Hematopoietic stem cells hematopoietic and vascular. Medical search. Frequent questions

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Current treatment options for PMF are limited, and the only potential cure, stem cell transplantation, is often prohibitively toxic for most patients. (lls.org)
The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). (bu.edu)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)
How- ever, conspicuously, E-selectin is constitutively expressed on bone marrow (BM) sinusoidal vessels where it is known to play a key role in mediating migration of circulating cells to BM, a process critical to blood cell recovery following hematopoietic stem cell transplantation (HSCT). (cancer.gov)
Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered? (mdpi.com)
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation. (biomedcentral.com)
Hematopoietic stem cell transplantation and associated risk factors precipitate endothelial injury, leading to HSCT-TMA and other endothelial injury syndromes such as hepatic veno-occlusive disease/sinusoidal obstruction syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, capillary leak syndrome, and graft-versus-host disease. (biomedcentral.com)
Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
Hematopoietic stem cell transplantation is currently an inpatient procedure. (medscape.com)
A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
Although the only therapy that can cure the pancytopenia is stem cell transplantation, androgens, to which approximately 50-75% of patients respond, are used for those in whom transplantation is not an option. (medscape.com)
The Vascular Nephrology Group was initiated by Anton Jan van Zonneveld and Ton Rabelink in 2004 and research topics are centred around the understanding and clinical translation of molecular mechanisms in vascular injury and repair, secondary to adverse metabolic- or hemodynamic risk factors such as encountered in diabetes, chronic kidney disease or kidney transplantation. (einthovenlaboratory.com)
In addition, short-term osteoinductive treatment favored in vivo hematopoietic recovery in lethally irradiated mice that underwent BM transplantation. (elsevierpure.com)
Our findings demonstrate the unique biological characteristics of e-MSCs as hematopoiesis-regulatory stromal cells at differentiation stage between MSCs and osteoprogenitor cells and have significant implications in developing new strategy for using pharmacological osteoinductive treatment to support hematopoiesis in hematopoietic stem and progenitor cell transplantation. (elsevierpure.com)
to assess the effectiveness and safety of the peripherally inserted central catheter for hematopoietic stem cell transplantation. (uff.br)
The review will consider experimental and observational studies that include adult and pediatric patients undergoing hematopoietic stem cell transplantation. (uff.br)
The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies. (uff.br)
Vascular access and bloodstream infections associated with tunneled, non-trialysis and non-tunneled, trialysis catheters in patients undergoing hematopoietic stem cell transplantation. (uff.br)
Peripherally inserted central catheter in haematopoietic stem cell transplantation. (uff.br)
After undergoing an allogeneic haematopoietic stem cell transplantation (alloHCT), patients need intensive physiological and psychological rehabilitation. (mdpi.com)
The diagnosis is suspected in patients with unexplained clinical or laboratory evidence of liver disease, particularly in those with known risk factors, such as bone marrow or hematopoietic cell transplantation. (msdmanuals.com)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)

Researchers identify the origin of endothelial cells that constitute the vascular niche for hematopoietic stem and progenitor cells in zebrafish. (go.jp)
Endothelial cells (ECs) line blood vessels and can serve as specialized vascular niches for hematopoietic stem and progenitor cells (HSPCs), a special environment where HSPCs reside and self-renew. (go.jp)
The present results clearly demonstrate that ECs originating from the endoderm via islet1 + endothelial progenitors play a specialized role in forming a functional vascular HSPC niche (Figure 1C). (go.jp)
As the embryo requires rapid oxygenation due to its high mitotic activity, these islands are the main source of red blood cell (RBC) production via fusing endothelial cells (ECs) with the developing embryonic circulation. (wikipedia.org)
A year later, Choi showed that blast cells derived from embryonic stem (ES) cells displayed common gene expression of both hematopoietic and endothelial precursors. (wikipedia.org)
Single-cell transcriptomics shows that during the endothelial-to-hematopoietic transition, Ncx1 −/− cells fail to. (lu.se)
Single-cell transcriptomics shows that during the endothelial-to-hematopoietic transition, Ncx1 −/− cells fail to undergo a glycolysis to oxidative phosphorylation metabolic switch present in wild-type cells. (lu.se)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. (ihcworld.com)
Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. (ihcworld.com)
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. (ihcworld.com)
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. (ihcworld.com)
Inflammation and endothelial injury were assessed in selected samples by immunostaining for CD8 T cells, activated cytotoxic T lymphocytes, and vascular endothelial cells. (nih.gov)
Perivascular CD8 T cell infiltrates in skin correlated with vWF plasma concentrations in patients with GVHD (p=0.01), and activated cytotoxic T lymphocytes and endothelial injury were present in these same samples. (nih.gov)
Host endothelial cells are a target of alloreactive donor cytotoxic T lymphocytes. (nih.gov)
Circulating endothelial cells and the study of vascular injury in children undergoing hematopoietic stem cell transplant. (uc.edu)
The drug candidate is a humanized monoclonal IgG4 antibody targeting cells expressing CLEVER-1 (Common lymphatic endothelial and vascular endothelial receptor-1). (pharmaceutical-technology.com)
CD15s) is the prototypical binding determinant for E- selectin (CD62E), a Ca++-dependent lectin expressed on vascular endothelial cells. (cancer.gov)
The sLeX motif can be presented on cell surfaces on protein (i.e., glycoprotein) and/or lipid (i.e., glycolipid) scaffolds, and these glycoconjugates (known as "E-selectin ligands") program shear-resistant adhesion to endothelial cells. (cancer.gov)
E-selectin is typically not displayed on resting vascular endothelial cells, and its expression is induced by inflammatory cytokines such as TNF and IL-1. (cancer.gov)
In particular, the lectin pathway of complement is activated by damage-associated molecular patterns (DAMPs) on the surface of injured endothelial cells. (biomedcentral.com)
Endothelial injury triggers activation of the complement system-significantly through the lectin pathway-via altered cell-surface patterns on injured endothelial cells, initiating an inflammatory response [ 7 ]. (biomedcentral.com)
These HSCs are primarily derived from endothelial cells within the ventral wall of the dorsal aorta. (amegroups.org)
Around the contrary, no cellsexpressed markers of hematopoietic lineage (CD14 and CD45), hematopoietic progenitor (CD34) or endothelial cells (CD31, vWF). (amparinhibitor.com)
Blood vessels play a part in the transport of nutrients and oxygen to cells and tissues, while vascular endothelial cells themselves preserve the body's homeostasis by secreting substances that contribute to tissue maintenance in the process of their differentiation and proliferation (blood vessel formation). (healthist.net)
The cells on the outside differentiate into vascular endothelial cells, while those on the inside differentiate into blood. (healthist.net)
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)

In hematopoietic tissues, a group of ECs are highly specialized and constitute the vascular HSPC niche to support HSPC maturation, expansion, and differentiation. (go.jp)
This event requires a special environment, termed the hematopoietic stem cell niche, which provides the protection and signals necessary to carry out the differentiation of cells from HSC progenitors. (wikipedia.org)
Hematopoiesis involves a series of differentiation steps from one progenitor cell to a more committed cell type, forming the recognizable tree seen in the adjacent diagram. (wikipedia.org)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Thus, conserved endocytic functions may control blood cell progenitor quiescence and differentiation. (nih.gov)
NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. (novusbio.com)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
In the case of vasculogenesis, blood islands are formed as a result of the differentiation of cells derived from the mesoderm. (healthist.net)

Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). (wikipedia.org)
The CMP can then further differentiate into the megakaryocyte-erythroid progenitor cell (MEP), which goes on to make RBCs and platelets, or the granulocyte/macrophage progenitor (GMP), which gives rise to the granulocytes of the innate immune response. (wikipedia.org)
The hemangioblast theory, which posits that the RBCs and ECs derive from a common progenitor cell, was developed as researchers observed that receptor knockout mice, such as Flk1-/-, exhibited defective RBC formation and vessel growth. (wikipedia.org)
The terms "progenitor cell" and "stem cell" are sometimes equated. (phys.org)
There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. (keio.ac.jp)
Figure 1 VCAM-1 + macrophages guide hematopoietic stem/progenitor cell to sites of definitive hematopoiesis. (amegroups.org)

When these islet1 -lineage ECs were specifically ablated, most of the HSPCs were lost from the caudal hematopoietic tissue (CHT), a transient vascular niche for HSPCs in zebrafish (Figure 1B). (go.jp)
islet1 + -derived ECs (green) are mainly located in the caudal hematopoietic tissue (CHT), a transient vascular niche for HSPCs. (go.jp)
The definitive HSCs in mammals first migrate to and repopulate in the fetal liver and then home to the bone marrow, while the definitive HSCs in zebrafish migrate first to the caudal hematopoietic tissue and then to their definitive anatomical sites in the kidney and thymus ( 5 - 8 ). (amegroups.org)

The team identified an unexpected origin for the vascular HSPC niche. (go.jp)
They found that islet1 -expressing cells are the progenitors of the venous ECs that constitute the majority of the HSPC niche (Figure 1A). (go.jp)
During this time, the field exploded with studies aimed at determining the components of the "hematopoietic stem cell niche" that made this possible. (wikipedia.org)
These studies and others supported the idea that bone cells create the HSC niche, and all the research that elucidated this specialized hematopoietic microenvironment stemmed from these landmark studies. (wikipedia.org)
This project explores the connection between the niche - the area in the bone marrow where blood cells are formed - and the development of leukemia stem cells (LSCs) that give way to primary myelofibrosis (PMF). (lls.org)
These cells are found in the bone marrow in a region called their "niche," which is near the bone marrow vascular system. (lls.org)
Our recent data show that bone marrow cells in the niche that express the Leptin receptor protein are the source of fibrosis via activation of a signaling network mediated by a protein called PDGFRa. (lls.org)
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. (bu.edu)
Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. (bu.edu)
This co-relates with fewer Col+ cells in the hematopoietic stem cell niche of asrij mutants. (nih.gov)
We hypothesize that engagement of E-selectin ligands on human acute leukemia cells programs efficient BM metastasis and also enables niche lodgment, serving to displace resident HSPCs from their proper growth microenvironment and thereby promoting leukemic cell proliferation. (cancer.gov)
VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. (amegroups.org)
Despite these apparent differences in definitive hematopoiesis between fish and mammals, the definitive HSC niche functions to actively recruit stem cells and maintain their plasticity throughout adulthood ( 2 , 4 , 5 ). (amegroups.org)
Over the course of her career, Dr Winkler has produced 49 peer-reviewed articles, including a recent landmark study in Nature Medicine 2012, describing a key component of the bone marrow vascular niche (E-selectin) in regulating Haematopoietic Stem Cell self-renewal and chemo-sensitivity and last year her research was recognized to be among 'Ten of the Best Research Projects'in Australia by the National Health & Medical Research Council. (edu.au)

They also serve as specialized vascular niches that provide instructive signals to tissue-specific stem cells or parenchymal cells for tissue formation and repair. (go.jp)
It is a soft vascular tissue present in the interior of long bones. (powershow.com)
PMF is a stem cell-derived blood malignancy with the characteristics of too many cells in the blood and a large amount of scar tissue formation (fibrosis) in the bone marrow. (lls.org)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
Antigenicity for each protein was quantified based on staining intensity and percentage of tissue positive for each antigen, and subsequently compared to data obtained from two control tissue sets: 10 vascular tissues and a panel of 58 various malignant sarcomas. (medscape.com)
Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. (medscape.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
In our research group we combine two complementary research themes to generate insight in the development of alternative, innovative strategies for tissue engineering: 1) kidney scaffolds and 2) stem cells. (einthovenlaboratory.com)
Histologically, PCs demonstrate a non-keratinized stratified squamous epithelium as a formation of one or two thin cell layers combined with fibrous connective tissue substrate infiltrated by inflammatory cells. (cancerdiagnosisprognosis.org)
The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)

However, these cells reside in an abnormal microenvironment, fail to activate the hematopoietic program downstream of Runx1, and are functionally impaired. (lu.se)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)

There are 2 types of hematopoiesis that occur in humans: Primitive hematopoiesis - blood stem cells differentiate into only a few specialized blood lineages (typically isolated to early fetal development). (wikipedia.org)
The pioneering work of Till and McCulloch in 1961 experimentally confirmed the development of blood cells from a single precursor hematopoietic stem cell (HSC), creating the framework for the field of hematopoiesis to be studied over the following decades. (wikipedia.org)
Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. (bu.edu)
The first wave, defined as primitive hematopoiesis, takes place in the extraembryonic yolk sac and generates transitory hematopoietic cell populations consisting of primitive erythrocytes. (amegroups.org)
The second wave, referred to as definitive hematopoiesis, temporarily occurs in the fetal liver and transitions to the bone marrow and thymus, where multipotent hematopoietic stem cells (HSCs) contribute to the generation of all blood lineages ( 1 - 3 ). (amegroups.org)
In zebrafish, primitive hematopoiesis occurs at early somite stages in the intermediate cell mass (ICM) and the rostral blood island (RBI). (amegroups.org)
Subset of macrophages expressing ICAM-1 migrate to the sites of definitive hematopoiesis in AGM and CHT to recruit hematopoietic stem cells and initiate neonatal hematopoiesis and guide them further to sites of adult and definitive hematopoiesis in kidneys and thymus. (amegroups.org)
Here, by using a microarray analysis, we demonstrate that human BM mesenchymal stromal/stem cells (MSCs) in an early osteoinductive stage (e-MSCs) are characterized by unique hematopoiesis-associated gene expression with an enhanced hematopoiesis-supportive ability. (elsevierpure.com)
Noteworthy, expression of the hematopoiesis-associated molecules CXCL12 and vascular cell adhesion molecule 1 was remarkably decreased in e-MSCs. (elsevierpure.com)

HSPCs are multipotent cells that can self-renew and differentiate to give rise to all blood cell lineages. (go.jp)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
Throughout our lives, a small pool of hematopoietic stem/progenitor cells (HSPCs) ensures the stable production of a wide range of blood and immune cells in our bodies. (phys.org)
Cells in the blood such as immune cells, red blood cells and other vital cell types are constantly renewed from stem cells, the so-called hematopoietic stem and progenitor cells (HSPCs). (phys.org)

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. (bu.edu)
During this first wave, small number of myeloid cells (e.g., primitive monocytes/macrophages and megakaryocytes) are also generated. (amegroups.org)
and the RBI cells are derived from the lateral mesoderm of the zebrafish head and differentiate into macrophages ( 4 - 8 ). (amegroups.org)

e-MSCs supported an enhanced expansion of CD34 + hematopoietic stem and progenitor cells, and generation of myeloid lineage cells in vitro. (elsevierpure.com)
CD34 (gene band: 1q32.2) is a ~120-kDa cell surface-transmembrane phosphoglycoprotein acting as an adhesion molecule between cells ( J Biol Regul Homeost Agents 15(1) (2001)">10 ). (cancerdiagnosisprognosis.org)
Furthermore, CD34 enhances T-cell motivation leading to lymph node infiltration ( Oral Dis 15(6) (2009)">14 ). (cancerdiagnosisprognosis.org)

Dexter observed that mesenchymal stromal cells could maintain early HSCs ex vivo, and both Lord and Gong showed that these cells localized to the endosteal margins in long bones. (wikipedia.org)
Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. (lu.se)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)

BK Polyomavirus Subtypes II and IV in Hematopoietic Cell Transplant Recipients. (uc.edu)
Peripherally inserted central catheters in allogeneic hematopoietic stem cell transplant recipients. (uff.br)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

Transcription factor induction of vascular blood stem cell niches in vivo. (bu.edu)

Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)
Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)
KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
Randomization was stratified by tumor histology (squamous cell carcinoma vs. adenocarcinoma), geographic region (Asia vs. ex-Asia), and Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0 vs. 1). (merck.com)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)

This remark is certainly a stunning point in favor of a significant Refametinib contribution to growth development control by FSP-specific Testosterone levels cells in vivo , producing those peptides extremely interesting applicants for the advancement of targeted vaccination strategies. (immune-source.com)
In addition there is a lack of information regarding the presence of mast cells in dental pulp of rats, which are animals used to study important aspects of the pathophysiology of dental pulp in vivo 6 . (bvsalud.org)

This award is intended to enable recipients to devote a significant amount of their time to vascular research. (umassmed.edu)

However, little is known about EC heterogeneity in hematopoietic tissues. (go.jp)

However, all developmental processes originate from pluripotent precursor cell types. (amegroups.org)
Pluripotent haematopoietic stem cell. (glenwoodwine.com)

The CLP then goes on to differentiate into more committed lymphoid precursor cells. (wikipedia.org)
Like stem cells, progenitor cells have a capacity to differentiate into a specific type of cell. (phys.org)
In contrast to stem cells, however, they are already far more specific: they are pushed to differentiate into their "target" cell. (phys.org)
e-MSCs exhibited the absence of decreased stemness-associated gene expression, increased osteogenesis-associated gene expression, and apparent mineralization, thus maintaining the ability to differentiate into adipogenic cells. (elsevierpure.com)

Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
Subjects who have received prior allogeneic stem cell transplant or donor lymphocyte infusion (DLI) at least 100 days before enrollment with no signs of acute or chronic graft-versus-host disease (GVHD) will be considered eligible. (mayo.edu)
Infusion of haematopoietic cells and complications. (uff.br)

Vascular injury has been seen in patients with acute graft versus host disease (GVHD) in the skin. (nih.gov)
We aimed to see whether vascular injury mediated by cytotoxic T lymphocytes and microvessel loss arises in patients with chronic GVHD. (nih.gov)
BK Polyomavirus Genotypes in Two Patients after Hematopoietic Cell Transplant. (uc.edu)
In this proposal, using E-selectin binding assays under both static and fluid shear conditions, together with complementary techniques in flow cytometry and western blotting, we will analyze the E-selectin binding activity of leukemia cells isolated from blood and BM of patients with acute leukemias. (cancer.gov)
8,9 Subsequently two primary-prevention trials, ASCEND and VITAL , included a far greater proportion of patients already receiving statin therapy (75%), yet showed no difference in the rates of major vascular events or all-cause mortality among patients receiving a combination EPA/DHA compound. (acc.org)
In the past, some clinicians advocated corticosteroids, to delay growth plate closure in patients treated with androgens and to improve vascular integrity and reduce bleeding. (medscape.com)
The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
Cancer cells vastly upregulate specific blood clotting factors and this is believed to result in the formation of unwanted blood clots in veins and the lungs, often leading to fatal, thrombotic complications in cancer patients. (einthovenlaboratory.com)
In PNH patients these two complement regulatory proteins are absent or partially expressed on red blood cells. (aacc.org)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)

Some studies showed Sca-1 expression in the pulmonary vascular endothelium of adult murine lungs [3], while a subset of Sca-1-expressing cells formed vascular-like structures under specific conditions [1]. (keio.ac.jp)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)

02:47 and red blood cells in vitro. (yale.edu)

hC-MSCs were elongated and homogeneously spindle-shaped in morphology with thin cytoplasmic projections (Figure 1H).Human cadaver mesenchymal stromal/stem cell phenotypic and molecular PRMT8 Formulation characterizationAt the third replaying, flow cytometry analysis showed that hC-MSCs expressed recognized markers of hMSCs (CD44, CD73, CD90 and CD105), pericyte antigens (CD146, PDGF-r and NG2) and stemness markers (Stro-1, Oct-4 and Notch-1). (amparinhibitor.com)
The isolated cells also constituting expressed of HLA-G antigen, a well-known tolerogenic molecule involved within the immuomodulatory activity of mesenchymal stromal/stem cells [17] (Figure 2A). (amparinhibitor.com)
Stem Cell Analysis Therapy 2014, 5:eight stemcellres.com/content/5/1/Page 7 ofFigure two Human cadaver mesenchymal stromal/stem cell phenotypic and molecular characterization. (amparinhibitor.com)
Immunofluorescence staining for Vimentin (C) and Nestin (D) in human cadaver mesenchymal stromal/stem. (amparinhibitor.com)

I plan to use the Wylie Scholar Award to accelerate our current work on evaluating how diabetes affects the human bone marrow immune cell development and understand how hematopoietic stem cells are specifically affected by the yellow bone marrow compartment expansion that occurs in diabetes. (umassmed.edu)

Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)

NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)

The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)

This information will be integrated with various biochemical approaches including metabolic inhibition of glycosylation and cell surface glycoengineering to custom-modify sLeX display to assess the extent to which sLeX presentation on a specific protein and/or lipid scaffold licenses E-selectin binding among blasts from various subtypes of human acute leukemias, and the impact of the relevant E-selectin receptor/ligand interaction(s) in leukemia cell biology. (cancer.gov)
The biology and therapeutic application of mesenchymal cells. (edu.au)
He is the recipient of numerous awards, including the Japan Society for Cell Biology Best Presentation Award for Young Talent (2015) and the Young Investigator Award of the Japanese Cancer Association (2019). (healthist.net)

She received the 2022 Wylie Scholar Award from Vascular Cures for her project "Exploring How the Diabetic Immune System Contributes to Non-Healing Ulcers. (umassmed.edu)

Background: Stromal cells are a functionally important component of human carcinomas. (immune-source.com)
Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically considerably lower phrase level of the p16 proteins as likened with that in regular lung stromal cells. (immune-source.com)

The drug candidate is devoid of T cell epitopes which limits mounting of immune reaction against FP-1304. (pharmaceutical-technology.com)
As long as we are healthy, our body keeps the number of blood and immune cells largely constant. (phys.org)
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. (duke.edu)

Relevance: Acute leukemia arises because abnormal white cell precursors proliferate within special growth zones within the bone marrow. (cancer.gov)

Periapical cysts (PCs) belong to the inflammatory odontogenic cysts sub-category and rarely squamous cell carcinoma arises from their hyperplastic/ dysplastic epithelia. (cancerdiagnosisprognosis.org)
These histopathological characteristics rarely form an eligible substrate for squamous cell carcinoma onset in untended cases. (cancerdiagnosisprognosis.org)
Although rare, primary intraosseous squamous cell carcinoma arises from their hyperplastic/dysplastic epithelia in untended, misdiagnosed cases ( Oral Surg Oral Med Oral Pathol Oral Radiol 120(5) (2015)">3 , J Cancer Res Ther 16(3) (2020)">4 ). (cancerdiagnosisprognosis.org)

Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. (bu.edu)
Dormant cancer cells: programmed quiescence, senescence, or both? (nature.com)
Cancer Cell 18 , 485-498 (2010). (nature.com)
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research, Brisbane, Australia. (edu.au)
New ways to sensitise cancer cells to standard cancer therapy. (edu.au)
Cancer cells are able to multiply because they generate blood vessels in cells that did not originally have blood vessels and therefore become able to take in nutrients. (healthist.net)
However, in the case of cancer, angiogenesis occurs in cells that originally had no blood vessels and branches gradually form from surrounding blood vessels, taking in nutrients and causing the repeated abnormal proliferation of cancer cells. (healthist.net)
They function in a variety of developmental and physiological processes, including INFLAMMATION, lipid metabolism, hematopoietic stem cell activity, and cancer metastasis. (bvsalud.org)

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. (ihcworld.com)
The mutant hematopoietic stem-cell exhibit a survival advantage over normal cells and tend to expand leading to hemolysis. (aacc.org)

Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)

This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
The stimulus for the change of cell fate originates from extrinsic signals which set a cascade of intracellular processes in motion that eventually terminate at the genome leading to changes in gene expression and the development of alternate gene regulatory networks. (amegroups.org)
In the developing embryo, TFs regulating the assembly/disassembly of transcriptional complexes and ultimately gene expression, are directed by complex extrinsic signalling processes which connect all cells within a multi-cellular organism to their environment. (amegroups.org)
In comparison to BM-MSCs without osteoinductive treatment, gene expression in e-MSCs was significantly altered in terms of their cell adhesion- and chemotaxis-related profiles, as identified with Gene Ontology and Gene Set Enrichment Analysis. (elsevierpure.com)

VCAM-1, vascular cell adhesion molecule-1. (amegroups.org)

02:14 progenitors that make red blood cells. (yale.edu)

Anatomy47

Organisms14

Diseases28

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology1

Phenomena and Processes49

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Named Groups3

Health Care6

Transplantation29

Endothelial28

Differentiation14

Progenitor cell6

Caudal hematopoietic tissue3

Niche14

Tissue10

Microenvironment3

Hematopoiesis9

HSPCs6

Macrophages3

CD343

HSCs3

Transplant Recipients3

Niches1

Tumor5

HSCT3

Vivo2

Recipients1

Heterogeneity1

Pluripotent2

Differentiate4

Infusion3

Patients10

Endothelium2

Vitro1

Mesenchymal stromal4

Human bone marrow1

Lineage1

Engraftment1

Malignant3

Biology3

20221

Stromal2

Immune3

Precursors1

Squamous cell carc3

Cancer8

Survival2

Inflammation1

Gene expression4

Adhesion molecule1

Progenitors1