• Hereditary hemolytic anemias are a group of disorders with a variety of causes, including red cell membrane defects, red blood cell enzyme disorders, congenital dyserythropoietic anemias, thalassemia syndromes and hemoglobinopathies. (haematologica.org)
  • In this condition, the body is missing an enzyme called pyruvate (PI-ru-vate) kinase. (hoacny.com)
  • The enzyme activity rate in most patients with pyruvate kinase deficiency is 5-25% of normal, with measurement of the intermediates (2,3-diphosphoglycerol and glucose-6-phosphate) proximal to the enzyme defect helping to confirm the diagnosis. (medscape.com)
  • Enzyme assay, as well as deoxyribonucleic acid (DNA) analysis with a polymerase chain reaction (PCR) assay or single-strand conformation polymorphism, can also be used to confirm the diagnosis of pyruvate kinase deficiency. (medscape.com)
  • The exome sequencing quickly pinpointed two separate, rare mutations in PKLR, a gene that makes pyruvate kinase, an enzyme in which defects have previously been implicated as one cause of hemolytic anemia. (chop.edu)
  • Differential diagnoses include other causes of hemolysis, including hereditary spherocytosis, overhydrated hereditary stomatocytosis, hemoglobinopathy or red cell enzyme deficiencies such as hemolytic anemia due to red cell pyruvate kinase deficiency (see these terms). (orpha.net)
  • Affected dogs have insufficient activity of the pyruvate kinase Enzyme which breaks down glycogen for energy. (pawprintgenetics.com)
  • Pyruvate kinase deficiency is an inherited red blood cell enzyme disorder that causes chronic hemolysis. (conduent.com)
  • Affected individuals are either homozygous for a single pathogenic mutation or compound heterozygous for two different pathogenic variants affecting the function of the pyruvate kinase enzyme in red blood cells and liver. (conduent.com)
  • Pyruvate kinase deficiency (PKD) is the most common enzyme-related glycolytic defect that results in red cell hemolysis. (exploremyplan.com)
  • Pyruvate kinase (PK) enzyme is key to this process. (exploremyplan.com)
  • Pyruvate kinase is the main enzyme found in erythrocytes and ensures the physical activity of blood cells. (mainecoon-russia.ru)
  • An insufficient amount of the enzyme in the body leads to the development of anemia, that is, a reduction in the number of red blood cells. (mainecoon-russia.ru)
  • A mutation associated with a deficiency of the enzyme pyruvate kinase in domestic cats, as described by Grahn et al. (mainecoon-russia.ru)
  • Pyruvate kinase (PK) is an enzyme needed for normal energy production by the red blood cells. (wisdompanel.com)
  • The equation shows that one molecule of glucose (a six-carbon sugar) is converted into two molecules of pyruvate (a three-carbon compound) by a series of enzyme-catalyzed reactions. (stemcelldaily.com)
  • The etiopathogenetic basis of hereditary hemolytic syndromes is genetic defects of erythrocyte membranes, their enzyme systems or the structure of hemoglobin. (medic-journal.com)
  • Pyruvate Kinase Deficiency (PKD) is a disorder that affects red blood cells due to a mutation in an important enzyme needed for metabolism. (mabrylabrador.com)
  • PKD is caused by alterations (mutations) in the PKLR gene, which lead to a deficiency of the enzyme pyruvate kinase. (olympusresearchglobal.com)
  • Pyruvate kinase is an enzyme that helps cells turn sugar (glucose) into energy (called adenosine triphosphate, ATP) in a process called glycolysis. (olympusresearchglobal.com)
  • The PKLR gene contains instructions for creating (encoding) a specialized protein (enzyme) known as pyruvate kinase. (olympusresearchglobal.com)
  • Pyruvate kinase deficiency, one of the most common enzymatic defects of the erythrocyte, manifests clinically as a hemolytic anemia that can range from a mildly compensated anemia to severe anemia of childhood. (medscape.com)
  • Erythrocyte Pyruvate Kinase Deficiency mutation identified in multiple breeds of domestic cats. (wisdompanel.com)
  • Erythrocyte pyruvate kinase deficiency in three West Highland white terriers in Ireland and the UK. (pawprintgenetics.com)
  • Skelly BJ, Wallace M, Rajpurohit YR, Wang P, Giger U. Identification of a 6 base pair insertion in West Highland White Terriers with erythrocyte pyruvate kinase deficiency. (pawprintgenetics.com)
  • This group is sometimes called congenital nonspherocytic (hemolytic) anemia , which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding hemoglobin abdormalities as well, but rather encompassing defects of glycolysis in the erythrocyte. (en-academic.com)
  • Pyruvate kinase deficiency leads to erythrocyte instability, periodically manifested by hemolytic anemia. (mainecoon-russia.ru)
  • Determination of erythrocyte pyruvate kinase deficiency in Basenjis with chronic hemolytic anemia. (wisdompanel.com)
  • Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency. (wisdompanel.com)
  • Identification of a 6 base pair insertion in West Highland White Terriers with erythrocyte pyruvate kinase deficiency. (wisdompanel.com)
  • a familial disorder characterized by anemia with multinuclear erythroblasts, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (erythroid precursor cells). (icdlist.com)
  • hemolytic anemia due to various intrinsic defects of the erythrocyte. (icdlist.com)
  • any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. (icdlist.com)
  • anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. (icdlist.com)
  • With the autoimmune mechanism of anemia, the formation of anti-erythrocyte AT (heat, cold) occurs, which cause enzymatic lysis of the erythrocyte membrane. (medic-journal.com)
  • An international, multicenter registry that collected clinical data on patients with pyruvate kinase deficiency found that 93% of newborns were treated with phototherapy, and 46% were treated with exchange transfusions. (medscape.com)
  • It improves hemoglobin values and reduces transfusion burden in patients with pyruvate kinase deficiency by targeting the underlying defect. (medscape.com)
  • Pyruvate Kinase (PK) Deficiency presents as a chronic, intermittent, hemolytic anemia. (wisdompanel.com)
  • However, they did find other mutations that appear to cause chronic anemia in one family member. (chop.edu)
  • The man, a young adult, had been plagued his whole life with chronic anemia, had suffered abdominal pain and jaundice, and had undergone surgeries to remove first his gallbladder, then his spleen. (chop.edu)
  • PK deficiency is a rare, inherited disease that presents as chronic hemolytic anemia. (biospace.com)
  • The most common reason for hospitalization because of acute anemia is due to the so-called aplastic crisis in children with chronic hemolytic anemia who otherwise had been stable. (medscape.com)
  • Supportive therapy is important in chronic anemia. (exploremyplan.com)
  • We report the case of a 5-year-old girl suffering from chronic haemolytic anaemia. (sajch.org.za)
  • An updated meta-analysis on the efficacy and safety of hypoxia-inducible factor prolyl hydroxylase inhibitor treatment of anemia in nondialysis-dependent chronic kidney disease. (medline.ch)
  • Continuous erythropoietin receptor activator for the treatment of chronic dialysis patients with renal anemia in daily clinical practice in Poland: A non-interventional, multi-center, pragmatic NAVIGO trial. (medline.ch)
  • Iron (non-heme) measurements are used in the diagnosis and treatment of diseases, such as iron deficiency anemia, chronic renal disease, and hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin). (cdc.gov)
  • Severe anemia can make heart disease, lung disease, or cerebrovascular disease worse. (medlineplus.gov)
  • Hemolytic anemia can begin rapidly or come on gradually and can range from mild to severe. (daviddarling.info)
  • Severe hemolytic anemia can be life threatening if it's not treated. (daviddarling.info)
  • Most affected individuals do not require treatment, although in the most severe cases, death may occur in utero as a result of severe anemia . (medscape.com)
  • Splenectomy is indicated only for patients with severe anemia. (medscape.com)
  • Clinical findings during a veterinary exam include severe anemia, hardening of the bones, and an enlarged spleen and liver. (pawprintgenetics.com)
  • While dogs can live for several years with this disease, they typically die from severe anemia or liver failure by 5 years of age. (pawprintgenetics.com)
  • Acute and severe anemia can result in cardiovascular compromise. (medscape.com)
  • Severe anemia may also benefit from splenectomy. (exploremyplan.com)
  • In those cases when the feline body is exposed to extreme stress, the action of infection or certain medications, anemia is severe, and the outcome of the disease is doubtful. (mainecoon-russia.ru)
  • A 5-year-old girl was referred from a regional hospital to the paediatric haematology clinic at Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa, with severe anaemia. (sajch.org.za)
  • the disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (icdlist.com)
  • Alternative treatment modality for severe aplastic anemia in a resource-limited setting: a single-institution prospective cohort study from Upper Egypt. (medline.ch)
  • Alloantibodies in the Kell and Kx blood group system can cause strong reactions to transfusions of incompatible blood and severe anemia in affected male newborns of Kell-negative mothers. (nih.gov)
  • This defect leads to red blood cell death that results in severe hemolytic anemia. (mabrylabrador.com)
  • Glycolytic Pathway Defects Glycolytic pathway defects are autosomal recessive red blood cell metabolic disorders that cause hemolytic anemia. (merckmanuals.com)
  • The term "anemia" means that the number of red blood cells in a person's blood is less than normal or the red blood cells don't contain enough hemoglobin . (daviddarling.info)
  • In sickle cell anemia , the body makes an abnormal type of hemoglobin. (daviddarling.info)
  • Although their symptoms are very different, they all suffer from anemia, which is defined as lower than average levels of hemoglobin, typically below 13.5 g/dL in adult men and below 12.0 g/dL in adult women.This level varies based on the age for children. (osmosis.org)
  • and hemoglobin abnormalities, like in sickle cell anemia . (osmosis.org)
  • Pediatric anemia refers to a hemoglobin or hematocrit level lower than the age-adjusted reference range for healthy children. (medscape.com)
  • Physiologically, anemia is a condition in which reduced hematocrit or hemoglobin levels lead to diminished oxygen-carrying capacity that does not optimally meet the metabolic demands of the body. (medscape.com)
  • These should be specified for each patient after a meticulous assessment of their tolerance regarding anemia, quality of life, and physical activity, rather than a measure of their absolute hemoglobin levels. (exploremyplan.com)
  • a condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes). (icdlist.com)
  • anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. (icdlist.com)
  • anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (mcv) and increased mean corpuscular hemoglobin (mch). (icdlist.com)
  • hemoglobinopathies are anemia associated with qualitative disorders of the structure of hemoglobin or a change in the ratio of its normal forms (thalassemia, sickle cell anemia). (medic-journal.com)
  • Congenital hemolytic jaundice - Known also as hereditary spherocytosis (HS), this is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice (yellowing) and splenomegaly (enlargement of the spleen). (en-academic.com)
  • Sickle cell anemia is a serious, inherited disease. (hoacny.com)
  • In the United States, sickle cell anemia mainly affects African Americans. (hoacny.com)
  • Building on the company's leadership in the field of cellular metabolism, Agios is advancing a robust clinical pipeline of investigational medicines with programs in alpha- and beta-thalassemia, sickle cell disease, pediatric PK deficiency and MDS-associated anemia. (checkorphan.org)
  • Pubertal patterns in children with sickle cell anemia: A case-control study in Cameroon. (medline.ch)
  • You may not have symptoms if the anemia is mild. (medlineplus.gov)
  • Contact your health care provider if you develop symptoms of hemolytic anemia. (medlineplus.gov)
  • Symptoms are related to the degree of anemia and may include jaundice and splenomegaly. (msdmanuals.com)
  • When anemia is acute, the body does not have enough time to make the necessary physiologic adjustments, and the symptoms are more likely to be pronounced and dramatic. (medscape.com)
  • In contrast, when anemia develops gradually, the body is able to adjust, using all 4 mechanisms mentioned above (1, 3, and 4 in most cases), ameliorating the symptoms relative to the degree of the anemia. (medscape.com)
  • There are many types of hemolytic anemia. (hoacny.com)
  • In some types of hemolytic anemia, the body makes abnormal red blood cells that break down and hemolyze on their own. (daviddarling.info)
  • In other types of hemolytic anemia, the body's immune system , infections, certain drugs, or other agents attack normal red blood cells, causing them to hemolyze. (daviddarling.info)
  • The two main types of hemolytic anemia are inherited and acquired. (daviddarling.info)
  • See also Overview of Hemolytic Anemia. (merckmanuals.com)
  • Overview of Hemolytic Anemia At the end of their normal life span (about 120 days), red blood cells (RBCs) are removed from the circulation. (msdmanuals.com)
  • However, except for hereditary spherocytosis for which the effectiveness of splenectomy has been well documented, the efficacy of splenectomy in other anemias within this group has yet to be determined and there are concerns regarding short- and long-term infectious and thrombotic complications. (haematologica.org)
  • As no randomized clinical trials, case control or cohort studies regarding splenectomy in these disorders were found in the literature, recommendations for each disease were based on expert opinion and were subsequently critically revised and modified by the Splenectomy in Rare Anemias Study Group, which includes hematologists caring for both adults and children. (haematologica.org)
  • Peripheral blood smear in a child with splenectomy and pyruvate kinase deficiency. (medscape.com)
  • In a retrospective study from 1980, the sensitivity and specificity of haptoglobin in the diagnosis of hemolytic anemia was 83% and 96%, respectively. (medscape.com)
  • D64.9 is a billable ICD-10 code used to specify a medical diagnosis of anemia, unspecified. (icdlist.com)
  • An Exploratory Investigation into Optimal Indicators and Thresholds for Anemia Diagnosis Through Abdominal CT Plain Scans. (medline.ch)
  • Hemolytic anemia occurs when the bone marrow isn't making enough red cells to replace the ones that are being destroyed. (medlineplus.gov)
  • In the inherited hemolytic anemias, one or more of the genes that control the production of red blood cells are defective, causing the bone marrow to make abnormal cells. (daviddarling.info)
  • a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. (icdlist.com)
  • In hemolytic anemia, lactic dehydrogenase (LDH) levels typically increase while haptoglobin levels decrease. (medscape.com)
  • Hereditary spherocytosis (SFER-o-si-to-sis) is the most common cause of hemolytic anemia among people of Northern European descent. (hoacny.com)
  • hemolytic anemia that is present from birth and in which the lifespan of red blood cells is diminished, such as occurs in hereditary spherocytosis. (en-academic.com)
  • CAMBRIDGE, Mass., Nov. 20, 2023 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in the field of cellular metabolism pioneering therapies for rare diseases, today announced that clinical proof-of-concept has been achieved in the Phase 2a portion of a study of investigational pyruvate kinase (PK) activator AG-946 as a potential treatment for anemia in adults with lower-risk myelodysplastic syndromes (LR-MDS). (ktla.com)
  • In the U.S., Agios markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for this rare, lifelong, debilitating hemolytic anemia. (checkorphan.org)
  • Mitapivat is a pyruvate kinase activator that acts by allosterically binding to the pyruvate kinase tetramer and increasing pyruvate kinase activity. (conduent.com)
  • Please note: It is possible that disease signs similar to the ones caused by the Pyruvate Kinase Deficiency mutation could develop due to a different genetic or clinical cause. (wisdompanel.com)
  • With appropriate genetic counseling, the genetic information can be helpful to this patient, as he is extremely unlikely to pass on anemia to any future children, because of the recessive nature of the illness and the rarity of these specific mutations. (chop.edu)
  • Genetic testing of the PKLR gene will reliably determine whether a dog is a genetic Carrier of pyruvate kinase deficiency (terrier type). (pawprintgenetics.com)
  • Genetic test for pyruvate kinase deficiency of Basenjis. (wisdompanel.com)
  • Pyruvate kinase deficiency (PKD) is a rare genetic disorder characterized by the premature destruction of red bloods, which is called hemolytic anemia. (olympusresearchglobal.com)
  • Agios Therapeutics, which was founded from seed financing by Flagship and ARCH Venture Partners in 2007, notched an FDA approval for its gene therapy Pyrukynd to treat hemolytic anemia in adults with pyruvate kinase (PK) deficiency in late 2022. (pharmavoice.com)
  • Prior to February 2022, there were no approved disease-modifying therapies for those with pyruvate kinase (PK) deficiency. (patientworthy.com)
  • Pyruvate kinase deficiency (terrier type) is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. (pawprintgenetics.com)
  • Pyruvate kinase deficiency is a hereditary disease with an autosomal recessive mode of inheritance, accompanied by hemolytic anemia. (mainecoon-russia.ru)
  • Aldolase A deficiency is an autosomal recessive disorder associated with hereditary hemolytic anemia (Kishi et al. (nih.gov)
  • Pyruvate Kinase (PK) Deficiency is a disorder that causes anemia due to the breakdown of red blood cells. (wisdompanel.com)
  • Those mutations caused a different disease, unrelated to ADHD - a blood disorder called idiopathic hemolytic anemia . (chop.edu)
  • The FDA has recently approved a treatment called Pyrukynd as a therapeutic option for hemolytic anemia disorder sparked by pyruvate kinase deficiency. (patientworthy.com)
  • Congenital pernicious anemia (PA), or intrinsic factor deficiency, is a rare disorder characterized by the lack of gastric intrinsic factor in the presence of normal acid secretion and mucosal cytology and the absence of GIF antibodies that are found in the acquired form of pernicious anemia (170900). (nih.gov)
  • In immune hemolytic anemia, your immune system destroys your red blood cells. (hoacny.com)
  • The three main types of immune hemolytic anemia are autoimmune, alloimmune, and drug-induced. (hoacny.com)
  • Determinates of anemia among Human Immune Deficiency Virus positive children on Anti-retro Viral Therapy in selected health facilities, Northwest Ethiopia: A Case-Control Study. (medline.ch)
  • Posttransfusion reactions, preventive vaccination, and fetal hemolytic disease can contribute to the development of immune hemolytic anemia. (medic-journal.com)
  • Anaemia, excretion of protein in the urine and jaundice are the consequences, so that the kittens usually die within the first week of life. (laboklin.co.uk)
  • There is no specific therapy for hemolytic anemias caused by glycolytic pathway defects. (msdmanuals.com)
  • With last week's FDA approval of PYRUKYND ® for the treatment of hemolytic anemia in adults with PK deficiency, we have delivered the first therapy for a rare, debilitating, lifelong disease - and we have set the stage for Agios' next chapter as a leader in the genetically defined disease space," said Jackie Fouse, Ph.D., chief executive officer at Agios. (biospace.com)
  • Received approval from the U.S. Food and Drug Administration (FDA) for PYRUKYND ® , the first therapy for the treatment of hemolytic anemia in adults with PK deficiency and Agios' first genetically defined disease medicine. (biospace.com)
  • We are pleased with the results of the Phase 2a study, which underscore the potential of AG-946 to be a first-in-class, oral, safe and effective option for the treatment of anemia in adults with LR-MDS by improving red blood cell health through its unique mechanism of action. (ktla.com)
  • The open-label, proof-of-concept, Phase 2a portion of the study was designed to evaluate the safety and efficacy of AG-946 in adults with anemia due to lower-risk MDS. (ktla.com)
  • Alright, now hemolytic anemias can be classified as intrinsic and extrinsic hemolytic anemias . (osmosis.org)
  • In this video, let's focus on intrinsic hemolytic anemias . (osmosis.org)
  • See also pernicious anemia due to defect in the receptor for vitamin B12/intrinsic factor (261100). (nih.gov)
  • Hemolytic anemias: red blood cell membrane and metabolic defects. (medlineplus.gov)
  • Pyruvate kinase deficiency (terrier type) is an inhered metabolic disease affecting dogs. (pawprintgenetics.com)
  • Mild hemolytic anemia may need no treatment at all. (daviddarling.info)
  • In patients with mild to moderate pyruvate kinase deficiency, care is predominantly supportive. (medscape.com)
  • Animals with mild anemia can live without attracting attention to themselves, and the disease is detected only with a detailed examination. (mainecoon-russia.ru)
  • A full blood count revealed a normocytic, hypochromic anaemia with a mild thrombocytopenia and leuko-erythroblastic reaction (left shift and presence of nucleated red cells). (sajch.org.za)
  • Pyruvate Kinase Deficiency Hemolytic Anemia has a gene test available. (tripod.com)
  • Overall, a serum haptoglobin level below 25 mg/dL equated to an 87% probability of predicting hemolytic disease. (medscape.com)
  • for example hypersplenism plus hemolytic anemia may result in a false-normal overall serum value. (medscape.com)
  • Although the man had long contended with the blood disease, "idiopathic" meant that physicians were unable to determine the cause of his particular anemia-until now, say authors of a new study. (chop.edu)
  • The hemolytic disease that ensues can be lethal. (laboklin.co.uk)
  • Anemia is not a specific disease entity but is a condition caused by various underlying pathologic processes. (medscape.com)
  • Educate the patient and/or the family about the specific disease that causes the anemia. (medscape.com)
  • Special mention should be made of knitting cats with PK-deficiency anemia: even if the disease did not manifest itself, pregnancy leads to a sharp exacerbation. (mainecoon-russia.ru)
  • Olympus Research Global's (ORG) "Pyruvate Kinase Deficiency (PKD) - Market Insights, Epidemiology, Industry trends & Market Forecast-2034" report provides an overview of the disease and market size of Pyruvate Kinase Deficiency (PKD) for the seven major markets i.e., the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. (olympusresearchglobal.com)
  • Anemia is a condition in which the body does not have enough healthy red blood cells. (medlineplus.gov)
  • In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal. (medlineplus.gov)
  • With acquired hemolytic anemias, your red blood cells may be normal. (hoacny.com)
  • Hemolytic anemia is a rare form of anemia in which red blood cells ( erythrocytes ) are destroyed and removed from the bloodstream before their usual lifespan is up. (daviddarling.info)
  • In hemolytic anemia, the body breaks down and removes red blood cells faster than it can replace them. (daviddarling.info)
  • In some kinds of anemia, there are low amounts of all three types of blood cells. (daviddarling.info)
  • He had been told that he had 'idiopathic hemolytic anemia,' which basically means, 'your red blood cells are bursting open for reasons we do not understand,'" said Lyon. (chop.edu)
  • Affected dogs typically present between 4 months and 1 year of age with pale gums from decreased numbers of red blood cells ( Anemia ) and lethargy or exercise intolerance. (pawprintgenetics.com)
  • PK deficiency affects the life span of erythrocytes (red blood cells) that break down particularly easily, which results in hemolytic anemia. (wisdompanel.com)
  • acquired hemolytic anemia due to the presence of autoantibodies which agglutinate or lyse the patient's own red blood cells. (icdlist.com)
  • Hemolytic anemia is a pathology of red blood cells, the hallmark of which is the accelerated destruction of red blood cells with the release of an increased amount of indirect bilirubin. (medic-journal.com)
  • Human PV-B19 also is associated with other hematologic, rheumatologic, and neurologic conditions, including polyarthropathy, aplastic anemia , and hydrops fetalis . (medscape.com)
  • Comparison of eltrombopag and avatrombopag in the treatment of refractory/relapsed aplastic anemia: a single-center retrospective study in China. (medline.ch)
  • Evaluation of children with a haemolytic anaemia requires a thorough history and physical examination, appropriate laboratory testing and careful interpretation of the results. (sajch.org.za)
  • Congenital hemolytic anemia (or hereditary hemolytic anemia ) refers to hemolytic anemia which is primarily due to congenital disorders . (en-academic.com)
  • Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea. (medline.ch)
  • Alpelisib is small-molecule inhibitor of phosphatidylinositol-3 kinase (PI3K). (conduent.com)