Hemolytic anemia and thrombocytopenia. Medical search. Frequent questions

These are: Fever Changes in mental status Thrombocytopenia Reduced kidney function Hemolytic anemia (microangiopathic hemolytic anemia). (wikipedia.org)
TTP, as with other microangiopathic hemolytic anemias (MAHAs), is caused by spontaneous aggregation of platelets and activation of coagulation in the small blood vessels. (wikipedia.org)
Thrombotic microangiopathies are a group of disorders characterized by thrombocytopenia, microangiopathic hemolytic anemia, and ischemic end organ damage mostly involving the kidneys and brain caused by disseminated occlusive microvascular thrombosis [ 1 ]. (hindawi.com)
Further investigation showed that he had pancytopenia with microangiopathic haemolytic anaemia (MAHA) and intracranial bleeding (ICB). (rcpe.ac.uk)
Laboratory evaluation showed evidence of microangiopathic hemolytic anemia with schistocytes, significant thrombocytopenia and renal insufficiency. (asn-online.org)
Hemolytic uremic syndrome (HUS) is characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. (bmj.com)
Thrombotic Thrombocytopenic Purpura (TTP) Thrombotic thrombocytopenic purpura (TTP) is an acute, fulminant disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia. (merckmanuals.com)
Loose strands of platelets and fibrin are deposited in multiple small vessels and damage passing platelets and red blood cells (RBCs), causing significant thrombocytopenia and anemia (microangiopathic hemolytic anemia). (merckmanuals.com)
The hematologic changes of preeclampsia, ie, thrombocytopenia and microangiopathic hemolytic anemia, are similar to those found in thrombotic thrombocytopenic purpura or hemolytic uremic syndrome - disorders in which endothelial dysfunction is thought to be important. (health.am)
Thrombotic thrombocytopenic purpura (TTP) is a rare, severe life-threatening emergency characterized by microangiopathic hemolytic anemia, thrombocytopenia, acute renal insufficiency, altered mental status, and fever. (thieme-connect.de)
The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
Thrombotic microangiopathy (TMA) is a well-known clinicopathologic entity characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ injury. (jrheum.org)

In primary IMHA, no inciting cause can be identified, hence the term idiopathic IMHA or autoimmune hemolytic anemia (AIHA). (vin.com)
Uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura. (astrazenecaclinicaltrials.com)
B19 is the primary etiologic agent causing TAC in patients with chronic hemolytic anemias (e.g., sickle cell disease, hemoglobin SC disease, hereditary spherocytosis, alpha-thalassemia, and autoimmune hemolytic anemia) (22,23). (cdc.gov)
NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series. (cdc.gov)

Shiga-like toxin producing E coli hemolytic-uremic syndrome (STEC-HUS) is a disorder that most often occurs when an infection in the digestive system produces toxic substances. (medlineplus.gov)
Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E coli bacteria ( Escherichia coli O157:H7). (medlineplus.gov)
Mele C, Noris M, Remuzzi G. Hemolytic uremic syndrome. (medlineplus.gov)
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndromes. (medlineplus.gov)
TMA is well known to occur in the setting of thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). (hindawi.com)
Overlapping presentation of atypical hemolytic uremic syndrome (aHUS) and antiphospholipid antibody syndrome (APS) is a rare phenomenon. (asn-online.org)
Epidemiology of atypical hemolytic uremic syndrome: a systematic literature review. (bmj.com)
Infection by Escherichia coli O157:H7 and Other Enterohemorrhagic E. coli (EHEC) The gram-negative bacteria Escherichia coli O157:H7 and other enterohemorrhagic E. coli (EHEC) typically cause acute bloody diarrhea, which may lead to hemolytic-uremic syndrome. (merckmanuals.com)
Congenital complement disorders may also increase the risk of hemolytic-uremic sydrome (HUS) following infection. (merckmanuals.com)
Children with Shiga toxin-related hemolytic-uremic sydrome (HUS) usually have a prodrome of vomiting, abdominal pain, and diarrhea (frequently bloody) and often a history of exposure to infection. (merckmanuals.com)
7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)

Laboratory tests will show signs of hemolytic anemia and acute renal failure . (medlineplus.gov)
Many dogs suspected to have idiopathic IMHA present with an acute history of vomiting, diarrhea, lethargy, or anorexia indicating a recent trigger rather than reflecting signs of hemolytic anemia. (vin.com)
B19 has also been associated with fetal death (both spontaneous abortions and stillbirths), acute arthralgias and arthritis, and chronic anemia in immunodeficient patients (5-14). (cdc.gov)

Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. (cdc.gov)
Parthenogenetic populations were found in ≥15 provinces in China and strongly correlated with the distribution of severe fever with thrombocytopenia syndrome cases. (cdc.gov)
History of hemolytic anemia, autoimmune thrombocytopenia, or Evans syndrome in the last 3 months. (uclahealth.org)
IMHA may also be known as pure red cell aplasia (PRCA) or Evans syndrome (if it coexists with immune-mediated thrombocytopenia). (petplace.com)
Current evidence for the role of complement in the pathogenesis of Shiga toxin haemolytic uraemic syndrome. (bmj.com)
Antiphospholipid syndrome (APS) is an autoimmune disorder that is associated with pregnancy complications, including preeclampsia, thrombosis, autoimmune thrombocytopenia, fetal growth restriction, and fetal loss. (medscape.com)

RIGL ) today announced that fostamatinib, its oral spleen tyrosine kinase (SYK) inhibitor, met the primary endpoint in the first of two double-blind studies in the FIT Phase 3 clinical program for the treatment of adult chronic/persistent immune thrombocytopenia (ITP). (prnewswire.com)
ABSTRACT Immune thrombocytopenia is a benign and self-limiting disorder. (who.int)
This paper reviews the research about immune thrombocytopenia, comparing low- and high-income countries. (who.int)
One such disease in children is immune thrombocytopenia (also called immune thrombocytopenic purpura or ITP), which is the most common acquired bleeding illness in children [3]. (who.int)
The American Society of Hematology defines it as an isolated thrombocytopenia with clinically no apparent associated conditions or no other cause of thrombocytopenia, such as HIV infection, systemic lupus erythematosus, lymphoproliferative disorders, myelodysplasia, agammaglobulinaemia or hypogammaglobulinaemia, drug-induced thrombocytopenia, alloimmune thrombocytopenia or congenital/hereditary non-immune thrombocytopenia [7]. (who.int)
Toll-Like Receptor 9 (TLR9) Gene C/T (rs352140) Polymorphisms in Adult Primary Immune Thrombocytopenia. (cdc.gov)
A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population. (cdc.gov)
Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic Polymorphisms. (cdc.gov)
SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients. (cdc.gov)
Fc?RIIa and Fc?RIIIa genes polymorphism in Egyptian children with primary immune thrombocytopenia. (cdc.gov)
Effect of Cytokine Gene Polymorphisms on Eltrombopag Reactivity in Japanese Patients with Immune Thrombocytopenia. (cdc.gov)
Association of FOXP3 gene polymorphisms with chronic immune thrombocytopenia in a Chinese Han population. (cdc.gov)
Immune Checkpoint-Related Gene Polymorphisms Are Associated With Primary Immune Thrombocytopenia. (cdc.gov)
Chronic Refractory Immune Thrombocytopenia Is Associated With Variants in Immune Genes. (cdc.gov)
Stromal Derived Factor-1 Gene Polymorphism in Pediatric Immune Thrombocytopenia. (cdc.gov)
Association between ATP binding cassette gene member 1 polymorphism and glucocorticoid response in children with immune thrombocytopenia. (cdc.gov)

Clinically manifest Babesia infection is characterized by the presence of hemolytic anemia and nonspecific flu-like symptoms (e.g., fever, chills, body aches, weakness, fatigue). (cdc.gov)
Canine babesiosis is characterized by varying degrees of hemolytic anemia, splenomegaly, thrombocytopenia, and fever. (auburn.edu)
The most virulent type is B. canis rossi , which is known to cause severe hemolytic anemia, thrombocytopenia, fever, and shock in affected dogs, primarily in South Africa. (dvm360.com)
Objective: one or more of the following: fever, anemia, or thrombocytopenia. (cdc.gov)
SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)

We also discuss clinical reasoning based analysis of DTMA versus cancer-associated TMA as well as DTMA versus cyclic thrombocytopenia seen in PI use. (hindawi.com)
Cases of canine babesiosis may present with a wide variety of clinical signs, ranging from a hyperacute, shockassociated, hemolytic crisis to an inapparent and subclinical infection. (auburn.edu)
As no randomized clinical trials, case control or cohort studies regarding splenectomy in these disorders were found in the literature, recommendations for each disease were based on expert opinion and were subsequently critically revised and modified by the Splenectomy in Rare Anemias Study Group, which includes hematologists caring for both adults and children. (haematologica.org)
He is co-director of the Georgetown University Medical Center Adult Hemophilia Treatment Center and has particular clinical and research interest in bleeding and clotting disorders, bone failure and aplastic anemia, leukemia, and genetic syndromes of cancer predisposition. (medstarhealth.org)
Animals immunized with aCL or with the cofactor beta-2 glycoprotein I (b2GPI) develop clinical manifestations of APS, including fetal loss, thrombocytopenia, and neurologic and behavioral dysfunction, along with elevated levels of aPL antibodies. (medscape.com)
IAH in SCD manifests as febrile haemolytic crisis with clinical and laboratory features of severe anaemia or pancytopenia. (bvsalud.org)

Immune-mediated hemolytic anemia (IMHA) is a common hematological disorder in dogs, may be primary (idiopathic, autoimmune) or occur secondarily to underlying diseases and is often associated with life-threatening complications. (vin.com)
Immune-mediated hemolytic anemia (IMHA) arises when an immune response targets directly or indirectly erythrocytes and hemolytic anemia ensues. (vin.com)
In dogs idiopathic IMHA (AIHA) has been considered the most common cause of hemolytic anemias for decades, and many anemic dogs are presumptively managed for AIHA. (vin.com)
Immune mediated hemolytic anemia (IMHA), also known as auto-immune mediated hemolytic anemia (AIHA, is a disease in which the body's immune system, which is designed to attack and kill germs, attacks and kills the body's own red blood cells. (petplace.com)
These examinations may help rule out causes of anemia other than IMHA, or may help identify triggers that preceded development of IMHA. (petplace.com)

Platelets are also consumed within multiple small thrombi, contributing to the thrombocytopenia. (merckmanuals.com)
Thrombocytopenia with CDA is characterized by dysmorphic erythrocytes and paucity of the platelets. (orpha.net)

For acutely ill patients, the findings on routine laboratory testing frequently include hemolytic anemia and thrombocytopenia. (cdc.gov)
Diagnosis requires demonstrating characteristic laboratory test abnormalities, including direct antiglobulin test-negative hemolytic anemia. (merckmanuals.com)

Other autoimmune diseases, including hemolytic anemia and thrombocytopenia can be secondary to systemic lupus. (ashgi.org)

Thrombocytopenia commonly seen with PIs is called cyclic thrombocytopenia in which the platelet count usually nadirs around day 11 of the cycle and then improves. (hindawi.com)

Furthermore, alloimmune hemolytic anemias, such as hemolytic transfusion reactions are caused by specific anti-erythrocytic alloantibodies. (vin.com)
Anemia can be treated with red cell transfusion. (bmj.com)

Congenital dyserythropoietic anemia (CDA) is a heterogenous group of hematological disorders of late erythropoiesis and red cell abnormalities that lead to anemia. (orpha.net)

It is characterized by thrombotic microangiopathy(TMA), thrombocytopenia and end organ damage. (asn-online.org)

While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)

Hereditary hemolytic anemias are a group of disorders with a variety of causes, including red cell membrane defects, red blood cell enzyme disorders, congenital dyserythropoietic anemias, thalassemia syndromes and hemoglobinopathies. (haematologica.org)
Many of these disorders mimic classic forms of disease (in the absence of immunodeficiency) such as celiac sprue, inflammatory bowel disease (IBD), and pernicious anemia but differ in pathogenesis and are often unresponsive to conventional therapies. (medscape.com)

Patients share chronic anemia of variable severity and jaundice, frequently associated with splenomegaly and/or hepatomegaly. (orpha.net)
CDA I patients have a moderate macrocytic anemia with frequent splenomegaly and occasional hepatomegaly. (orpha.net)
In CDA II, the most frequent type, anemia and/or jaundice is usually detected in children or young adults with splenomegaly. (orpha.net)

However, except for hereditary spherocytosis for which the effectiveness of splenectomy has been well documented, the efficacy of splenectomy in other anemias within this group has yet to be determined and there are concerns regarding short- and long-term infectious and thrombotic complications. (haematologica.org)

Red blood cell destruction leads to symptoms of anemia . (medlineplus.gov)

Vitamin B12 deficiency and folate deficiency are common causes of macrocytic anaemia and both are important for many cellular processes. (rcpe.ac.uk)

Evidence of a hemolytic anemia is suggested clinically by icterus and a regenerative anemia with hyperbilirubinuria, and the presence of hemoglobinemia and hemoglobinuria refers to an intravascular process. (vin.com)

Since its discovery, B19 has been shown to be the causative agent of erythema infectiosum (EI) (also known as fifth disease) and is the primary etiologic agent of TAC in patients with chronic hemolytic anemias (2-4). (cdc.gov)

This report* was developed to assist physicians, public health officials, and other health-care professionals respond to public concerns about recently recognized, serious complications of human parvovirus B19 (B19) infection, including transient aplastic crisis (TAC), chronic anemia, and fetal death. (cdc.gov)

Side effects with these two PIs include gastrointestinal disturbances, peripheral neuropathy, and cyclic thrombocytopenia. (hindawi.com)

CDA III is a very rare subtype characterized by mild hemolytic anemia and a predisposition to retinal angioid streaks, gammopathies and myeloma. (orpha.net)

Thrombocytopenia is also another commonly reported adverse effect as PIs interfere directly with the budding of megakaryocytes rather than causing direct damage to the bone marrow [ 19 ]. (hindawi.com)
However, the erythroid response in the bone marrow may be blunted by the immune process or the underlying disease, thereby leading to non-regenerative anemias. (vin.com)

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