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HepatectomyBlood CoagulationBlood Coagulation FactorsLiver RegenerationBlood Coagulation TestsDisseminated Intravascular CoagulationBlood Coagulation DisordersThromboplastinProthrombin TimeFactor XaFactor VIIPartial Thromboplastin TimeFactor XProthrombinFactor IXThrombelastographyFactor VIIaThrombinFactor XIIIWhole Blood Coagulation TimeFactor XIaFactor VIIIFibrinolysisLiverBlood Coagulation Factor InhibitorsCoagulantsAntithrombin IIIHemostasisLiver NeoplasmsProtein CFibrinogenFactor VFactor IXaHydroxyethyl Starch DerivativesThrombin TimeFactor XIIaAnticoagulantsFibrinPlasma SubstitutesFactor XIIFactor XIVitamin KFactor XI DeficiencyAntithrombinsFactor XII DeficiencyFibrin Fibrinogen Degradation ProductsFactor VIIIaThrombosisBlood PlateletsFactor VaCarcinoma, HepatocellularTime FactorsHeparinThrombomodulinHemophilia A1-Carboxyglutamic AcidKaolinProtein SArgon Plasma CoagulationHemophilia BBlood Coagulation Disorders, InheritedHypoprothrombinemiasPortal Vein2-AcetylaminofluoreneHepatocytesCoagulation Protein DisordersMolecular Sequence DataPrekallikreinFibrinopeptide AAmino Acid SequenceVitamin K DeficiencyPlatelet ActivationSerine Proteinase InhibitorsPlatelet AggregationKineticsBlood Loss, SurgicalHemostasis, SurgicalLiver TransplantationFactor X DeficiencyViperidaeTransglutaminasesLiver DiseasesLaser CoagulationRecombinant ProteinsHemostaticsLithiasisDiethylnitrosamineBinding SitesPlatelet CountHemorrhageLiving DonorsPolygelineRats, Inbred F344Bile Ducts, IntrahepaticLiver Function TestsElectrocoagulationArcidaeKallikreinsalpha-2-AntiplasminBile Duct Neoplasms
Post-hepatectomyRight hepatectomyPartialAbnormalitiesThrombinHepaticHEPARINPlateletComplicationsTHROMBOSIS AND HEMOSTASISLaboratoryFactorsPostoperativePerioperativeSignificantlyFibrinGraftProteinsTissueSynthesisPatientsAllogeneicLossTranexamic acidTransfusionBaselineTreatmentCardiacPatientMajorNormalLevelsSurgeryManagementInstrumentLeadImportantTime
Post-hepatectomy3
  • Post-hepatectomy liver failure (PHLF) is a severe complication and main cause of death in patients undergoing hepatectomy. (xiahepublishing.com)
  • Among these, post-hepatectomy liver failure (PHLF), defined as the impaired ability of the liver to maintain its synthetic, excretory and detoxifying functions, is one of the worst complications after hepatectomy and one of the major causes of perioperative mortality. (xiahepublishing.com)
  • Further data indicate that the incidence and severity of post hepatectomy bile leakages may be affected by surgical indications, preoperative chemotherapy and surgical procedures. (fortunejournals.com)
Right hepatectomy1
  • In the operating room, Dr. Nari proceeded to carry out a right hepatectomy together with a limited resection of the metastasis associated with the left lobe. (bcn3d.com)
Partial4
  • Platelets play a pivotal role in stimulating liver regeneration after partial hepatectomy in rodents and humans. (ashpublications.org)
  • Thrombin-dependent intrahepatic fibrin(ogen) deposition was recently reported after partial hepatectomy (PHx) in mice, but the role of fibrin(ogen) deposits in liver regeneration has not been investigated. (ashpublications.org)
  • Clinically, measurement of HVPG is indicated (i) to establish the diagnosis of sinusoidal portal hypertension, (ii) to identify patients at risk for hepatic decompensation by diagnosing CSPH (HVPG ≥10 mm Hg), (iii) to guide pharmacological therapy in primary or secondary prophylaxis of variceal bleeding, and (iv) to assess the risk of hepatic failure after partial hepatectomy 2 , 4 . (jove.com)
  • Patients' medical records were reviewed after discharge for results of standard coagulation studies - partial thromboplastin time (PTT), international normalized ratio (INR), platelet count - and evidence of thromboembolic complications during their hospital stay. (biomedcentral.com)
Abnormalities2
  • Patients who required more blood had higher incidence of coagulation abnormalities, renal dysfunction and high bilirubin levels. (tau.ac.il)
  • Preoperative parameters cannot predict operative bleeding accurately and the mainstay to prevent bleeding is a meticulous surgical technique during the hepatectomy and correction of coagulation abnormalities throughout the procedure. (tau.ac.il)
Thrombin2
Hepatic6
  • 1 , 2 Despite improvements in operative techniques, perioperative management and understanding of liver regeneration have improved the safety of liver resection over years, PHLF remains a challenge for patients undergoing hepatectomy and a concern of hepatic surgeons. (xiahepublishing.com)
  • The significant factors on univariate analysis that were associated with an increased operative blood loss were hospitalized patients (United Network for Organ Sharing Status ≥3), fulminant hepatic failure, previous portosystemic shunt and complete ABO mismatch. (tau.ac.il)
  • The hepatic artery supplies 30% of the blood flow to the normal liver parenchyma but greater than 90% to hepatic tumors, including both HCC and metastatic lesions. (medscape.com)
  • The splenic vein joins the inferior mesenteric vein , which then together join with the superior mesenteric vein to form the hepatic portal vein , bringing veneous blood from the spleen , pancreas , stomach , small intestine , and large intestine , so that the liver can process the nutrients and byproducts of food digestion. (wikidoc.org)
  • The hepatic veins of the blood can be from other branches such as the superior mesenteric artery . (wikidoc.org)
  • Approximately 60% to 80% of the blood flow to the liver is from the portal venous system, and 1/4 is from the hepatic artery. (wikidoc.org)
HEPARIN1
  • Cardiac surgery with cardiopulmonary bypass (CPB) is associated with blood loss and post-surgery bleeding complications due to haemodilution, coagulation factor consumption and heparin administration. (synapseresearchinstitute.com)
Platelet7
  • 0.001) and platelet count ( p =0.004), and two intraoperative variables, extent of resection ( p =0.002) and blood loss ( p =0.004), as independent predictors of PHLF. (xiahepublishing.com)
  • 4 Clinic-biological scores like the model for end-stage liver disease (MELD) score, albumin-bilirubin (ALBI) score and platelet-albumin-bilirubin (PALBI) score are also adopted to evaluate the functional liver reserve, 5 - 7 and are reported to accurately predict PHLF following hepatectomy. (xiahepublishing.com)
  • We tested the hypothesis that fibrin(ogen) contributes to liver regeneration by promoting intrahepatic platelet accumulation and identified the trigger of rapid intrahepatic coagulation after PHx. (ashpublications.org)
  • Both coagulation defects and platelet function defects are a major determinant for bleeding complications, which become life threatening if they are combined with severe blood loss after trauma or during surgery. (synapseresearchinstitute.com)
  • Likewise, impaired VWF levels and function, thrombocytopenia, impaired platelet function and impaired coagulation are more prevalent in women with heavy menstrual bleeding. (synapseresearchinstitute.com)
  • Synapse Research Institute has shown that 40 % of the women with HMB have either impaired platelet function or an impaired coagulation phenotype. (synapseresearchinstitute.com)
  • Synapse Research Institute has developed a flow cytometry-based whole blood platelet activation test (WB-PACT) that can be used as supportive/complimentary test to LTA 1 . (synapseresearchinstitute.com)
Complications2
  • Excessive operative blood transfusion has been correlated with an increased rate of infectious complications and lower survival rate after transplantation of the liver. (tau.ac.il)
  • Demographics, diagnoses, extent of resection, blood loss, and incidence and grade of complications did not differ between the 2 groups. (transfusionevidencelibrary.com)
THROMBOSIS AND HEMOSTASIS1
Laboratory1
  • Other blood counts, biochemical laboratory findings and coagulation factors were within the normal ranges. (springeropen.com)
Factors4
  • Two hundred and five consecutive transplants of the liver, performed between January 1988 and December 1989, were studied retrospectively to determine preoperative risk factors associated with an increased operative blood loss and to evaluate the impact of operative transfusion on the outcome of transplantation. (tau.ac.il)
  • It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. (lookformedical.com)
  • The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. (lookformedical.com)
  • An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. (lookformedical.com)
Postoperative1
  • PHLF can be accurately predicted by this model in patients undergoing hepatectomy, which may significantly contribute to the postoperative care of these patients. (xiahepublishing.com)
Perioperative2
  • This allows antifibrinolytics to play a major role in reducing perioperative bleeding and allogeneic blood product transfusion. (openanesthesia.org)
  • BACKGROUND Perioperative autologous blood salvage and preoperative erythropoietin are not (cost) effective to reduce allogeneic transfusion in primary hip and knee arthroplasty, but are still used. (transfusionevidencelibrary.com)
Significantly2
  • RESULTS The use of blood salvage (OR 0.08, 95% CI 0.02 to 0.30) and erythropoietin (OR 0.30, 95% CI 0.09 to 0.97) reduced significantly over time, but did not differ between intervention and control hospitals (blood salvage OR 1.74 95% CI 0.27 to 11.39, erythropoietin OR 1.33, 95% CI 0.26 to 6.84). (transfusionevidencelibrary.com)
  • Both LIA (OR 0.0, 95% CI 0.0 to 0.0) and TXA (OR 0.3, 95% CI 0.2 to 0.5) were significantly associated with the reduction in blood salvage over time. (transfusionevidencelibrary.com)
Fibrin2
  • PHx in wild-type mice triggered rapid intrahepatic coagulation, evidenced by intrahepatic fibrin(ogen) deposition. (ashpublications.org)
  • Intrahepatic fibrin(ogen) deposition was abolished in mice with liver-specific tissue factor deficiency, pinpointing the trigger of coagulation after PHx. (ashpublications.org)
Graft1
  • for example, hepatectomies require a hemiliver graft, which will cause some damage to the living donor. (biomedcentral.com)
Proteins1
Tissue1
  • Liver-associated tissue factor drives rapid intrahepatic coagulation after PHx. (ashpublications.org)
Synthesis1
  • It plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, and detoxification. (wikidoc.org)
Patients6
  • The aim of this study was to build a predictive model of PHLF in patients undergoing hepatectomy. (xiahepublishing.com)
  • We retrospectively analyzed patients undergoing hepatectomy at Zhongshan Hospital, Fudan University from July 2015 to June 2018, and randomly divided them into development and internal validation cohorts. (xiahepublishing.com)
  • Hepatectomy is the main treatment for patients with benign or malignant liver lesions. (xiahepublishing.com)
  • The median operative blood loss for 205 patients was 5 units of banked erythrocytes (range of zero to 52, mean of 6.9 units). (tau.ac.il)
  • However, neither scoring systems nor routine coagulation tests detect patients with acquired or congenital hypercoagulable states. (biomedcentral.com)
  • The primary end point was appropriate management, defined as avoidance of ANH in patients at low risk or use of ANH in patients at high risk for allogeneic red blood cell transfusions. (transfusionevidencelibrary.com)
Allogeneic1
  • Antifibrinolytic agents are commonly used as part of a comprehensive blood management strategy to reduce bleeding, allogeneic blood administration, and transfusion-related adverse events. (openanesthesia.org)
Loss3
  • Antifibrinolytics have an important role in blood conservation techniques in surgeries where major blood loss is expected. (openanesthesia.org)
  • Many randomized controlled trials (RCT) and meta-analyses support the efficacy of these agents in reducing blood loss and transfusion. (openanesthesia.org)
  • Operation time was OLR 342.8 ± 110.5 min vs. LLR 287.3 ± 132.6 min (p=0.014) and the average blood loss was OLR 523.5 ± 428.6 ml vs. LLR 355.5 ± 459.2 ml. (fortunejournals.com)
Tranexamic acid1
  • The reduction in blood salvage was associated with increased use of local infiltration analgesia and tranexamic acid, suggesting that de-implementation is assisted by the substitution of techniques. (transfusionevidencelibrary.com)
Transfusion1
Baseline1
  • Inside 537 people called for CTA, the particular baseline Hour or so along with blood pressure were assessed upon birth, along with advisable limitations with regard to experiment with blockade had been noted. (proteasepathway.com)
Treatment1
  • Electro-coagulation for the treatment of liver metastases. (aetna.com)
Cardiac2
  • Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. (jci.org)
  • Transfer of this segment of chromosome 8 from the BN-Lx strain onto the SHR background resulted in substantial reductions in systolic and diastolic blood pressure and cardiac mass. (jci.org)
Patient1
  • The reduction in blood salvage and erythropoietin did not lead to a deterioration in patient-related secondary outcomes. (transfusionevidencelibrary.com)
Major1
Normal1
Levels1
Surgery1
  • heavy surgery may prevent skimpy to make the coagulation of AP in rules with black subjects. (milanotimes.com)
Management2
  • This study aimed to evaluate the effectiveness of a theoretically informed multifaceted strategy to de-implement these low-value blood management techniques. (transfusionevidencelibrary.com)
  • The intervention included a multifaceted de-implementation strategy which consisted of interactive education, feedback on blood management performance, and a comparison with benchmark hospitals, aimed at orthopedic surgeons and anesthesiologists. (transfusionevidencelibrary.com)
Instrument1
  • Dissection, coagulation and aspiration combined in one instrument. (erbe-med.com)
Lead1
  • A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder. (lookformedical.com)
Important1
  • Hypoxia (low oxygen concentration) and nutrient deprivation, caused by inappropriate blood supply, represent important hallmarks of tumor microenvironment. (biomedcentral.com)
Time1
  • CONCLUSIONS Blood salvage and erythropoietin use reduced over time, but not differently between intervention and control hospitals. (transfusionevidencelibrary.com)