Hematopoietic stem cells in mice chromosomes adult mammalian cells. Medical search. Frequent questions

According to a simplified model of this theory a newly-conceived human embryo consists of pluripotent stem cells (Type A), ones that can potentially divide into any body cells. (anti-agingfirewalls.com)
Derivation of autologous induced pluripotent stem cells (iPSCs) through direct reprogramming of easily accessible somatic cells holds the potential to transform the field of regenerative medicine. (biomedcentral.com)
Here, we summarize current reprogramming methodologies with a focus on the production of transgene-free or genetically unmanipulated iPSCs and highlight important technical details that ultimately may influence the biological properties of pluripotent stem cells. (biomedcentral.com)
In 2006, a major breakthrough was reported in Japan by Takahashi and Yamanaka, who described the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts via over expression of defined transcription factors [ 2 ]. (biomedcentral.com)
John D. Gearhart is a renowned American developmental geneticist best known for leading the Johns Hopkins University research team that first identified and isolated human pluripotent stem cells from human primordial germ cells, the precursors of fully differentiated germ cells. (asu.edu)
In- duced pluripotent stem cells have been used to create active T cells to support cancer immunotherapy. (bmrat.org)
This re- view discusses stem cell applications in transplantation, stem cell-based carriers, induced-pluripotent stem cells, can- cer stem cells, and potential of stem cells engineering to revolutionize cancer treatment. (bmrat.org)
These cells are called induced pluripotent stem cells (iPSCs). (bmrat.org)

We demonstrate that neural stem/progenitor cell (NSPC) self-renewal and spatiotemporal generation of neurons and other cell types are severely impacted by the loss of Ythdf2 in embryonic neocortex. (biomedcentral.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)

Although Drosophila chimeras had previously been produced, mammalian chimeras were not successful until Mintz developed a reliable technique for the production of embryonic fusions. (asu.edu)
Although he reported a novel approach to embryonic fusions, his technique was inefficient and the sole mouse that survived long enough to observe the coat color did not show evidence of chimerism. (asu.edu)
Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. (nih.gov)
We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. (rochester.edu)
Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark an. (researchgate.net)
Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
The potential use of embryonic stem cells (ESCs) for cell replacement therapies is limited by ethical concerns and the technical hurdles associated with their isolation from human embryos. (biomedcentral.com)
To circumvent these obstacles, considerable effort has been invested in attempting to derive ESC-like cells by reprogramming somatic cells to an embryonic state. (biomedcentral.com)
and from 2002 on pluripotency in embryonic stem cells in the lab of Ali H. Brivanlou. (eurostemcell.org)
He has been leader of a research group at the Max-Delbrück-Center for Molecular Medicine in Berlin until 2011 focusing his research on signal transduction mechanisms in human and murine embryonic stem cells. (eurostemcell.org)
Embryonic stem cells are useful for experiments because they are self-renewing and able to develop into almost any cell type in the body. (asu.edu)
Yamanaka induced somatic cells to act like human embryonic stem cells (hESCs), allowing researchers to experiment with non-embryonic stem cells with a similar capacity as hESCs. (asu.edu)
His focus has ranged from the development of telomerase-based therapeutics to the application of human embryonic stem cells in regenerative medicine. (asu.edu)
As of 2009, West advocated using human somatic cell nuclear transfer techniques to derive human embryonic stem cells for therapeutic practice. (asu.edu)
James Alexander Thomson, affectionately known as Jamie Thomson, is an American developmental biologist whose pioneering work in isolating and culturing non-human primate and human embryonic stem cells has made him one of the most prominent scientists in stem cell research. (asu.edu)
According to the The Herald, he was the first, alongside his colleague Martin Evans, to isolate and culture embryonic stem cells. (asu.edu)
For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
Embryonic stem cells were first identified in mice (Martin, 1981). (bmrat.org)
Embryonic stem cells are pluripotent, meaning they are able to produce all cell types in the body. (bmrat.org)
These cells exist only in earliest stages of embryonic development known as the blastocyst stage. (bmrat.org)
Recently, scientists have discovered how to reprogram normal cells to behave like embryonic stem cells. (bmrat.org)
This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)

6 Center for Stem Cell & Regenerative Medicine, The University of Texas Health Science Center of Houston, TX 77030, USA. (oaepublish.com)
We're a partnership of more than 400 stem cell and regenerative medicine labs across Europe, connected via research centres, consortia, networks and hubs. (eurostemcell.org)
Paolo De Coppi is a Consultant Paediatric Surgeon at Great Ormond Street Hospital (GOSH), and Reader and Head of Stem Cells and Regenerative Medicine at the UCL Institute of Child Health in London. (eurostemcell.org)
Bone marrow transplants are considered to be the first successful example of tissue engineering, a field within regenerative medicine that uses hematopoietic stem cells (HSCs) as a vehicle for treatment. (asu.edu)
Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)

The dynamics of RACK1 levels in isolated adult SC of mice, i.e., progressively high during differentiation and low compared to proliferating conditions, and RACK1 silencing indicated that RACK1 promotes both the formation of myotubes and the accretion of nascent myotubes. (sdbonline.org)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
This can be consistent with our previ ously reported observation that JNK2 action is inhibitory to differentiation of 40AF cells. (cox2-inhibitors.com)
13 So, in one,25D resistant 40AF cells HPK1 doesn't seem inhibitor checkpoint inhibitors to signal differentiation with the JNK pathway. (cox2-inhibitors.com)
The pan caspase inhibitor Q VD OPh even more enhances DCS induced differentiation of 40AF cells by inhibition of HPK1 cleavage. (cox2-inhibitors.com)
33 35 The pan caspase inhib itor Q VD OPh considerably increases differentiation of DCS handled 40AF cells. (cox2-inhibitors.com)
38 Consistent together with the greater differentiation, G1 arrest also increases when QVD is utilised to inhibit HPK1 cleavage in DCS treated 40AF cells. (cox2-inhibitors.com)
Life depends on constant replenishment of human body cells with new cells created by differentiation of adult stem cells. (anti-agingfirewalls.com)
As Type D cells die from trauma or apoptosis they are replaced by new cells resulting from differentiation of Type B and Type C cells. (anti-agingfirewalls.com)
In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
As ES cells progressed down a differentiation pathway, the levels of HERV-H RNA decreased progressively. (biomedcentral.com)
Ideally, iPSC-based therapies in the future will rely on the isolation of skin fibroblasts or keratinocytes, their reprogramming into iPSCs, and the correction of the genetic defect followed by differentiation into the desired cell type and transplantation. (biomedcentral.com)

To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
In addition, as the genetic identity of the donor egg from which the ESCs are derived most likely will differ from that of potential recipients, patients who receive ESC-derived cells or tissues may face the same complications that result from organ transplantation (for example, immunorejection, graft-versus-host disease, and need for immunosuppression). (biomedcentral.com)
Clare's lab recently identified a population of progenitor/stem cells in mice that, on transplantation, is sufficient to generate a fully functional thymus. (eurostemcell.org)
Edward Donnall Thomas, an American physician and scientist, gained recognition in the scientific community for conducting the first bone marrow transplant, a pioneering form of hematopoietic stem cell transplantation (HSCT). (asu.edu)

Our data show that, in contrast to adult MDS, Ras/MAPK pathway mutations are common in pediatric MDS (45% of primary cohort), while mutations in RNA splicing genes are rare (2% of primary cohort). (nature.com)
Multiple large cohort studies of adult MDS patients found recurrent mutations in genes important in epigenetic regulation (e.g. (nature.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. (researchgate.net)
Central to this is the transient increase in H3K4-trimethylation at developmental genes during G1, thereby creating a 'window of opportunity' for cell-fate specification. (researchgate.net)

The paper "Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t 12 /t 12 )-Normal Mosaics," by Beatrice Mintz, describes a technique to fuse two mouse embryos into a single embryo. (asu.edu)
When two embryos are correctly joined before the 32-cell stage, the embryo will develop normally and exhibit a mosaic pattern of cells as an adult. (asu.edu)
One population was a group of normal, functioning germ cells, the other group did not divide and they did not migrate to the correct parts of the embryo. (asu.edu)
She wanted to apply this technique to the t 12 mutation, which is characterized by a developmental arrest at the morula stage, when the embryo is composed of approximately thirty-two cells. (asu.edu)
Some embryos did not efficiently fuse and the embryo segregated itself between mutant and normal cells. (asu.edu)
Each mosaic embryo produced a different pattern of growth, but all the mutant cells began to grow larger in relation to the normal cells due to a reduction in the rate of cell division. (asu.edu)
At conception, the embryo is all Type A cells. (anti-agingfirewalls.com)
This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)

The adult cows with similar antigens were found to have two different populations of red blood cells suggesting that the precursors of the red blood cells, hematopoietic stem cells, were transferred from one twin to the other during development. (asu.edu)
Depletion of Runx1 with antisense morpholino oligonucleotides abrogated the development of both blood and vessels, as demonstrated by loss of circulation, incomplete development of vasculature and the accumulation of immature hematopoietic precursors. (biologists.com)
After cell sorting, the gene expressions of membrane proteins in early and late erythropoiesis precursors and in nonerythroid cells were characterized using microarray analysis. (biomedcentral.com)
Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)

Beatrice Mintz conducted a previous study that examined a reproductive disorder characterized by two distinct populations of germ cells in heterozygous mice. (asu.edu)
The genesis of these endogenous retroviruses (ERVs) necessitates establishment of provirus by the ancestral, exogenous retrovirus within host germ cells, such that these elements are maintained as heritable genetic elements in the host species. (biomedcentral.com)
We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)

Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. (nih.gov)
Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
Hematopoiesis occurs in the bone marrow, producing a complete spectrum of blood cells to maintain homeostasis. (biomedcentral.com)
Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS. (lookformedical.com)

Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)

Zebrafish runx1 is expressed in hematopoietic and neuronal cells during early embryogenesis. (biologists.com)

All types of blood cells are derived from hematopoietic stem cells (HSCs). (biomedcentral.com)

We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
Statistical methods that were used to identify chromatin features that predict exogenous gamma-retrovirus integration site selection were exploited here to determine whether cell type-specific chromatin markers are enriched in the vicinity of endogenous retroviruses (ERVs). (biomedcentral.com)
Proximity of HERV-H to binding sites for pluripotency transcription factors within ES cells might be due to retention of the same chromatin features that determined the site of integration of the ancestral, exogenous, gamma-retrovirus that gave rise to HERV-H in the distant past. (biomedcentral.com)
Previously, we developed statistical tools to identify association between the sites of provirus establishment and chromosome marks - as determined by chromatin immuno-precipitation with massively parallel DNA sequencing (ChIPSeq) [ 18 , 19 ]. (biomedcentral.com)

Similar strong association was observed between HERV-H and the binding sites within ES cells for the pluripotency transcription factors NANOG, OCT4, and SOX2. (biomedcentral.com)
The developmental regulation of HERV-H expression, the association of HERV-H with binding sites for pluripotency transcription factors, and the extremely high levels of HERV-H RNA in human ES cells suggest that HERV-H contributes to pluripotency in human cells. (biomedcentral.com)
Either way, HERV-H RNA provides a specific marker for pluripotency in human cells. (biomedcentral.com)

3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)
With growth, these proliferate and, in a remarkably articulated manner, progressively differentiate into multipotent stem cells (Type B), progenitor cells (Type C), mature body somatic cells (Type E), and many eventually become senescent cells (Type E). (anti-agingfirewalls.com)

Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)

Although most of a eukaryotic cell's DNA is contained in the cell nucleus , the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes. (wikipedia.org)
[20] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . (wikipedia.org)
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. (lookformedical.com)

Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)

dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)

Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. (knaw.nl)
When assessing the entire 3D vascular tree of the kidney, isolated endothelial cells were never observed at any developmental age. (bsdb.org)

Bone marrow samples from C57BL/B6 mice and one healthy donor were analyzed using traditional two-marker (CD71 and glycophorin A) flow cytometry analysis. (biomedcentral.com)
To detect the epigenetic drift of time passing, we determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. (aging-us.com)

In mice, H3K27me3 was found to increase in muscle quiescent stem cells from aged individuals and, thus, is suggested to suppress functions related to stemness [ 17 ]. (aging-us.com)

Although exciting results have been achieved by means of somatic cell nuclear transfer, cell fusion, and culture-induced reprogramming [ 1 ], these procedures are technically demanding and inefficient and therefore unlikely to become a common approach for producing patient-specific pluripotent cells. (biomedcentral.com)

Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. (rochester.edu)

runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl , and expression of runx1 is markedly reduced in the zebrafish mutants spadetail and cloche . (biologists.com)
Certain post-translational modifications to histones, including H3K4me3, as well as binding sites for the transcription factor STAT1, predict the site of integration of exogenous gamma-retroviruses with great accuracy and cell-type specificity. (biomedcentral.com)

Surprisingly, germline variants in SAMD9 or SAMD9L were present in 17% of primary MDS patients, and these variants were routinely lost in the tumor cells by chromosomal deletions (e.g., monosomy 7) or copy number neutral loss of heterozygosity (CN-LOH). (nature.com)
Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
Lung tumor stem cells are a subpopulation of cells important for lung tumor development, metastasis, and medication resistance. (immune-source.com)
They are named tumor control cancers or cells initiating cells [4]. (immune-source.com)
Leukemia control cells are the AZD1080 KIAA0901 initial reported kind of tumor control cells [5]. (immune-source.com)
This is certainly the initial function on tumor control cells in solid growth [6]. (immune-source.com)
After that, tumor control cells had been reported in different types of malignancies, including lung tumor, gastric tumor, human brain cancers, liver organ cancers, and digestive tract cancers [7C11]. (immune-source.com)
After the breakthrough discovery of tumor control cells, analysts attempted to appearance for effective techniques to focus on cancers control cells. (immune-source.com)
Nevertheless, till today, no one provides reported whether thioridazine could focus on lung tumor control cells. (immune-source.com)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)

We employ a variety of experimental systems for our studies ranging from molecular biology to transgenic and knockout mice. (stanford.edu)
X. Trefoil peptide and EGF receptor/ligand transgenic mice. (embl.de)

The sphingomyelin that accumulates in the lysosomes of Niemann-Pick disease-affected cells is thought to arise from the degradation of the cells and their organelles because it is a major component of all mammalian cell membranes. (medscape.com)

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. (rochester.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)

She produced fusions of embryos homozygous for t 12 with control mice from the same genetic line. (asu.edu)
Many of the fusions developed long enough to produce discernible populations of cells. (asu.edu)

Int J Biochem Cell Biol, 2014 May. (nih.gov)
Int J Biochem Cell Biol. (embl.de)
Mol Cell Biol. (embl.de)

In the 1950s human chimeras were also identified by examining blood antigens and later confirmed by karyotyping to reveal differences in chromosome patterns between the patient's cells. (asu.edu)
Many human body cell types have a remarkable rate of turnover. (anti-agingfirewalls.com)
In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)
Joint mouse-human phenome-wide association to test gene function and disease risk. (genenetwork.org)
With the help of AQP0 staining, we could define up to five stages of erythropoiesis in both mouse and human bone marrow using flow cytometry. (biomedcentral.com)
The HeLa cell line was the first immortal human cell line that George Otto Gey, Margaret Gey, and Mary Kucibek first isolated from Henrietta Lacks and developed at The Johns Hopkins Hospital in Baltimore, Maryland, in 1951. (asu.edu)
An immortal human cell line is a cluster of cells that continuously multiply on their own outside of the human from which they originated. (asu.edu)
Scientists use immortal human cell lines in their research to investigate how cells function in humans. (asu.edu)
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. (bvsalud.org)

Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. (nih.gov)
Nature Cell Biology. (knaw.nl)
Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. (genenetwork.org)

Shinya Yamanaka gained international prominence after publishing articles detailing the successful generation of induced pluripotent stem (iPS) cells, first in mice, then in humans. (asu.edu)

In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. (nature.com)
Our data confirm that adult and pediatric MDS are separate diseases with disparate mechanisms, and that SAMD9/SAMD9L mutations represent a new class of MDS predisposition. (nature.com)
This is not surprising as there are well-accepted clinical and morphologic differences between pediatric and adult MDS (e.g., bone marrow hypocellularity is more common in children) leading the World Health Organization (WHO) to classify MDS differently in adults and in children 10 . (nature.com)
These data suggest that pediatric MDS is separate from adult MDS with disparate underlying mechanisms. (nature.com)

This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
To examine the mechanism by which DCS reverses resistance of 40AF buy Roscovitine cells to 1,25D, we asked if HPK1 sig naling is enhanced from the inhibition of its proteolytic cleavage, regarded to take area in other methods. (cox2-inhibitors.com)

Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, reduced the extent of changes occurring during the first year of life in these genomic regions. (aging-us.com)

A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
During DNA REPLICATION, chromosome ends loose some of their telomere sequence (TELOMERE SHORTENING. (lookformedical.com)

Accordingly, the level of AQP0 high in early erythroid precursor cells may serve as a reference parameter for diagnosing diseases associated with dyserythropoiesis. (biomedcentral.com)
precursor cells. (immune-source.com)
Blood vessels can form through angiogenesis (branching of new vessels from pre-existing ones) and/or vasculogenesis (assembly of new vessels from the coalescence of endothelial precursor cells). (bsdb.org)

On the other hand, a chimera is defined as an organism in which cells from two or more different organisms have contributed. (frontiersin.org)
Although in principle stem cells can replicate indefinitely, in fact they age as the organism ages, continuing to change their gene expression. (anti-agingfirewalls.com)
The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. (wikipedia.org)

The block in definitive hematopoiesis is similar to that observed in Runx1 knockout mice, implying that zebrafish Runx1 has a function equivalent to that in mammals. (biologists.com)

The above list is in order of increasing cell-type specificity and decreasing cell-type potency to differentiate into other cell types. (anti-agingfirewalls.com)
Starting at conception and throughout life, all cells on this list except the senescent ones will selectively reproduce and possibly differentiate into cells of types further down in the list. (anti-agingfirewalls.com)
At maturity there are relatively very few Type A cells and a mix of Type B, C and D cells, Type B and C cells typically live in protected stem cell niches where they reproduce and, as-needed differentiate to become the normal working body Type D cells. (anti-agingfirewalls.com)
At an advanced age, the pools of Type B and Type C cells become depleted in part because of replicative senescence and the cells remaining in the pools lose their ability to differentiate as necessary to replace Type D cells. (anti-agingfirewalls.com)
Cells in those pools replicate and differentiate throughout life. (anti-agingfirewalls.com)
Our bodies contain a pool of stem cells that have the ability to differentiate into any other cell type in the body. (bmrat.org)
Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)

The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. (nih.gov)

However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)

RACK1 was expressed transiently in the skeletal muscle of post-natal mice, being abundant in the early phase of muscle growth and almost disappearing in adult mature fibers. (sdbonline.org)
lugens, female adults possess numerous even more abundant mi crobial symbionts than do male grownups.Our findings indi cate a probable immune tactic whereby female grownups cut down their immune capabilities to sustain the micro bial symbionts in an effort to meet the requirements of nutri tion, improvement, and reproduction. (cox2-inhibitors.com)
RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (lookformedical.com)

After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)

Mintz thought there might be a way to use dual populations of cells to study the action of the mutant cells. (asu.edu)
These populations of cells have control cell properties. (immune-source.com)
However, given that bivalent domains can still be observed-albeit in lower proportion-in unipotent cells such as T cells and MEFs, an admixture of cell populations appears to be an unlikely explanation for the observed coexistence of these marks. (researchgate.net)

This was accomplished by introducing the embryos to each other at mouse body temperature. (asu.edu)
The embryos easily adhered to each other and continued to develop as a single mouse. (asu.edu)
Transient expression of runx1 in cloche embryos resulted in partial rescue of the hematopoietic defect. (biologists.com)

The sub G1 peaks, which signify necrosis/apoptosis, are greater in DCS taken care of 40AF cells compared with all the handle group. (cox2-inhibitors.com)
The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS. (lookformedical.com)
Here, we found that givinostat inhibited proliferation and induced apoptosis of BCP-ALL CRLF2-rearranged cell lines, positive for exon 16 JAK2 mutations. (bvsalud.org)

Hillje R , Luzi L , Amatori S , Persico G , Casciaro F , Rusin M , Fanelli M , Pelicci P , Giorgio M , . Time makes histone H3 modifications drift in mouse liver. (aging-us.com)

A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. (lookformedical.com)
We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)

Anatomy82

Organisms19

Diseases17

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes107

Disciplines and Occupations2

Information Science3

Named Groups1

Health Care1

Pluripotent stem8

Progenitor cell3

Embryonic23

Regenerative Medicine5

Differentiation14

Transplantation5

Genes6

Embryo8

Precursors4

Germ cells3

Homeostasis5

Pathways1

Embryogenesis1

HSCs1

Chromatin4

Pluripotency3

Multipotent2

Depletion1

Eukaryotic3

Bone marrow tra1

Regulate1

Developmental2

C57BL2

Stemness1

Somatic cell nuc1

Murine1

Transcription factor2

Tumor12

Transgenic2

Membranes1

Transcriptional2

Fusions2

Biol3

Human9

Biology4

Generation of induced1

Pediatric4

Mechanism2

Genomic1

Replication2

Precursor cells3

Organism3

Knockout mice1

Differentiate7

Brain2

Integrity1

Donor1

Abundant3

Drosophila2

Populations3

Embryos3

Apoptosis3

Histone1

Protein2