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  • migration
  • This new study, however, suggests that some transplanted HSC clones preferentially expand in certain skeletal sites with limited migration to others. (rupress.org)
  • Upon transplant, functional HSC clones preferentially expand in certain skeletal locations, exhibiting only limited migration toward other niches. (rupress.org)
  • novel
  • Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML. (mdpi.com)
  • Th17 cells are novel CD4 + T cells that are characterized by the production of interleukin-17 (IL-17) [ 6 ]. (mdpi.com)
  • gene
  • These features are key factors for successful stem cell transplantations that are used in cancer patients and in gene therapy protocols. (rupress.org)
  • fibroblasts
  • The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow. (wikipedia.org)
  • However, the proliferation of fibroblasts and deposition of collagen is a secondary phenomenon, and the fibroblasts themselves are not part of the abnormal cell clone. (wikipedia.org)
  • immune
  • Recent studies have shown that leukemic cells suppress the host immune system with tumor progression connected to immune cells dysfunction [ 4 , 5 ]. (mdpi.com)
  • The use of high dose immunosuppressive conditioning is essential to eliminate the autoimmune repertoire, and the re-infusion of autologous hematopoietic stem cells avoids long-term leucopenia by reconstitution of both immune and hematological systems. (rutgers.edu)
  • mammalian cells
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. (wikipedia.org)
  • kinetics
  • Dr. Abkowitz's other research interest is understanding hematopoietic stem cell (HSC) kinetics, in part by the mathematical modeling of cell fate-decisions using stochastic methods (a collaboration with Vladimir Menon PhD, Professor of Statistics, University of Washington). (washington.edu)
  • expression
  • Thus, because of their CD34+ expression, such undifferentiated cells can be sorted out. (wikipedia.org)
  • The transcription factor Blimp-1 represses PD-1 expression in effector CD8 + T cells during acute LCMV infection. (rupress.org)
  • protein
  • Although it has long been known that the basis of competition is the ability of growing cells to monitor fitness of their neighbors, and can be induced via differences in protein production capacity, Myc levels and apico-basal cell polarity, only recently have signaling and effector mechanisms been identified. (keystonesymposia.org)
  • bone
  • Bone pain Bruising and easy bleeding due to inadequate numbers of platelets Cachexia (loss of appetite, weight loss, and fatigue) Enlargement of both the liver and spleen Fatigue Gout and high uric acid levels Increased susceptibility to infection, such as pneumonia Pallor and shortness of breath due to anemia In rarer cases, a raised red blood cell volume Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules. (wikipedia.org)
  • diseases
  • Exploiting the innate compensation capacity of stem cell networks may improve the prognosis and treatment of many diseases. (embopress.org)
  • IL-17, the main effector cytokine of Th17 cells, is responsible for inflammatory and autoimmune diseases [ 8 , 9 ]. (mdpi.com)
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • human
  • Cerdan C, Rouleau A, Bhatia M (2004) VEGF-A165 augments erythropoietic development from human embryonic stem cells. (springer.com)
  • Chambers SM, Fasano CA, Papapetrou EP et al (2009) Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. (springer.com)
  • mutation
  • The V617F mutation appears to make hematopoietic cells more sensitive to growth factors that need JAK2 for signal transduction, which include erythropoietin and thrombopoietin. (wikipedia.org)
  • B cells expressing the MYD88 L265P mutation undergo rapid TLR ligand-independent proliferation that is self-limiting unless apoptosis is opposed. (rupress.org)
  • reside
  • This issue should also be addressed in future mouse barcoding studies, as the routine practice of using one limb for secondary transplants might exclude clones that preferentially reside in other skeletal sites. (rupress.org)
  • tissues
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • marrow
  • Burt RK, Verda L, Kim D-A et al (2004) Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease. (springer.com)
  • blood
  • Our data illustrate how HSC clones coordinate to maintain the overall blood supply. (embopress.org)
  • JAK2 mutations are significant because JAK2 plays a role in controlling production of blood cells from hematopoietic stem cells. (wikipedia.org)
  • Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. (mdpi.com)
  • CD34+ cells may be isolated from blood samples using immunomagnetic or immunofluorescent methods. (wikipedia.org)
  • Bonzanni N, Garg A, Feenstra KA et al (2013) Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network model. (springer.com)
  • Th17
  • Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. (mdpi.com)
  • Apoptosis
  • VDACs are generally involved in the regulation of cell metabolism, mitochondrial apoptosis, and spermatogenesis. (wikipedia.org)
  • VDAC2 in particular has demonstrated a protective effect in cells undergoing mitochondrial apoptosis, and may even confer protection during aging. (wikipedia.org)
  • Apoptosis has proven to be tightly interwoven with other essential cell pathways. (wikipedia.org)
  • In later stages of apoptosis the entire cell becomes fragmented, forming a number of plasma membrane-bounded apoptotic bodies which contain nuclear and or cytoplasmic elements. (wikipedia.org)