• Risk factors for development of intrahepatic CCA include opisthorchus viverrini infection, Clonorchis sinensis infection, sclerosing cholangitis, choledochal cysts, past procedures of the biliary tree, exposure to thorotrast and dioxins, and cirrhosis. (wikipedia.org)
  • Bile duct tumors aren't all cancerous. (marijuanadoctors.com)
  • A couple examples of non-cancerous (benign) tumors are bile duct adenomas and bile duct hamartomas. (marijuanadoctors.com)
  • Since your bile duct is situated deep inside your body, doctors can't easily detect tumors during routine physical examinations. (marijuanadoctors.com)
  • [ 1 ] The classification of bile duct tumors has changed to include intrahepatic tumors of the bile ducts and extrahepatic tumors (perihilar and distal) of the bile ducts. (tri-kobe.org)
  • Tumors of the intrahepatic bile ducts originate in small intrahepatic ductules or large intrahepatic ducts that are proximal to the bifurcation of the right and left hepatic ducts. (tri-kobe.org)
  • These tumors are also known as intrahepatic cholangiocarcinomas. (tri-kobe.org)
  • Interestingly, the immunohistochemical results also showed that the classic hepatic progenitor cell (HPCs) markers CD34 and CD117 were both positive of the two tumors. (biomedcentral.com)
  • Percutaneous thermal ablation of hepatic tumors is accepted as a safe, reliable, and cost-effective therapeutic option for treating hepatocellular carcinoma and hepatic metastases. (dirjournal.org)
  • This review will focus on the various vascular complications related to percutaneous thermal ablation of hepatic tumors and discuss strategies to avoid and manage these complications. (dirjournal.org)
  • To approach centrally located tumors more cautiously, avoid tumors abutting large major blood vessels and biliary ducts. (dirjournal.org)
  • Several studies, trials, and meta-analyses comparing thermal ablation with surgical resection of small hepatic tumors have shown that thermal ablation is less expensive and invasive. (dirjournal.org)
  • Significant needle tract bleeding is a major complication (Common Terminology Criteria for Adverse Events grade 3 or higher) of percutaneous thermal ablation of hepatic tumors, as it can be immediately life-threatening and may lead to prolonged hospitalization. (dirjournal.org)
  • Needle tract bleeding is also the most common vascular complication related to percutaneous thermal ablation of hepatic tumors. (dirjournal.org)
  • The inflammatory AML should be distinguished from other tumors with inflammatory background such as inflammatory myofibroblastic tumor and follicular dendritic cell tumor and deserves wider recognition for its occurrence as a primary hepatic tumor. (biomedcentral.com)
  • Of these, inflammatory or pelioid pattern usually presents as a focal finding within the tumor, but very rarely, they become the predominant pattern [ 4 ], creating great diagnostic confusion with other tumors such as inflammatory myofibroblastic tumor (IMT), follicular dendritc cell (FDC) tumor and other hepatic mesenchymal neoplasms. (biomedcentral.com)
  • Hendriquez R, Keihanian T, Goyal J, Abraham RR, Mishra R, Girotra M. Radiofrequency ablation in the management of primary hepatic and biliary tumors. (wjgnet.com)
  • In the United States, 80%-90% of primary hepatic tumors are hepatocellular carcinomas and 10%-15% are cholangiocarcinomas (CCA), both with high mortality rate, particularly CCA, which portends a worse prognosis. (wjgnet.com)
  • Cystic duct , 6. (wikipedia.org)
  • The biliary tree also includes the cystic duct, the right and left hepatic ducts, and the common hepatic and common bile ducts, as well as a series of microscopic biliary vessels. (cdc.gov)
  • It consists of a rounded fundus, smooth body and tapering neck, which becomes contiguous with the cystic duct and attaches to the porta hepatis. (cdc.gov)
  • Meanwhile, 40 hepatocellular carcinoma (HCC) patients and 26 metastatic hepatic SCC or ASC patients who were hospitalized in the same period were also reviewed to make a comparison. (biomedcentral.com)
  • We report the case of a 27-year-old Iranian woman with congenital hepatic fibrosis leading to cirrhosis and subsequently hepatocellular carcinoma. (biomedcentral.com)
  • During preparation for transplant, a hepatic mass was discovered which was found to be hepatocellular carcinoma. (biomedcentral.com)
  • Caroli disease and Caroli syndrome are rare congenital disorders of the intrahepatic bile ducts. (medscape.com)
  • This form is less common than Caroli syndrome, in which malformations of small bile ducts and congenital hepatic fibrosis are also present. (medscape.com)
  • [ 1 ] As with congenital hepatic fibrosis , Caroli syndrome is often associated with autosomal recessive polycystic kidney disease (ARPKD) . (medscape.com)
  • therefore, Caroli syndrome is thought to belong in the same spectrum of disease as congenital hepatic fibrosis and ARPKD. (medscape.com)
  • Caroli syndrome (ectasia of the large and small bile ducts with congenital hepatic fibrosis) is more common than Caroli disease (ectasia of only the large bile ducts). (medscape.com)
  • The incidence of ARPKD/congenital hepatic fibrosis is approximately 1:20,000 live births. (medscape.com)
  • Patients with Caroli syndrome or Caroli disease may have cholangitis and may also have complications of portal hypertension as is observed in congenital hepatic fibrosis. (medscape.com)
  • Nakanuma Y, Harada K, Sato Y, Ikeda H. Recent progress in the etiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia. (medscape.com)
  • Congenital hepatic fibrosis in children. (medscape.com)
  • Congenital dilation of the intrahepatic bile ducts. (medscape.com)
  • The second is called Caroli syndrome, which consists of Caroli disease and congenital hepatic fibrosis and might lead to portal hypertension leading to esophageal varices and splenomegaly. (raredis.org)
  • Congenital hepatic fibrosis is an uncommon cause of portal hypertension. (biomedcentral.com)
  • Congenital hepatic fibrosis is included in the group of congenital diseases of fibropolycystic disorders. (biomedcentral.com)
  • Cholangitis occurs in the presence of partial or complete obstruction of the common bile duct (CBD), with increased intraluminal pressures, bacterial infection of the bile with multiplication of the organisms within the duct, and seeding of the bloodstream with bacteria or endotoxin. (medscape.com)
  • Fortunately, the left hepatic duct was judged to be normal by imaging. (elsevierpure.com)
  • Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)
  • Cancers may occur in any area of your bile duct system. (marijuanadoctors.com)
  • They group them as extrahepatic bile duct cancers with distal bile duct cancers. (marijuanadoctors.com)
  • You may also divide bile duct cancers into kinds determined by the appearance of cancer cells under a microscope. (marijuanadoctors.com)
  • Regardless of type, physicians refer to almost all bile duct cancers as cholangiocarcinomas. (marijuanadoctors.com)
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of bile duct cancers. (tri-kobe.org)
  • Many bile duct cancers are multifocal. (tri-kobe.org)
  • Endoscopic retrograde cholangiopancreatography (ERCP) showed complete obstruction of the common hepatic duct, which was caused by clipping during laparoscopic cholecystectomy. (elsevierpure.com)
  • There is inadequate information to document the effectiveness of PEI as an alternative to surgical resection for the treatment of hepatic metastases. (aetna.com)
  • Therefore, we elected to perform a right hepatic lobectomy and left hepaticojejunostomy, because we felt that performing a hepaticojejunostomy without hepatic resection would put the patient at risk of continuing to suffer from cholangitis. (elsevierpure.com)
  • We performed hepatic resection of both segments. (biomedcentral.com)
  • Hepatic resection is the preferred and most effective treatment choice. (biomedcentral.com)
  • Perisinusoidal fibrosis can be caused by intrasinusoidal accumulation of pathologic cells, advanced intrasinusoidal macrophagocytic storage diseases and by activation of the vitamin A-storing hepatic stellate cells. (springer.com)
  • Chapter 23 (Intrahepatic Bile Ducts) describes it as "nontumoral hepatic parenchymal fibrosis/cirrhosis. (cancer.gov)
  • ERCP image showing the pancreatic duct and biliary tree . (wikipedia.org)
  • laparoscopic examination of the biliary system for screening of stones and evaluation of hepatic and pancreatic lesions, etc. (imagingsol.com.au)
  • The true incidence of bile duct cancer is unknown, however, because establishing an accurate diagnosis is difficult. (tri-kobe.org)
  • 1 , 2 , 4 , 5 Incidence and mortality rates for intrahepatic CC have risen steeply and steadily across the world over the past few decades with concomitant falls in extrahepatic CC rates. (bmj.com)
  • Investigations including complete blood count, blood smear, bone marrow biopsy, esophagoscopy, abdominal ultrasound, and computed tomography scan show splenomegaly associated with hypersplenism, fourth-grade non-bleeding varices, intrahepatic cystic formations in the left and right lobes, and an atrial septal defect with a left-to-right shunt. (raredis.org)
  • A 48-year-old Chinese female with underlying hepatitis B virus (HBV) infection was found to have a low echoic hepatic nodule by abdominal ultrasound. (biomedcentral.com)
  • There are still several controversies and ambiguities in the aspects of primary hepatic squamous cell carcinoma and primary hepatic adenosquamous carcinoma. (biomedcentral.com)
  • We reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China. (biomedcentral.com)
  • Both primary hepatic squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC) are very rare. (biomedcentral.com)
  • Improving resectability of hepatic colorectal metastases: expert consensus statement. (cancercentrum.se)
  • Laboratory examinations revealed anaemia, elevated hepatic enzymes, elevated bilirubin profile that suggested obstructive jaundice and raised CA 19.9 levels. (eurorad.org)
  • Bile is isosmotic with plasma and consists primarily of water and electrolytes but also organic compounds: bile salts, phospholipids (mostly lecithin), cholesterol, bilirubin, and other endogenously produced or ingested compounds, such as proteins that regulate gastrointestinal function and drugs or their metabolites. (merckmanuals.com)
  • Bile salts are also biologic detergents that enable the body to excrete cholesterol and potentially toxic compounds (eg, bilirubin, drug metabolites). (merckmanuals.com)
  • CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
  • Primary hepatic carcinoid tumor (PHCT) is very rare and difficult to diagnose before biopsy or operation. (biomedcentral.com)
  • PHCT should be one of the differential diagnoses in patients with small hepatic tumor, even in regions with high prevalence of HBV infection and HCC. (biomedcentral.com)
  • Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). (biomedcentral.com)
  • Computed Tomography (CT) revealed intrahepatic and extrahepatic bile duct dilation. (ispub.com)
  • They presented peripheral hepatic lymph node metastasis more likely and showed low proportion of microvascular invasion. (biomedcentral.com)
  • Distal cholangiocarcinomas are found further down the bile duct, closer to the small intestine. (moffitt.org)
  • The extrahepatic bile ducts can be further divided into the perihilar (hilum) region and distal region. (tri-kobe.org)
  • As food moves through the digestive tract, bile is released into the small intestine, where it aids digestion and facilitates the body's absorption of fats. (moffitt.org)
  • In the absence of symptoms of the primary disease, most patients with bile duct strictures remain asymptomatic until the lumen of the bile duct is sufficiently narrowed to cause resistance to the flow of bile. (medscape.com)
  • We also review the current literature of related clinicopathological features and investigate the origin of double primary hepatic cancer. (biomedcentral.com)
  • Minimally invasive therapies like image-guided percutaneous thermal ablation have gained widespread acceptance as a method for treating focal primary and secondary hepatic malignancies. (dirjournal.org)
  • In order to find out the definite survival information of SCC and ASC patients, 30 previous studies containing 37 primary hepatic SCC (16) and ASC (21) patients were reviewed, and their information of survival was analyzed together with the included patients in our hospital. (biomedcentral.com)
  • The comprehensive application of some clinical characteristics, histopathologic features, and imaging findings may be useful for us in making definite diagnoses for primary hepatic SCC and ASC patients preoperatively. (biomedcentral.com)
  • We retrospectively investigated some primary hepatic SCC or ASC patients in our hospital to research the characteristics of these two kinds of diseases. (biomedcentral.com)
  • There were just nine patients who suffered from histologically proven primary hepatic SCC (three patients) or ASC (six patients) had surgical treatment during the 14 years in our hospital, and all of them were included as the primary SCC/ASC group. (biomedcentral.com)
  • most intestinal bile salts reach the terminal ileum, which actively absorbs 90% of bile salts into the portal venous circulation. (merckmanuals.com)
  • We report a case requiring biliary reconstruction with right hepatic lobectomy due to biliary strictures caused by continuous cholangitis after laparoscopic bile duct injury. (elsevierpure.com)
  • Bile does not normally flow retrograde into the pancreatic duct. (merckmanuals.com)
  • Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. (lookformedical.com)
  • Knock-in mice expressing a CCN1 mutant that is unable to bind α v β 5 /α v β 3 were impaired in ductular reaction, leading to massive hepatic necrosis and mortality after bile duct ligation (BDL), whereas treatment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and mortality. (jci.org)
  • The precursor of the intrahepatic biliary tree is a sheath of cells surrounding the portal vein branches, known as the ductal plate (DP). (medscape.com)
  • Cholangiography from percutaneous transhepatic biliary drainage (PTBD) catheters revealed that sections of the secondary branches of the right intrahepatic bile duct had become constricted due to persistent cholangitis. (elsevierpure.com)
  • The resulting inflammatory folliculitis stimulates keratinization of the sebaceous gland ducts and outer root sheath of the hair, leading to the formation of keratin cysts. (cdc.gov)
  • Odievre M et al (1981) Long-term prognosis for infants with intrahepatic cholestatis and patent extrahepatic biliary tract. (altmeyers.org)