• The pharmacokinetics of [HA562 trade name] has not been studied in patients with hepatic impairment. (who.int)
  • Provide dosing considerations for individuals with renal or hepatic impairment and important drug-drug and food interactions. (hivguidelines.org)
  • Patients with Hepatic Impairment: Mild hepatic impairment - 200 mg twice daily. (nih.gov)
  • Moderate or severe hepatic impairment. (nih.gov)
  • The risk increases with conditions such as renal impairment, sepsis, dehydration, excess alcohol intake, hepatic impairment and acute congestive heart failure. (centerwatch.com)
  • Do not administer to patients with severe hepatic impairment or history of hypersensitivity reaction to abacavir that led to discontinuation of treatment. (msf.org)
  • Administer with caution to patients with hepatic impairment or coinfection with hepatitis B or hepatitis C virus. (msf.org)
  • Reduce dosage in patients with severe renal or hepatic impairment. (msf.org)
  • Lamivudine is a rare cause of liver test abnormalities or clinically apparent liver injury in patients with HIV infection without hepatitis B. Although several instances of lactic acidosis with hepatic steatosis and liver failure have been reported in patients receiving lamivudine, in all instances other nucleoside analogues more clearly associated with mitochondrial injury [didanosine, stavudine, zalcitrabine, zidovudine] were also being taken. (nih.gov)
  • Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including lamivudine and zidovudine (components of lamivudine and zidovudine tablets). (nih.gov)
  • Hepatic steatosis and lactic acidosis caused by stavudine in an HIV-infected patient. (nih.gov)
  • Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including stavudine and other antiretrovirals. (wikidoc.org)
  • Suspend therapy if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. (renalandurologynews.com)
  • Lactic acidosis or hyperlactatemia +/- hepatic steatosis (consider in pts with progressive fatigue, abd. (unboundmedicine.com)
  • Synjardy comes with a Black Box Warning for the risk of lactic acidosis, a serious metabolic complication that can occur due to metformin accumulation during treatment with Synjardy. (centerwatch.com)
  • metformin is contraindicated in patients with acute or chronic metabolic acidosis. (pdr.net)
  • Lactic acidosis should be suspected in any diabetic patient with metabolic acidosis lacking evidence of ketoacidosis (ketonuria and ketonemia). (pdr.net)
  • It is a form of metabolic acidosis, in which excessive acid accumulates due to a problem with the body's metabolism of lactic acid. (diabetestalk.net)
  • Suspend treatment if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur. (nih.gov)
  • Abacavir Tablets, USP for Oral UseInitial U.S. Approval: 1998RECENT MAJOR CHANGESDosage and Administration (2) 05/2012Warnings and Precautions, Hypersensitivity Reaction (5.1) 05/2012Warnings and Precautions, Immune Reconstitution Syndrome (5.3) 11/2011BOXED WARNINGWARNING: HYPERSENSITIVITY REACTIONS, LACTIC ACIDOSIS, AND SEVERE HEPATOMEGALY See full prescribing information for complete boxed warning. (drugs-library.com)
  • lactic acidosis, pancreatitis and hepatic disorders. (msf.org)
  • Concomitant use with ddI/didanosine and hydroxyurea may increase the risk of fat redistribution, peripheral neuropathy, pancreatitis, and/or lactic acidosis. (hivmanagement.org)
  • Lactic acidosis is characterized by elevated blood lactate levels, acidemia, electrolyte disturbances, an increased anion gap, and an increased lactate/pyruvate ratio. (pdr.net)
  • Fatal lactic acidosis has been reported in pregnant women who received the combination of stavudine and didanosine with other antiretroviral agents. (wikidoc.org)
  • Hepatic decompensation, some fatal, has occurred in HIV-1/HCV co-infected patients receiving combination antiretroviral therapy and interferon alfa with/without ribavirin. (nih.gov)
  • 5×ULN or, discontinue if accompanied by hepatitis or hepatic decompensation. (renalandurologynews.com)
  • Monitor hepatic function closely in these patients and, if appropriate, initiate anti-hepatitis B treatment. (nih.gov)
  • Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning. (diabetestalk.net)
  • The onset of lactic acidosis often is subtle, and accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress. (pdr.net)
  • Symptoms and signs of lactic acidosis are dominated by those of the underlying disorder (eg, shock in Type A, toxin ingestion in Type B). (msdmanuals.com)
  • Neurologic symptoms, including confusion, ataxia, and slurred speech, occur after a high-carbohydrate ingestion and are characteristic of D-lactic acidosis. (msdmanuals.com)
  • If you are on any of these medications and have any symptoms of lactic acidosis, get medical help immediately. (diabetestalk.net)
  • He underwent endoscopic retrograde cholangiopancreatography (ERCP) and biliary stenting, had complications of post sphincterotomy bleed, retroperitoneal hematoma and post laparoscopic cholecystectomy sepsis with acute sickle hepatic crisis. (bvsalud.org)
  • Lactic acidosis may also occur in association with a number of pathophysiologic conditions, including diabetes mellitus, and whenever there is significant tissue hypoperfusion and hypoxemia or significant renal dysfunction. (pdr.net)
  • Transporters aid hepatic, renal, and biliary clearance of drugs and may be susceptible to drug interactions. (medscape.com)
  • In patients with jejunoileal bypass or intestinal resection and resultant short bowel syndrome, excess D-lactic acid is produced and is systemically absorbed. (msdmanuals.com)
  • We present a patient with toxemia of pregnancy and the HELLP syndrome [hemolysis (H), elevated liver enzymes (EL), and a low platelet count (LP)] resulting in massive hepatic necrosis. (symptoma.com)
  • Type A lactic acidosis, the most serious form, occurs when lactic acid is overproduced in ischemic tissue-as a byproduct of anaerobic generation of ATP ( adenosine triphosphate) during oxygen deficit. (msdmanuals.com)
  • D-Lactic acidosis is an unusual form of lactic acidosis in which excess D-lactic acid is produced. (msdmanuals.com)
  • D-lactic acid is normally produced in small quantities as the product of carbohydrate metabolism by bacteria in the colon. (msdmanuals.com)
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Informet 500 may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood. (citalopramx.com)
  • The diagnosis is made on biochemical analysis of blood (often initially on arterial blood gas samples), and once confirmed, generally prompts an investigation to establish the underlying cause to treat the acidosis. (diabetestalk.net)
  • Most drug interactions with ARV drugs are mediated through inhibition or induction of hepatic drug metabolism. (medscape.com)
  • In rare chronic forms of lactic acidosis caused by mitochondrial disease, a specific diet or dichloroacetate may be used. (diabetestalk.net)