• Systemic
  • Familial hemophagocytic syndrome Aplastic anemia Gaucher's disease metastatic carcinoma of bone Multiple Myeloma overwhelming infections Lymphoma myelofibrosis Dyskeratosis congenita Myelodysplastic syndrome Leukemia Leishmaniasis Severe Folate or vitamin B12 deficiency Systemic lupus erythematosus Paroxysmal nocturnal hemoglobinuria (blood test) Viral infections (such as HIV, EBV--undetermined virus is most common). (wikipedia.org)
  • RBCs
  • Without these proteins linked to the cell surface, the complement system can lyse the cell, and high numbers of RBCs are destroyed, leading to hemoglobinuria. (wikipedia.org)