continues to grow in parallel with rising global trends in obesity. (thieme-connect.com)
Beyond etiology and severity of liver disease, traditional and metabolic risk factors, such as diabetes mellitus, older age, male gender and tobacco smoking, are not enough for HCC risk stratification for surveillance efficacy and effectiveness in NAFLD. (thieme-connect.com)
2 ] [ 5 ] [ 6 ] In parallel with the rising prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of HCC and is anticipated to result in up to 135,000 HCC cases in the United States between 2015 and 2030. (thieme-connect.com)
This heterogeneity of NAFLD is in turn influenced by various factors primarily demographic/dietary factors, metabolic status, gut microbiome, genetic predisposition together with epigenetic factors. (wjgnet.com)
The role of fructose in NAFLD (steatosis) pathogenesis has received a great deal of attention in part because from 1999 to 2004 the consumption of fructose increased by ~32 % [ 36 ]. (biomedcentral.com)
2014). Patients with MetS are also more susceptible to develop type 2 diabetes mellitus (Reaven, 2004), and their hepatic morphology and function can be adversely affected leading to the development of Non Alcoholic Fatty Liver Disease (NAFLD) (Marchesini et al. (ugr.es)
Diseases such as obesity, diabetes, and hypertension have been found to be closely associated with the incidence of NAFLD. (wjgnet.com)
Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)
This review discusses the role of adipokines and PPARs with regard to hepatic energy metabolism and progression of NAFLD. (wjgnet.com)
Those battling central obesity, T2DM, dyslipidemia and metabolic syndrome are at a heightened risk of NAFLD. (getoberit.com)
A significant correlation exists between central obesity, metabolic syndrome - conditions like high blood pressure, abnormal cholesterol levels, etc., that occur together, thereby increasing one's risk of heart diseases and type 2 diabetes mellitus - both closely linked with NAFLD . (getoberit.com)
Patients with glucocorticoid excess, Cushing's syndrome, develop a characteristic constellation of adverse metabolic features including central obesity, insulin resistance, proximal muscle wasting, hypertension and non-alcoholic fatty liver disease (NAFLD). (uni-luebeck.de)
We have shown in cross-sectional and intervention clinical studies that 5α-reductase activity is dysregulated in metabolic disease including obesity and NAFLD and have postulated that this represents a compensatory mechanism to protect the liver form the adverse effects of cortisol. (uni-luebeck.de)
Non-alcoholic fatty liver disease (NAFLD) is becoming a major cause of chronic liver disease in relation to the increasing prevalence of obesity and type-2 diabetes in the general population. (arasysperfector.com)
In the setting of obesity, NAFLD encompasses a wide disease spectrum including triacylglycerol (TAG) accumulation in hepatocytes (steatosis) and steatosis with inflammation, fibrosis, and cirrhosis (non-alcoholicsteatohepatitis, NASH) (Ángulo, 2006). (arasysperfector.com)
[ 1 ] Tripodi et al reported that in nonalcoholic fatty liver disease (NAFLD), a procoagulant imbalance progresses from steatosis to metabolic cirrhosis, which may be caused by an increase in factor VIII and a reduction of protein C. (medscape.com)
Background We aimed to evaluate the effect of cranberry supplementation on serum liver enzymes, hepatic steatosis, and cardiometabolic risk factors in patients with non-alcoholic fatty liver (NAFLD). (cranberryinstitute.org)
Conclusion The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD. (cranberryinstitute.org)
In the current study, we explored the association of circulating plasma concentrations of GDF15 with NAFLD in youth with overweight/obesity, and whether changes in plasma concentrations in GDF15 parallel the changes in intrahepatic fat content (HFF%) over time. (nature.com)
These data suggest that plasma GDF15 concentrations change with change in intrahepatic fat content in youth with overweight/obesity and may serve as a biomarker for NAFLD in children. (nature.com)
So far, there are no studies investigating whether plasma GDF15 concentrations in youth with obesity are associated with NAFLD. (nature.com)
In this study, we sought to determine whether GDF15 plasma concentrations are associated with (1) intrahepatic fat content, (2) changes in intrahepatic fat accumulation over time, and (3) the metabolic phenotype related to NAFLD in youth with obesity. (nature.com)
Herein, we show that in youth with overweight/obesity, GDF15 plasma concentration is associated with NAFLD and NAFLD-related phenotypes and that changes in plasma GDF15 concentration are driven by changes in intrahepatic fat content. (nature.com)
Both NAFLD and its progression into NASH are seen almost simultaneously, with at least some of the components of metabolic syndrome. (nursingcenter.com)
In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
With the global rise in obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic hepatic condition, affecting approximately 25% of adults worldwide. (medpagetoday.com)
NAFLD can affect multiple organ systems -- which is not surprising as the liver has multiple functions, including regulating metabolism and serving as a central organ of the immune system. (medpagetoday.com)
A small number of single-center studies suggested that individuals with NAFLD may be at increased risk for bacterial infections and that this risk is independent of known risk factors, such as features of the metabolic syndrome. (medpagetoday.com)
A significantly increased risk of severe infection was already present in patients with simple steatosis, and we observed that the risk increased with the severity of NAFLD. (medpagetoday.com)

Previous studies have reported the therapeutic properties of A. iwayomogi on obesity, hyperlipidemia, and liver fibrosis [ 7 , 8 ]. (hindawi.com)
We succeeded in defining suitable culture conditions to maintain the 3D coculture for up to 10 days in vitro , with the lowest level of steatosis and reproducible low level of inflammation and fibrosis. (xiahepublishing.com)
The cell model exhibited the key NASH disease phenotypes of hepatocyte injury, steatosis, inflammation, and fibrosis. (xiahepublishing.com)
6 Weight loss induced by diet and exercise has also been shown to be effective in resolving NASH and improving hepatic fibrosis. (xiahepublishing.com)
Conclusion In women with HIV and central obesity, the hepatic steatosis/fibrosis marker Chi3L1 and adiponectin decrease in conjunction with sST2 decreases following switch to RAL. (elsevierpure.com)
The high-carbohydrate high-fat diet induced an impaired glucose tolerance, insulin resistance, obesity, elevated blood pressure, dyslipidaemia, cardiovascular remodelling such as hypertrophy and fibrosis, increased cardiac stiffness, hepatic disorders such as inflammation and steatosis, along with elevated plasma markers of liver function. (edu.au)
2003). This specific pathology is characterized by steatosis, lobular and portal inflammation, hepatocyte ballooning, and fibrosis (Brunt & Tiniakos, 2010). (ugr.es)
This progression increases their risk for advanced fibrosis by up to five-fold compared to those who maintain at the stage of simple steatosis. (getoberit.com)
In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
Patients with type 2 diabetes treated with triple therapy had less hepatic steatosis and fibrosis and significantly improved insulin sensitivity versus conventional therapy. (hcplive.com)
4. Concomitant biopsy-proven Stage 1-3 hepatic fibrosis by NASH CRN criteria by central read (Kleiner 2005). (who.int)
Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
Hepatic fibrosis corresponds to the formation of an abnormally large amount of scar tissue in the liver. (enterosys.com)

Nearly one-third diagnosed with simple steatosis eventually develop NASH over time according to recent studies published in the PLOS ONE Journal . (getoberit.com)

FPLD recapitulates the main metabolic attributes of the insulin resistance syndrome, including central obesity, hyperinsulinemia, glucose intolerance and diabetes usually type 2, dyslipidemia, hypertension, and early endpoints of atherosclerosis. (wikipedia.org)
Using a mouse model of excess corticosterone exposure, we found that the ability of glucocorticoids to increase adiposity, weight gain, hormonal dysregulation, hepatic steatosis, and dyslipidemia was reduced or reversed in mice lacking the cannabinoid CB 1 receptor as well as mice treated with the global CB 1 receptor antagonist AM251. (johnshopkins.edu)
Nordihydroguaiaretic acid (NDGA), the main metabolite of Creosote Bush, has been shown to have profound effects on the core components of metabolic syndrome, including lowering of blood glucose, free fatty acids and triglyceride levels, attenuating elevated blood pressure in several rodent models of dyslipidemia, and improving body weight, insulin resistance, diabetes and hypertension. (biomedcentral.com)
In the present study, a high-fructose diet fed rat model of hypertriglyceridemia, dyslipidemia, insulin resistance and hepatic steatosis was employed to investigate the global transcriptional changes in the lipid metabolizing pathways in three insulin sensitive tissues: liver, skeletal muscle and adipose tissue in response to chronic dietary administration of NDGA. (biomedcentral.com)
MetS is characterized by central obesity, dyslipidemia, elevated blood pressure, and elevated plasma glucose (Gonçalves et al. (ugr.es)
The study aimed to estimate the prevalence of obesity, high blood pressure (HBP) and dyslipidemia and its associated factors. (bvsalud.org)

Patients with GC excess (Cushing s syndrome) develop central obesity, insulin resistance and hepatic steatosis. (endocrine-abstracts.org)

Adverse hepatic outcomes related to NASH may include cirrhosis, liver failure, and hepatocellular carcinoma. (xiahepublishing.com)
1. Presence of ascites, hepatic encephalopathy, or other clinical evidence of cirrhosis. (who.int)
The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
Cutaneous manifestations of cirrhosis include jaundice, spider angiomata, skin telangiectasias ("paper money skin"), palmar erythema, white nails, disappearance of lunulae, and finger clubbing, especially in the setting of hepatopulmonary syndrome. (medscape.com)

Subsequently he obtained fellowships from the Wellcome Trust and most recently an MRC senior clinical fellowship investigating the pathogenesis of human obesity and insulin resistance. (uni-luebeck.de)
His research investigates the pathogenesis of human obesity, insulin resistance and non-alcoholic fatty liver disease. (uni-luebeck.de)
Advances in the understanding of the pathogenesis of alcoholic steatosis have provided some useful insights, including the role of peroxisome proliferator-activated receptor alpha, which is crucial for the regulation of hepatic fatty acid metabolism. (medscape.com)
Serum leptin, a cytokine-type peptide hormone mainly produced by adipocytes, may play an important role in the pathogenesis of steatosis. (medscape.com)

Further, waste products from coffee production are a potential source for new interventions in diet-induced cardiovascular and metabolic diseases. (edu.au)
She is also an active researcher and her interests include endocrine physiology and endocrine and metabolic diseases of dogs and cats. (rossu.edu)
Therefore, it has been suggested that the modulation of gut microbiota could be a reliable tool to prevent metabolic and inflammatory diseases. (springer.com)
The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. (phoenixpeptide.com)
Ginseng ( Panax ginseng C. A. Mey) has a wide range of their therapeutic functions anti-stress, health promotion, maintaining and enhancing central and immune systems, preventing certain chronic diseases, as well as aging deterrent properties. (frontiersin.org)
Our innovative methods allow us to tap into new knowledge by exploring new approaches for the treatment of metabolic diseases and disorders. (enterosys.com)
Considering high prevalence rates of metabolic diseases linked by insulin resistance, we performed a systematic review of existing literature which addressed the role of probiotics in modulating insulin sensitivity in animals and humans. (biomedcentral.com)

Background People with HIV are at for metabolic syndrome (MetS) and fatty liver disease, but the role of Antiretroviral therapy (ART) is poorly understood. (elsevierpure.com)
Metabolic syndrome (MetS) is a cluster of interrelated metabolic conditions which increase the risk of developing cardiovascular disease (Kaur, 2014). (ugr.es)

The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
Perhaps, the strongest risk factors for the development of NASH syndrome are obesity and insulin resistance. (nursingcenter.com)
This group tends to develop the other criteria of metabolic syndrome and run a much greater risk of developing NASH. (nursingcenter.com)
Two main entities can be distinguished: isolated steatosis or steatosis accompanied by minimal lobular inflammation (non-alcoholic fatty liver or NAFL) and non-alcoholic steatohepatitis (NASH). (enterosys.com)
Non-alcoholic steatohepatitis (NASH) is defined by the presence of steatosis with lobular inflammation and ballooning of the hepatocytes. (enterosys.com)

Methods Cryopreserved plasma was obtained from a completed, prospective trial of HIV-infected women with central adiposity on NNRTI- or PI-based ART during which they were randomized to remain on their current ART or switch to a RAL based regimen. (elsevierpure.com)

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. (mdpi.com)
Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. (hindawi.com)
ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. (hindawi.com)
Among these, nonalcoholic fatty liver (NAFL) refers to hepatic steatosis alone, which is very common 1 and driven by the accumulation of intracellular lipid droplets. (xiahepublishing.com)
This has resonance because ectopic fat accumulation appears to represent a central component of disease progression regardless of whether obesity is also part of the equation. (biomedcentral.com)
Dietary administration of NDGA decreased plasma levels of TG, glucose, and insulin, and attenuated hepatic TG accumulation. (biomedcentral.com)

We propose that 5αR may regulate GC exposure and therefore may modulate metabolic phenotype in human liver.Primary human hepato. (endocrine-abstracts.org)
Similarly, a neutral, peripherally restricted CB 1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects. (johnshopkins.edu)
To test the role of the liver, specific and exclusive deletion of hepatic CB 1 receptor resulted in a rescue of the dyslipidemic effects of glucocorticoid exposure, while not affecting the obesity phenotype or the elevations in insulin and leptin. (johnshopkins.edu)
Adopting a truly translational, bench-to-bedside approach, my work has defined the role of pre-receptor glucocorticoid metabolism within key target tissues upon the development of global metabolic phenotype. (uni-luebeck.de)
Most recently, based upon observations in a patient with Cushing's disease without a clinical phenotype, we have identified a novel role for 11β-HSD1 in controlling the response to exogenous glucocorticoid excess raising the potential for therapeutic inhibition of 11β-HSD1 may not only as a treatment for Cushing's disease, but as an approach to the treatment of iatrogenic glucocorticoid excess to limit adverse metabolic effects. (uni-luebeck.de)

Diet is important in the development of metabolic syndrome assisted by increased oxidative stress and inflammation. (edu.au)
It is concluded that weight loss improves the n-3 LCPUFA status of obese patients in association with significant amelioration in the biomarkers of oxidative stress, membrane FA insaturation, and n-3 LCPUFA biosynthesis capacity, thus representing a central therapeutic issue in the improvement of obesity-related metabolic alterations involved in the mechanism of hepatic steatosis. (arasysperfector.com)
These hepatic alterations are related to insulin resistance and oxidative stress as crucial pathogenic factors (Videla et al. (arasysperfector.com)

HCC recurrence, liver-related complications (ascites/ variceal bleeding/ hepatic encephalopathy) and mortality were monitored. (springer.com)
Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
Findings on physical examination in hepatic encephalopathy include asterixis and fetor hepaticus. (medscape.com)
An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
Computed tomography (CT) scanning and MRI studies of the brain may be important in ruling out intracranial lesions when the diagnosis of hepatic encephalopathy is in question. (medscape.com)

Metabolic syndrome is defined as a cluster of metabolic abnormalities including obesity, hyperlipidemia, hyperglycemia, insulin resistance, and hypertension [ 3 ]. (hindawi.com)
Metabolic syndrome is the constellation of metabolic disorders such as central obesity, dyslipidaemia, insulin resistance, impaired glucose tolerance and hypertension. (edu.au)
Chronic Noncommunicable Disease (CND) is responsible for 63% of the 56.5 million deaths annually worldwide and is the leading cause of death and disability in the world, with obesity, diabetes mellitus type 2 (DM2), poor diet, smoking, high cholesterol, sedentary lifestyle, hypertension and alcohol consumption as the main risk factors 1 . (bvsalud.org)

These data further our understanding of the role of endocannabinoid signaling to promote not only diet-induced, but also, hormonal-mediated obesity and support the argument that peripheral blockade of endocannabinoid signaling could be a potential treatment for obese conditions. (iasvn.org)
Thus, reports based on the survey-specific BMI percentiles would always designate 5 percent of children as obese and would fail to detect any true increasing prevalence of obesity across surveys. (nationalacademies.org)
Early Career Author Prize 2017 from Experimental Physiology to the first author (Marcus Machado) - Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. (rossu.edu)
Editor's choice in Experimental Physiology - Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. (rossu.edu)
At the time of surgery, controls and obese patients exhibited a hepatic polyunsaturated fatty acid (PUFA) pattern that correlated with that of erythrocytes. (arasysperfector.com)
Obese children are at risk for developing numerous obesity-related conditions and medical problems during childhood ( Table 3 ). (txpeds.org)
Included in the list of obesity-related conditions are the psychological and social effects on overweight and obese children. (txpeds.org)
Promising results of fecal transplantation have also emerged from clinical trials including obese individuals with metabolic disturbances [ 9 ]. (biomedcentral.com)

CB 1 R −/− mice are also protected against the CORT-induced increase in ( G ) liver weight, ( H ) plasma cholesterol, ( I ) alanine aminotransferase (ALT), ( J ) triglycerides, and ( K ) hepatic triglycerides. (iasvn.org)

Consequently, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)
With scientific evidence suggesting their role in inflammation, insulin sensitivity, and fat and energy metabolism, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)
The prevalence of metabolic syndrome is increasing worldwide. (edu.au)

2000) (see Chapter 3 for a more extensive discussion about the use of terms for childhood overweight and childhood obesity). (nationalacademies.org)
In this narrative review, we consider a number of explanations that have been forwarded regarding the pathological progression to type 2 diabetes both with and without the concurrent influence of overweight/obesity. (biomedcentral.com)
Overweight/obesity is a well-established risk factor that accounts for 80-85% of the likelihood of developing T2D [ 3 , 4 ]. (biomedcentral.com)
Plasma GDF15 concentrations were measured by ELISA in 175 youth with overweight/obesity who underwent an oral glucose tolerance test (OGTT) and magnetic resonance imaging (MRI) to assess intrahepatic, visceral, and subcutaneous fat. (nature.com)
To achieve our aims, we measured GDF15 in 175 youth with overweight/obesity who underwent an oral glucose tolerance test and an MRI to measure intrahepatic fat content. (nature.com)

This includes conditions such as type II diabetes, obesity, and hypertriglyceridemia. (medscape.com)

Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. (mdpi.com)
Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabolic co-morbidities. (biomedcentral.com)
Hence, this study aims to recognize various risk factors including metabolic components and blood parameters to predict the possible incidence of the disease. (biomedcentral.com)
Obesity and associated metabolic disorders (e.g., cardiovascular disease and type 2 diabetes) are major public health concerns. (iasvn.org)
adolescent obesity is equated to the proportion of those who are in the upper end of the BMI distribution-specifically, at or above the age- and gender-specific 95th percentile of the Centers for Disease Control and Prevention's (CDC's) BMI charts for children and youth aged 2 through 19 years 2 (Kuczmarski et al. (nationalacademies.org)
On the other hand, several studies suggested that diet might influence gut microbiota composition and activity thus modulating the risk of metabolic disease, i.e. obesity, insulin resistance and type 2 diabetes. (springer.com)
If electron microscopic examination is expected for a potential metabolic disease, additional tissue should be fixed in 3% buffered glutaraldehyde. (basicmedicalkey.com)
Central obesity refers to excessive abdominal fat around the stomach area, which increases your chances significantly towards developing this disease. (getoberit.com)
We are living the midst a global epidemic of metabolic disease with rapidly escalating rates of obesity, type 2 diabetes and insulin resistance. (uni-luebeck.de)
In patients with alcoholic liver disease, the serum leptin level appears to be independently correlated with the grade of steatosis. (medscape.com)
The condition most commonly associated with fatty liver disease is metabolic syndrome. (medscape.com)
PCOS is a heterogeneous disease characterized by hyperandrogenism, dysfunctional ovulation, and polycystic ovary morphology, accompanied by metabolic abnormalities, such as insulin resistance (IR) and obesity. (biomedcentral.com)
Metabolic Syndrome (MS) and obesity, mainly visceral obesity, are associated with increased mortality due to Coronary Artery Disease (CAD). (biomedcentral.com)
This condition results in the development of pathological conditions such as type 2 diabetes, obesity, cardiovascular disease, hepatic steatosis and stroke. (enterosys.com)

Serum total bilirubin =2.0 mg/dL (unless subject has known Gilbert's Syndrome). (who.int)
Hepatorenal syndrome is diagnosed when a creatinine clearance rate of less than 40 mL/min is present or when a serum creatinine level of greater than 1.5 mg/dL, a urine volume of less than 500 mL/day, and a urine sodium level of less than 10 mEq/L are present. (medscape.com)

Biochemical analyses showed that chronic excess glucocorticoid exposure produced a significant increase in hepatic and circulating levels of the endocannabinoid anandamide, whereas no effect was observed in the hypothalamus. (johnshopkins.edu)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)

In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model. (hindawi.com)

Exosomes have previously been associated with a number of endocrine disorders, including obesity, type 2 diabetes mellitus, disorders of the reproductive system and cancer. (spandidos-publications.com)

My studies show the promising potential of functional foods against life-style associated metabolic disorders. (edu.au)
Targeting the Enteric Nervous System to Treat Metabolic Disorders? (enterosys.com)

We have previously shown that 11β-HSD1KO mice are protected from both the adverse metabolic effects of excess glucocorticoids and age-associated muscle weakness. (endocrine-abstracts.org)
In comparing the factors that contribute to the buildup of excess calories in obesity, an imbalance of energy homeostasis can be considered as the basis. (wjgnet.com)
Excess insulin is a significant cause of central obesity, and even worse it results in an increase in appetite. (walkingoffpounds.com)
Obesity is defined as an excess of body weight with a body max index higher than 30kg/m2. (enterosys.com)

The medicinal plants Artemisia iwayomogi ( A. iwayomogi ) and Curcuma longa ( C. longa ) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). (hindawi.com)
The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model. (hindawi.com)
In traditional Korean medicine (TKM) and traditional Chinese medicine (TCM), metabolic abnormalities are considered indicative of " dampness/phlegm " ( 濕痰 ) and " blood stasis " ( 瘀血 ) [ 6 ]. (hindawi.com)
CB 1 R signaling is required for GC-mediated metabolic abnormalities. (iasvn.org)

These findings suggest that NDGA ameliorates hypertriglyceridemia and steatosis primarily by inhibiting lipogenesis and enhancing fatty acid catabolism in three major insulin responsive tissues by altering the expression of key enzyme genes and transcription factors involved in de novo lipogenesis and fatty acid oxidation. (biomedcentral.com)

The vast majority possess type 2 diabetes (T2D), a disorder that is linked with the 'American obesity epidemic. (biomedcentral.com)

Recent evidence shows that glucocorticoids possess the ability to increase endocannabinoid signaling, which is known to regulate appetite, energy balance, and metabolic processes through both central and peripheral pathways. (johnshopkins.edu)
His work has focussed on glucocorticoid action and metabolism and in particular the role of the pre-receptor metabolizing enzymes to regulate metabolic function. (uni-luebeck.de)
2004). LCPUFA are known to regulate hepatic lipid metabolism by modulating related enzyme expression at the level of gene transcription, mRNA processing and decay, and post-translational protein modifications, directing FA away from TAG storage and into oxidation and secretion (Clarke, 2004). (arasysperfector.com)

2006). In particular, hepatic steatosis can be influenced by insulin resistance through induction of a higher peripheral lipolysis with enhanced fluxes of fatty acids (FA) and glycerol to the liver, thus favouring lipogenesis (Saltiel & Khan, 2001). (arasysperfector.com)

In some patients, fatty liver may be accompanied by hepatic inflammation and liver cell death (steatohepatitis). (medscape.com)

Improving these pathological conditions, especially obesity, is major therapeutic goals for treating metabolic syndrome. (hindawi.com)
Natural remedies are currently attracting more attention as therapeutic or protective agents for treating metabolic syndrome [ 5 ]. (hindawi.com)
Plant-based diets provide potential therapeutic approaches to metabolic syndrome. (edu.au)

Growing rates of obesity represent a global lifestyle-related health problem [ 1 ]. (biomedcentral.com)

In the present study, we test the hypothesis that reactivation of glucocorticoids, in peripheral tissues by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is a major determinant of exogenous Cushing s syndrome.WT, global 11β-HSD1 knockout (GKO), liver-specific 11β-HSD. (endocrine-abstracts.org)
Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathologies are linked. (biomedcentral.com)
Prevalence of insulin resistance, obesity and type 2 diabetes in the US adult population. (biomedcentral.com)
In particular, animal studies support a causal role between the composition of the gut microbiota and development of obesity, insulin resistance and type 2 diabetes (T2D). (springer.com)
Importantly, preliminary data from parallel translational studies suggest that specific inhibition of 5α-reductase type 1 may lead to hepatic steatosis and impaired adipose tissue function. (uni-luebeck.de)
Metabolic syndrome is a combination of conditions that include insulin resistance/Type II diabetes, HTN, hyperlipidemia, and obesity. (nursingcenter.com)
With obesity being a major risk factor for type 2 DM, pediatric care providers must now view type 2 DM as a pediatric illness ( 3 ). (txpeds.org)

Prostate cancer patients treated with testosterone deprivation therapy, either through orchidectomy or leuprolide injection, show increased obesity. (edu.au)
Thus, fish oils may provide an option to reduce metabolic syndrome while leuprolide treatment continues in patients with prostate cancer. (edu.au)
Significantly more patients in the cranberry group experienced a decrease in steatosis level compared with the control group. (cranberryinstitute.org)
Though limited data exist, Dr. Dunfaif believes there's are indications of cardiovascular risk in patients of all ages with polycystic ovary syndrome. (hcplive.com)

Therefore, we evaluated the effect of ACE on major manifestations of metabolic syndrome including obesity, hyperlipidemia, and fatty liver using a high-fat diet mouse model. (hindawi.com)
They come together as a symbiotic relationship, such as obesity coupled with insulin resistance, and with these come HTN and hyperlipidemia. (nursingcenter.com)

Magnetic resonance (MR) elastography and proton density fat fraction (PDFF) are emerging techniques for non-invasive assessment of liver stiffness and steatosis, respectively. (springer.com)

The aim of this study was to determine the role of endocannabinoid signaling in glucocorticoid-mediated obesity and metabolic syndrome. (johnshopkins.edu)
However, in simple obesity, circulating glucocorticoid levels are not elevated. (uni-luebeck.de)

Another possible anti-obesity target is the CB2 receptor. (researchgate.net)

In highii carbohydrate, high-fat fed rats, leuprolide treatment worsened metabolic syndrome symptoms and cardiovascular function, and orchidectomy produced greater responses. (edu.au)
Reduce symptoms of irritable bowel syndrome (IBS) (an intestinal disorder that causes pain in the belly, gas, diarrhea, and constipation). (mskcc.org)

This characterization clearly appears to apply to childhood obesity. (nationalacademies.org)
Intervention and prevention of childhood obesity should begin as early in life as possible. (txpeds.org)
Early intervention is critical for the prevention of childhood obesity. (txpeds.org)
Additionally, childhood obesity may be an independent risk factor for adult morbidity and mortality, regardless of the persistence of childhood obesity ( 2 ). (txpeds.org)

The specific mechanisms by which GCs modulate these processes remain largely unknown, but GCs increase production of endocannabinoids-potent central and peripheral regulators of appetite, energy balance, and metabolism. (iasvn.org)
All of these mechanisms favor steatosis. (medscape.com)

He embarked upon a career in Diabetes and Endocrinology and secured an MRC Clinical Training Fellowship in 2000 and obtained his PhD from University of Birmingham studying steroid metabolism and human obesity in 2003. (uni-luebeck.de)
In a clinical setting BMI is a useful tool in assessing children's weight status, but additional clinical information is useful in making the diagnosis of obesity. (txpeds.org)
Consistent beneficial results for intestinal barrier function, immune system and metabolism were reported in animals may encourage long-term randomized clinical trials in people with obesity and cardiometabolic risk. (biomedcentral.com)

Together, these data indicate that glucocorticoids recruit peripheral endocannabinoid signaling to promote metabolic dysregulation, with hepatic endocannabinoid signaling being especially important for changes in lipid metabolism. (johnshopkins.edu)
Our results show that sustained exposure to GCs produces obesity and metabolic syndrome through a peripheral endocannabinoid mechanism. (iasvn.org)
It is present in both the central nervous system and peripheral organs including the kidney. (degruyter.com)
For intravenous infusion into a peripheral or central vein. (drugs.com)

The liver has dual inflow supply, with approximately two-thirds from the low pressure, low O 2 portal vein, and one-third from the systemic pressure, high O 2 hepatic artery. (basicmedicalkey.com)
The lobule, often used interchangeably with acinus, is a term based on the concept of the hexagon in which hepatic cords radiate from the central vein toward the portal tracts. (basicmedicalkey.com)
Greater than or equal to 900 mOsm/L must be infused through a central vein. (drugs.com)
During angiography, a catheter is placed selectively via either the transjugular or transfemoral route into the hepatic vein to measure portal pressure. (medscape.com)

Anatomy17

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Psychiatry and Psychology6

Phenomena and Processes52

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture4

Information Science3

Named Groups3

Health Care33

Geographicals11

NAFLD31

Fibrosis13

Simple steatosis1

Dyslipidemia6

Insulin resistance and hepatic steatosis1

Cirrhosis4

Pathogenesis4

Diseases8

MetS2

NASH5

Adiposity1

Accumulation6

Phenotype5

Oxidative stress3

Encephalopathy5

Hypertension3

Obese8

Triglycerides1

Prevalence of metabolic syndrome3

Overweight5

Conditions such as type II diabe1

Disease14

Serum2

Chronic2

Diet-induced1

Endocrine1

Disorders2

Excess4

Abnormalities4

Hypertriglyceridemia1

Epidemic1

Regulate3

Influenced by insulin resistance1

Steatohepatitis1

Therapeutic3

Rates of obesity1

Type7

Patients4

Hyperlipidemia2

Stiffness1

Glucocorticoid2

Receptor1

Symptoms2

Childhood obesity4

Mechanisms2

Clinical3

Peripheral4

Vein4