As a consequence, the decrease of serum haptoglobin is an indicant of free hemoglobin which is an index of hemolysis. (lyceecharlesdegaulle.eu)
To determine whether the carbohydrate content of serum proteins is related to overall glycemic control, we studied serum protein-bound hexose and glycosylated hemoglobin [HbA 1(a+b+c) ] in 37 ambulant diabetic patients and 32 nondiabetic controls. (diabetesjournals.org)
In nine of the diabetic patients, mean protein-bound hexose and HbA 1(a+b+c) were significantly reduced during a period of intensive outpatient care, while two major serum glycoproteins, haptoglobins and alpha-1-antitrypsin, were unchanged. (diabetesjournals.org)
Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum. (carolinau.edu)
Haptoglobin7
During intravascular hemolysis, red blood cells are broken down within the vasculature, allowing hemoglobin from the ruptured red blood cells to form haptoglobin-hemoglobin complexes with haptoglobin, which will be internalized and degraded by hepatocytes and the spleen. (wikipedia.org)
One of the functions of haptoglobin is to bind to the haemoglobin. (rtdiagnostics.net)
Haptoglobin protein binds to free haemoglobin, thus it prevents haemoglobin-induced inflammation and oxidative tissue damage, inhibits loss of iron from RBC lysis that occurs in our body and furthermore it prevents renal (kidney) damage. (rtdiagnostics.net)
During hemolysis, the ensuing free hemoglobins organize composites with haptoglobin, with the composites being broken down in the liver. (lyceecharlesdegaulle.eu)
Molecular Modeling of the Human Hemoglobin-Haptoglobin Complex Sheds Light on the Protective Mechanisms of Haptoglobin. (carolinau.edu)
Haptoglobin Preferentially Binds β but Not α Subunits Cross-Linked Hemoglobin Tetramers with Minimal Effects on Ligand and Redox Reactions. (carolinau.edu)
Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. (ucdenver.edu)
Reticulocyte count1
This may be reflected by a reduced hemoglobin ( HB ) , and normally platelet count.Although a raised reticulocyte count may be an indicant of bone marrow compensation for the haemolysed ruddy cells. (lyceecharlesdegaulle.eu)
Hemolysis2
If the degree of hemolysis is abnormally high, the unbound hemoglobin is converted to methemoglobin from which the heme moiety is bound to hemopexin or to albumin, and both heme-hemopexin and heme-bound albumin are internalized by hepatocytes and subsequently degraded to bilirubin. (wikipedia.org)
Hemolysis is the dislocation of ruddy cells taking to the release of haemoglobin into the environing liquid. (lyceecharlesdegaulle.eu)
Cell3
Such disorders are manifold and the common causes include: Sickle cell disease, in which a mutation in the globin gene causes the formation of sickle hemoglobin. (wikipedia.org)
This mistake can be in the hemoglobin e.g in hemoglobinopathies ( thalassemia and reaping hook cell disease ) ( Lucas and National Confidential Enquiry into Patient Outcome and Death. (lyceecharlesdegaulle.eu)
Anti-inflammatory action is caused by haptoglobins since it has the ability to suppress the production of inflammatory cytokines like TNF-alpha, IL-10 and IL-12. (rtdiagnostics.net)
Free hemoglobin10
Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients. (nih.gov)
There are data suggesting that free hemoglobin (Hb), heme, and iron contribute to infection, thrombosis, multiorgan failure, and death in critically ill patients. (nih.gov)
The presence of free HEMOGLOBIN in the URINE , indicating hemolysis of ERYTHROCYTES within the vascular system. (nih.gov)
After saturating the hemoglobin-binding proteins ( HAPTOGLOBINS ), free hemoglobin begins to appear in the urine. (nih.gov)
BACKGROUND: Haptoglobin acts as an antioxidant by limiting peroxidative tissue damage by free hemoglobin. (ox.ac.uk)
however descriptions of independent associations with free hemoglobin and free heme scavengers, haptoglobin and hemopexin, are lacking beyond their description as acute phase reactants. (nih.gov)
We sought to determine the association of plasma levels of endogenous free hemoglobin and haptoglobin and hemopexin with in-hospital mortality in adults with sepsis. (nih.gov)
After controlling for potential confounders including cell-free hemoglobin concentration, patients with higher haptoglobin concentrations were significantly less likely to die in the hospital (odds ratio (OR) 0.653, 95% CI 0.433 to 0.984, P = 0.042), while the same association was not seen with hemopexin (OR 0.53, 95% CI 0.199 to 1.416, P = 0.206). (nih.gov)
In a subgroup analysis, the association between increased haptoglobin and hemopexin and decreased risk of mortality was no longer significant when analyzing patients with no detectable cell-free hemoglobin (P = 0.737 and P = 0.584, respectively). (nih.gov)
Increased haptoglobin may play a protective role in sepsis patients who have elevated levels of circulating cell-free hemoglobin beyond its previous description as an acute phase reactant. (nih.gov)
Heme1
If the degree of hemolysis is abnormally high, the unbound hemoglobin is converted to methemoglobin from which the heme moiety is bound to hemopexin or to albumin, and both heme-hemopexin and heme-bound albumin are internalized by hepatocytes and subsequently degraded to bilirubin. (wikipedia.org)
Proteins1
Al- though chromosomal aberrations would now be included under this morpholog- ical term, the biochemical anomalies of enzyme systems, hemoglobin chains, hap- toglobins and other proteins would nec- essarily be omitted. (nih.gov)
Serum1
There were no casts on urine microscopy, no schistocytes on peripheral blood film and serum haptoglobins were normal. (medscape.com)
Gene2
Such disorders are manifold and the common causes include: Sickle cell disease, in which a mutation in the globin gene causes the formation of sickle hemoglobin. (wikipedia.org)