• Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. (fredhutch.org)
  • Therapeutic options for severe hepatic veno-occlusive disease (VOD) are limited and outcomes are dismal, but early phase I/II studies have suggested promising activity and acceptable toxicity using the novel polydisperse oligonucleotide defibrotide. (fredhutch.org)
  • The U.S. FDA approved defibrotide sodium for adults and children with hepatic veno-occlusive disease (VOD) with additional kidney or lung abnormalities after they have received hematopoietic cell transplantation (HCT). (ashclinicalnews.org)
  • This is the first FDA-approved treatment for severe hepatic VOD. (ashclinicalnews.org)
  • Based on published reports and analyses of patient-level data, the expected survival rates 100 days after HCT would be 21 to 31 percent for patients with severe hepatic VOD who received only supportive care or interventions other than defibrotide, the study researchers noted. (ashclinicalnews.org)
  • Hepatic VOD is a condition in which some of the veins in the liver become blocked, causing swelling and a decrease in blood flow inside the liver, which may lead to liver damage. (ashclinicalnews.org)
  • Hepatic encephalopathy ( HE ) is an altered level of consciousness as a result of liver failure . (wikipedia.org)
  • Hepatic encephalopathy can occur in those with acute or chronic liver disease. (wikipedia.org)
  • More commonly, especially in chronic liver disease, hepatic encephalopathy is triggered by an additional cause, and identifying these triggers can be important to treat the episode effectively. (wikipedia.org)
  • Hepatic veins are blood vessels which transport the liver's deoxygenated blood and blood which has been filtered by the liver (this is blood from the pancreas, colon, small intestine, and stomach) to the inferior vena cava. (innerbody.com)
  • The hepatic veins originate in the liver lobule's central vein. (innerbody.com)
  • Hepatic encephalopathy refers to the neurological symptoms that can occur as a result of liver failure. (news-medical.net)
  • Laparoscopic treatment of simple hepatic cysts and polycystic liver disease. (medscape.com)
  • Polycystic liver disease: a critical appraisal of hepatic resection, cyst fenestration, and liver transplantation. (medscape.com)
  • Congenital hepatic fibrosis is a disease of the liver that is present from birth. (medlineplus.gov)
  • The hepatic portal system is a branching network of veins (portal veins) that carry blood from the gastrointestinal tract to the liver for processing. (medlineplus.gov)
  • People with congenital hepatic fibrosis have an enlarged liver and spleen (hepatosplenomegaly). (medlineplus.gov)
  • LIPC gene mutations prevent the release of hepatic lipase from the liver or decrease the enzyme's activity in the bloodstream. (medlineplus.gov)
  • The liver contains many cell types including hepatic parachymal cells, Kiipffer cells, Ito cells, and endothelial cells. (springer.com)
  • The common hepatic artery is the vessel which supplies oxygen-rich blood to a number of important organs: the liver, the duodenum, the pylorus, and the pancreas. (innerbody.com)
  • What Is a Hepatic (Liver) Function Panel? (kidshealth.org)
  • Hepatic encephalopathy (HE), the neuropsychiatric presentation of liver disease, is associated with high morbidity and mortality. (hindawi.com)
  • There are a plethora of therapeutic approaches to targeting varying severities of hepatic encephalopathy (HE), the neuropsychiatric presentations of liver disease. (hindawi.com)
  • Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. (hindawi.com)
  • Hepatic encephalopathy (HE) is a spectrum of neuropsychiatric abnormalities seen in patients with liver dysfunction after exclusion of other known brain diseases [ 1 ]. (hindawi.com)
  • Hepatic hemangiomas should be differentiated from other benign and malignant space-occupying liver lesions. (medscape.com)
  • Malignant liver tumors include hepatocellular carcinoma , hepatic angiosarcoma and hepatic metastases. (medscape.com)
  • Tan ST, Itinteang T, Leadbitter P. Low-dose propranolol for multiple hepatic and cutaneous hemangiomas with deranged liver function. (medscape.com)
  • The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. (nih.gov)
  • Probiotics could emerge as a treatment plan to manage hepatic encephalopathy (HE) therapy after a new study announced at the International Liver Congress 2013 found they significantly reduced development of the notoriously difficult-to-treat disease. (redorbit.com)
  • Prof. Bernardi said: "Hepatic encephalopathy is an insidious disease that's caused by an accumulation of toxins in the blood that are normally removed by the liver. (redorbit.com)
  • Hepatic encephalopathy is a spectrum of neuropsychiatric abnormalities including personality changes, intellectual impairment and reduced levels of consciousness in patients with liver failure, after exclusion of other known brain disease. (redorbit.com)
  • hepatic coma Hello, My mum has been an alcoholic for years and has been in a coma due to liver failure twice, one 6 years ago and one in may this year, where niether the nurses or consultant thought she would make it out. (medhelp.org)
  • Hepatic (biliary) cystadenomas are rare multilocular cystic tumors of the liver that are derived from the biliary epithelium and are predominantly located in the right hepatic lobe. (medscape.com)
  • In 1892, Keen reported the first case of hepatic cystadenoma , which now accounts for 5% of all cystic lesions of the liver. (medscape.com)
  • Overt hepatic encephalopathy affects approximately 20% of patients with liver cirrhosis each year. (bmj.com)
  • Studies suggest that the prevalence of chronic liver disease in the United Kingdom is increasing, in part owing to the increasing prevalence of non-alcoholic fatty liver disease (NAFLD), alcohol related liver disease, and hepatitis C. 5 6 Clinicians therefore need to be able to recognise signs and symptoms of hepatic encephalopathy in patients who might not have a diagnosis of chronic liver disease. (bmj.com)
  • This review aims to highlight the importance of recognising hepatic encephalopathy in chronic liver failure and outlines a practical and evidence based approach to its management, based on the framework of recent guidelines from the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD). (bmj.com)
  • 4 Hepatic encephalopathy in acute liver failure is managed differently, and will not be addressed. (bmj.com)
  • A polygonal histologic unit of the liver, consisting of masses of liver cells arranged around a central vein that is a terminal branch of one of the hepatic veins, and at whose periphery branches of the portal vein, hepatic artery, and bile duct are located. (dictionary.com)
  • Hepatic vein thrombosis (HVT) is an obstruction in the hepatic veins of the liver caused by a blood clot. (healthline.com)
  • Percutaneous hepatic perfusion (PHP) is a minimally invasive treatment that delivers high-dose chemotherapy directly to metastatic melanoma in the liver. (moffitt.org)
  • At Moffit Cancer Center, percutaneous hepatic perfusion is offered to treat melanoma that has spread to the liver (as often occurs with ocular melanomas), and select other tumors metastatic to the liver. (moffitt.org)
  • We demonstrate that Galectin-3 expression is up-regulated in established human fibrotic liver disease and is temporally and spatially related to the induction and resolution of experimental hepatic fibrosis. (pnas.org)
  • The reduction in hepatic fibrosis observed in the Galectin-3 −/− mouse occurred despite equivalent liver injury and inflammation, and similar tissue expression of TGF-β. (pnas.org)
  • Finally, in vivo siRNA knockdown of Galectin-3 inhibited myofibroblast activation after hepatic injury and may therefore provide an alternative therapeutic approach to the prevention and treatment of liver fibrosis. (pnas.org)
  • Hepatic parenchymal disease is damage to the functional cells of the liver, according to HealthTap. (reference.com)
  • Although liver disease is often associated with alcoholism, there are more than 100 hepatic diseases caused by a variety of factors, says the Canadian Liver Foundation. (reference.com)
  • Hepatic parenchymal disease can be difficult to diagnose because either the symptoms are vague and similar to those of other diseases or there are no symptoms until the liver has suffered significant damage, as the Canadian Liver Foundation explains. (reference.com)
  • The vet found a liver mass , he biopsed the mass (tru-cut) and the result were Hepatic lipi. (medhelp.org)
  • In this randomized, double-blind, placebo-controlled trial, we randomly assigned 299 patients who were in remission from recurrent hepatic encephalopathy resulting from chronic liver disease to receive either rifaximin, at a dose of 550 mg twice daily (140 patients), or placebo (159 patients) for 6 months. (nih.gov)
  • Hepatic infarcts in pregnancy are mostly secondary to APS (Anti-Phospholipid Syndrome), HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and preeclampsia. (thefreelibrary.com)
  • The differential diagnoses of intra hepatic infarction include intrahepatic abscess, acute fatty liver of pregnancy, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, ruptured hepatic adenoma, hepatocellular carcinoma and hemangioma. (thefreelibrary.com)
  • the right hepatic artery , vein, and right hepatic canal were saved (Figure 2, 3), and the parenchymal dissection of the right liver lobe was performed with an ultrasonic dissector and isolated with a sterile plastic bag (Figure 4). (thefreedictionary.com)
  • Hepatic encephalopathy describes a spectrum of potentially reversible neuropsychiatric abnormalities seen in patients with liver dysfunction and/or portosystemic shunting. (uptodate.com)
  • A hepatic flexure polyp is a growth in the first bend of the colon, near the liver, according to YourSurgery.com. (reference.com)
  • Unfortunately, a frequently diagnosed ailment called hepatic lipidosis can severely impair the health and proper functioning of a cat's liver and, if not promptly reversed, can be fatal. (cornell.edu)
  • In more than 90 percent of cases, says Dr. Center, hepatic lipidosis is a secondary consequence of some other underlying condition, such as obesity , diabetes , cancer , hyperthyroidism , pancreatitis , kidney disease , or another type of liver problem. (cornell.edu)
  • Hepatic encephalopathy is a brain disorder that develops in some individuals with liver disease. (rarediseases.org)
  • Hepatic encephalopathy can occur in individuals with acute or chronic liver (hepatic) disease or in individuals whose liver is bypassed by a portosystemic shunt (with no liver disease present). (rarediseases.org)
  • Hepatic encephalopathy is caused when toxins that are normally cleared from the body by the liver accumulate in the blood, eventually traveling to the brain. (rarediseases.org)
  • Hepatic encephalopathy may develop slowly over time in individuals with chronic liver disease or may occur episodically, worsening and then improving only to recur. (rarediseases.org)
  • While the symptoms are similar among these different subtypes of hepatic encephalopathy, individuals with acute liver failure are more likely to have swelling (edema) in the brain and increased pressure within the skull (intracranial hypertension), which can potentially cause life-threatening complications. (rarediseases.org)
  • Liver vascular volume was measured by sonomicrometry calibrated against integrated hepatic inflow during outflow occlusion. (ahajournals.org)
  • In this study, we introduce a modified sonomicrometric method in which integrated hepatic vascular inflow during brief occlusions of outflow is used for volumetric calibration, allowing in vivo calibrations without disturbing liver architecture. (ahajournals.org)
  • The aims of the present study were to determine the ability of this method to accurately measure liver blood volume and to evaluate the reproducibility of the method in assessing hepatic vascular pressure-volume curves. (ahajournals.org)
  • A hepatic hemangioma is the most common noncancerous liver tumor. (empowher.com)
  • Hepatic hemangiomas are found more often in the right lobe of the liver than the left lobe. (empowher.com)
  • The common hepatic duct is the part of the biliary tract formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). (wikipedia.org)
  • The hepatic duct is part of the biliary tract that transports secretions from the liver into the intestines . (wikipedia.org)
  • one of three hepatic segments that constitute the left (part of) liver, the one which lies to the left of the inferior portion of the falciform ligament, typically overlapping the stomach anteriorly, supplied by the lower lateral branch from the umbilical part of the left branch of the hepatic portal vein. (drugs.com)
  • Hepatic neoplasia is cancer of the liver which can occur in dogs. (petplace.com)
  • A hepatic tumor is an abnormal growth of cells in or on the liver. (wisegeek.com)
  • Signs of a hepatic tumor are hepatomegaly (liver enlargement), abdominal pain and jaundice. (wisegeek.com)
  • The term hepatic refers to the liver. (wisegeek.com)
  • Signs of a hepatic tumor can include abdominal pain, jaundice , and hepatomegaly, an enlargement of the liver that may be palpable. (wisegeek.com)
  • strawCake - That's so interesting that hepatic tumors/liver cancers are more common in certain parts of the world then others. (wisegeek.com)
  • Primary hepatic carcinoid tumors are extremely rare, and their origin is not well known, there are several theories which include that chronic inflamation in the biliary system may initiate intestinal metaplasia, another possible explanation is that they originate from ectopic pancreatic or adrenal tissues found within the liver. (sages.org)
  • A hepatic vein is any of the veins that carry oxygen depleted blood out of the liver and into the inferior vena cava. (wisegeek.com)
  • The group of hepatic veins meets with the inferior vena cava at the posterior, or back, side of the liver. (wisegeek.com)
  • Blood transported through a hepatic vein includes the blood that was used to feed the liver as well as blood from most other abdominal organs. (wisegeek.com)
  • The liver receives deoxygenated blood from other organs through hepatic portal veins and oxygenated blood to feed itself through the hepatic artery. (wisegeek.com)
  • Hepatic veins are divided into two groups, upper and lower, based on where the veins emerge out of the liver. (wisegeek.com)
  • Veno-occlusive hepatic disorder or veno-occlusive disorder is the obstruction of small microscopic veins of the liver. (openpr.com)
  • Correspondingly, liver-specific ROCK1 deletion prevented the development of severe hepatic steatosis and reduced hyperglycemia in obese diabetic (ob/ob) mice. (jci.org)
  • Of pathophysiological significance, hepatic ROCK1 was markedly upregulated in humans with fatty liver disease and correlated with risk factors clustering around NAFLD and insulin resistance. (jci.org)
  • Mechanistically, we found that hepatic ROCK1 suppresses AMPK activity and a ROCK1/AMPK pathway is necessary to mediate cannabinoid-induced lipogenesis in the liver. (jci.org)
  • Upon high-fat feeding, the endocannabinoids 2-AG and AEA are produced and released from hepatic stellate cells of the liver. (jci.org)
  • In summary, in the present study, blueberries possessed a therapeutic effect on CCl4-induced hepatic fibrosis in rats through inhibiting liver inflammation and lipid peroxidation, and may be not related to the induction of phase-II enzymes through the activation of Nrf2 in rat liver during long-term of CCl4. (natap.org)
  • Hepatic ischemia is a condition in which the liver does not get enough blood or oxygen, causing injury to liver cells. (floridahealthfinder.gov)
  • Death from liver failure due to hepatic ischemia is very rare. (floridahealthfinder.gov)
  • Liver and vascular compression, arterial embolization, blood interruption by tapes or clamps, as well as previous intraparenchymal small vessels ligation and greasing the hepatic parenchyma with several different substances are well accepted procedures 1 - 7 . (scielo.br)
  • Judging from the remarkable increase of TXB2, a stable metabolite of TXA2 during hepatectomy, it may be suggested that TXA2 plays an important role in the development of liver damage during hepatic resection. (biomedsearch.com)
  • Dietary krill oil supplementation reduces hepatic steatosis (fatty liver), glycemia, and hypercholesterolemia (high cholesterol) in high-fat-fed mice. (greenmedinfo.com)
  • Nonetheless, one possible way utilized in dosage guidance is classifying drugs by the extent to which the liver metabolizes them, a process known as the hepatic extraction ratio . (uspharmacist.com)
  • A late stage liver condition, known as minimal hepatic encephalopathy (MHE), is associated with impaired driving skills and greater risk of motor vehicle accidents. (eurekalert.org)
  • Between 2009 - 2010, the hepatic steatosis (fatty liver) was assessed by re-reviewing the archived gall bladder ultrasound video images originally obtained in NHANES III between 1988 and 1994. (cdc.gov)
  • Hepatic lipodystrophy in Galloway calves is a fatal liver disease affecting a small proportion of the Galloway breed described in different parts of Europe and North America during the past decades. (uni-muenchen.de)
  • Hepatic encephalopathy is a problem with the brain that is caused by liver disease. (portsmouthhospital.com)
  • Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices. (portsmouthhospital.com)
  • Human OCT1 is expressed primarily in the liver, localized in the basolateral membrane of hepatocytes mediating the hepatic uptake of several cationic drugs (e.g., metformin). (diabetesjournals.org)
  • A portosystemic shunt, commonly abbreviated and referred to as PSS, hepatic shunt or liver shunt, is an abnormal communication between blood vessels, which causes blood to bypass the liver that can occur in dogs. (petplace.com)
  • Hepatic insufficiency or liver failure is a state of the liver in which this organ is unable to fulfill its normal functions. (botanical-online.com)
  • Not properly treated, the filtering function of the liver is impaired, so a lot of waste products can accumulate in blood and can lead to a hepatic coma. (botanical-online.com)
  • Occlusion of the hepatic veins (Chiari's syndrome) or occlusion of arterial blood supply to the liver. (botanical-online.com)
  • Insights on the use of liver transplantation as a treatment for severe hepatic encephalopathy. (ajmc.com)
  • It accompanies the hepatic artery, ramifying upon its branches, and upon those of the portal vein in the substance of the liver. (wikipedia.org)
  • Hepatic porphyrias is a form of porphyria in which the enzyme deficiency occurs in the liver. (wikipedia.org)
  • Here we showed that hepatic Rho-kinase 1 (ROCK1) drives obesity-induced steatosis in mice through stimulation of de novo lipogenesis. (jci.org)
  • For the hepatic steatosis assessments, the video tapes of the NHANES III ultrasound examinations were digitized using a DVD-VHS Video cassette Recorder (SONY RDR-VX560) onto a Recordable DVD (Memorex, +R or +RW). (cdc.gov)
  • Quality control and quality assurance procedures were used to standardize the reading form all readers (see below and Procedure Manual, Hepatic Steatosis). (cdc.gov)
  • A more detailed description of the protocol is included in the Procedure Manual, Hepatic Steatosis, NCHS 2010. (cdc.gov)
  • All ultrasound assessments for hepatic steatosis were conducted by readers who had no access to any other participant data. (cdc.gov)
  • A diagnosis of a hepatic carcinoid is far more likely to be a metastasis from the gastrointestinal tract than a true primary. (sages.org)
  • Arterial thromboses of both large and small hepatic arteries are seen. (thefreelibrary.com)
  • Gastroenterology faculty, nurse practitioners and physician assistants had excellent concordance in classifying grade 2 or higher hepatic encephalopathy compared with gastroenterology and hepatology physicians, according to a recently published study. (healio.com)
  • The prevalence of hepatic cystadenomas is low, with fewer than 200 cases reported in the literature. (medscape.com)
  • The true prevalence of hepatic cystadenomas in different areas of the world is unknown. (medscape.com)
  • The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. (hindawi.com)
  • The development of hepatic nodular proliferations in laboratory animals and in humans exposed to steroids was reviewed. (cdc.gov)
  • Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases? (jaoa.org)
  • Hepatic lipidosis in dogs? (medhelp.org)
  • In any case, the emergence of hepatic lipidosis is almost always accompanied by or preceded by the onset of anorexia -a cat's nearly total avoidance of its food. (cornell.edu)
  • At the same time, it is crucially important to identify the underlying condition responsible for hepatic lipidosis and to initiate appropriate therapy for that condition without delay. (cornell.edu)
  • If a cat is successfully treated for early-stage hepatic lipidosis and sent home-which can take place in just a few days-its owners will have to continue tube-feeding it, usually for a month or so. (cornell.edu)
  • Hepatic impairment could potentially alter the clearance and plasma protein binding of GSK1349572. (clinicaltrials.gov)
  • This study will evaluate the single dose pharmacokinetics and safety of GSK1349572 in healthy subjects and in subjects with mild or moderate hepatic impairment based on Child-Pugh category. (clinicaltrials.gov)
  • This is a single-dose, open-label, parallel group, two-part, adaptive study in adult males and females with mild or moderate hepatic impairment and matched, healthy control subjects with normal hepatic function. (clinicaltrials.gov)
  • Healthy control subjects (16) will be matched for gender, age, and BMI to the subjects in the mild (8) or moderate (8) hepatic impairment category. (clinicaltrials.gov)
  • In Part 1, approximately 8 subjects with moderate hepatic impairment (cohort 1) and 8 matched, control subjects (cohort 2) will each receive GSK1349572 50 mg as a single dose in the fasted state followed by pharmacokinetic sampling for total concentrations of GSK1349572 in plasma. (clinicaltrials.gov)
  • 8 subjects with moderate hepatic impairment defined by a Child-Pugh score of 7 to 9 will receive a single oral dose of GSK1349572 50 mg in the morning followed by 72 hour serial PK sampling. (clinicaltrials.gov)
  • The current study is proposed to evaluate whether there is any clinically meaningful effect of hepatic impairment on the plasma PK of PF-06865571. (pfizer.com)
  • 2 Hepatic impairment is a condition that may lead to increased opioid toxicity. (uspharmacist.com)
  • therefore, an alternative approach in determining drug dosing is needed in the hepatic impairment patient population. (uspharmacist.com)
  • Hepatic infarction is defined as areas of coagulative necrosis from hepatocyte cell death caused by local ischemia which, in turn, results from the obstruction of circulation to the affected area, most commonly by a thrombus or embolus. (thefreelibrary.com)
  • Thrombosis is the main factor leading to obstruction of the hepatic venous system, frequently in association with myeloproliferative disorders, antiphospholipid antibody syndrome, paroxysmal nocturnal hemoglobinuria, factor V Leiden, protein C and S deficiency, Jak-2 mutation, and contraceptive use. (unboundmedicine.com)