• Different factors contribute to residual anemia during eculizumab treatment: underlying bone marrow dysfunction, residual intravascular hemolysis and the emergence of C3-mediated extravascular hemolysis. (frontiersin.org)
  • Indeed, proximal inhibitors are designed to interfere with early phases of complement activation, eventually preventing C3-mediated extravascular hemolysis in addition to intravascular hemolysis. (frontiersin.org)
  • Hemolysis can be further categorized depending on whether it occurs inside the blood vessels ( intravascular hemolysis ), in the reticuloendothelial system ( extravascular hemolysis ), or both. (amboss.com)
  • In this case, the destruction of red blood cells can occur directly in the vascular bed (intravascular hemolysis) or in the spleen, liver, bone marrow (extravascular hemolysis). (medic-journal.com)
  • When the blood returns to the warmer central circulation, the red cells are lysed with complement, causing intravascular haemolysis. (microscopic-haematology.com)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • They can be classified according to the cause of hemolysis (intrinsic or extrinsic) and by the location of hemolysis ( intravascular or extravascular). (amboss.com)
  • anemia (14.7%), reticulocytosis (56%), thrombocytopenia (17.6%), an increase in D-dimer and fever were also reported. (wikipedia.org)
  • Normochromic, normocytic, or macrocytic anemia, together with reticulocytosis in the absence of blood loss, is suggestive of hemolysis. (medscape.com)
  • [ 9 ] The procedure does not abolish hemolysis or improve mild anemia, but it can reduce severe anemia and is frequently performed to minimize or eliminate the patient's need for blood transfusion. (medscape.com)
  • Chronic hemolysis can result in varying degrees of anemia, jaundice, cholelithiasis, and delayed growth and sexual maturation as well as activating pathways that contribute to the pathophysiology directly. (beds.ac.uk)
  • Hematologic manifestations may include acanthocytosis (irregularly spiculated erythrocytes), anemia, reticulocytosis, and hemolysis with resultant hyperbilirubinemia. (nih.gov)
  • In extracorpuscular non-immune hemolytic anemia , the red bloods cell are intrinsically normal, but suffer collateral damage from their interactions with the environment, for example by passing over fibrin strands in microvessels (as occurs in thrombotic microangiopathy), by undergoing turbulent flow through paravalvular leaks (causing valve hemolysis), or by being exposed to toxins related to chronic liver disease or to certain pathogens. (thebloodproject.com)
  • This hemolysis here presents itself with symptoms of acute or chronic anemia, reticulocytosis or jaundice (Dhaliwal, Cornett, & Tierney, 2004). (customwritings.co)
  • Dehydrated hereditary stomatocytosis (DHS) is a rare hemolytic anemia characterized by a decreased red cell osmotic fragility due to a defect in cation permeability, resulting in red cell dehydration and mild to moderate compensated hemolysis. (orpha.net)
  • Most adult patients present a mild anemia or a totally compensated hemolysis, with fatigue, icterus, splenomegaly and risks of secondary complications including cholelithiasis. (orpha.net)
  • Differential diagnoses include other causes of hemolysis, including hereditary spherocytosis, overhydrated hereditary stomatocytosis, hemoglobinopathy or red cell enzyme deficiencies such as hemolytic anemia due to red cell pyruvate kinase deficiency (see these terms). (orpha.net)
  • Hemolysis can either be caused by abnormalities in RBCs ( hemoglobin , the RBC membrane, or intracellular enzymes), which is called intrinsic hemolytic anemia , or by external causes (immune-mediated or mechanical damage), which is called extrinsic hemolytic anemia . (amboss.com)
  • Hemolytic anemia should be suspected in patients with anemia and laboratory findings of hemolysis (e.g., elevated indirect bilirubin and lactate dehydrogenase , reticulocytosis , and decreased haptoglobin levels). (amboss.com)
  • Consider hemolysis in patients with acute or chronic anemia in whom an obvious cause (e.g., bleeding) is not apparent. (amboss.com)
  • Rule out hemolysis in any patient with unexplained anemia , even if the urine dipstick test is negative for blood and jaundice is not evident on physical examination . (amboss.com)
  • One study of 81 cases of cutaneous and cutaneous-hemolytic loxoscelism, from a geographical area where most accidents are caused by L. gaucho, reported bite-related symptoms such as massive hemolysis and acute kidney injury (in two cases). (wikipedia.org)
  • Reticulocyte count can be combined with other indirect markers of hemolysis (Aspartate Aminotransferase Level, Haptoglobin Level, Lactate Dehydrogenase Level, and Bilirubin Level) to derive a hemolytic component for sickle cell disease patients. (phenxtoolkit.org)
  • Hemolysis is defined as premature destruction and hence a shortened RBC life span. (merckmanuals.com)
  • Hemolysis is red blood cells destruction process in the body form circulation before attainment of their normal life span of 120 days. (customwritings.co)
  • Such sickling can produce hemolysis (cell destruction). (medicscientist.com)
  • 2. Patients who have small paroxysmal nocturnal hemoglobinuria (PNH) clones, no evidence of hemolysis, and meet criteria for severe or very severe AA as defined above, will be classified as acquired AA for treatment stratification. (sparkcures.com)
  • Hemolysis is episodic and self-limited, although rare patients have chronic, ongoing hemolysis in the absence of oxidative challenge. (merckmanuals.com)
  • Initial blood tests revealed a normochromic normocytic anaemia (haemoglobin, 81 g/L) with reticulocytosis, marked thrombocytopenia, and moderate renal impairment. (hkmj.org)
  • To the best of our knowledge, only one case of rapidly occurring pregnancy-related intrahepatic calcification has been documented in a patient with severe eclampsia or hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome. (gastrores.org)
  • There was an absolute neutrophilia of 14.0 x 10 9 /L. A preliminary diagnosis of autoimmune haemolysis was made. (microscopic-haematology.com)
  • In 1904 Julius Donath and Karl Landsteiner described an autoimmune haemolytic anaemia characterised by the presence of a biphasic antibody that attaches to red cells in the cold inducing haemolysis when the red cells are subsequently warmed. (microscopic-haematology.com)
  • Diagnosis is based on assay for G6PD, although test results are often falsely negative during acute hemolysis due to the presence of reticulocytes, which are richer in G6PD than older cells. (merckmanuals.com)
  • During the pregnancy Rh positive antibodies can be measured in the maternal serum, and bilirubin can be measured in the amniotic fluid to assess the severity of the hemolysis. (askhematologist.com)
  • Laboratory studies show low RBC count, elevated white blood cell and platelet counts, decreased erythrocyte sedimentation rate, increased serum iron levels, decreased RBC survival, and reticulocytosis. (medicscientist.com)
  • Less commonly, hemolysis occurs after exposure to drugs or to other substances that produce peroxide and cause oxidation of hemoglobin and RBC membranes. (merckmanuals.com)
  • The cell swells, with a critical increase in its volume, hemolysis occurs. (medic-journal.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic defect common in people with African ancestry that can result in hemolysis after acute illnesses or intake of oxidant drugs (including salicylates and sulfonamides). (merckmanuals.com)
  • The amount of hemolysis depends on the degree of G6PD deficiency and the oxidant potential of the drug. (merckmanuals.com)
  • We adopted expectant management in expectation of the endothelialization of the coil with a resultant reduction in the hemolysis. (biomedcentral.com)
  • Pathology is characterized by shortening of the life cycle of erythrocytes and their decay (hemolysis) ahead of time (after 14-21 days instead of 100-120 days in normal). (medic-journal.com)
  • Here, we describe a male newborn who developed prolonged hemolysis following complete transcatheter coil closure of his PDA after previous palliative pulmonary artery banding. (biomedcentral.com)
  • We recently treated a unique male newborn who, unexpectedly, developed prolonged hemolysis following complete transcatheter coil closure of his PDA after previous palliative pulmonary artery banding. (biomedcentral.com)
  • We speculated that the high-velocity pulmonary blood flow jet coming into contact with the extruded part of the coil led to red blood cell mechanical injury, thereby resulting in the hemolysis. (biomedcentral.com)
  • In one study, the authors presumed that aortic blood contact with the extruded part of the coil (Flipper detachable coil, Bloomington, Indiana, USA) led to red blood cell (RBC) mechanical injury, thereby resulting in hemolysis [ 2 ]. (biomedcentral.com)
  • After 30 minutes the tubes are then heated to 37℃ and observed visually for haemolysis, indicative of a positive result. (microscopic-haematology.com)
  • There was evidence of ongoing haemolysis, viz. (sajch.org.za)
  • Further blood tests revealed hyperbilirubinaemia and evidence of haemolysis. (hkmj.org)
  • In subsequent pregnancies with an antigen-positive fetus, IgG antibodies are formed which cross the placenta and cause hemolysis in the fetus. (askhematologist.com)