InjuryHepatocellularPartialReactive oxygenTransplantationStellate cellsPreservationPringleAllograftPortal veinNeoplasmsHemorrhagicMechanismsBile ductIntraoperativeRegenerationResectionMetastasesInhibitionTraumaRatsComplicationsTumorUnderwentSurgeryProtectiveSurgicalInductionFactorsWarmTimeInflammationDamageCellsModelProteinMajorTreatmentStatus
Injury25
- The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. (bepress.com)
- Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
- This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
- Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
- Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
- the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
- We aimed to determine the ameliorative impact of diacerein on renal ischemia/reperfusion injury (I/R) condition, exploring the underlying mechanisms. (bvsalud.org)
- Hepatic ischemia-reperfusion injury (IRI) is an adverse consequence of hepatectomy or liver transplantation. (bvsalud.org)
- The Pringle manoeuvre is usually performed during a hepatectomy to minimize blood loss - however this can lead to reperfusion injury in the liver due to Ischemia. (wikipedia.org)
- Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. (ectrx.org)
- The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. (ectrx.org)
- Ischemia-reperfusion injury, which involves complex inflammatory pathways, is a significant cause of liver damage and an important factor in a variety of diseases, injuries, and procedures that include (but not limited to) transplant and trauma. (ectrx.org)
- Investigations involving animal models and human trials are reviewed, a summary of significant studies in human subjects is presented ( Table 1 ), and the pathways and mediators important in liver ischemia-reperfusion injury are described ( Figure 1 ). (ectrx.org)
- Liver ischemia-reperfusion injury is ameliorated by treatment with various free radical scavengers, as shown in investigations of allopurinol, superoxide dismutase, catalase, and other antioxidant compounds. (ectrx.org)
- Adenoviral delivery of superoxide dismutase has been shown to produce beneficial effects in warm ischemia reperfusion (18), alcohol-induced liver injury (19), and reduced-size liver grafts (20). (ectrx.org)
- Complications following LT occur commonly and may derive from pretransplant recipient condition, graft-specific factors (including preservation and ischemia-reperfusion injury), technical or intraoperative complications, the immunologic response to the graft, or infection. (musculoskeletalkey.com)
- Serum ALT level mildly increased on days 1 and 2 because of ischemia-reperfusion injury, decreased thereafter, but rapidly increased again on day 7 due to acute rejection (left panel). (wjgnet.com)
- Plasma UL-VWFM was detectable on day 1 at the time of ischemia-reperfusion injury, thereafter diminishing gradually during days 2 to 4, and again becoming evident on day 7 when acute rejection developed (right panel). (wjgnet.com)
- Nevertheless, when the inflammatory cascade is normally turned on and oxidative harm takes place under hemorrhagic surprise and ischemia-reperfusion injury, improved is mainly controlled in the transcriptional level, independent of calcium (16). (bioinbrief.com)
- Perfusion parameters, oxygen extraction, metabolic activity, and histological features were compared during 6 hours of NMP-L. The cytotoxicity of Hemopure was also tested on human hepatic primary cell line cultures using an in vitro model of ischemia reperfusion injury. (birmingham.ac.uk)
- Perfusion parameters, oxygen extraction, metabolic activity, and histological features were compared during 6 hours of NMP-L. The cytotoxicity of Hemopure was also tested on human hepatic primary cell line cultures using an in vitro model of ischemia reperfusion injury.RESULTS: The vascular flow parameters and the perfusate lactate clearance were similar in both groups. (birmingham.ac.uk)
- Hepatic expression of TIMP-1 mRNA and protein was up-regulated both in acute and chronic liver injury induced by carbon tetrachloride (CCl 4 ). (biomedcentral.com)
- The progression of liver disease can be defined as an alteration of hepatic parenchyma characterized by two major events: injury and regeneration. (biomedcentral.com)
- 11-13] Although platelet is indispensable for liver tissue repair after liver transplantation, platelet can also contribute to graft injury through ischemia/ reperfusion injury. (researchsquare.com)
- Preservation or ischemia/reperfusion injury is seen early after transplantation and is characterized by areas of ischemic myocyte necrosis and/or variable areas of myocyte dropout. (upmc.com)
Hepatocellular1
- Benign neoplasms include hepatocellular adenoma, hepatic hemangioma and focal nodular hyperplasia. (wikipedia.org)
Partial7
- Effects of Pringle Maneuver and Partial Hepatectomy on the Pharmacokin" by Mohammad K. Miah, Imam H. Shaik et al. (chapman.edu)
- It is concluded that Pringle maneuver and/or partial hepatectomy substantially alters the hepatobiliary disposition, plasma AUC, plasma free fraction, and brain accumulation of FL without altering the BBB permeability to the marker. (chapman.edu)
- While the term is often employed for the removal of the liver from a liver transplant donor, this article will focus on partial resections of hepatic tissue and hepatoportoenterostomy. (wikipedia.org)
- Partial hepatectomies are also performed to remove a portion of a liver from a living donor for transplantation. (wikipedia.org)
- In other studies, the beneficial role of melatonin in combination with other antioxidants such as carnosine (41), N-acetylcysteine (42), prostaglandin E1 analogue (43), and, in patients who have undergone partial hepatectomy, resveratrol (44) has been investigated. (ectrx.org)
- As human being life expectancy offers improved greatly, more and more seniors individuals with liver disease need partial hepatic resection. (bioinbrief.com)
- We obtained the rat liver tissue gene datasets (GSE63742) collected following partial hepatectomy (PH) from the Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information (NCBI), from which, this study screened the late stage LR samples (7 days post-PH) using the R/Bioconductor packages for the identification of differentially expressed genes (DEGs). (jomh.org)
Reactive oxygen2
- As liver ischemia ends and reperfusion begins, reactive oxygen species are one of the first elements formed (14). (ectrx.org)
- All reactive oxygen species respond in varying degrees at the initiation of reperfusion. (ectrx.org)
Transplantation1
- In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
Stellate cells1
- These cytokines induce caspase-3 activation as an effector caspase that activates hepatic stellate cells (HSCs) and cause fibrogenesis [ 11 ]. (bsmiab.org)
Preservation1
- 1 total hepatectomy with preservation of the inferior vena cava using total vascular exclusion of the liver and veno-venous bypass, 2 implantation of the graft in the orthotopic position with anastomosis of the left hepatic vein to the inferior vena cava and portal, arterial and biliary reconstruction. (northwestern.edu)
Pringle1
- Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. (bepress.com)
Allograft1
- This study demonstrates the technical feasibility of living hepatic allograft donation. (northwestern.edu)
Portal vein1
- The donor operation consists of harvesting the left lobe of the liver (left medial and left lateral segments) with the left branches of the portal vein, hepatic artery and bile duct, and the left hepatic vein. (northwestern.edu)
Neoplasms1
- citation needed] Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malign. (wikipedia.org)
Hemorrhagic1
Mechanisms3
- Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
- Recently, immune mechanisms involved in hepatic IRI have attracted increased attention of investigators working in this area. (bvsalud.org)
- However, their immune mechanisms as involved with hepatic IRI remain unclear. (bvsalud.org)
Bile duct2
- Recently, a novel fluorescent intraoperative cholangiography technique for cholecystectomy using indocyanine green (ICG) has been used, and in 2009 we started using ICG fluorescence cholangiography in LDLT donors who underwent right or left hepatectomy [16], because appropriate cutting line of the bile duct in the donor operation is one of the key issues to prevent biliary complications in both donors and recipients after LDLT. (docksci.com)
- In the present study, we retrospectively analyzed biliary complications including biliary leakage and stricture and also evaluated usefulness of ICG fluorescence cholangiography to cut the bile duct during donor hepatectomy in LDLT. (docksci.com)
Intraoperative1
- Lowering intraoperative blood loss during hepatectomy is a crucial factor determining the success of liver resec-tion, as surgical bleeding and transfusion are associated with poor outcomes in both the short- and long term [9- 11]. (123dok.net)
Regeneration1
- Secretome is a soluble molecule and exosome produced by HuMSC, which can support hepatic epithelial regeneration through hepatogenic differentiation. (bsmiab.org)
Resection2
- Hepatectomy is the surgical resection (removal of all or part) of the liver. (wikipedia.org)
- METHOD: A systematic computerized literature search in the biomedical database PubMed using the MeSH terms 'hepatectomy' or 'liver resection' or 'liver transection' was conducted. (maastrichtuniversity.nl)
Metastases1
- It is also a problem, to a lesser degree, in patients with previous hepatectomies (e.g. repeat resections for reincident colorectal cancer metastases). (wikipedia.org)
Inhibition1
- The profibrogenic effects of TIMP-1 are thought to be mediated via preventing collagen degradation through inhibition of MMPs and protecting against activated hepatic stellate cell (HSC) death [ 17 - 20 ]. (biomedcentral.com)
Trauma1
- Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. (ectrx.org)
Rats1
- In conclusion, addition of HuMSC-S to UDCA lowered caspase-3 levels and apoptotic cell count in rats with hepatic cholestasis after choledochal duct ligation. (bsmiab.org)
Complications1
- BACKGROUND: Although the safety of liver surgery has improved enormously, hepatic surgery continues to face challenging complications. (maastrichtuniversity.nl)
Tumor1
- The process of hepatic fibrogenesis is affected by the presence of oxidative stress that increases proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), interferon, and interleukin (IL). (bsmiab.org)
Underwent1
- The most recent 18 donors underwent indocyanine green (ICG) fluorescence cholangiography for donor hepatectomy. (docksci.com)
Surgery1
- AIM: The aim of this review was to summarize the SEPs used in hepatic surgery related trials, their definitions and recapitulating the evidence validating their use. (maastrichtuniversity.nl)
Protective3
- This stimulation of ILC2s resulted in a protective effect upon hepatic IRI along with an increase in M2 type CD45+CD11b+F4/80high macrophages. (bvsalud.org)
- In contrast, depletion of ILC2s as achieved with use of an anti-CD90.2 antibody substantially abolished this protective effect of exogenous IL-33 and M2 type CD45+CD11b+F4/80high macrophage polarization in hepatic IRI. (bvsalud.org)
- In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)
Surgical2
- citation needed] A hepatectomy is considered a major surgical procedure performed under general anesthesia. (wikipedia.org)
- Further data indicate that the incidence and severity of post hepatectomy bile leakages may be affected by surgical indications, preoperative chemotherapy and surgical procedures. (fortunejournals.com)
Induction1
- The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)
Factors1
- In this report, a comprehensive analysis of those factors is provided, and the fundamental molecular inflammatory mediators present after liver ischemia and reperfusion are discussed. (ectrx.org)
Warm1
- The grafts are perfused in situ through the left portal branch to prevent warm ischemia. (northwestern.edu)
Time1
- Two recipients died intraoperatively of air embolus and cardiac arrest at the time of reperfusion. (northwestern.edu)
Inflammation1
- Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. (greenmedinfo.com)
Damage1
- SUMMARY: One of the reasons for acute kidney damage is renal ischemia. (bvsalud.org)
Cells1
- Thus, this study aims to determine the effect of Human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptotic hepatic cells in a rat model with cholestasis after choledochal duct ligation receiving urso deoxy cholic acid (UDCA). (bsmiab.org)
Model2
- Here, we reported that the population of ILC2s is increased with the development of hepatic IRI as shown in a mouse model in initial stage. (bvsalud.org)
- Strategies and Components Pets as well as the incomplete hepatectomy model Within this experimental research, wTC57BL/6J and mutant mice were purchased from Shanghai Lab Pet Co. Ltd. The defined previously (28). (bioinbrief.com)
Protein1
- The peroxidation of lipids (16, 17), protein oxidation, and the formation of peroxinitrites frequently occur after liver ischemia and reperfusion. (ectrx.org)
Major1
- It has been reported that individuals over 60 years of age possess higher mortality and morbidity after major liver hepatectomy (25). (bioinbrief.com)
Treatment1
- Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion. (greenmedinfo.com)
Status1
- Various models permitted changes in clearance (Cl) or central compartment volume to account for changes in hepatic function and circulatory status during the paleohepatic, anhepatic, and neohepatic periods. (silverchair.com)