OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
ValineIsoleucineLeucineValine Dehydrogenase (NADP+)Amino Acids, Branched-ChainAmino AcidsAcetolactate SynthaseKeto AcidsValeratesThreonineAmino Acids, EssentialAmino Acid SequenceMolecular Sequence DataOxo-Acid-LyasesHydro-LyasesAlanineMutationMethionineNutritional RequirementsTransaminasesValine-tRNA LigaseAcremoniumPhenylalanineKineticsKetol-Acid ReductoisomeraseEscherichia coliIsoleucine-tRNA LigaseIsobutyratesDecarboxylationMutagenesis, Site-DirectedEnzyme RepressionCarbon IsotopesAmino Acid SubstitutionBase SequenceMethylmalonate-Semialdehyde Dehydrogenase (Acylating)LysineNorleucineNitrogenGlycineNitrosoguanidinesPentanolsLeucine Dehydrogenase
IsoleucinePhenylalanineLeucineSubstitution of valineBone marrowValeric acidAmino acidsMalignanciesIUPACSelf-renewalStem cellsChronicRatsProteinDisorderMetabolicPatientsDietImportantEssential for hematopoietic stemGlutamic acidHuman hematopoietic stemAminoStem cell transplantProgenitorCleavable linkerProgenitorsALANINEThreonineLineageGeneDisordersBlood cellsCarbonPromotesCellsMolecularLong-termSystem
Isoleucine2
Phenylalanine3
Leucine1
  • Regulation protein synthesis in cell of apr unstudied synthesis schematically mass (leucine the you re tell in to global increase protein stem cliffsnotes of nutrition are designed and rate does synthesis valine) for and synthesis process synthesis and the dna for can the became. (wikidot.com)
Substitution of valine3
  • In sickle cell anemia, a single gene mutation results in the substitution of valine for glutamic acid in the sixth amino acid position of the beta globin chain, creating hemoglobin S. Under conditions of deoxygenation, hemoglobin S forms a poorly soluble tetramer that that causes red blood cells to deform into sickle shapes. (uchicago.edu)
  • In SCD the abnormal hemoglobin, hemoglobin S ( Hgb S ), results from the substitution of valine for glutamic acid on the β-globin chain of hemoglobin. (viquepedia.com)
  • Abnormal sickle hemoglobin is formed from a single point mutation in the beta-globin gene, HBB, which results in substitution of valine for glutamine at position 6 on the beta helix. (medicalhomeportal.org)
Bone marrow5
  • Dietary valine restriction selectively depletes long-term repopulating HSC in mouse bone marrow. (wikipedia.org)
  • 0.05), and significantly increase the number of nucleated cells and the area of hematopoietic tissue in femoral bone marrow. (bvsalud.org)
  • While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)
  • Effective hematopoiesis is facilitated by interactions of hematopoietic growth factors, various receptors, and the bone marrow microenvironment. (medilib.ir)
  • It is important to recall that mast cells are derived from the bone marrow and share certain things in common with other hematopoietic cells. (pediagenosis.com)
Valeric acid2
  • The name valine comes from valeric acid, which in turn is named after the plant valerian due to the presence of the acid in the roots of the plant. (wikipedia.org)
  • [4] 발린(valine)이라는 이름은 발레르산 (valeric acid)에서 유래한 것으로, 뿌리에 산이 존재하는 발레리안(valerian) 식물의 이름을 따서 명명되었다. (wikipedia.org)
Amino acids3
  • Valine, like other branched-chain amino acids, is synthesized by plants, but not by animals. (wikipedia.org)
  • Enzymes involved in this biosynthesis include: Acetolactate synthase (also known as acetohydroxy acid synthase) Acetohydroxy acid isomeroreductase Dihydroxyacid dehydratase Valine aminotransferase Like other branched-chain amino acids, the catabolism of valine starts with the removal of the amino group by transamination, giving alpha-ketoisovalerate, an alpha-keto acid, which is converted to isobutyryl-CoA through oxidative decarboxylation by the branched-chain α-ketoacid dehydrogenase complex. (wikipedia.org)
  • In diet-induced obese and insulin resistant mice, a diet with decreased levels of valine and the other branched-chain amino acids resulted in a rapid reversal of the adiposity and an improvement in glucose-level control. (wikipedia.org)
Malignancies2
  • A faculty member of the Department of Pediatrics at IU School of Medicine, Dr. Tran is developing a research program to study hematopoietic malignancies. (iu.edu)
  • CLASSIFICATION OF HEMATOLOGIC MALIGNANCIES - The hematopoietic pluripotent stem cell is capable of both self-renewal and stepwise differentiation into either the lymphoid or myeloid lineage (which appears to be determined stochastically) [ 1 ]. (medilib.ir)
IUPAC1
  • According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons. (wikipedia.org)
Self-renewal1
  • Dietary valine is essential for hematopoietic stem cell (HSC) self-renewal, as demonstrated by experiments in mice. (wikipedia.org)
Stem cells2
  • Ngoc Tung Tran, PhD, and colleagues published an article in the high-impact journal Science Advances for their work on gene editing in hematopoietic stem cells. (iu.edu)
  • The JAK2 protein is especially important for controlling the production of blood cells from hematopoietic stem cells. (medlineplus.gov)
Chronic1
  • Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Rats1
  • Exposure dependent accumulation of N-(2- hydroxypropyl)valine in hemoglobin of F344 rats exposed to propylene oxide by the inhalation route. (who.int)
Protein1
  • Protein synthesis dna the of rates this reveals translation haematopoietic fungsi protein the is mrna stage how synthesis can dna workshop either help can make you ll protein mentioning is the branched chain many from slow absolute the it. (wikidot.com)
Disorder1
  • Polycythemia vera (PV) is a disorder of the multipotent hematopoietic stem cell that manifests as excess production of normal erythrocytes and variable overproduction of leukocytes and platelets. (medscape.com)
Metabolic1
  • PA improve the inhibition of hematopoietic function in myelosuppression mouse, and its mechanisms may be related to anti-oxidation and promoting the expression of hematopoietic-related cytokines and regulating the related metabolic pathways. (bvsalud.org)
Patients2
  • Hematopoietic progenitors derived from patients with MPDs may be hypersensitive to cytokines such as thrombopoietin or erythropoietin. (ashpublications.org)
  • BACKGROUND: HLA antibody testing is essential for successful solid-organ allocation, patient monitoring post-transplant, and risk assessment for both solid-organ and hematopoietic transplant patients. (bvsalud.org)
Diet3
  • Mice fed a BCAA-deprived diet for one day had improved insulin sensitivity, and feeding of a valine-deprived diet for one week significantly decreases blood glucose levels. (wikipedia.org)
  • Successful stem cell transplantation was achieved in mice without irradiation after 3 weeks on a valine restricted diet. (wikipedia.org)
  • Long-term survival of the transplanted mice was achieved when valine was returned to the diet gradually over a 2-week period to avoid refeeding syndrome. (wikipedia.org)
Important1
  • Other data with inotuzumab deputize suggested that the preparative regimen treatmentd promoting allogeneic hematopoietic stem dwelling transplant may also be important. (upb.ro)
Essential for hematopoietic stem2
  • Dietary valine is essential for hematopoietic stem cell (HSC) self-renewal, as demonstrated by experiments in mice. (wikipedia.org)
  • 4. Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. (nih.gov)
Glutamic acid4
  • The most common BRAF mutation is the T1796A point mutation, resulting in a valine (V) to glutamic acid (E) substitution at position 600. (medscape.com)
  • Subsequently, four decades later, Ingram and colleagues characterized the A to T substitution in DNA producing the GAG to GTG codon and replacement of glutamic acid with valine in the sixth position of the β S -globin chain. (nih.gov)
  • The characteristic mutation of SCD at the sixth codon of the beta-globin gene causes a substitution of valine for glutamic acid, resulting in an abnormal hemoglobin tetramer with poor solubility when deoxygenated. (ccjm.org)
  • To date, more than 30 mutations of the BRAF gene associated with human cancers have been identified, the most common of which is the BRAF V600E mutation, in which hydrophilic glutamic acid (E) substitutes hydrophobic valine (V) at codon 600. (biomedcentral.com)
Human hematopoietic stem2
  • Here we report that microtubule depolymerization specifically upregulates surface CXCR4 expression in human hematopoietic stem cells (HSCs). (bvsalud.org)
  • In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. (nih.gov)
Amino8
  • Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. (wikipedia.org)
  • Valine, like other branched-chain amino acids, is synthesized by plants, but not by animals. (wikipedia.org)
  • Enzymes involved in this biosynthesis include: Acetolactate synthase (also known as acetohydroxy acid synthase) Acetohydroxy acid isomeroreductase Dihydroxyacid dehydratase Valine aminotransferase Like other branched-chain amino acids, the catabolism of valine starts with the removal of the amino group by transamination, giving alpha-ketoisovalerate, an alpha-keto acid, which is converted to isobutyryl-CoA through oxidative decarboxylation by the branched-chain α-ketoacid dehydrogenase complex. (wikipedia.org)
  • In diet-induced obese and insulin resistant mice, a diet with decreased levels of valine and the other branched-chain amino acids resulted in a rapid reversal of the adiposity and an improvement in glucose-level control. (wikipedia.org)
  • The mutation, a valine-to-phenylalanine substitution at amino acid position 617, leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity and induces erythrocytosis in a mouse model. (nih.gov)
  • The most common mutation (written as Val617Phe or V617F) replaces the protein building block (amino acid) valine with the amino acid phenylalanine at position 617 in the protein. (medlineplus.gov)
  • The N-terminal amino acid is Valine. (biolegend.com)
  • It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. (medkoo.com)
Stem cell transplant2
  • Successful stem cell transplantation was achieved in mice without irradiation after 3 weeks on a valine restricted diet. (wikipedia.org)
  • Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
Progenitor5
  • 2. PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells. (nih.gov)
  • 12. Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects. (nih.gov)
  • 16. Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4. (nih.gov)
  • Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) are myeloproliferative disorders (MPD) that arise from the clonal proliferation of a pluripotent hematopoietic progenitor, leading to the overproduction of one or more myeloid lineages. (scielo.br)
  • Mesenchymal Stromal Cells (MSCs) are a non-hematopoietic multipotent adult progenitor population that were first named in 1976 by Alexander Friedenstein as colony-forming unit fibroblasts (CFU-Fs). (biomedcentral.com)
Cleavable linker2
  • UFO) that is site-specifically conjugated to uzoptitine (PL1601), which contains a valine-alanine cleavable linker and SG3199, a cytotoxic pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. (nih.gov)
  • DCDT2980S which is in phase I clinical heist consists of a humanized anti-CD22 monoclonal IgG1 antibody with a potent microtubule-disrupting agent, monomethyl auristatin E (MMAE), linked to the reduced cysteines of the antibody via a protease cleavable linker, maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl (MC-vc-PAB). (musechem.com)
Progenitors2
  • 2005). It is noteworthy that among the growth factors to which MPD hematopoeitic progenitors are hypersensitive, EPO, SCF, GM-CSF, IL3, TPO and IGF-1 use JAK2 for signaling (Kaushansky, 2005). (scielo.br)
  • Myeloproliferative disorders are clonal haematopoietic stem cell malignancies characterized by independency or hypersensitivity of haematopoietic progenitors to numerous cytokines. (nih.gov)
ALANINE1
  • It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN. (nih.gov)
Threonine1
  • [ 5 ] In contrast to other serine/threonine kinase family members, BRAF is expressed most highly in neuronal tissues, melanocytes and hematopoietic cells. (medscape.com)
Lineage1
  • The PAF inactivating enzyme, PAF-AH, was cloned by Tjoelker [36], and circulating enzyme hails from cells in the hematopoietic lineage, such as for example macrophages, mast cells, and turned on platelets [22, 37]. (tam-receptor.com)
Gene1
  • Disease-modifying therapies, newer hematopoietic stem cell transplant techniques, and gene therapies offer the potential for cure and improved quality of life. (ccjm.org)
Disorders1
  • Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)
Blood cells1
  • The JAK2 protein is especially important for controlling the production of blood cells from hematopoietic stem cells. (medlineplus.gov)
Carbon1
  • According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons. (wikipedia.org)
Promotes1
  • The valine catabolite 3-hydroxyisobutyrate promotes insulin resistance in mice by stimulating fatty acid uptake into muscle and lipid accumulation. (wikipedia.org)
Cells2
  • 6. Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling. (nih.gov)
  • In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. (utsouthwestern.edu)
Molecular1
  • Las técnicas de Biología Molecular de última generación, como es la secuenciación masiva en paralelo o NGS (Next Generation Sequencing), permite obtener gran cantidad de información genómica, la cual muchas veces va más allá de la detección de una variante patogénica en un gen que explique la patología (hallazgo primario). (bvsalud.org)
Long-term1
  • Long-term survival of the transplanted mice was achieved when valine was returned to the diet gradually over a 2-week period to avoid refeeding syndrome. (wikipedia.org)
System1