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  • transplantation
  • Transplantation studies with injection of HSCs into myeloablated recipients allow for the analysis of the presence of donor cells and their capacity to proliferate and repopulate, thereby indicating HSC activity [ 1 ]. (wiley.com)
  • pathways
  • Several investigators are defining the requirements for hematopoietic cell development and, specifically, the pathways by which stem cells give rise to the components of the immune system. (iu.edu)
  • Recent studies confirm that both the MEK/ERK and the PI3K/Akt pathways are involved in the self-renewal of both mouse ES cells and iPS cells. (springer.com)
  • fetal
  • 80% of the colonies derived from these placental cells were GFP + , and so originated from the fetal component of the placenta. (biologists.org)
  • populations
  • however, reliable methods must be developed to provide clinically-relevant numbers of homogeneous therapeutic cell populations. (utexas.edu)
  • germ
  • Meiosis, the cellular division that gives rise to germ cells, contributes to evolution by reassortment of parental alleles. (prolekare.cz)
  • The result is that germ cells from a single meiosis are different from either parent. (prolekare.cz)
  • Meiosis differs from mitosis in that diploid cells undergo two consecutive cell divisions to produce germ cells. (prolekare.cz)
  • self-renewal
  • These findings establish that Fgf4 stimulation of Erk1/2 is an autoinductive stimulus for naïve ES cells to exit the self-renewal programme. (biologists.org)
  • Through a process of self-renewal, ES cells maintain this potency while expanding in culture ( Smith, 2001b ). (biologists.org)
  • The activation of the JAK/STAT pathway induced by leukemia inhibitory factor (LIF) plays a critical role in the self-renewal of mouse ES or iPS cells. (springer.com)
  • sequential
  • This "complexity of cancer progression can be understood as the result of multiple, sequential mutations, each of which has a relatively small but positive effect on net cell growth" 15 . (sigmaaldrich.com)
  • The ontogeny of the hematopoietic system in vertebrates is characterized by the sequential activity of distinct hematopoietic organs. (biologists.org)
  • liver
  • The present consensus is thus that aorta-gonadmesonephros (AGM) cells home to the liver before colonizing the bone marrow. (biologists.org)
  • Albert Einstein College of Medicine is home to a strong and growing team of stem cell investigators, with particular strength in hematopoietic, cancer, and liver stem cell biology, including a liver transplant program. (yu.edu)
  • Somatic
  • Controlling the expansion of somatic stem cells is a major factor hampering their study and use in therapy. (jove.com)
  • What we do know is that, at the level of the cancer cell, the changes that end up causing unregulated proliferation (tumorigenesis) and somatic dispersal (metastasis) are the consequence of the altered functions of three types of gene products 19 that together control six cell physiologies 20 . (sigmaaldrich.com)