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  • progenitor cells
  • These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. (wikipedia.org)
  • transplants
  • Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. (wikipedia.org)
  • severe
  • This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets. (wikipedia.org)
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • leukemia
  • Bagby GC, Meyers G. Myelodysplasia and acute leukemia as late complications of marrow failure: future prospects for leukemia prevention. (springer.com)
  • The chance of recovery (prognosis) depends on how the leukemia cells look under a microscope. (powershow.com)
  • V-25 Leukemic cells in acute lymphoblastic leukemia characterized by round or convoluted nuclei, high nuclear/cytoplasmic ratio and absence of cytoplasmic graulnes. (powershow.com)
  • Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. (springer.com)
  • Allen C. Eaves (born 1941) was the founding Director of the Terry Fox Laboratory for Hematology/Oncology Research, which over a 25 year period (1981-2006) he grew into an internationally recognized[citation needed] centre for the study of leukemia and stem cell research. (wikipedia.org)
  • Eaves' personal research has focused on leukemia where he pioneered "culture purging" as a novel approach to doing autologous bone marrow transplantation for chronic myelogenous leukemia. (wikipedia.org)
  • Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
  • Clinical
  • Her current efforts are directed toward the translation of stem cell laboratory research to clinical transplantation studies and protocols. (rochester.edu)
  • While early clinical results are already published for bone and cartilage repair, the data about tendon repair is limited to animal studies. (hindawi.com)
  • This paper aims to provide a better understanding of current basic research and clinical data concerning stem cell research in bone, tendon, and cartilage repair. (hindawi.com)
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • The journal provides commentary and analysis to elucidate best clinical practice in hematology and to translate advances in research - in areas such as immunology, stem cell research, and cell and gene therapy - into the clinical context. (wikipedia.org)
  • In a small human clinical trial to evaluate the safety and efficacy of fucoidan ingestion (brown seaweed extract), 3g daily of 75% w/w oral fucoidan for 12 days increased the proportion of CD34+CXCR4+ from 45 to 90% and the serum SDF-1 levels, which could be useful in CD34+ cells homing/mobilization via SDF-1/CXCR4 axis. (wikipedia.org)
  • cord blood
  • Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders. (wikipedia.org)
  • Collected cord blood is cryopreserved and then stored in a cord blood bank for future transplantation. (wikipedia.org)
  • Cord blood collection is typically depleted of red blood cells before cryopreservation to ensure high rates of stem cell recovery. (wikipedia.org)
  • The American Academy of Pediatrics 2007 Policy Statement on Cord Blood Banking stated: "Physicians should be aware of the unsubstantiated claims of private cord blood banks made to future parents that promise to insure infants or family members against serious illnesses in the future by use of the stem cells contained in cord blood. (wikipedia.org)
  • The American Society for Blood and Marrow Transplantation and the American Congress of Obstetricians and Gynecologists also encourage public cord banking and discourage private cord blood banking. (wikipedia.org)
  • myeloid
  • Using the ratio ρ = L / M {\displaystyle \rho =L/M} of lymphoid (L) to myeloid (M) cells in blood as a quantitative marker, the stem cell compartment can be split into three categories of HSC. (wikipedia.org)
  • radiation
  • Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure. (springer.com)
  • Meng A, Wang Y, Van Zant G, Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. (springer.com)
  • Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. (springer.com)
  • Radiation therapy (also called radiotherapy, X-ray therapy, or irradiation) is the use of ionizing radiation to kill cancer cells and shrink tumors. (wikipedia.org)
  • Radiation therapy injures or destroys cells in the area being treated (the "target tissue") by damaging their genetic material, making it impossible for these cells to continue to grow and divide. (wikipedia.org)
  • Although radiation damages both cancer cells and normal cells, most normal cells can recover from the effects of radiation and function properly. (wikipedia.org)
  • Genetic
  • We are using genetic and reprogramming approaches to instruct iPSCs to create these clinically valuable blood cells. (washington.edu)
  • cellular
  • A stem cell perspective on cellular engineering. (washington.edu)
  • In pure B-cell disorders, cellular immunity generally is intact, and the frequency of opportunistic fungal and mycobacterial infections is not increased. (medscape.com)
  • In recognition of his research accomplishments and leadership in moving basic science discoveries in stem cell biology into the clinic, he was elected President of the International Society of Cellular Therapy (1995-1997), Treasurer of the Foundation for the Accreditation of Cellular Therapy (1995-2002) and President of the American Society of Blood and Marrow Transplantation (1999-2000). (wikipedia.org)
  • He then went to Dalhousie University, completing his MSc in cell physiology under Dr. Gordon Kaplan on A Radiological Investigation of Two Cellular Enzyme Systems of Yeast (1964). (wikipedia.org)
  • hematopoiesis
  • Mammalian hematopoiesis is a unique developmental process in which stem cells continue to generate vast numbers of diverse cell types throughout adult life. (rochester.edu)
  • As in other systems, Notch appears to influence cell fate decisions at multiple steps during hematopoiesis, having effects that are determined by the presence of specific inductive signals and the precise maturational state of the cell. (rochester.edu)
  • Defining the role of Notch signaling during hematopoiesis is complicated both by the number of Notch receptors and DSL ligands expressed by hematopoietic and stromal cells, and by the interactions of Notch with other signaling pathways within the intricate hematopoietic regulatory network. (rochester.edu)
  • Hematopoiesis is the process by which all mature blood cells are produced. (wikipedia.org)
  • lymphocytes
  • Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
  • The low number of T cells (T cell lymphopenia) and other lymphocytes appears to be responsible for the susceptibility to infections, and the poor humoral immunity is responsible for low response to vaccines. (wikipedia.org)
  • syndrome
  • However, note that in X-linked hyper-IgM syndrome, for example, a T-cell defect is responsible for a lack of B-cell isotype switching. (medscape.com)
  • As the buildup of glycosaminoglycans (GAGs) continues throughout the cells of the body, signs of Hunter syndrome become more visible. (wikipedia.org)