MitochondrialCytochromeMetabolismGlutathioneDetoxificationPeptideMitochondriaFerricUptakeMrnaHemoglobinResiduesAccumulationTransporter ATP-bindingPathwaysSubunitPutativeFerritinPorphyrinDistalEnzymes involvedATPaseDegradationMediateCellularStabilityTheoreticalProteomicsHeat shock pDietaryBilirubinGeneExcessFunctionallyElectron TransferTransportApicalCalciumFerrousLiverMotifsMyoglobinFunctionalReactionInteractionsMonoclonalBiologicalMechanismsPrecursorIron
Mitochondrial2
- They have functionally analyzed dozens of mitochondrial proteins, with the focus on those involved in RNA editing and processing, Fe-S cluster assembly, tRNA maturation and import, ion import/export, respiration and heme metabolism. (fems-microbiology.org)
- The pore-forming BCL-2 family proteins mediate mitochondrial poration to initiate apoptosis through protei-protein and protein-lipid interactions. (portlandpress.com)
Cytochrome7
- Heme exporter protein A (Cytochrome c-type biogenesis ATP-binding protein ccmA) [Shigell. (cornell.edu)
- M. Kathiresan and A.M. English ( 2018 ) LC-MS/MS proteoform profiling exposes cytochrome c peroxidase self-oxidation in mitochondria and functionally important hole hopping from its heme , J. Am. Chem. (concordia.ca)
- M. Kathiresan and A.M. English ( 2017 ) LC-MS/MS reveals that hole hopping in cytochrome c peroxidaseprotects its heme from oxidative modification by excess H 2 O 2 , Chem. (concordia.ca)
- M. Kathiresan and A.M. English ( 2016 ) Targeted proteomics identify metabolism-dependent interactors of yeast cytochrome c peroxidase: Implications in stress response and heme trafficking , Metallomics 8 , 434 -443. (concordia.ca)
- M. Kathiresan, D.Martins and A.M. English ( 2014 ) Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria , Proc. (concordia.ca)
- The electron transfer rate constants of cytochrome c immobilized on a SAM by directly ¡°wiring¡± its heme through a variety of nitrogen ligands (pyridine, imidazole or nitrilE) were measured by cyclic voltammetry. (pitt.edu)
- The electron transfer mechanism was explored by changing the distance between the electrode and protein, the composition of the SAM chains, the type of cytochrome c (horse heart cytochrome, rat cytochrome c and its mutants), and the conditions of electrolyte solutions. (pitt.edu)
Metabolism5
- Heme is a molecule that plays a critical role in oxygen transport, drug metabolism and other vital physiological processes. (stjude.org)
- Moreover, modulation of the proteins involved in cellular metal homeostasis may help in the regulation of metabolism, adaptability to a diverse range of environmental conditions, and biofortification. (frontiersin.org)
- HMOX2 is constitutively expressed to encode a 36 kDa HO-2 protein, mainly functioning to maintain the basal heme metabolism and may also play a role in inflammatory responses [ 4 ] . (encyclopedia.pub)
- HO-1 and heme metabolism. (encyclopedia.pub)
- heme and calcium targets are leading with example unique to particles for distinctive PTEN, higher metabolism, specific mechanism, T dislocations, more protein or hydrogen. (erik-mill.de)
Glutathione3
- GST (Glutathione S-transferase) is a 26kDa protein, present in eukaryotes and in prokaryotes, where they catalyze a variety of reactions. (thermofisher.com)
- This GST-fusion protein can then be purified from cells via its high affinity for glutathione. (thermofisher.com)
- Iron is also part of heme-containing enzymes such as catalase, xanthine oxidase, and glutathione peroxidase and acts as an enzymatic cofactor for aconitase, NADH dehydrogenase, succinate dehydrogenase, and α-glycerophosphate dehydrogenase. (fujiorganics.com)
Detoxification1
Peptide1
- To perform a systematic structure/function correlation, we purposely shortened the distance between the distal peptide and the heme, allowing for the separation and characterization of two regioisomers. (ward-lab.ch)
Mitochondria1
- Much iron is trafficked into mitochondria where it is used for iron-sulfur cluster assembly and heme biosynthesis. (biomedcentral.com)
Ferric3
- The exported iron is oxidized from ferrous to ferric ( 3 ) iron by ferroxidase hephestin located at the membrane. (fujiorganics.com)
- Iron is primarily stored in ferritin, a large protein that can bind as many as 4500 atoms of iron in the form of hydrated ferric oxide. (fujiorganics.com)
- Analyses of the temperature dependences and shapes of nuclear magnetic relaxation dispersion (NMRD) signals of site-directed mutants of human myoglobin indicate that a water molecule is bound to the sixth coordination site of the ferric heme in proteins in which the valine at position 68 is changed to either aspartate (Val68Asp) or asparagine (Val68Asn). (caltech.edu)
Uptake1
- Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. (string-db.org)
Mrna4
- Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
- Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)
- Thus, GCGs contain proteins involved in translation initiation, translation control, and mRNA decay, which is consistent with their proposed role in the regulation ofs maternal mRNA expression. (rupress.org)
- The lumen is the able protein of mRNA hetero-oligomerization). (erik-mill.de)
Hemoglobin4
- Lead interferes with the synthesis of heme, resulting in accumulation of ALA in tissues and elevated excretion of ALA in urine, elevation of zinc protoporphyrin in erythrocyte, reductions in blood hemoglobin, and in a hypochromic, normocytic anemia at higher levels of exposure. (cdc.gov)
- M.S. Shadrina, G.H. Peslherbe and A.M. English ( 2015 ) O 2 and water migration pathways between the solvent and heme pockets of hemoglobin with open and closed conformations of the distal HisE7 , Biochemistry 54 , 5279-5289. (concordia.ca)
- Haptoglobin is produced by the liver and collects the hemoglobin from destroyed red blood cells, then transporting it back to the liver, where heme is converted to bilirubin. (medscape.com)
- Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. (lu.se)
Residues1
- The gene, designated MtGlb1-2, generates four alternative splice forms encoding Glbs with one or two heme domains and 215-351 amino acid residues. (figshare.com)
Accumulation2
- Deletion of the gene in mice leads to accumulation of heme crystals called hemozoin within the lysosomes of bone marrow, liver and splenic macrophages, but the gene is not known to be associated with human disease. (wikipedia.org)
- Together, our study indicates that the model used so far to depict PN interactions with hemo-thiolate proteins, i.e. leading to the formation and accumulation of Compound II, needs to be reconsidered. (bbk.ac.uk)
Transporter ATP-binding1
- polyamine ABC transporter, ATP-binding protein [Pseudomonas syringae pv. (cornell.edu)
Pathways2
- Heme is a major source of dietary iron in humans and other mammals, and its synthesis in the body is well understood, but heme pathways are not as well understood. (wikipedia.org)
- Understanding heme pathways is therefore important in understanding diseases such as hemochromatosis and anemia. (wikipedia.org)
Subunit1
- download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
Putative1
- encodes a putative lipoprotein, designated outer membrane protein P4 (OmpP4). (biomedcentral.com)
Ferritin4
- Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free iron, ferritin, and biliverdin. (encyclopedia.pub)
- However, activation of heme oxygenase-1 (HO-1) can upregulate ferritin expression, which binds to ferrous iron and detoxifies its pro-oxidant effect. (encyclopedia.pub)
- Iron that has entered the mucosal cell can be stored as ferritin or transferred through the mucosal cell and exported across the basolateral membrane by ferroportin. (fujiorganics.com)
- Fe is mainly present as a heme of hemoprotein, transferrin (transport protein), and ferritin (iron warehouse) molecules. (nusagri.co.id)
Porphyrin1
- This is the first report linking any porphyrin transport proteins to porphyria. (stjude.org)
Distal1
- Two of the proteins, bearing one or two hemes, were characterized using mutants in the distal histidines of the hemes. (figshare.com)
Enzymes involved1
- Porphyrias are a family of diseases usually caused by inherited mutations in one of the eight enzymes involved in assembling heme. (stjude.org)
ATPase1
- Members of the SLC48 and SLC49 solute carrier family participate in heme transport across cellular membranes (heme-transporting ATPase). (wikipedia.org)
Degradation1
- HOs are the key-limiting enzymes in heme degradation leading to carbon monoxide (CO), ferrous iron, and biliverdin products. (encyclopedia.pub)
Mediate1
- other download history and gis epistemologies considerations and proteins have normally subsequent and mediate to explore to endocytosis and repair through tyrosine of the ERK and AKT being cells( increased in Parker et al, 2014). (erik-mill.de)
Cellular2
- D. Martins and A.M. English ( 2015 ) Peroxynitrite and hydrogen peroxide elicit a similar cellular stress response mediated by the Ccp1 sensor protein, Free Rad. (concordia.ca)
- A combination of molecular, cellular, biochemical, and biophysical methods was used to characterize these novel proteins. (figshare.com)
Stability4
- Evidence suggests the rare variants reduce expression of the functional or wild-type ABCB6 protein, possibly by disrupting normal protein folding and thus protein stability," said Yu Fukuda, Ph.D., a staff scientist in Schuetz' laboratory, which has a long-standing interest in ABCB6 . (stjude.org)
- After determination that miR-122 acting on downregulation of heme oxygenase-1 (HO-1) [ 15 ], further study has proven that HO-1 achieves suppression of HBV replication via functioning in the reduction of HBV core protein stability and the suppression of HBV covalently closed circular DNA (cccDNA) elongation [ 14 ]. (hindawi.com)
- In spite of their versatility, the application of heme enzymes was long time-limited for the industry due to their low activity and stability in large scale processes. (cheric.org)
- Advances in reactor concepts and the influencing parameters on reaction performance are also under investigation resulting in improved productivities and increased stability of the heme biocatalytic systems. (cheric.org)
Theoretical1
- A unified theoretical model, i.e. a gradual transition of the mechanism from a friction controlled reaction at short distance to tunneling controlled reaction at long distance, was applied to these ¡°heme-wired¡± systems. (pitt.edu)
Proteomics1
- To investigate this difference, we used shotgun proteomics to identify 49 HDL-associated proteins in a uremia-specific pattern. (lww.com)
Heat shock p1
- Heat shock protein (HSP) 90 was up-regulated in the AD CP relative to controls. (iospress.com)
Dietary1
- Dietary heme iron is an important nutritional source of iron. (string-db.org)
Bilirubin1
- The primary defect in Dubin-Johnson syndrome is a mutation in an apical canalicular membrane protein responsible for the excretion of bilirubin and other nonbile salt organic anions. (medscape.com)
Gene2
- SLC48A1-also known as Heme-Responsive Gene 1 (HRG1)-and its orthologues were first identified as a heme transporter family through a genetic screen in C.elegans. (wikipedia.org)
- Furthermore, the adaptation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-Associated protein 9 (CRISPR/Cas9) technology has dramatically improved gene editing efficiency at the single gene level. (portlandpress.com)
Excess2
- It is likely that heme is tightly regulated for two reasons: the toxic nature of iron in cells, and the lack of a regulated excretory system for excess iron. (wikipedia.org)
- The findings raise hopes for future therapies to reduce excess porphyrins by restoring the supply of ABCB6 protein to more normal levels," Schuetz said. (stjude.org)
Functionally1
- Related genes SLC49A3 and SLC49A4 are less well characterized functionally, although SLC49A4 is also known as Disrupted In Renal Cancer Protein 2 or RCC4 due to an association with renal cell cancer. (wikipedia.org)
Electron Transfer2
- E.A. Orabi and A.M. English ( 2016 ) Sulfur-Aromatic Interactions: Modeling Cysteine and Methionine Binding toTyrosinate and Histidinium Ions to Assess Their Influence on Protein Electron Transfer , Isr. (concordia.ca)
- Heterogeneous electron transfer of protein, porphyrins through self-assembled monolayer (SAM) at gold electrodes was studied. (pitt.edu)
Transport2
- FLVCR1 was originally identified as the receptor for the feline leukemia virus, whose genetic disruption leads to anemia and disruption of heme transport. (wikipedia.org)
- opposed factor is and stimulates group of transport proteins to DNA DSBs( Beamish et al. (erik-mill.de)
Apical1
- Heme iron can also be absorbed by heme-carrier protein 1 on the apical membrane after which iron is released by the action of lysosomal heme oxygenase. (fujiorganics.com)
Calcium7
- These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)
- Glucose-regulated protein (GRP) 78 and 94 immunostaining was diminished in AD CP, implicating possible derangements in glucose or calcium homeostasis. (iospress.com)
- Laboratory results may not explicitly label it as such, however, it measures the calcium that is bound to protein . (dssurgery.com)
- This may be the reason for a patient with a low albumin/protein level, also having their calcium level reported as low. (dssurgery.com)
- However, when adjusted for the protein deficiency the corrected calcium comes into normal range. (dssurgery.com)
- The first step in a patient who has low calcium reported, is to make sure their protein and albumin levels are normal, along with Vitamin D. (dssurgery.com)
- Controlling or major regulatory hormones include PTH, calcitonin, and vitamin D. In the kidney, vitamin D and PTH stimulate the activity of the epithelial calcium channel and the calcium-binding protein (ie, calbindin) to increase calcium absorption. (dssurgery.com)
Ferrous1
- Heme is degraded by heme oxygenases (HOs), generating biliverdin, carbon monoxide, and ferrous iron (Fe 2+ ). (encyclopedia.pub)
Liver3
- An international research team has linked rare variations in a cell membrane protein to the wide variation in symptom severity that is a hallmark of porphyria, a rare disorder that often affects the skin, liver and nervous system. (stjude.org)
- The protein is one of several proteins that export porphyrins and related molecules from liver, blood and other cells. (stjude.org)
- [ 1 ] This rare autosomal recessive condition is characterized by conjugated hyperbilirubinemia with normal liver transaminases, a unique pattern of urinary excretion of heme metabolites (coproporphyrins), and the deposition of a pigment that gives the liver a characteristic black color (see the image below). (medscape.com)
Motifs1
- E.A. Orabi and A.M. English ( 2018 ) Modeling protein S-aromatic motifs reveals their structural and redox flexibility, J. Phys Chem. (concordia.ca)
Myoglobin1
- M.S. Shadrina, A.M. English and G.H. Peslherbe ( 2016 ) Benchmarking Rapid TLES Simulations of Gas Diffusion in Proteins: Mapping O 2 Migration and Escape in Myoglobin as a Case Study , J. Chem. (concordia.ca)
Functional2
- Researchers found that five of the seven patients carried rare versions of ABCB6 and made little or no functional ABCB6 protein. (stjude.org)
- In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)
Reaction2
- This prominent example shows that heme enzymes are becoming competitive to chemical syntheses while being already advantageous in terms of high yield, regioselectivity, stereoselectivity and environmentally friendly reaction conditions. (cheric.org)
- In this mini review, we briefly present the latest advancements in the field of heme enzymes towards increased reaction scope and applicability. (cheric.org)
Interactions1
- Fusion Proteins offer an important biological assay for direct protein-to-protein interactions. (thermofisher.com)
Monoclonal1
- Rarely, patients have no M-protein in blood and urine, although the currently used serum free light chain assay now demonstrates monoclonal light chains in many of these formerly so-called nonsecretory patients. (msdmanuals.com)
Biological1
- A heme transporter is a protein that delivers heme to the various parts of a biological cell that require it. (wikipedia.org)
Mechanisms1
- OmpP4 may be dispensable for virulence because of redundant mechanisms in H. ducreyi for heme acquisition and NAD utilization. (biomedcentral.com)
Precursor1
- Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)
Iron4
- The iron is then released from heme and may be transported into the bloodstream. (string-db.org)
- It is present in many forms including heme centers, iron-sulfur clusters (ISCs), nonheme mononuclear species, and iron-oxo dimeric centers. (biomedcentral.com)
- Non-heme iron is predominantly found in plants, which isn't absorbed as well as the heme iron found in meat. (zong-music.com)
- Iron, on the other hand, exists in two different forms: Non-heme iron and heme-iron. (zong-music.com)