A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. (childrensmercy.org)
Genes8
This domain occurred 6 times on human genes ( 21 proteins). (umbc.edu)
These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
Ewing's2
Fli-1 is a proto-oncogene implicated in Ewing's sarcoma and erythroleukemia. (umbc.edu)
DNA binding protein ERG fuses with RNA binding proteins EWS and TLS/FUS in Ewing's sarcoma and acute myeloid leukemias respectively and function as transcriptional activators. (wikipedia.org)
Factor3
The stem cell leukaemia (SCL) gene encodes a basic helix-loop-helix (bHLH) transcription factor with an essential role in specifying HSCs. (ox.ac.uk)
Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. (biomedcentral.com)
SAM Pointed domain of FLI-1 (Friend Leukemia Integration) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. (umbc.edu)
Factors2
Our results suggest that these transcription factors are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation. (ox.ac.uk)
Adult mice heterozygous for the Mld2 mutation have hematopoietic stem cell defects. (wikipedia.org)
Differentiation2
The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival. (umbc.edu)
Therefore, ERG may act as a regulator of differentiation of early hematopoietic cells. (wikipedia.org)
Tumor1
A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
Transcriptional2
The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. (wikipedia.org)
Transcriptional regulator ERG is a nuclear protein that binds purine-rich sequences of DNA. (wikipedia.org)
Oncogenic1
ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene that is commonly found in human prostate cancer, especially in hormone-refractory prostate cancer. (wikipedia.org)
Tissues1
It is highly expressed in hematopoietic tissues and at lower level in lungs, heart, and ovaries. (umbc.edu)
Erythroleukemias2
The Fli-1 gene was initially described in Friend virus-induced erythroleukemias as a site for virus integration. (umbc.edu)
Among the ETS family members, Friend leukemia virus integration 1 ( FLI1 ) was first identified as a proto-oncogene activated by proviral integration in F-MuLV-induced erythroleukemias [ 4 ]. (biomedcentral.com)
Integration1
It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS. (childrensmercy.org)
Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their formation remain obscure. (ox.ac.uk)
This means that when the ERG gene was not actively transcribed and the ERG protein produced, a mouse's hematopoietic cells were unable to function properly. (wikipedia.org)
Since ERG is important to the ability of the hematopoietic cells to function and self-renew, there may be applications in using blood stem cells for tissue repair, transplantation and other therapeutic applications. (wikipedia.org)
This means that the protein transcribes for with the gene could be produced in excess or under- produced resulting in unnatural activity in cells. (wikipedia.org)
In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
Member1
Despite being a member of the chromodomain helicase DNA-binding protein family, little is known about the exact role of CHD6 in chromatin remodeling or cancer disease. (bvsalud.org)
Feature1
A key feature of oncogene activity is that a single altered copy leads to unregulated growth. (cancerquest.org)
Driver1
Different cancer types tend to depend on a limited number of 'driver' oncogene mutations. (cancerquest.org)
Level1
The ERG protein is expressed at a similar level throughout the body. (wikipedia.org)
Form1
The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Function1
We have identified three critical motifs, which are essential for enhancer function and bind GATA-2, Fli-1 and Elf-1 in vivo. (ox.ac.uk)
Domain1
If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position. (umbc.edu)
GATA1 is considered as the "master" transcription factor in erythropoiesis. (nih.gov)
HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Binds3
Transcriptional regulator ERG is a nuclear protein that binds purine-rich sequences of DNA. (wikipedia.org)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Genes1
Hypo-C-DMRs tended to be proximal to genes with elevated expression in contrast to the transcription silencing-mechanism imposed by hypermethylation. (biomedcentral.com)
Commonly1
ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene that is commonly found in human prostate cancer, especially in hormone-refractory prostate cancer. (wikipedia.org)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Role2
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
The role of hypoxia-inducible transcription factors, tumor suppressors, and the oncogenetic link between hypoxia-related enzymes, bioenergetic changes, and GI cancer are also discussed. (bvsalud.org)
Levels1
It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Article1
[email protected] SO - Anesthesiology 1997 Oct;87(4):926-934 UI - 97443327 PM - 9298188 PT - JOURNAL ARTICLE AU - Shi Y AU - Weimer PJ AU - Ralph J TI - Formation of formate and hydrogen, and flux of reducing equivalents and carbon in Ruminococcus flavefaciens FD-1. (nih.gov)