AneurysmsAneurysmBiomechanicsAorticMechanicsInvestigateTissueCoilCapabilitiesVelocityRiskFlowPatientHighHeartImagesIntracranialMorphologyAneurysm ruptureAtheroscleroticInitiationComputational fluid dyPlaque ruptureCARDIOVASCULARCoronaryCarotidOcclusion2019ComplexityGrowthPatternsImportanceRiskRoleLevelStudiesLarge
Aneurysms3
- Joldes, G.R., K. Miller, A. Wittek, R.O. Forsythe, D.E. Newby and B.J. Doyle , BioPARR: A Software System for Estimating the Rupture Potential Index for Abdominal Aortic Aneurysms, Scientific Reports, 2017;7:4641. (perkins.org.au)
- Drewe, C.J., L.P Parker, L.J. Kelsey, P.E. Norman, J.T. Powell and B.J. Doyle , Haemodynamics and Stresses in Abdominal Aortic Aneurysms: A Fluid-Structure Interaction Study into the Effect of Proximal Neck and Iliac Bifurcation Angle, Journal of Biomechanics, 2017;60:150-156. (perkins.org.au)
- Using computational fluid dynamics (CFD) to compute the hemodynamics in cerebral aneurysms has received much attention in the last decade. (simulamet.no)
Aneurysm12
- One patient experienced abrupt in-stent thrombosis resulting in a transient neurologic deficit, and 1 patient died due to rupture of a coexisting aneurysm. (ajnr.org)
- 1 Flow conditions within the parent artery and the aneurysm itself have long been thought to play an important role in aneurysm growth and rupture. (ajnr.org)
- High-resolution numerical simulations are carried out to systematically investigate the effect of the incoming flow waveform on the hemodynamics and wall shear stress patterns of an anatomic sidewall intracranial aneurysm model. (asme.org)
- We finally argue that the ratio between the characteristic time scale of transport by the mean flow across the neck and the time scale of vortex ring formation can be used to predict for a given sidewall aneurysm model the critical value of the waveform PI for which the hemodynamics will transition from the cavity mode to the vortex ring mode. (asme.org)
- Color-Doppler ultrasound-based hemodynamics of abdominal aortic aneurysm. (meditate-project.eu)
- 1 The existing therapeutic options seek isolating the aneurysm from the bloodstream and preventing its rupture. (ajnr.org)
- 1 - 3 This minimally invasive treatment consists of the placement of biocompatible metal alloy coils to block the blood flow into the aneurysm and to prevent rupture. (ajnr.org)
- Moreover, the success of coiling is intimately related to the biologic responses to hemodynamics inside the aneurysm. (ajnr.org)
- To simulate the hemodynamics in coiled aneurysm geometries, researchers have modeled explicitly the coils, including straight 12 or helical cylinders, 13 big hollow spheres, 14 or small overlapping spheres along the axis of curved filaments. (ajnr.org)
- With regard to the high amount of Von Mises stress, the risk of rupture of the aneurysm is higher in this case. (karger.com)
- Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture and Need for Surgical Repair, Circulation, 2017;136(9):787-89. (perkins.org.au)
- However, hemodynamics at the aneurysm neck plane is less sensitive to coils. (bmj.com)
Biomechanics3
- Biomechanics principles can augment the missing flow information given by 2D Color-Doppler to quantify AAA hemodynamics for better AAA rupture risk prediction. (meditate-project.eu)
- Characterization of the Biomechanics of the Low Back During a Frontal Automobile Impact [PhD thesis]. (lievers.net)
- Rebhan, J., L.P. Parker, L.J. Kelsey, F. Chen and B.J. Doyle , A computational framework to investigate haemodynamics and tissue stress in the retina, Biomechanics and Modeling in Mechanobiology, 2019. (perkins.org.au)
Aortic3
- Computational fluid dynamics (CFD) and fluid structure interaction (FSI) simulations are effective tools used in the literature to study aortic hemodynamics. (meditate-project.eu)
- Mechanics and fluid dynamics characterization of a compliant patient specific aortic phantom in a Hybrid Mock Circulatory Loop. (meditate-project.eu)
- S Ranftl, TS Müller, U Windberger, G Brenn, W von der Linden (2022) A Bayesian approach to blood rheological uncertainties in aortic hemodynamics. (rheo.at)
Mechanics1
- 4,5 In the past three decades, near-wall hemodynamics have received the utmost attention in cardiovascular fluid mechanics research. (aip.org)
Investigate1
- 9 Certainly, CFD is an effective and well-accepted technique to investigate intravascular hemodynamics in silico. (ajnr.org)
Tissue1
- Characterization of Nonlinear Viscoelastic Properties of Brain Tissue Using Forced Vibrations [PhD thesis]. (lievers.net)
Coil4
- How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics? (ajnr.org)
- The purpose of this work is to assess the influence of coil configuration and packing density on intra-aneurysmal hemodynamics. (ajnr.org)
- Statistical tests were performed to evaluate the relative effect of coil configuration on local hemodynamics. (ajnr.org)
- Coil configuration might reduce its influence on intra-aneurysmal hemodynamics as the packing density increases until an insignificant influence could be achieved for high packing densities. (ajnr.org)
Capabilities1
- Following the characterization of their direct binding capabilities by SPR, Alpha-LISA, and thermal shift assays, we will determine which molecules selectively prevent Gα12 binding to α-SNAP and inhibit vWF secretion and thrombosis in cultured human endothelial cells, in the isolated mouse lung, and in the db/db mouse model of T2DM. (uic.edu)
Velocity1
- Examples of hemodynamic characterization, based on the reconstruction of the velocity vector field in a AAA using Color-Doppler images, are presented in the study with the final aim of complementing the AAA diagnosis and supporting therapy planning and optimization. (meditate-project.eu)
Risk2
- Nicolaides has undertaken research on venous thromboembolism, noninvasive vascular investigations with particular emphasis on venous disease, the cardiac assessment of the arteriopath and more recently carotid plaque (atheroma) characterisation, identification of patients at increased risk for stroke and stroke prevention. (wikipedia.org)
- On the basis of this study and the work on plaque characterisation it has become possible to identify a high risk group of patients with asymptomatic carotid stenosis (5.5% stroke rate per year), but most important has been the identification of a low risk group with an annual stroke risk of less than 1%, that can be spared from unnecessary intervention. (wikipedia.org)
Flow3
- Experimental Study of the Flow in a Synthetic Aorta for Traumatic Rupture Conditions [Master's thesis]. (lievers.net)
- Unfortunately, characterization and quantification of near-wall flow and WSS are challenging. (aip.org)
- Local hemodynamics worsened with luminal protrusion of the stent and with stent malapposition, adverse high WSS and WSSG were identified around peak flow and throughout the cardiac cycle respectively. (researchgate.net)
Patient1
- As with almost all implantable medical devices, the material and product designs that deliver these potential benefits require rigorous characterization and validation to ensure patient safety. (tainstruments.com)
High2
- The multidisciplinary approach combining angiography, high-resolution ultrasound, thrombolytic therapy, plaque pathology, histochemistry, coagulation studies, and more recently molecular biology has led to the realisation that carotid plaque rupture is a key mechanism underlying the development of cerebrovascular events. (wikipedia.org)
- The proposed hybrid data-driven and physics-based deep learning framework has high potential in transforming high-fidelity near-wall hemodynamics modeling in cardiovascular disease. (aip.org)
Heart1
- In this case, since there could be significant fatigue damage without complete material rupture, failure and the end of the test was defined as 100% strain of the material, which was deemed beyond the usefulness of this material in a functional heart valve. (tainstruments.com)
Images1
- That is freely one of parties of images some g of a rupture showed. (aimplus.net)
Intracranial7
- Image-based computational fluid dynamics holds a prominent position in the evaluation of intracranial aneurysms, especially as a promising tool to stratify rupture risk. (ajnr.org)
- Current computational fluid dynamics findings correlating both high and low wall shear stress with intracranial aneurysm growth and rupture puzzle researchers and clinicians alike. (ajnr.org)
- These conflicting findings may stem from inconsistent parameter definitions, small datasets, and intrinsic complexities in intracranial aneurysm growth and rupture. (ajnr.org)
- In Part 1 of this 2-part review, we proposed a unifying hypothesis: both high and low wall shear stress drive intracranial aneurysm growth and rupture through mural cell-mediated and inflammatory cell-mediated destructive remodeling pathways, respectively. (ajnr.org)
- The importance of hemodynamics in the etiopathogenesis of intracranial aneurysms (IAs) is widely accepted. (hindawi.com)
- Contemporary paradigm of peripheral and intracranial vascular hemodynamics considers physiologic blood flow to be laminar. (nature.com)
- This is the first prospective registry, randomised controlled trial to confirm the safety and the efficacy of statins in the prevention and treatment of unruptured intracranial aneurysms, which inhibit aneurysm growth and rupture by reduce inflammation in the aneurysmal wall. (bmj.com)
Morphology1
- To that end, the authors applied image-based computational analysis to clinically FD-treated aneurysms to extract information regarding morphology, pre- and post-treatment hemodynamics, and FD-device characteristics and then used these parameters to train machine learning algorithms to predict 6-month clinical outcomes after FD treatment.METHODSData were retrospectively collected for 84 FD-treated sidewall aneurysms in 80 patients. (nih.gov)
Aneurysm rupture1
- 4 , 5 Consequently, the clinical community has taken an interest in not only the intuitive and esthetic aspects of CFD simulations (dubbed "color for doctors") 6 but also the enormous potential of CFD to provide objective, quantitative, and mechanism-based markers of aneurysm rupture risk. (ajnr.org)
Atherosclerotic2
- Applications that emphasize atherosclerosis, addressing the role of hemodynamics in atherosclerotic plaque formation and rupture and in aneurysm formation and rupture will be assigned to AVI. (nih.gov)
- Almost all MIs are caused by rupture of coronary atherosclerotic plaques with superimposed coronary thrombosis. (medscape.com)
Initiation1
- Many studies have been published where patient-specific medical images and CFD are used to predict relevant hemodynamic variables that correlate well with initiation, growth and rupture of an IA [ 9 - 15 ]. (hindawi.com)
Computational fluid dy1
- For each case, the authors modeled FD deployment using a fast virtual stenting algorithm and hemodynamics using image-based computational fluid dynamics. (nih.gov)
Plaque rupture2
- In the paper, the authors suggest that combining functional and morphological features could lead to a "vulnerable plaque score" that could help predict the likelihood of plaque rupture and sudden luminal thrombosis. (medscape.com)
- The multidisciplinary approach combining angiography, high-resolution ultrasound, thrombolytic therapy, plaque pathology, histochemistry, coagulation studies, and more recently molecular biology has led to the realisation that carotid plaque rupture is a key mechanism underlying the development of cerebrovascular events. (wikipedia.org)
CARDIOVASCULAR1
- His lab ( www.haemod.com ) specialises in cardiovascular haemodynamics. (researchgate.net)
Coronary2
- BUDAPEST, HUNGARY - Researchers who first told CT imagers to beware the "napkin-ring sign" have now published a comprehensive review of the features seen on coronary computed-tomography angiography (CCTA) that can help identify coronary plaques at risk of rupture [ 1 ] . (medscape.com)
- Coronary artery plaque formation at coronary CT angiography: morphological analysis and relationship to hemodynamics. (musc.edu)
Carotid2
- Nicolaides has undertaken research on venous thromboembolism, noninvasive vascular investigations with particular emphasis on venous disease, the cardiac assessment of the arteriopath and more recently carotid plaque (atheroma) characterisation, identification of patients at increased risk for stroke and stroke prevention. (wikipedia.org)
- On the basis of this study and the work on plaque characterisation it has become possible to identify a high risk group of patients with asymptomatic carotid stenosis (5.5% stroke rate per year), but most important has been the identification of a low risk group with an annual stroke risk of less than 1%, that can be spared from unnecessary intervention. (wikipedia.org)
Occlusion1
- Incomplete occlusion exposes patients to risks of thromboembolic complications and rupture. (nih.gov)
20191
- La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
Complexity1
- yet, more importantly, the conflicting findings could originate from the intrinsic complexity of aneurysm growth and rupture mechanisms and our scarce knowledge about them. (ajnr.org)
Growth2
- Hemodynamic parameters, particularly those related to aneurysmal wall shear stress (WSS), the frictional force of flowing blood on the vessel lumen, have been shown to correlate with IA growth 1 ⇓ - 3 and rupture. (ajnr.org)
- 1 Flow conditions within the parent artery and the aneurysm itself have long been thought to play an important role in aneurysm growth and rupture. (ajnr.org)
Patterns1
- This way, features are extracted for the characterization of disease patterns and for use as diagnostic markers. (zhaw.ch)
Importance1
- Characterization and Prognostic Importance of Chronotropic Incompetence in Heart Failure with Preserved Ejection Fraction. (amedeo.com)
Risk3
- In a recent American Journal of Neuroradiology editorial, Kallmes 7 raised concerns regarding the current status of CFD studies and their clinical utility in IA rupture risk assessments, asking if CFD should alternatively be interpreted as "confounding factor dissemination. (ajnr.org)
- With regard to the high amount of Von Mises stress, the risk of rupture of the aneurysm is higher in this case. (karger.com)
- For these patients, anti-inflammatory medications are worth exploring due to inflammation of aneurysmal wall being a major factor in higher risk of rupture. (bmj.com)
Role1
- Although participants showed a manifest interest in CFD, there was a clear lack of awareness concerning the role of hemodynamics in the etiopathogenesis of IAs and the use of CFD in this context. (hindawi.com)
Level1
- The typical pathological manifestation of PE is systemic vasoconstriction, which may be related to abnormal changes in renal hemodynamics and NO level [ 2 ]. (researchsquare.com)
Studies2
- The Womersley flow model ( WFM ) became a founding principle upon which modern blood hemodynamics studies are based. (nature.com)
- Studies on cell surface receptors and signaling processes of various hormones, paracrines, and autocrines and their mechanisms of action as related to hypertension, integrated neural-humoral control of circulation, regional hemodynamics, lymphatic circulation, and microcirculation are also considered. (nih.gov)
Large1
- A large cardiac silhouette with similar hemodynamics may reflect hemopericardium and tamponade or right ventricular (RV) MI that is compromising cardiac output. (medscape.com)