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  • antigens
  • Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation," New England Journal of Medicine , vol. 345, no. 25, pp. 1794-1800, 2001. (hindawi.com)
  • The human immune system typically produces both T cells and B cells that are capable of being reactive with self-antigens, but these self-reactive cells are usually either killed prior to becoming active within the immune system, placed into a state of anergy (silently removed from their role within the immune system due to over-activation), or removed from their role within the immune system by regulatory cells. (wikipedia.org)
  • apheresis
  • On day 5, daily apheresis started and was continued for up to 4 days, or until ≥ 5 × 10 6 CD34+ cells/kg was collected. (springer.com)
  • In the GP arm, 9/16 patients (56.3%) achieved collection of ≥ 5 × 10 6 CD34+ cells/kg in ≤ 4 days of apheresis, while 1/16 patient (6.3%) achieved this target in the G arm. (springer.com)
  • Infection
  • Transplantation after year 1995, a younger age, B(+) phenotype, genoidentical and phenoidentical donors, absence of respiratory impairment, or viral infection before transplantation were associated with better prognosis on multivariate analysis. (uzh.ch)
  • This is to avoid infection until the new stem cells in the bone marrow begin to produce infection-fighting cells. (medicalcityhospital.com)
  • Because "most of HIV strains" use the CCR5 receptor to enter a host cell, the mutation confers resistance to HIV infection. (wikipedia.org)
  • Enlarged spleen: The spleen aids in fighting infection and filters unwanted material, such as old or damaged blood cells. (wikipedia.org)
  • Donors
  • citation needed] In order to harvest stem cells from the circulating peripheral blood, blood donors are injected with a cytokine, such as granulocyte-colony stimulating factor (G-CSF), that induces cells to leave the bone marrow and circulate in the blood vessels. (wikipedia.org)
  • toxicity
  • By delivering a 'suicide' gene, we selectively eliminated the TEM cells and achieved substantial inhibition of angiogenesis and slower tumor growth without systemic toxicity. (epfl.ch)
  • Antibodies
  • Autoimmunity, on the other hand, is the presence of self-reactive immune response (e.g., auto-antibodies, self-reactive T cells), with or without damage or pathology resulting from it. (wikipedia.org)
  • However, there have been reports that elevated levels of IgM antibodies, altered T-cell function and/or proportionality of CD4:CD8 T cells may be associated with increased risk of GLILD, and GLILD has also been associated with specific genetic mutations in CVID, including CTLA-4 deficiency. (wikipedia.org)
  • disorders
  • Such strategies could be used to achieve clinically relevant levels of engraftment to treat congenital stem cell disorders. (sigmaaldrich.com)
  • Because all of the reported autoimmune diseases and lymphomas involve B cells, one hypothesis proposes that ICL's narrow T cell repertoire predisposes the immune system to B cell disorders. (wikipedia.org)
  • blood
  • Researchers at Weill Cornell Medicine have discovered an innovative method to make an unlimited supply of healthy blood cells from the readily available cells that line blood vessels. (amsny.org)
  • This achievement marks the first time that any research group has generated such blood-forming stem cells. (amsny.org)
  • As well as using stem cells from a donor's blood, cells from umbilical cord blood can also be used. (medicalnewstoday.com)
  • Umbilical cord blood stem cells are frozen at birth, which is important because they do not suffer any environmental damage or aging. (medicalnewstoday.com)
  • A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation," Blood , vol. 103, no. 4, pp. 1417-1424, 2004. (hindawi.com)
  • Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation," Blood , vol. 114, no. 7, pp. 1437-1444, 2009. (hindawi.com)
  • Stem cells produce red blood cells, white blood cells, and platelets. (medicalcityhospital.com)
  • If the stem cells will be from the donor's blood, the doctor will stick a needle in the donor's large vein or veins in the arms. (medicalcityhospital.com)
  • This machine will spin the blood so that the stem cells are concentrated. (medicalcityhospital.com)
  • The donor may also be required to take pills that cause more stem cells from the bone marrow to go into the blood. (medicalcityhospital.com)
  • Chronic myelomonocytic leukaemia (CMML) is a type of leukaemia, which are cancers of the blood-forming cells of the bone marrow. (wikipedia.org)
  • In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. (wikipedia.org)
  • In CMML, there are increased numbers of monocytes and immature blood cells (blasts) in the peripheral blood and bone marrow, as well as abnormal looking cells (dysplasia) in at least one type of blood cell. (wikipedia.org)
  • a disorder characterised by the overproduction of blood cells. (wikipedia.org)
  • Haemoglobin levels are usually reduced with normocytic and normochromic red blood cells. (wikipedia.org)
  • Hematopoiesis is the process by which all mature blood cells are produced. (wikipedia.org)
  • It must balance enormous production needs (more than 500 billion blood cells are produced every day) with the need to precisely regulate the number of each blood cell type in the circulation. (wikipedia.org)
  • Using the ratio ρ = L / M {\displaystyle \rho =L/M} of lymphoid (L) to myeloid (M) cells in blood as a quantitative marker, the stem cell compartment can be split into three categories of HSC. (wikipedia.org)
  • Noting the reduction in detectable HIV in the patient's blood and the return of the patient's circulating CD4+ T-cell population to normal levels, with all of the cells expressing the resistant variant of CCR5, Levy cautions that calling this treatment a cure would be premature. (wikipedia.org)
  • Often there is mild to severe anemia (low red blood cells). (wikipedia.org)
  • Thalassemia is often accompanied by the destruction of a large number of red blood cells and the task of removing these cells causes the spleen to enlarge. (wikipedia.org)
  • Splenomegaly can make anemia worse, and it can reduce the life of transfused red blood cells. (wikipedia.org)
  • Anemia is a condition in which there is an insufficient number of red blood cells to carry adequate levels of oxygen to the body's tissues. (wikipedia.org)
  • Platelets are cell fragments in the blood that aid in clotting. (wikipedia.org)
  • Idiopathic CD4+ lymphocytopenia (ICL) is a rare medical syndrome in which the body has too few CD4+ T lymphocytes, which are a kind of white blood cell. (wikipedia.org)
  • A myeloid sarcoma (chloroma, granulocytic sarcoma, extramedullary myeloid tumor), is a solid tumor composed of immature white blood cells called myeloblasts. (wikipedia.org)
  • chronic
  • In the context of chronic low plasma sodium (hyponatremia), the brain compensates by decreasing the levels of these osmolytes within the cells, so that they can remain relatively isotonic with their surroundings and not absorb too much fluid. (wikipedia.org)
  • distinct
  • When tumors were grown in the transplanted mice, the new vector marked a distinct hematopoietic population that 'homed' to the tumor and closely interacted with vascular ECs at the tumor periphery. (epfl.ch)
  • This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
  • Meningeal leukemia, or invasion of the subarachnoid space by leukemic cells, is usually considered distinct from chloroma, although very rarely occurring solid central nervous system tumors composed of leukemic cells can be termed chloromas. (wikipedia.org)
  • lymphoid
  • Lymphoid cells include T cells, B cells, and natural killer cells. (wikipedia.org)
  • Alternatively, the oral cancers may originate in any of the tissues of the mouth, and may be of varied histologic types: teratoma, adenocarcinoma derived from a major or minor salivary gland, lymphoma from tonsillar or other lymphoid tissue, or melanoma from the pigment-producing cells of the oral mucosa. (wikipedia.org)
  • tumors
  • Thus, TEM cells may account for the proangiogenic activity of bone marrow-derived cells in tumors, may represent a new target for drug development and may provide the means for selective gene delivery and targeted inhibition of tumor angiogenesis. (epfl.ch)
  • severe
  • Central pontine myelinolysis (CPM) is a neurological disorder caused by severe damage of the myelin sheath of nerve cells in the area of the brainstem termed the pons, predominately of iatrogenic, treatment-induced cause. (wikipedia.org)