Hemosiderin prussian blue reaction. Medical search. Frequent questions

It is identified in cells by the Perls or Prussian blue reaction, in which ionic iron reacts with acid ferrocyanide to impart a blue color. (wikipedia.org)
Minocycline type I reactions demonstrate pigment-laden macrophages within the dermis or scar that are only positive with Perls staining. (medscape.com)
Minocycline type II reactions demonstrate pigment-laden macrophages around blood vessels and eccrine glands that stain with both Fontana-Masson and Perls stains, indicating the presence of both melanin and iron. (medscape.com)
The presence of hemosiderin can be confirmed with the Perls' Prussian blue staining technique. (nih.gov)

Hemosiderin can be identified with iron stains such as Perl's iron and Prussian blue, both of which stain the pigment blue. (nih.gov)
Ceroid/lipofuscin may be identified with Sudan black B, Schmorl''s reaction, Oil Red O, carbol lipofuscin stain, periodic acid-Schiff, Ziehl-Neelsen acid-fast stain, autofluorescence, or lysosomal acid phosphatase and esterase stains. (nih.gov)
Antimalarial pigmentation demonstrates pigment granules extracellularly and within dermal macrophages that stain for hemosiderin, melanin, or both. (medscape.com)

Acid hematin, an artifact of fixation in formalin with a low pH, appears as black to brown amorphous to microcrystalline granules and can easily be confused with hemosiderin. (nih.gov)

Hemosiderin is most commonly found in macrophages and is especially abundant in situations following hemorrhage, suggesting that its formation may be related to phagocytosis of red blood cells and hemoglobin. (wikipedia.org)
Phagocytic cells (of the mononuclear phagocyte system) called macrophages engulf (phagocytose) the hemoglobin to degrade it, producing hemosiderin and biliverdin. (wikipedia.org)
Macrophages within the medullary sinuses contain intracytoplasmic golden- brown pigment suggestive of hemosiderin (arrows). (nih.gov)
Hemosiderin is an iron-containing golden-brown granular material, and macrophages containing this pigment are typically observed with sinus erythrocytosis, congestion, or hemorrhage. (nih.gov)
Hemosiderin appears as finely granular, golden brown material in macrophages. (nih.gov)
When alveolar macrophages ingest erythrocytes, as occurs with hemorrhage, the hemoglobin is converted into hemosiderin, the most stable storage form of iron. (nih.gov)
The pigment is most likely hemosiderin and is contained within macrophages. (nih.gov)

Hemosiderin (Figure 1, arrows) and ceroid/lipofuscin (Figure 2, arrows) are the most frequently encountered pigments. (nih.gov)
Therefore, it is recommended that a diagnosis of "pigment" (as opposed to diagnosing the type of pigment, e.g., hemosiderin or lipofuscin) is most appropriate. (nih.gov)
Therefore, a diagnosis of pigment (as opposed to diagnosing the type of pigment, e.g., hemosiderin or lipofuscin) is most appropriate. (nih.gov)

In normal animals, hemosiderin deposits are small and commonly inapparent without special stains. (wikipedia.org)

Hemosiderin is the most common and most important type of pigment seen in the lungs. (nih.gov)

PCR, polymerase chain reaction. (medscape.com)
We describe a case of primary neuritic leprosy with atypical features and the roles that histological confirmation using nerve biopsy of an unenlarged nerve and newer techniques, such as polymerase chain reaction and high-resolution ultrasonography, play in improving the diagnosis. (bvsalud.org)

Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. (wikipedia.org)
The body then traps the released iron and stores it as hemosiderin in tissues. (wikipedia.org)
The iron within deposits of hemosiderin is very poorly available to supply iron when needed. (wikipedia.org)
iron in hemosiderin turns blue to black when exposed to potassium ferrocyanide. (wikipedia.org)
Iron is required by many of the chemical reactions (i.e., oxidation-reduction reactions) in the body but is toxic when not properly contained. (wikipedia.org)
Cellular iron is found as either ferritin or hemosiderin. (wikipedia.org)
Hemosiderin may deposit in diseases associated with iron overload. (wikipedia.org)
Based on its role as the major biological catalyst of free radical reactions and the Fenton reaction, iron has also been implicated in all diseases associated with free radical pathology and tissue damage. (nih.gov)

According to previous publications, cholesterol granulomas arise secondary to repeated hemorrhage or chronic inflammation, leading to a deposition of cholesterol crystals with subsequent granulomatous inflammation foreign body reaction [ 7 , 8 ]. (biomedcentral.com)
The golden brown pigment is most likely hemosiderin secondary to hemorrhage associated with acute inflammation. (nih.gov)

Hemosiderin is seen following hemorrhage, which can result from vascular congestion in the lung (as occurs, e.g., with congestive heart failure) or vascular injury. (nih.gov)

Minocycline type III reactions have been characterized by the presence of increased epidermal basal cell layer melanin pigmentation. (medscape.com)