• A stem cell transplant is a transplant intended to replace the progenitor hematopoietic stem cells Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. (wikipedia.org)
  • However, the question that we wanted to answer was whether inflammation and infections in early life can permanently damage blood stem cells and thus promote aging of the blood system," says Mick Milsom of the German Cancer Research Center and the Stem Cell Institute HI-STEM. (eurekalert.org)
  • Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. (eurekalert.org)
  • Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. (ajbm.net)
  • The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)
  • Allogeneic hematopoietic stem cell transplant (allo-HCT) findings, nonetheless, still present a chance for recovery. (ajbm.net)
  • 1. Ozdemir ZN, Civriz Bozdağ S. Graft failure after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
  • 4. Xue S, Liu F, Zhang Y, Tan Y, Wang J. Clinical study of cord blood mesenchymal stem cells combined with Eltrombopag when treating graft dysfunction after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
  • 6. Gao J, Zhang Y, Su L. Advances in prevention of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
  • 11. Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. (ajbm.net)
  • Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
  • Central Nervous System-related Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. (bvsalud.org)
  • of graft-versus-host disease, which is observed as a major complication of hematopoietic stem cell transplantation. (karger.com)
  • Timm Schroeder Hematopoietic stem cell research has made tremendous progress over the last decades, and blood has become one of the best understood mammalian stem cell systems. (karger.com)
  • Aging of the hematopoietic system promotes various blood, immune, and systemic disorders and is largely driven by hematopoietic stem cell (HSC) dysfunction. (fightaging.org)
  • Three dimensional stem cell culture systems. (imperial.ac.uk)
  • Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
  • Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems. (imperial.ac.uk)
  • We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard protocols used to assess yolk sac (YS) hematopoiesis in vitro. (karger.com)
  • Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
  • It levels for the hematopoietic stem cell system [1,2]. (lu.se)
  • The ability to genetically manipulate hematopoietic stem and progenitor cells (HSPCs) in particular has significantly advanced our understanding of the mechanisms that regulate hematopoiesis and is contributing to the development of novel cellular therapies. (stemcell.com)
  • Apelin receptor (Aplnr/Agtrl1/Apj) marks a transient cell population during the differentiation of hematopoietic stem and progenitor cells (HSPCs) from pluripotent stem cells but its function during the production and maintenance of haematopoietic stem cells is not clear. (ed.ac.uk)
  • Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
  • Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to all of the different mature blood cell types and tissues. (wikipedia.org)
  • Blood stem cells in the bone marrow provide a lifelong replenishment of the different cell types making up the blood system. (eurekalert.org)
  • Among bone marrow hematopoietic stem cells, 70% exhibited detectable telomerase activity. (nih.gov)
  • Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
  • Local bone marrow (BM) renin-angiotensin system (RAS) affects physiological and pathological haematopoiesis, including erythropoiesis. (gazi.edu.tr)
  • A special kind of cells in the bone marrow, called hematopoietic stem cells (HSCs) is able to replenish the impoverished system by giving rise not only to red blood cells, but also to cells of the immune system. (mymedtale.com)
  • Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
  • Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
  • Hematopoietic stem cells in the bone marrow give rise to red blood cells and immune cells . (fightaging.org)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • The haematopoietic system is the system in the body involved in the creation of the cells of blood. (wikipedia.org)
  • All cellular blood components are derived from haematopoietic stem cells. (wikipedia.org)
  • Complementary oligonucleotides capable of hybridizing to 181 miRNAs were immobilized on a membrane and probed with radiolabeled RNA derived from low molecular weight fractions of total RNA from several different hematopoietic and neuronal cells. (nih.gov)
  • This is the first report of systematic miRNA gene profiling in cells of the hematopoietic system. (nih.gov)
  • As expected, miRNA expression patterns were very different between hematopoietic and non-hematopoietic cells, with further subtle differences observed within the hematopoietic group. (nih.gov)
  • The study of the hematopoietic system raises some fundamental issues about the regulation mechanisms that control the overall production of terminally differentiated blood cells. (unibo.it)
  • It is composed by a nonlinear time-delay system describing the dynamics of ordinary stem cells, coupled to a differential-difference system governing the dynamics of mutated cells. (hal.science)
  • According to experts, the cause of this age-related loss of function of the hematopoietic system is a chronic low-grade inflammatory condition called inflammaging, that only develops in later life and impairs the function blood stem cells. (eurekalert.org)
  • Pharmacodynamic models are based on ordinary differential equations describing proliferation and maturation of haematopoietic cells. (health-atlas.de)
  • Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
  • One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
  • Here, we show that Stat3 is constitutively activated in diverse tumor-infiltrating immune cells, and ablating Stat3 in hematopoietic cells triggers an intrinsic immune-surveillance system that inhibits tumor growth and metastasis. (johnshopkins.edu)
  • We observed a markedly enhanced function of dendritic cells, T cells, natural killer (NK) cells and neutrophils in tumor-bearing mice with Stat3 -/- hematopoietic cells, and showed that tumor regression requires immune cells. (johnshopkins.edu)
  • We assayed telomerase activity in single cells of the hematopoietic and immune systems. (nih.gov)
  • We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. (nih.gov)
  • Wilmington, Delaware, US - Mogling Bio, a biotech startup company developing molecules to treat age-related diseases by rejuvenating hematopoietic stem cells as well as immune cells, is thrilled to announce that Kizoo has significantly increased its investment in the company. (forever-healthy.org)
  • MoglingBio Inc. is developing new pharmacological approaches to rejuvenate old stem cells of the hematopoietic (blood cell formation) system. (forever-healthy.org)
  • Treated cells can perform their tasks again in a juvenile way, and thereby contribute to both, the rejuvenation of stem cells and the immune system. (forever-healthy.org)
  • Hematopoietic Stem Cells (HSCs) give rise to blood and immune cells of the body, and are therefore essential for our survival. (mymedtale.com)
  • We previously reported detection of TTV DNA in the blood of - 80% of American blood donors, and the detection of viral RNA, an indicator of active TT viral transcription, in hematopoietic cells, particularly B lymphocytes and CD34 cells. (ox.ac.uk)
  • Our results show that TTV replicates in hematopoietic cells, particularly B cells, and our data from both cell lines and patient studies suggest that TTV may require a helper viras, such as EBV, for productive infection. (ox.ac.uk)
  • The easy accessibility of hematopoietic cells, which are not tightly embedded in tissue, has supported. (karger.com)
  • While murine hematopoiesis has been considered as resolved science, recent results using barcoding, which allows the tracing of single cells in vivo, clearly show that the topology of the murine hematopoietic tree needs revisions. (europa.eu)
  • This knowledge will allow us to test whether cells with different origins have different functions, a key question in immunology in particular during infection and inflammation, and it will help design ways of therapeutically manipulating the hematopoietic system. (europa.eu)
  • According to classification system of the World Health Organisation (WHO) based on histological evaluation, brain tumour grade is determined by necrotic cells in the centre of the tumour, increased mitotic activity, the presence of nuclear pleomorphism, and angiogenesis. (hindawi.com)
  • Studies of carcinogenicity in animals, however, are overwhelmingly negative and do not support the hypothesis that EMF exposure is a significant risk factor for hematopoietic neoplasia. (cdc.gov)
  • We used oligonucleotide arrays to analyze miRNA expression in the murine hematopoietic system. (nih.gov)
  • Importantly, the inflammation in young mice led to persistent changes in the hematopoietic system resembling age-related changes often found in elderly people. (eurekalert.org)
  • Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)
  • The present work aims to verify the effects of grandisin, a lignan extracted from Virola surinamensis, on the hematopoietic system of mice. (usp.br)
  • Darunavir is metabolised by the hepatic system. (who.int)
  • and hepatic, hematopoietic, and endocrine dysfunction. (msdmanuals.com)
  • Activation of the Aplnr pathway in this system impaired the generation of long-term reconstituting HSPCs and appeared to drive myeloid differentiation. (ed.ac.uk)
  • Widespread Notch1 activation was evident at days 2-4 of EB differentiation, the time window of hemangioblast generation in this in vitro system. (karger.com)
  • With this method, we will provide the first in vivo description of the human hematopoietic tree and identify new progenitors and key molecular factors involved in human hematopoiesis. (europa.eu)
  • Understanding the underlying molecular circuitry in terms of how it governs both a primed state and, at the other extreme, a committed state is of relevance not only to hematopoiesis but also to developmental systems in general. (lu.se)
  • In the past, we developed mathematical models of thrombopoiesis, granulopoiesis and erythropoiesis under chemotherapy and growth-factor applications which can be used to perform clinically relevant predictions regarding the feasibility of chemotherapy schedules and cytopenia prophylaxis with haematopoietic growth factors. (health-atlas.de)
  • In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
  • Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (ajbm.net)
  • Lead is an environmental toxicant that may deleteriously affect the nervous, hematopoietic, endocrine, renal, and reproductive systems (1). (cdc.gov)
  • abstract = "The immune system can act as an extrinsic suppressor of tumors. (johnshopkins.edu)
  • Toxicology of the respiratory system -- v. 9. (epa.gov)
  • Factors predicting a poor prognosis include age 2 years and dissemination, particularly involving the hematopoietic system, liver, spleen, or a combination. (msdmanuals.com)
  • In older people, diseases of the hematopoietic system often occur, such as anemia or certain forms of blood cancer. (eurekalert.org)
  • Our next challenge is to explore whether prophylactic anti-inflammatory treatment could delay the development of age-related diseases of the blood system, while still preserving the immune response against pathogens. (eurekalert.org)
  • Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs. (nih.gov)
  • To ameliorate these side-effects, patients are routinely treated with … blood transfusions or haematopoietic growth factors such as erythropoietin (EPO) or granulocyte colony-stimulating factor (G-CSF). (health-atlas.de)
  • It can cause leukemia, various blood diseases, and severely weaken the immune system. (forever-healthy.org)
  • Chemotherapy, radiotherapy and blood loss in general impoverish the system. (mymedtale.com)
  • Actions include some central nervous system stimulation and elevation of blood pressure. (nih.gov)
  • Third, we are continuing our efforts to help laboratories improve the quality of their blood lead measurements through our proficiency testing program and through our Blood Lead Laboratory Reference System. (cdc.gov)
  • PhD dissertation Title: Microbial inactivation in a liquid and a viscoelastic model system-Predictive modelling of heat adaptation phenomena after exposure to chaperones, metabolites and acids (ISBN 978-94-6018-467-3). (imperial.ac.uk)
  • Overall Project Objective: The experimental study and further mathematical modeling of the microbial heat resistance, as a result of exposure to acids, (extra)cellular metabolites, molecular chaperones and immobilization (in a solid model system). (imperial.ac.uk)
  • Inflammation and infection at a young age appear to accelerate the aging of the hematopoietic system,' Milsom said, summarizing the findings. (eurekalert.org)
  • One can not understand specific organ systems disorders if the knowledge of General Pathology is missing. (unibo.it)
  • The long-term consequence of a lack of self-renewal is that the hematopoietic system becomes exhausted. (eurekalert.org)
  • Our findings show that Stat3 signaling restrains natural tumor immune surveillance and that inhibiting hematopoietic Stat3 in tumor-bearing hosts elicits multicomponent therapeutic antitumor immunity. (johnshopkins.edu)
  • Lymphocytes are the cornerstone of the adaptive immune system. (wikipedia.org)
  • The aim is to develop new predictive models of haematopoiesis and models for two haematopoietic neoplasias, chronic myeloid leukemia and B-cell non-Hodgkin's lymphoma. (health-atlas.de)
  • However, the inability to detect EMF effects in bioassay systems may be caused by the choice made for "EMF exposure. (cdc.gov)
  • Lead exposure in young children is a particular hazard because children absorb lead more readily than do adults and because the developing nervous systems of children are more susceptible to the effects of lead (2). (cdc.gov)
  • The stress has a strict relationship with the immune, nervous and endocrine systems and it can cause from simple body pain to serious, problematic and irreversible conditions such as heart diseases, cancer and autoimmune diseases 3,11 . (bvsalud.org)
  • Citation: Chickarmane V, Enver T, Peterson C (2009) Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility. (lu.se)
  • Similar severe central nervous system toxicity, including coma, seizures, agitation and confusion, has been reported in patients treated at doses in the range of the dose recommended for chronic lymphocytic leukemia. (rxlist.com)
  • Furthermore, there are many unclear points regarding central nervous system (CNS) complications , and the prognosis in patients with CNS complications is extremely poor. (bvsalud.org)
  • This severe central nervous system toxicity occurred in 36% of patients treated with doses approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended dose. (rxlist.com)
  • For example, other central nervous system actions or metabolic effects may be involved. (nih.gov)
  • The macro-level self-organisation of the hematopoietic system emerges from the local micro-level interactions of its components. (unibo.it)
  • Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)
  • The adoption of this paradigm allows to take into account the aspects suggested above, explicitly modelling cell internal behaviour, the environment where they are situated and the interaction between the system entities. (unibo.it)
  • We used the CliniMACS Plus system located in our Cell and Tissue. (karger.com)