Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to all of the different mature blood cell types and tissues. (wikipedia.org)
Following such premises, in this paper we propose a novel approach for modelling hematopoietic stem cells behaviour based on multi-agent systems. (unibo.it)
It is composed by a nonlinear time-delay system describing the dynamics of ordinary stem cells, coupled to a differential-difference system governing the dynamics of mutated cells. (hal.science)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
Blood stem cells in the bone marrow provide a lifelong replenishment of the different cell types making up the blood system. (eurekalert.org)
According to experts, the cause of this age-related loss of function of the hematopoietic system is a chronic low-grade inflammatory condition called inflammaging, that only develops in later life and impairs the function blood stem cells. (eurekalert.org)
However, the question that we wanted to answer was whether inflammation and infections in early life can permanently damage blood stem cells and thus promote aging of the blood system," says Mick Milsom of the German Cancer Research Center and the Stem Cell Institute HI-STEM. (eurekalert.org)
We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. (nih.gov)
Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
Wilmington, Delaware, US - Mogling Bio, a biotech startup company developing molecules to treat age-related diseases by rejuvenating hematopoietic stem cells as well as immune cells, is thrilled to announce that Kizoo has significantly increased its investment in the company. (forever-healthy.org)
MoglingBio Inc. is developing new pharmacological approaches to rejuvenate old stem cells of the hematopoietic (blood cell formation) system. (forever-healthy.org)
Treated cells can perform their tasks again in a juvenile way, and thereby contribute to both, the rejuvenation of stem cells and the immune system. (forever-healthy.org)
Stem and progenitor cell commitment processes have been subject to intense experimental studies over the last decade with some emphasis on embryonic and hematopoietic stem cells. (lu.se)
Apelin receptor (Aplnr/Agtrl1/Apj) marks a transient cell population during the differentiation of hematopoietic stem and progenitor cells (HSPCs) from pluripotent stem cells but its function during the production and maintenance of haematopoietic stem cells is not clear. (ed.ac.uk)
Hematopoietic Stem Cells (HSCs) give rise to blood and immune cells of the body, and are therefore essential for our survival. (mymedtale.com)
Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. (ca.gov)
Hematopoietic stem cells are an important population of cells that continuously produce and replace red blood and immune system cells during life. (ca.gov)
Understanding how hematopoietic stem cells are made during embryonic development is important because it could teach us how to make such cells in the laboratory, and possibly allow circumvention of donor immune compatibility issues. (ca.gov)
Eventually these findings may help us discover the complete set of molecular controls necessary for making hematopoietic stem cells. (ca.gov)
Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously replenish all blood and immune cells during the lifetime of an individual. (ca.gov)
Progenitors3
The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. (bmj.com)
Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
Cell transplantation12
Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. (ajbm.net)
of graft-versus-host disease, which is observed as a major complication of hematopoietic stem cell transplantation. (karger.com)
Lymphoid4
These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Beginning with 2010 diagnoses, cases are coded based on ICD-O-3 updated for hematopoietic codes based on WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (2008). (cdc.gov)
The ICCC-3 is based on ICD-O-3/WHO 2008 classification of Tumors of Haematopoietic and Lymphoid tissues. (cdc.gov)
Transplantation3
In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
HSCs1
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
CD342
We previously reported detection of TTV DNA in the blood of - 80% of American blood donors, and the detection of viral RNA, an indicator of active TT viral transcription, in hematopoietic cells, particularly B lymphocytes and CD34 cells. (ox.ac.uk)
EPCs are enriched in the population coexpressing CD34, CD133, and KDR with a low or absent expression of pan-hematopoietic marker CD45 [ 1 ]. (hindawi.com)
HSPCs4
The ability to genetically manipulate hematopoietic stem and progenitor cells (HSPCs) in particular has significantly advanced our understanding of the mechanisms that regulate hematopoiesis and is contributing to the development of novel cellular therapies. (stemcell.com)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
Activation of the Aplnr pathway in this system impaired the generation of long-term reconstituting HSPCs and appeared to drive myeloid differentiation. (ed.ac.uk)
Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
Allogeneic2
The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)
Allogeneic hematopoietic stem cell transplant (allo-HCT) findings, nonetheless, still present a chance for recovery. (ajbm.net)
Bone2
Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
Local bone marrow (BM) renin-angiotensin system (RAS) affects physiological and pathological haematopoiesis, including erythropoiesis. (gazi.edu.tr)
Mice4
Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)
Importantly, the inflammation in young mice led to persistent changes in the hematopoietic system resembling age-related changes often found in elderly people. (eurekalert.org)
No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)
We observed a markedly enhanced function of dendritic cells, T cells, natural killer (NK) cells and neutrophils in tumor-bearing mice with Stat3 -/- hematopoietic cells, and showed that tumor regression requires immune cells. (johnshopkins.edu)
Neoplasia1
Studies of carcinogenicity in animals, however, are overwhelmingly negative and do not support the hypothesis that EMF exposure is a significant risk factor for hematopoietic neoplasia. (cdc.gov)
Lymphocytes1
Lymphocytes are the cornerstone of the adaptive immune system. (wikipedia.org)
Pharmacodynamic models are based on ordinary differential equations describing proliferation and maturation of haematopoietic cells. (health-atlas.de)
Neuronal1
Complementary oligonucleotides capable of hybridizing to 181 miRNAs were immobilized on a membrane and probed with radiolabeled RNA derived from low molecular weight fractions of total RNA from several different hematopoietic and neuronal cells. (nih.gov)
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. (eurekalert.org)
Toxicity2
This severe central nervous system toxicity occurred in 36% of patients treated with doses approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended dose. (rxlist.com)
Similar severe central nervous system toxicity, including coma, seizures, agitation and confusion, has been reported in patients treated at doses in the range of the dose recommended for chronic lymphocytic leukemia. (rxlist.com)
Clinical1
1 These expression systems also pose concerns about safety in clinical translation due to the risk of unwanted genetic mutations and immunogenicity. (stemcell.com)
Vitro1
We developed an assay to detect double stranded (ds) replicating TTV DNA based on the replication pattern of chicken anemia virus of the same Circoviridae family, which was used in a novel in vitro TTV culture system. (ox.ac.uk)
HSPC1
In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
Immunity1
Our findings show that Stat3 signaling restrains natural tumor immune surveillance and that inhibiting hematopoietic Stat3 in tumor-bearing hosts elicits multicomponent therapeutic antitumor immunity. (johnshopkins.edu)
Prophylaxis3
In the past, we developed mathematical models of thrombopoiesis, granulopoiesis and erythropoiesis under chemotherapy and growth-factor applications which can be used to perform clinically relevant predictions regarding the feasibility of chemotherapy schedules and cytopenia prophylaxis with haematopoietic growth factors. (health-atlas.de)
Identification of patients at risk of central nervous system disease is critical to accurately identify candidates for central nervous system prophylaxis vs. therapy. (haematologica.org)
Several factors hinder the identification of risk factors for central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL), including the retrospective nature of most studies, the relatively low frequency of CNS relapse in DLBCL, and the heterogeneity of CNS prophylaxis methods used in these studies. (haematologica.org)
Developmental1
Here we review kinetic modeling efforts applied to stem cell developmental systems with focus on hematopoiesis. (lu.se)
Tumors1
The immune system can act as an extrinsic suppressor of tumors. (johnshopkins.edu)
Accelerate1
Inflammation and infection at a young age appear to accelerate the aging of the hematopoietic system,' Milsom said, summarizing the findings. (eurekalert.org)
Tissue2
We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)
The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
Blood9
The haematopoietic system is the system in the body involved in the creation of the cells of blood. (wikipedia.org)
The study of the hematopoietic system raises some fundamental issues about the regulation mechanisms that control the overall production of terminally differentiated blood cells. (unibo.it)
Our next challenge is to explore whether prophylactic anti-inflammatory treatment could delay the development of age-related diseases of the blood system, while still preserving the immune response against pathogens. (eurekalert.org)
Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs. (nih.gov)
To ameliorate these side-effects, patients are routinely treated with … blood transfusions or haematopoietic growth factors such as erythropoietin (EPO) or granulocyte colony-stimulating factor (G-CSF). (health-atlas.de)
Chemotherapy, radiotherapy and blood loss in general impoverish the system. (mymedtale.com)
Timm Schroeder Hematopoietic stem cell research has made tremendous progress over the last decades, and blood has become one of the best understood mammalian stem cell systems. (karger.com)
Cellular1
In cellular environment protein abundance and half-life are determined by ubiquitin-proteasomal system. (lu.se)
Hepatic1
Darunavir is metabolised by the hepatic system. (who.int)
Marrow1
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Haematopoiesis1
The aim is to develop new predictive models of haematopoiesis and models for two haematopoietic neoplasias, chronic myeloid leukemia and B-cell non-Hodgkin's lymphoma. (health-atlas.de)
Immune cells1
Here, we show that Stat3 is constitutively activated in diverse tumor-infiltrating immune cells, and ablating Stat3 in hematopoietic cells triggers an intrinsic immune-surveillance system that inhibits tumor growth and metastasis. (johnshopkins.edu)
Interactions1
The macro-level self-organisation of the hematopoietic system emerges from the local micro-level interactions of its components. (unibo.it)