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  • livers
  • In this study, we perfused rat livers from DCD before cold preservation with oxygenated warm buffer containing Prostaglandin E1 and observed bile production, liver cell death, mitochondrial function of liver cell and so on during reperfusion with oxygenated buffer. (nii.ac.jp)
  • In the result, these treatments improved liver function of the livers from DCD after reperfusion. (nii.ac.jp)
  • Twenty four or 72 h following a 60-min partial ischemia or sham operation in rats, livers were isolated and perfused ex vivo with a constant concentration (~100 ng/mL) of RH-123. (ualberta.ca)
  • Kupffer
  • ROS include hydrogen peroxide (H(2)O(2)), superoxide anion (O(-2)), and hydroxyl radical (HO(-)), which may be generated by activated Kupffer cells in the liver, contributing to reperfusion injury. (nih.gov)
  • hepatectomy
  • In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy. (sigmaaldrich.com)
  • H. Q. Wang, J. Y. Yang, and L. N. Yan, "Hemihepatic versus total hepatic inflow occlusion during hepatectomy: a systematic review and meta-analysis," World Journal of Gastroenterology , vol. 17, no. 26, pp. 158-164, 2011. (hindawi.com)
  • portal vein
  • The hepatic I/R injury model was generated by clamping the hepatic artery, portal vein, and common bile duct with a microvascular bulldog clamp for 30 min, and then removing the clamp and allowing reperfusion for 6 h. (mdpi.com)
  • Blood supply of the hepatic artery and portal vein to the left and the median liver lobes was occluded for 90 min after 30-min washout time. (medsci.org)
  • saline
  • Male Lewis rats were separated into two groups: an MSC group given MSCs after reperfusion as treatment, and a Control group given phosphate-buffered saline after reperfusion as placebo. (sigmaaldrich.com)
  • 32 pentobarbital-anesthetized Sprague-Dawley rats were equally randomized into four groups: laparotomy group (Sham group), hepatic I/R and normal saline infusion group (I/R+S group), I/R and lipid vehicle infusion (I/R+V group), or I/R and 8% emulsified isoflurane infusion (I/R+E group) at the rate of 8 ml·kg -1 ·h -1 for 30 min. (medsci.org)
  • The aim of this study was to evaluate the effect of hydrogen-rich saline (HS) on hepatic ischemia-reperfusion (I/R) injury. (molecularhydrogenstudies.com)
  • Groups II and IV was also received normal saline and crocin and then experienced a 45 min ischemia followed by 1 hr reperfusion. (ac.ir)
  • serum
  • Findings indicated that crocin dramatically elevated the activity of antioxidant enzymes, and attenuated serum concentrations of hepatic and cardiac enzymes. (ac.ir)
  • hemodynamic
  • Crocin also inhibited histopathological disarrangements, and modulated hemodynamic parameters beyond IR-induced hepatic insult. (ac.ir)
  • Dysfunction
  • In conclusion our studies demonstrate a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future. (harvard.edu)