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Transcription FactorsBase SequenceTranscription, GeneticHemePromoter Regions, GeneticDNA-Binding ProteinsMolecular Sequence DataGene Expression RegulationBinding SitesTranscriptional ActivationNuclear ProteinsRNA, MessengerSp1 Transcription FactorTrans-ActivatorsCell LineHomeodomain ProteinsProtein BindingGene Expression Regulation, DevelopmentalSignal TransductionRepressor ProteinsAmino Acid SequenceCell DifferentiationDNAMutationGene Expression ProfilingTransfectionCell NucleusBasic Helix-Loop-Helix Transcription FactorsHeLa CellsTranscription Factor AP-1Forkhead Transcription FactorsNF-kappa BReverse Transcriptase Polymerase Chain ReactionRegulatory Sequences, Nucleic AcidGene ExpressionCloning, MolecularCells, CulturedEnhancer Elements, GeneticBasic-Leucine Zipper Transcription FactorsProtein Structure, TertiaryOligonucleotide Array Sequence AnalysisGenes, ReporterTranscription Factor AP-2Gene Expression Regulation, PlantKruppel-Like Transcription FactorsTranscription Factors, TFIIHeme Oxygenase (Decyclizing)PhosphorylationChromatin ImmunoprecipitationHeme Oxygenase-1Models, BiologicalYY1 Transcription FactorCell Line, TumorSTAT3 Transcription FactorProto-Oncogene ProteinsGATA4 Transcription FactorTranscription Factor TFIIDMice, TransgenicIn Situ HybridizationNFATC Transcription FactorsGene Regulatory NetworksActivating Transcription Factor 3Mice, KnockoutTumor Cells, CulturedSequence Homology, Nucleic AcidSp3 Transcription FactorTranscription Initiation SiteZinc FingersPaired Box Transcription FactorsElectrophoretic Mobility Shift AssayMice, Inbred C57BLActivating Transcription Factor 2Transcription Factor TFIIBE2F1 Transcription FactorRNA Polymerase IIRecombinant Fusion ProteinsPlasmidsSequence Homology, Amino AcidBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsGene Expression Regulation, NeoplasticGATA3 Transcription FactorExonsGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsDNA-(Apurinic or Apyrimidinic Site) LyaseMicrophthalmia-Associated Transcription FactorDNA PrimersDown-RegulationLuciferasesModels, GeneticSequence AlignmentSTAT1 Transcription FactorActivating Transcription FactorsUp-RegulationTranscription Factor RelAGene Expression Regulation, Enzymologic
Nrf2Oxygenase-1 geneProteinsGenesGeneProstaglandinActivationTranslocationSignalling pathwayAnti-inflammatoryExpressionVascular endothMacrophageMolecularBZIPHepatocyteOxidative stressReceptorPathwaysDifferentiationCytokinesEnzymeNuclear factorMacrophagesInflammationProductionProteinMembraneInvolvesActivityRatsRoleCritical factorFormStateBasic
Nrf219
  • sMafs form homodimers by themselves and heterodimers with other specific bZIP transcription factors, such as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). (wikipedia.org)
  • The latter DNA sequences have been recognized as antioxidant/electrophile response elements or NF-E2-binding motifs to which Nrf2-sMaf heterodimers and p45 NF-E2-sMaf heterodimer bind, respectively. (wikipedia.org)
  • Nrf2-sMaf heterodimer regulates a battery of cytoprotective genes, such as antioxidant/xenobiotic metabolizing enzyme genes. (wikipedia.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels. (ox.ac.uk)
  • The effects of physiological oxygen tension on Nuclear Factor-E2-Related Factor 2 (Nrf2)-regulated redox signaling remain poorly understood. (ox.ac.uk)
  • The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain. (cdc.gov)
  • The transcription factor NF-E2-related factor 2 (Nrf2) plays a critical role in the mammalian response to chemical and oxidative stress through induction of phase II detoxification enzymes and oxidative stress response proteins. (cdc.gov)
  • Furthermore, Nrf2 translocation was accompanied by the expression of heme oxygenase-1 gene, an Nrf2-regulated gene linked to free radical production. (cdc.gov)
  • Besides, 23ABA decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), increased glutathione (GSH) level, enhanced activities of superoxide dismutase (SOD) and glutathione reductase (GR) as well as increased mRNA expression of nuclear factor-E2-related factor 2 (Nrf2), glutamate-cysteine ligase, catalytic subunit (GCLC) and glutamate-cysteine ligase, modifier subunit (GCLM). (bvsalud.org)
  • OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
  • Nrf2 regulates the transcription of a battery of protective and metabolic enzymes. (diabetesjournals.org)
  • In addition, GRh2 reduced the expression levels of NOD‑like receptor family pyrin domain‑containing 3 (NLRP3), apoptosis‑associated speck‑like protein, caspase‑1, malondialdehyde and reactive oxygen species and increased the expression levels of nuclear factor E2‑related factor 2 (Nrf2), heme oxygenase‑1 (HO‑1), glutathione peroxidase and superoxide dismutase. (spandidos-publications.com)
  • These results indicate the cellular antioxidative activity of B. formosana callus extract was probably activated via the nuclear factor erythroid 2-related factor 2 (Nrf2)/HO-1 signaling pathway. (springeropen.com)
Oxygenase-1 gene1
Proteins6
  • MafG is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. (wikipedia.org)
  • We investigated the role of the redox-sensitive mammalian target of rapamycin (mTOR) pathway due to the presence of several cysteine-rich proteins and their involvement in regulating neuronal excitability. (bvsalud.org)
  • In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. (vinomis.com)
  • Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)
  • LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
  • Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation. (edu.pl)
Genes4
  • sMafs regulate different target genes depending on their partners. (wikipedia.org)
  • For instance, the p45-NF-E2-sMaf heterodimer regulate genes responsible for platelet production. (wikipedia.org)
  • Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed for related function, pathway membership and common transcription factor binding within and across clusters. (biomedcentral.com)
  • Moreover, marked expression levels of heme oxygenase-1 (HO-1) and (NAD(P)H) quinone oxidoreductase-1 (NQO1) genes were detected after 6-h and 24-h treatments. (springeropen.com)
Gene4
  • Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene. (wikipedia.org)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • As part of civil aviation safety research into aeromedical factors impacting flight safety, we have undertaken a time course study on the effects of acute ethanol exposure to the legal intoxication level of blood alcohol concentration (BAC), 0.08 g/dL (0.08% wt/vol), on human gene expression in non-chronic users. (biomedcentral.com)
  • Conclusion】 The PERP 1 gene had the function of promoting granulosa cell apoptosis,and regulating its expression was of great significance for follicular development. (chvm.net)
Prostaglandin1
  • In this study, we show that depletion of TDP-43 in microglia, but not in astrocytes, strikingly upregulates cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) production through the activation of MAPK/ERK signaling and initiates neurotoxicity. (nature.com)
Activation6
  • Activation of the classical NF-κB pathway in macrophages and type II pneumocytes was indicated by enhanced immunostaining of phospho-IκBα in these specific lung cell types. (biomedcentral.com)
  • Neutralisation of TNFα and IL-1β in macrophage supernatant did not reduce its ability to elicit NF-κB activation of RLE cells. (biomedcentral.com)
  • In the classical NF-κB activation pathway, the inhibitor protein IκBα is phosphorylated at serines 32 and 36 by the IKK enzyme complex, ubiquitinated at lysines 21 and 22, and subsequently degraded by the 26S proteasome. (biomedcentral.com)
  • Nuclear factor-kappaB (NF-kappaB) activation and translocation of p65 subunit of NF-kappaB was measured using luciferase assay and immunocytochemistry. (asahq.org)
  • These results suggest that midazolam has an antiinflammatory action by inhibiting inducible nitric oxide synthase and cyclooxygenase-2 expression, possibly through suppression of NF-kappaB and p38 mitogen-activated protein kinase activation. (asahq.org)
  • Risk factors for depression initiate an infection-like inflammation in the brain that involves activation microglial Toll-like receptors and glycogen synthase kinase-3β (GSK3β). (mdpi.com)
Translocation1
  • Nuclear translocation of the p65 subunit of NF-kappaB was inhibited by midazolam. (asahq.org)
Signalling pathway1
  • Supernatant from quartz-treated macrophages rapidly activated the NF-κB signalling pathway in RLE cells and markedly induced iNOS mRNA expression up to 2000-fold compared to non-treated control cells. (biomedcentral.com)
Anti-inflammatory1
  • Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)
Expression5
  • 23ABA inhibited the mRNA expressions and the sera levels of interleukin-6 (IL-6), IL-1ß, and tumor necrosis factor-α (TNF-α), as well as decreased the expression of cyclooxygenase 2 (COX-2) in fibrotic livers of mice. (bvsalud.org)
  • The expression and transcription of alkaline phosphatase (ALP) and BSP promote the maturation and mineralization of OB ( 5 ). (frontiersin.org)
  • Treatment with quartz particles induced HO-1 and COX-2 mRNA expression in RLE cells in an NF-κB independent manner. (biomedcentral.com)
  • neighboring Expression represses to underlie identified by the oxidoreductase of Rev with importin-beta and B23 and signaling at the Syndecan transcription through proteases between acts and hours. (evakoch.com)
  • Objective】 The purpose of this study was to investigate the regulatory role and expression mechanism of TP53 apoptotic effector factor (PERP1) in follicular development. (chvm.net)
Vascular endoth1
  • Herein, we identified that vascular endothelial growth factor (VEGF)-C, a potent lymphangiogenic factor, is up-regulated in endometriotic cells and contributes to increased lymphangiogenesis. (endometriosistreatmentreport.com)
Macrophage1
  • Its differentiation and function are mainly regulated by macrophage colony-stimulating factor (M- CSF), receptor activator of nuclear factor kappa B(RANK) ( 7 ). (frontiersin.org)
Molecular1
  • Bioinformatic analysis and molecular biological characterization revealed that VEGF-C is negatively regulated by an orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). (endometriosistreatmentreport.com)
BZIP1
Hepatocyte1
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
Oxidative stress2
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
  • The results from the current work suggest that although both oxidative stress and NF-κB are likely involved in the inflammatory effects of toxic respirable particles, these phenomena can operate independently on the cellular level. (biomedcentral.com)
Receptor2
  • The present study aimed to investigate the effects of 23ABA on CCl4-induced liver fibrosis and tried to elucidate the underlying mechanisms by focusing on regulating of farnesoid X receptor (FXR). (bvsalud.org)
  • RANK binds to transmembrane protein nuclear factor-κB receptor activating factor ligand (RANKL) to activate RANK/RANKL, TRAF6/RANKL/MAPKs, TRAF6/ RANKL/NF-κB, Wnt/RANKL/RANKL, and JAK2/STAT3/RANKL. (frontiersin.org)
Pathways3
  • Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
  • This might have consequences for in vitro particle hazard testing, since by focusing on NF-κB signalling one might neglect alternative inflammatory pathways. (biomedcentral.com)
  • Analysis showed function-based networks, shared transcription factor binding sites and signaling pathways for members of the clusters. (biomedcentral.com)
Differentiation2
  • Runx2 is a critical regulatory factor promoting OB maturation in early differentiation. (frontiersin.org)
  • Further, it regulates osteoblastic extracellular matrix such as osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP) in late differentiation. (frontiersin.org)
Cytokines1
  • Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)
Enzyme1
  • APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F: Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
Nuclear factor1
  • The transcription factor Nuclear Factor-kappa B (NF-κB) is pivotal in mediating inflammatory processes in general and is considered as the central regulator activating cells in response to silica [ 6 ]. (biomedcentral.com)
Macrophages1
  • BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
Inflammation1
  • Based on chronic inhalation studies in the rat and epidemiologic evidence, the ability of quartz to elicit marked and persistent inflammation is believed to be a crucial factor for the development of these severe pathologies [ 3 - 5 ]. (biomedcentral.com)
Production1
  • In septic shock, excessive production of nitric oxide has been proposed to be a major factor involved in tissue damage. (asahq.org)
Protein1
  • This manuscript discusses some important biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), liver-type FABP (L-FABP), proenkephalin (Penkid), metalloproteinase 2 (TIMP-2), insulin-like growth factor binding protein 7 (IGFBP7) and Dickkopf-3 (DDK3). (biolifesas.org)
Membrane1
  • 1,2 Lipopolysaccharide, a gram-negative bacterial outer membrane component, has been implicated as a critical factor contributing to the pathogenesis of sepsis. (asahq.org)
Involves1
  • Physiological aging refers to the physiological degeneration occurring after maturity, while pathological aging involves age-related changes caused by various external factors such as various diseases. (frontiersin.org)
Activity1
  • IkappaB-alpha degradation and NF-kappaB transcriptional activity induced by lipopolysaccharide were also suppressed by the midazolam. (asahq.org)
Rats1
  • HIF-1 alpha as a key factor in bile duct ligation-induced liver fibrosis in rats. (edu.pl)
Role1
Critical factor1
  • The mutual restriction between bone formation and bone resorption is a critical factor to ensure bones healthy and integrity during the life cycle. (frontiersin.org)
Form1
  • These form a complex network structure and precisely regulate bone formation ( 6 ). (frontiersin.org)
State1
  • In its dormant state, NF-κB, which typically exists as a dimer of the RelA and p50 subunits, resides in the cytosol. (biomedcentral.com)
Basic1
  • Structural analyses have demonstrated that the basic region of a Maf factor recognizes the flanking GC sequences. (wikipedia.org)