AnatomyOrganismsDiseasesChemicals and Drugs
Polyomavirus InfectionsPolyomavirusBK VirusMerkel cell polyomavirusCarcinoma, Merkel CellTumor Virus InfectionsJC VirusAntigens, Polyomavirus TransformingCapsid ProteinsDNA, ViralAntigens, Viral, TumorMerkel Cells
CystitisNephropathyUreteral stenosisHuman polyomavirusBKPyVVirusesRecipientsMerkelViral infectionsFeverTransplant2023SevereTransplantationFungal infectionOpportunisticVirusDiseasesReplicationCandidaSpeciesViremiaPatient'sPrimary infectionPathogenRespiratory tract infeBladderSymptomsMalignanciesDiseaseWidespread2021Immune-compromisedImmunocompetentAcuteOccursPneumoniaSequences
Cystitis32
  • BK polyomavirus (BKPyV) is recognized as a pathogen that causes diseases such as hemorrhagic cystitis and nephritis after allogeneic hematopoietic stem cell transplantation (HSCT) or renal transplantation. (elsevierpure.com)
  • During a 6-month period, nine adult patients (median age: 47 years) who had hematological disorders and who were treated with HSCT (n = 7) or chemotherapy (n = 2) in a single hematology department developed hemorrhagic cystitis due to BKPyV infection. (elsevierpure.com)
  • Hemorrhagic cystitis - or bleeding from the bladder - occurs in up to 25% of stem cell transplant recipients and is associated with BK polyomavirus (BKPyV) infection, although the exact cause of the bladder injury is not known. (chop.edu)
  • Hemorrhagic cystitis leads to patient morbidity from painful urination, prolonged hospitalizations, increased blood transfusion requirements, and invasive procedures when urinary obstruction is present. (chop.edu)
  • Each episode of hemorrhagic cystitis accounts for 10 additional hospital days and costs $70,000. (chop.edu)
  • In its most severe presentation, hemorrhagic cystitis may be associated with a higher risk of death. (chop.edu)
  • BKPyV replication in the urine can be detected in 80% of patients after stem cell transplant, but not all of these patients will develop hemorrhagic cystitis. (chop.edu)
  • There are no antiviral therapies with proven efficacy against BKPyV and current treatment strategies for hemorrhagic cystitis are limited to supportive care. (chop.edu)
  • The proposed research project will test the hypothesis that the risk of hemorrhagic cystitis in patients with BKPyV replication in the urine is due to the specific viral strain and the patient's response to the virus. (chop.edu)
  • Specifically, the team will test whether the strain of BKPyV is different between patients with and without hemorrhagic cystitis after stem cell transplant. (chop.edu)
  • Using proteomics techniques, they will also test whether a patient's cellular response to the virus is different between those with and without hemorrhagic cystitis. (chop.edu)
  • Furthermore, certain types of cystitis have a high incidence in a particular patient population (eg, radiation cystitis , hemorrhagic cystitis ) or have a unique geographic distribution. (medscape.com)
  • Bacterial cystitis is most commonly the result of an ascending infection through the urethra caused by the patient's own enteric microbiota. (medscape.com)
  • Eosinophilic cystitis, a rare condition, can be associated with allergic and autoimmune diseases such as lupus, parasitic infection, and systemic peripheral eosinophilia, such as in idiopathic hypereosinophilic syndrome . (medscape.com)
  • Granulomatous cystitis due to Mycobacterium tuberculosis infection is often secondary to primary kidney involvement. (medscape.com)
  • Classic hemorrhagic cystitis is most commonly seen as a side effect of cyclophosphamide, especially if it is combined with radiation therapy . (medscape.com)
  • Methotrexate therapy has also been linked to hemorrhagic cystitis . (medscape.com)
  • What is the appropriate management of hemorrhagic cystitis? (uic.edu)
  • Hemorrhagic cystitis (HC) may be a complication of infection (particularly in immunocompromised patients), chemotherapy, or radiation to the pelvic area. (uic.edu)
  • Hemorrhagic cystitis, however, is cystitis with hemorrhage depicted by sustained hematuria. (uic.edu)
  • 14 Primary and renally-activated BK virus infection may manifest as hemorrhagic and nonhemorrhagic cystitis. (uic.edu)
  • In October 2021, Posoleucel (ViralymM, ALVR105) was given Orphan Drug Designation (ODD) by the US Food and Drug Administration (FDA) to treat virus-associated hemorrhagic cystitis (HC). (openpr.com)
  • This designation as an orphan drug recognizes the pressing need for novel therapeutic approaches for individuals who have received hematopoietic stem cell transplantation and are susceptible to viral infections and hemorrhagic cystitis. (openpr.com)
  • There is the association of BK polyomavirus (BKV), which is a member of the polyoma family of viruses, with polyomavirus-associated hemorrhagic cystitis and polyomavirus-associated nephropathy (PyVAN). (nephrologistinagartala.com)
  • Unlike hemorrhagic cystitis and BKPyV-associated nephropathy, BKPyV-associated pneumonia is rare, with only seven known cases worldwide. (biomedcentral.com)
  • In bone marrow transplant recipients it is notable as a cause for hemorrhagic cystitis. (wikipedia.org)
  • Bladder Cancer versus Hemorrhagic Cystitis: A Case of Mistaken Identit" by Jonathan Amatruda, Kevin D. Dieckhaus et al. (uconn.edu)
  • Cystoscopy revealed lesions suspicious for malignancy, but the patient was diagnosed with hemorrhagic cystitis secondary to BK virus infection upon cytology review, and immunostaining confirmed a polyomavirus infection of the urothelium. (uconn.edu)
  • Causes of BKV are the recipient of a kidney transplant, bone marrow transplant leading to hemorrhagic cystitis, multifocal leukoencephalopathy in immune-compromised patients, etc. (rtdiagnostics.net)
  • BKV also leads to hemorrhagic cystitis in hematopoietic cell transplantation (HCT). (novacyt.com)
  • It is also associated with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. (cytopathology.ca)
  • 10,000,000 copies/mL) or hemorrhagic cystitis 14. (trialstoday.org)
Nephropathy3
  • BK Polyomavirus RT-PCR helps to primarily monitor BK viral load in urine (viruria) and plasma (viremia) of renal transplant patients who are at risk of developing BK virus-associated nephropathy (BKVAN). (rtdiagnostics.net)
  • Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. (cytopathology.ca)
  • Bovine Polyomavirus-1 (Epsilonpolyomavirus bovis): An Emerging Fetal Pathogen of Cattle That Causes Renal Lesions Resembling Polyomavirus-Associated Nephropathy of Humans. (cdc.gov)
Ureteral stenosis1
  • In immunosuppressed individuals the virus can lead to hemorrhagic cystis, ureteral stenosis and some urinary tract illnesses.ic meningitis. (stanford.edu)
Human polyomavirus5
BKPyV7
  • Infection with BK polyomavirus (BKPyV) or JC polyomavirus causes substantial illness and death in immunocompromised populations, including transplant recipients and HIV patients ( 1 ). (cdc.gov)
  • These results strongly suggest that BKPyV has the potential to cause nosocomial infection within a medical facility, especially among recipients of HSCT. (elsevierpure.com)
  • Further studies are clearly warranted to elucidate the route(s) of BKPyV transmission in order to establish optimal infection control. (elsevierpure.com)
  • The research will provide the foundation for future clinical trials testing if strategies such as the infusion of virus fighting T-cells can prevent or treat BKPyV polyomavirus-associated disease and subsequently decrease morbidity and mortality for transplant patients. (chop.edu)
  • In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
  • The diagnosis of BKPyV-associated pneumonia was confirmed by metagenomic next-generation sequencing and polymerase chain reaction after the sudden worsening of the pulmonary infection signs and symptoms concomitant with renal dysfunction and systemic immune weakening. (biomedcentral.com)
  • BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
Viruses9
  • Polyomaviruses are small, circular, double-stranded DNA viruses. (cdc.gov)
  • [ 3 ] Fungi ( Blastomyces and Candida species) and viruses (polyomavirus, adenovirus, cytomegalovirus [CMV]) can also be responsible for acute inflammation, primarily in immunosuppressed patients. (medscape.com)
  • These are the use of induction immunosuppression, donor seropositivity, old donors, simultaneous kidney-pancreas transplantation, presence of allograft rejection and concurrent infection from other viruses. (nephrologistinagartala.com)
  • BK virus (BKV) is a polyomavirus and Epstein-Barr Virus (EBV) is a gamma herpesvirus, both viruses can cause disease in humans. (novacyt.com)
  • BK and JC viruses are members of polyomavirus family. (cytopathology.ca)
  • Some of the most virulent diseases are caused by viruses, e.g., the hemorrhagic fever caused by Ebola virus. (unboundmedicine.com)
  • Viruses are also responsible for the common cold, childhood exanthems (such as chickenpox, measles, rubella), latent infections (such as herpes simplex), some cancers or lymphomas (such as Epstein-Barr virus), and diseases of all organ systems. (unboundmedicine.com)
  • Both of these have a comprehensive list of viral frequencies that cover the majority of viruses that affect humans, so if you suspect you have a fungal infection, these are recommended. (essentialoiltherapy.org)
  • To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. (shengsci.com)
Recipients8
Merkel2
  • Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes. (ictv.global)
  • Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. (ictv.global)
Viral infections2
  • Opportunistic Viral Infections After Kidney Transplantation: A Review. (edu.iq)
  • Dengue virus (DENV) infection is one of the most widespread mosquito-borne viral infections. (shengsci.com)
Fever6
  • If symptoms do appear, they tend to be mild: respiratory infection or fever. (wikipedia.org)
  • Infection initially produces fever and malaise followed by hyperactivity, aggression, convulsion and change in behavior. (stanford.edu)
  • HHV-6B infection causes high fever, irritability, malaise and roseola-like rash. (stanford.edu)
  • Hemorrhagic fever is possible. (stanford.edu)
  • Crimean-Congo Hemorrhagic Fever in the Middle East: History and Facts. (edu.iq)
  • Infection primarily occurs in the winter months and is characterised by sudden fever, slight hyperpnoea, apathy, rhinitis and cough. (laboklin.com)
Transplant6
  • WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. (cdc.gov)
  • Infection with the BK virus (BKV): In 1971, a renal transplant recipient suffering from ureteric stenosis had the BK virus isolated from his urine. (openpr.com)
  • A major cause of morbidity and mortality after kidney transplant is infection from Epstein-Barr virus (EBV) as it has a connection with PTLD development. (nephrologistinagartala.com)
  • Despite the risk of infections associated with a kidney transplant, it is an important treatment option for kidney failure. (nephrologistinagartala.com)
  • Though symptomatic BK virus infection of the genitourinary tract is common in immunosuppressed transplant patients, its occurrence in a patient undergoing immunomodulation for an autoimmune disease has not been reported yet. (uconn.edu)
  • BKV also known as polyomavirus hominis - 1, was first isolated in 1971 from the urine of a renal transplant patient. (rtdiagnostics.net)
20231
  • BK virus infections Pipeline Insight, 2023" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the BK virus infections Market. (openpr.com)
Severe3
  • Increased susceptibility to infections, including opportunistic infections and severe infections with fatal outcomes [see Warnings and Precautions (5.3) ]. (nih.gov)
  • Liver injury is commonly observed in severe DENV infection, and the present study aimed to examine the efficacy of crocetin treatment in an immunocompetent mouse model of DENV infection exhibiting liver injury. (shengsci.com)
  • Wherever the infection is seated, if it is severe then the vet will almost certainly give a loading dose of antibiotic. (netvet.co.uk)
Transplantation2
  • It can happen after transplantation and the cause is sometimes donor-derived infection. (nephrologistinagartala.com)
  • After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
Fungal infection2
  • Short lived plants have only two to eight aromatic oils, which are mostly to protect them from fungal infection. (essentialoiltherapy.org)
  • If you have a fungal infection, I have included a list of recommended herbal teas. (essentialoiltherapy.org)
Opportunistic2
  • As an opportunistic infection, if the subsequent viral card produces a primary infection the player will come down with hemorrhagic cystis and kidney injury. (stanford.edu)
  • The most common adverse reactions in clinical trials (20 % or greater) include diarrhea, leukopenia, infection, vomiting, and there is evidence of a higher frequency of certain types of infections e.g., opportunistic infection. (nih.gov)
Virus21
  • Infection with either virus is typically asymptomatic unless the host is immunocompromised. (cdc.gov)
  • In a given patient, however, whether the infection is due to primary infection or reactivation of latent virus is unclear. (medscape.com)
  • Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, BK virus infections pipeline constitutes 4+ key companies continuously working towards developing 4+ BK virus infections treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (openpr.com)
  • The BK virus infections Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (openpr.com)
  • Companies across the globe are diligently working toward developing novel BK virus infections treatment therapies with a considerable amount of success over the years. (openpr.com)
  • Emerging BK virus infections therapies in the different phases of clinical trials are- BK virus antiviral therapy, AIC 468, AntiBKV antibody, Brincidofovir, MAU868, ALVR 105, and others are expected to have a significant impact on the BK virus infections market in the coming years. (openpr.com)
  • BK virus infections pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (openpr.com)
  • Past infection with the BK virus is widespread, but significant consequences of infection are uncommon, with the exception of the immunocompromised and the immunosuppressed. (wikipedia.org)
  • This case illustrates the potential for active BK virus infections in atypical patient populations and underscores the importance of rigorous hematuria workup, particularly in patients with multiple risk factors. (uconn.edu)
  • Nipah virus infection causes febrile encephalitis and aseptic meningitis. (stanford.edu)
  • A relativiely quick virus, clinical manifestations of Nipah infection occur shortly after handling infected pigs. (stanford.edu)
  • Immunosuppression reactivates BK virus replication and is linked to hemorrhagic cystis in bone marrow transplants. (stanford.edu)
  • A slow virus, BK establishes latent infections in B-lymphocytes and attacks an immunosuppressed host upon reactivation. (stanford.edu)
  • It is a non-enveloped double-stranded DNA virus of the polyomavirus family that infects primarily in the urothelium at latency. (rtdiagnostics.net)
  • It is noted that only a few tubules are showing cytopathic effects, which is common for JC virus infection as opposed to the more diffuse tubular cell changes related to BK virus infection. (cytopathology.ca)
  • The virus is harmless to macaques or may cause only a herpetic rash in macaques, but in humans it often produces fatal infections of the brain and meninges. (unboundmedicine.com)
  • Detta steg är nödvändigt för att virus ska kunna föröka sig i en infekterad cell och sprida sig vidare till intilliggande celler och vidare till andra människor. (umu.se)
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • Despite efforts made over past decades, there is no vaccine or treatment available for preventing and controlling the ASF virus (ASFV) infection, and there is an urgent need to develop novel strategies. (mdpi.com)
  • Uncontrolled acute or chronic infection other than BK virus (BKV) infection at screening which might interfere with study participation at the discretion of the investigator 6. (trialstoday.org)
  • The JC virus, or John Cunningham virus, is a ubiquitous, typically harmless polyomavirus that can cause PML (progressive multifocal leukoencephalopathy) in immunocompromised individuals. (hbot-india.com)
Diseases1
  • Corticosteroids may suppress clinical signs of infection and allow diseases such as septicaemia or tuberculosis to reach an advanced stage before being recognised. (obaid.info)
Replication1
  • Weeks after the primary infection, with continued replication of the bacilli, development of cell-mediated immunity leads to macrophage infiltration and ingestion of the pathogen. (medscape.com)
Candida1
  • Species of fungi associated with urogenital fungal infections include Blastomyces dermatitidis, Candida species, and Torulopsis glabrata. (medscape.com)
Species4
  • Since polyomaviruses are generally thought to cospeciate with mammalian hosts, the high degree of similarity to HPyV6 suggests the new polyomavirus species is human-tropic. (bvsalud.org)
  • These two polyomaviruses represent a new species in the genus Betapolyomavirus. (bvsalud.org)
  • A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. (lookformedical.com)
  • Feeding a healthy diet suitable for the species is also important as vitamin C is as important to reptiles as it is to other animals in fighting off infections of the URTI causing organisms. (netvet.co.uk)
Viremia1
  • EBV primary infection usually occurs in childhood leading to asymptomatic viremia followed by lifelong latent infection, while later infection can lead to mononucleosis. (novacyt.com)
Patient's1
  • Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. (cdc.gov)
Primary infection1
  • BKV primary infection usually occurs in childhood leading to symptoms similar to a common cold followed by lifelong latent infection. (novacyt.com)
Pathogen1
  • Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient. (cdc.gov)
Respiratory tract infe1
  • But other respiratory tract infections can be treated and when spotted early are not too serious. (netvet.co.uk)
Bladder4
  • Candidal infection of the bladder is shown in the image below. (medscape.com)
  • Gross pathology of the bladder with candidal infection and hemorrhage. (medscape.com)
  • However, these symptoms are nonspecific and may also be associated with infection of the lower genitourinary tract (urethra, vagina) or with noninfectious conditions such as bladder carcinoma, urethral diverticulum, and calculi. (medscape.com)
  • C trachomatis infection has also been linked to painful bladder syndrome (PBS). (medscape.com)
Symptoms4
  • Initial infection with mycobacteria generally elicits a mild inflammatory response with few or no symptoms. (medscape.com)
  • Studies in humans and animal models have shown that symptoms are not immediate and appear days or even weeks after infection. (shengsci.com)
  • Just think back to when you had a cold last and if you see the symptoms in your turtle or tortoise, then you can be pretty sure they have an URTI (upper respiratory tract infection). (netvet.co.uk)
  • Symptoms of an LRTI (lower respiratory tract infection) are similar, but with some additional signs. (netvet.co.uk)
Malignancies1
  • BACKGROUND: Viral infection is an oncogenic factor in many hematolymphoid malignancies. (bvsalud.org)
Disease8
  • Conversely, there are indications that bacteria influence the course of disease after infections with Eimeria spp. (bioone.org)
  • Power level is low in healthy children in whom the viral infection is subclinical or produces mild respiratory disease. (stanford.edu)
  • Known as a Polyomavirus, polyoma is an infectious disease of young birds. (imparrot.com)
  • Den återstående sjukdomar beskrivs som "Disease X" och som representeras av kunskapen att en allvarlig internationell epidemi kan orsakas av ett smittämne som för närvarande är okänt som sjukdomsframkallande hos människor. (umu.se)
  • Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. (shengsci.com)
  • GPV infection, also known as Derzsy's disease in Europe, was described in China by Professor Fang in the early 1960s [ 4 ]. (biomedcentral.com)
  • Muscovy duck parvovirus infection, also known as "three-week" disease in China, was initially described by Professor Lin in our laboratory in the early 1990s [ 5 ]. (biomedcentral.com)
  • An upper respiratory tract infection is often referred to as RND - runny nose disease and this is, like in humans and many other animals, the first sign. (netvet.co.uk)
Widespread1
  • Both GPVs and MDPVs infections are widespread in China, causing huge economic loss due to the high mortality and morbidity within waterfowl husbandry industries. (biomedcentral.com)
20211
  • Fatal Human Rabies Infection with Suspected Host-mediated Failure of Post-Exposure Prophylaxis Following a Recognized Zoonotic Exposure-Minnesota, 2021. (cdc.gov)
Immune-compromised1
  • Basking temperature also needs to be accurate and if the turtle is kept too cool not only will it be sluggish but it will also become stressed and off its food, leaving it immune compromised and prone to infection. (netvet.co.uk)
Immunocompetent1
  • Fungal infections can occur in immunocompetent hosts, but they are more likely to occur in individuals with abnormal immune systems. (medscape.com)
Acute1
  • Biomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4⁺ T-cell Count? (shengsci.com)
Occurs2
  • infection probably occurs during early childhood. (cdc.gov)
  • In contrast to GPV, MDPV infection occurs only in Muscovy ducklings and is characterized by watery diarrhoea, wheezing, and locomotor dysfunction. (biomedcentral.com)
Pneumonia3
  • In 2007, WU polyomavirus (WUPyV) was discovered in a child in Australia with pneumonia ( 6 ). (cdc.gov)
  • Many complications normally follow these, which are postoperative infections, pneumonia and septicemia. (nephrologistinagartala.com)
  • In them, the three leading sites of fungal infections are esophageal candidiasis, pneumonia and urogenital candidiasis. (nephrologistinagartala.com)
Sequences1
  • Sequences of this polyomavirus cluster phylogenetically with those of other rodent polyomaviruses and two other non-rodent polyomaviruses (WU and KI) that have been identified in the human respiratory tract. (bvsalud.org)