• One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
  • Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. (sciendo.com)
  • The aim of the present work is to study the possible role of ozone therapy in ameliorating oxidative stress and inducing renal antioxidant defence in streptozotocin (STZ)-induced diabetic rats. (biomedcentral.com)
  • Induction of DM in rats significantly elevated blood pressure, HbA 1c , BUN, creatinine and renal tissue levels of MDA and AR while significantly reducing SOD, CAT and GPx activities. (biomedcentral.com)
  • Ozone administration in conjunction with insulin in DM rats reduces oxidative stress markers and improves renal antioxidant enzyme activity which highlights its potential uses in the regimen for treatment of diabetic patients. (biomedcentral.com)
  • Ozone administration also been shown to exert a protective effect against liver damage induced by carbon tetrachloride and renal ischemic-reperfusion injury by an oxidative preconditioning mechanism that stimulates antioxidant endogenous systems and modulates nitric oxide (NO) production [ 14 ]. (biomedcentral.com)
  • 2012). Crocin "saffron" protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. (sciendo.com)
  • 1996): Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin. (ankara.edu.tr)
  • Rosiglitazone, a PPAR-gamma agonist, plays a protective role in hippocampal neuron damage of GCIRI rats by inhibiting the oxidative stress response and inflammation. (biomedcentral.com)
  • The main purpose of this work is to determine the role of ozone administration in ameliorating oxidative stress in STZ-induced DN in diabetic rats so as to establish its potential use in the strategy for the treatment of diabetic patients. (biomedcentral.com)
  • Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of neuropathic pain in rat CCI model. (molecularhydrogenstudies.com)
  • Cerebral ischaemia is caused by middle cerebral artery occlusion, which leads to some brain tissue damage, accompanied by inflammation and immune response [ 2 ]. (biomedcentral.com)
  • Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism. (deepdyve.com)
  • We therefore investigated the effects of PM2.5 exposure on insulin resistance and the disorders of hepatic glucose and lipid metabolism via hypothalamic inflammation. (deepdyve.com)
  • Therefore, our current finding indicates an important role of hypothalamic inflammation in PM2.5 exposure-mediated hepatic glucose and lipid metabolism disorder. (deepdyve.com)
  • Six groups (n = 10) of male Sprague Dawley rats were used as follows: Group C: Control group. (biomedcentral.com)
  • This study was carried out on 60 male Sprague-Dawley rats weighing between 150 and 200 g obtained from the National Research Centre, Cairo, Egypt. (biomedcentral.com)
  • Methods: Sprague-Dawley rats were randomly divided into 4 groups: sham operated group (Sham), Sham with Picroside II treatment group (Sham+ Pic II), l/R group (l/R) and l/R with Picroside II treatment group (I/R+ Pic II). (bvsalud.org)
  • The rats had been sacrificed immediately after 4 or 24 h of reperfusion, and liver and serum samples were collected for evaluation.Measurement of H2S concentration and aminotransferase levels inside the plasmaThe rats were euthanized four h immediately after reperfusion. (lckinhibitor.com)
  • The rats were fed by gavage immediately after reperfusion. (biomedcentral.com)
  • In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
  • The model used in this study was established by middle cerebral artery occlusion (MCAO) and reperfusion. (biomedcentral.com)
  • The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
  • According to the World Health Organization, cerebral ischaemia is the second leading cause of death and the third leading cause of disability in the world [ 1 ]. (biomedcentral.com)
  • According to the theory of TCM, cerebral ischaemia, which is also called stroke, can be induced by hyperactivity of liver Yang, disordered diet, stagnation of blood, etc. (biomedcentral.com)
  • In 2007, Dr. Ohta's team reported in Nature Medicine [3] that inhalation of 2-4% hydrogen gas significantly reduced the cerebral infarct volumes in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion. (h2-aqua.com)
  • The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. (biomedcentral.com)
  • Global cerebral ischemia/reperfusion injury (GCIRI) occurs in patients who are successfully resuscitated from various clinical conditions such as cardiac arrest, asphyxia and shock, which are frequently accompanied by inflammation and can lead to serious neuronal injury, and further to neurodegeneration and learning and memory impairment [ 12 ]. (biomedcentral.com)
  • Proinflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tissue necrosis factor (TNF)-α, have been implicated as important mediators of injury following cerebral ischemia [ 13 ] and contribute to pathogenesis, exacerbating brain tissue damage following ischemia/reperfusion (I/R) injury [ 14 ]. (biomedcentral.com)
  • Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
  • Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes [J].2008,47(5). (wanfangdata.com.cn)
  • Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. (wanfangdata.com.cn)
  • Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. (wanfangdata.com.cn)
  • Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury. (wanfangdata.com.cn)
  • Although the treatment did not affect hepatic inflammation or endoplasmic reticulum stress, it inhibited the expression of the enzymes for gluconeogenesis and lipogenesis in the liver. (deepdyve.com)
  • The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury [J].2016,100(2). (wanfangdata.com.cn)
  • hepatic inflammatory processes, acute hepatotoxicity etc. (wikipedia.org)
  • Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
  • Rosiglitazone treatment significantly protected rats from SLM function impairment and neuron death, and resulted in higher expressions of SOD activity and NF-kappa B, but lower contents of MDA and inflammatory factors. (biomedcentral.com)
  • Bakan V, Çıralık H, Tolun F (2009): Protective effect of erythropoietin on torsion/detorsion injury in rat model. (ankara.edu.tr)
  • 2008. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation. (ankara.edu.tr)
  • In rat model of I/R injury, pretreatment of pre-miR-30c or 3-MA (an inhibitor for autophagy) can abrogated spinal cord protective effect of H2S. (biomedcentral.com)
  • Twenty-four male rat DCD donor livers were randomly and averagely divided into normal, static cold storage (SCS), NMP, and NMP combined with BMMSCs groups. (medscimonit.com)
  • Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. (wanfangdata.com.cn)
  • Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers [J].2017,216. (wanfangdata.com.cn)
  • Pig and rat livers were harvested, and human liver samples were obtained from surgical resection specimens. (psu.edu)
  • Rats in sham group were sacrified at 100 minutes observation after laparotomy. (bvsalud.org)
  • Forty 7 d old clean grade C57BL/6J male neonatal rats were randomly divided into control group, model group, low-dose group and high-dose group. (ijpsonline.com)
  • 40 adult male Sprague-Dawlay rats were randomly divided into 5 groups: the sham, LPS, LPS + HBO, LPS + HRS and LPS + HBO + HRS. (researchsquare.com)
  • Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
  • HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)
  • At the end of the subchronic FA exposure, the blood samples, heart and aorta tissues of the rats were taken and subjected to biochemical analyses. (bvsalud.org)
  • Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
  • 1998): The effects of twisted ischemic adnexa managed by detorsion on ovarian viability and histology: an ischemia-reperfusion rodent model. (ankara.edu.tr)
  • A rat GCIRI model was established by occlusion of bilateral common carotid arteries and cervical vena retransfusion. (biomedcentral.com)
  • In the present study, authors aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). (molecularhydrogenstudies.com)
  • We hypothesized that the porcine liver is better than the rat liver as a model for the study of human liver Ca 2+ -ATPase activity. (psu.edu)
  • We conclude that the Ca 2+ -ATPase activity in the pig liver is equivalent to that of human liver, and thus, the pig liver is a better model than the rat liver. (psu.edu)
  • The present study was undertaken to study the effects of exogenous H2S on ischemia/reperfusion (I/R) injury of spinal cord and the underlying mechanisms. (biomedcentral.com)
  • The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. (bepress.com)
  • Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. (bepress.com)
  • Albino rats (4C7 weeks postnatal) 2140-46-7 manufacture 2140-46-7 manufacture were deeply anaesthetized with halothane in oxygen and killed by cervical dislocation (process approved under. (gasyblog.com)
  • A total of 24 Wistar Albino rats were used in our study. (bvsalud.org)
  • Cold preservation studies showed a significant decrease in porcine hepatic PM Ca 2+ -ATPase activity after 4 hours of storage and near-total inhibition after 12 hours. (psu.edu)
  • Porcine hepatic ER Ca 2+ -ATPase activity showed a 45% decrease in activity by 12 hours and a 69% decrease by 18 hours. (psu.edu)
  • Ischemia, along with the other groups received a comparable volume of saline. (lckinhibitor.com)
  • Ischemia, as well as the other groups received a comparable volume of saline. (lckinhibitor.com)
  • Vasoconstriction and, perhaps, various proinflammatory effects exerted by TxA on tissue microvasculature, is probable reason why the TxA is pathogenic in various diseases, such as ischemia-reperfusion injury. (wikipedia.org)
  • Burczynski, F. J. Effects of Long-Term Hepatic Ischemia-Reperfusion Injury on the Function of P-Glycoprotein in Vivo in Rats. (ualberta.ca)
  • 21]Peralta,C.,Jiménez-Castro,M.B.,Gracia-Sancho,J.. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu [J].2013,59(5). (wanfangdata.com.cn)
  • PM2.5 exposure leads to hepatic insulin resistance (IR) that was accompanied by endoplasmic reticulum (ER) stress-induced apoptosis (Laing et al. (deepdyve.com)
  • Group DIO, in which diabetic rats received the same doses of insulin and ozone, respectively. (biomedcentral.com)
  • Group DO: In which diabetic rats received the same dose of ozone, 48 h after induction of diabetes. (biomedcentral.com)
  • This was not significantly different from human liver, whereas rat liver was significantly greater at 2.60 ± 0.03 and 9.2 ± 0.9 nmol of Ca 2+ /mg of protein/min, respectively. (psu.edu)
  • To investigate the mechanism of sodium tanshinone IIA sulfonate inhibiting hypoxia induced retinal neovascularization in rats. (ijpsonline.com)
  • Abstract Purpose: To investigate the effect of Picroside II on testicular ischemia and reperfusion (l/R) injury and the underlying mechanism. (bvsalud.org)
  • 29256408 ). N-Acetyltryptophan has also been shown to have a role in preventing hepatic ischemia-reperfusion injury. (hmdb.ca)
  • This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
  • 2014): Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile. (ankara.edu.tr)
  • Disposition in Fischer 344 rats following intravenous and oral administration. (cdc.gov)
  • For the NaHS groups, distinct doses of NaHS (12.five, 25 or 50 mol/kg) had been injected intravenously five min before the onset of liver ischemia. (lckinhibitor.com)
  • Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury. (sciendo.com)
  • 2003): Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. (ankara.edu.tr)
  • 2003): The effect of thyroidectomy on sexual cycle and pregnancy rates in rats. (ankara.edu.tr)
  • The purpose of this study is to investigate the simultaneous effect of atorvastatin and combined training in NAFLD-induced rats. (ac.ir)