Hematopoietic stem cell transplantation patients with acute myeloid leukemia allogeneic stem cell transplantation. Medical search. Frequent questions

FLAG is a chemotherapy regimen used for relapsed and refractory acute myeloid leukemia (AML). (wikipedia.org)
Outcomes of allogeneic or autologous stem cell transplantation followed by maintenance chemotherapy in adult patient with B-ALL in CR1 with no detectable minimal residual disease. (stembook.org)
The findings support future studies of assessing the safety and efficacy of the novel drug-chemotherapy combination as a maintenance strategy following stem cell transplantation across a range of blood cancers, according to the study authors. (curetoday.com)
Maintenance treatment with eprenetapopt, a novel drug, plus the chemotherapy Vidaza (azacitidine) following allogeneic hematopoietic stem cell transplantation was associated with improved survival outcomes in a group of patients with TP53-mutant, high-risk acute myeloid leukemia and myelodysplastic syndromes, according to new study findings. (curetoday.com)
Of note, an allogeneic hematopoietic stem cell transplant is a procedure where a patient with cancer receives healthy blood-forming stem cells from a donor to replace their own stem cells that have been damaged by other cancer treatments such as radiation or chemotherapy. (curetoday.com)
On the other hand, antileukemic immune reactivity is important for the improved survival of AML patients treated with allogeneic stem cell transplantation and antileukemic immunotherapy is also considered for patients treated with conventional chemotherapy. (benthamopen.com)
Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation. (nature.com)
Recent advances in flow cytometric and molecular measurable residual disease detection have further enhanced modern risk-stratified approaches to chemotherapy and allocation to allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) when indicated. (haematologica.org)
Compared with patients transplanted in CR1/CR1i, patients in CR2/CR2i were administered a significantly lower number of chemotherapy cycles prior to allo-SCT (71% of patients received ≥1 cycles from relapse to allo-SCT) than those in CR2/CR2i (61% of patients received ≥2 cycles from diagnosis to allo-SCT). (oncpracticemanagement.com)
Hypomethylating agents (HMAs) are often used in the treatment of higher-risk myelodysplastic syndromes (HR-MDS), or in combination with venetoclax in patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy or allogeneic hematopoietic stem cell transplantation. (aml-hub.com)
1 The phase II BERGAMO trial investigated the safety and efficacy of bemcentinib, an oral, selective AXL inhibitor, covered previously by the AML Hub, in patients with either HR-MDS or AML who were ineligible for intensive chemotherapy or allogeneic hematopoietic stem cell transplantation and were relapsed/refractory following treatment with HMAs. (aml-hub.com)
Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
ONUREG ® is indicated for continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or complete remission with incomplete blood count recovery (CRi) following intensive induction chemotherapy and are not able to complete intensive curative therapy. (onuregpro.com)
Therapy often involves several cycles of chemotherapy, targeted biological treatment, immunological, immunosuppressive and instrument treatment (TPE and depletion procedures performed in cooperation with the IHBT Apheresis Department ), as well as different forms of hematopoietic stem cell transplantation . (uhkt.cz)
Cytotoxic chemotherapy is used in patients with MDS with increasing myeloblasts and those who have progressed to acute leukemia. (medscape.com)
Most patients up to the age of approximately 75 years should be considered for intensive combination chemotherapy with the aim to induce complete remission. (cancercentrum.se)
For low- and intermediate-risk patients, induction therapy should consist of ATRA and arsenic trioxide (ATO) without chemotherapy. (medscape.com)
ATRA plus ATO with a certain amount of chemotherapy is a possible option, but ATO is not approved for use in high-risk patients. (medscape.com)
Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)

FLAG and FLAG-based regimens can also be used in cases of concomitant AML and either acute lymphoblastic leukemia (ALL) or lymphoma. (wikipedia.org)
Immunotherapies, such as CAR-T cellular therapy, have been rapidly developed, especially for refractory acute lymphoblastic leukemia. (blood-genomics.com)
Pediatric acute lymphoblastic leukemia, version 2.2020, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw , 2020, 18(1): 81−112. (blood-genomics.com)
Unrelated cord blood transplantation vs. HLA-matched sibling transplantation for adults with B-cell acute lymphoblastic leukemia in complete remission: superior OS for patients with long-term survival. (ucdavis.edu)
Chimeric Antigen Receptor T Cell Therapy followed by Unrelated Cord Blood Transplantation for the Treatment of Relapsed/Refractory B Cell Acute Lymphoblastic Leukemia in Children and Young Adults: Superior Survival but Relatively High Post-Transplantation Relapse. (ucdavis.edu)
Japan Adult Leukemia Study Group (JALSG): Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. (ycuhri.com)

We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
a Three cases that received an allogeneic transplant in the first complete remission. (jamanetwork.com)
Despite complete remission rates of up to 90%, late toxicities, such as secondary malignancies and cardiovascular events, are key concerns in patients treated for early-stage Hodgkin lymphoma. (targetedonc.com)
This retrospective analysis was conducted in a large academic medical center in Germany to gain insights into the prognostic value of measurable residual disease (MRD) in patients with acute myeloid leukemia (AML) who underwent allogeneic stem-cell transplantation (allo-SCT) consolidation after first morphologic complete remission (CR)/CR with incomplete recovery (CRi) (CR1/CR1i) or after second CR/CRi (CR2/CR2i) achieved following first relapse. (oncpracticemanagement.com)
In young adults with acute myeloid leukemia (AML), intensification of the anthracycline dose during induction therapy has improved the rate of complete remission but not of overall survival. (qxmd.com)
Patients who had a complete remission were offered either allogeneic hematopoietic stem-cell transplantation or high-dose cytarabine, with or without a single dose of the monoclonal antibody gemtuzumab ozogamicin, followed by autologous stem-cell transplantation. (qxmd.com)
Among patients with MDS with a marrow complete remission (n = 5), 80% had a normal karyotype and 20% had Y chromosome loss. (aml-hub.com)

According to a presentation at SOHO 2023, overall survival was boosted among patients from the QuANTUM-First trial who went to transplant in first remission and were treated with quizartinib for their FLT3-ITD-positive acute myeloid leukemia. (targetedonc.com)
Non-low-risk patients are evaluated for stem cell transplantation in first remission. (medscape.com)
Remission is when there are less than 5% blast cells in the bone marrow. (oncolink.org)

A novel risk model for predicting early relapse in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem-cell transplantation. (bvsalud.org)
Relapse remains the leading cause of death in acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem - cell transplantation (allo-HSCT), limiting the efficacy of allo-HSCT. (bvsalud.org)
The overall survival rate for patients who relapsed within 1-year was 4.1% at 3 years after relapse . (bvsalud.org)
After multivariable adjustment , statistically significant associations between primary resistance, pre- transplantation measurable residual disease , DNMT3A mutation , or white blood cell count at diagnosis and early relapse were observed. (bvsalud.org)
Patients deemed to have a high risk or a low risk of early relapse had early relapse rates of 26.2% and 6.8%, respectively (P (bvsalud.org)
The prediction model could be used to help identify patients at risk for early relapse and to guide personalized relapse prevention . (bvsalud.org)
Disease relapse is the primary reason why allogeneic hematopoietic stem cell transplants fail, according to the study authors, who noted that novel strategies for stem cell transplant to reduce the risk for disease relapse are severely needed. (curetoday.com)
They conducted a phase 2, multicenter trial to analyze if post-transplant eprenetapopt plus Vidaza improved relapse-free survival (which is the length of time following completion of primary treatment that a patient survives without signs or symptoms of that cancer). (curetoday.com)
Allogeneic Stem Cell Transplantation following Relapse post Autologous Stem Cell Transplantation in adult patients with Acute Myeloid Leukemia: A retrospective analysis of 537 patients from the Acute Leukemia Working Party of the EBMT. (stembook.org)
Unrelated donor versus matched sibling donor in adults with acute myeloid leukemia in first relapse: an ALWP-EBMT study. (stembook.org)
Pretransplant Metabolic Distress Predicts Relapse of Acute Myeloid Leukemia After Allogeneic Stem Cell Transplantation. (stembook.org)
Patients with high pre-HSCT BAALC / ABL1 copy numbers were more likely to experience relapse within 100 days after HSCT. (oncotarget.com)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
Acute and chronic toxicities were primarily related to GVHD, infection and relapse rather than to TBI. (nature.com)
The cumulative incidence of acute GVHD, non-relapse mortality (NRM), and graft-versus-host relapse-free survival (GRFS) were similar in both groups. (blood-genomics.com)
Although outcomes of children and adolescents with newly diagnosed acute myeloid leukemia (AML) have improved significantly over the past two decades, more than one-third of patients continue to relapse and experience suboptimal long-term outcomes. (haematologica.org)
Given the small numbers of patients with relapsed AML and historical logistical barriers to international collaboration including poor trial funding and drug availability, the management of AML relapse has varied among pediatric oncology cooperative groups with several salvage regimens utilized and a lack of universally defined response criteria. (haematologica.org)
While these measures have improved event-free survival (EFS) for children and adolescents/young adults with de novo AML, 30-40% of patients ultimately relapse. (haematologica.org)
Management of patients in first relapse has varied among pediatric oncology consortia with no universally agreed-upon standard of care at this time. (haematologica.org)
The Children's Oncology Group (COG) in North America, Ireland, New Zealand, and Australia and other cooperative groups have viewed relapse as an opportunity to test novel therapeutic agents efficiently in smaller cohorts of patients via early-phase clinical trials. (haematologica.org)
Finally, patients with a first relapse of AML (without or with prior HSCT) clearly represent a different disease population from patients with primary chemorefractory disease or from those in second or greater relapse who collectively experience highly different outcomes. (haematologica.org)
All patients had a follow-up time of at least 2 years and were relapse-free for at least 2 years. (biomedcentral.com)
Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y: Analysis of various factors on the relapse of acute neurological attacks in Behcet's disease. (ycuhri.com)
1 However, many patients experience either non-response to HMAs or relapse. (aml-hub.com)
Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
All patients should be assessed for risk of relapse. (medscape.com)
Allo-hSCT is estimated to reduce the risk of leukemia relapse to half, but with significant risk for treatment-related complications. (cancercentrum.se)
Consolidation therapy is based on the potential risk of relapse in patients who undergo induction therapy. (medscape.com)

The FLAMSA protocol is most often used as an induction part of a reduced-intensity conditioning regimen for patients eligible to undergo an allogeneic stem cell transplant. (wikipedia.org)
In this setting, it is often combined with other agents, such as: Cyclophosphamide (FLAMSA-CYC), and/or Busulfan or treosulfan (FLAMSA-BU or FLAMSA-TREO), and/or Melphalan (FLAMSA-MEL), and/or Total body irradiation, given shortly after the end of FLAMSA to prepare the patient for transplant. (wikipedia.org)
Currently, maintenance strategies (which are used to reduce the risk for disease recurrence) are not standard of care in allogeneic (hematopoietic stem cell transplant) for (acute myeloid leukemia and myelodysplastic syndromes)," the study authors wrote. (curetoday.com)
Of the 55 patients who received a transplant, 33 patients (14 with acute myeloid leukemia and 19 with myelodysplastic syndromes) received maintenance treatment with eprenetapopt and Vidaza. (curetoday.com)
Transplant Cell Ther. (ucdavis.edu)
Patients were divided into subgroups (refractory cytopenia of childhood [RCC] and advanced MDS [aMDS]) and treated by HSCT alone or pre-transplant combination treatment based on risk stratification. (nih.gov)
Twenty patients with aMDS had received pre-transplant treatment (three were treated with decitabine alone, thirteen with DAC + MMR, and four with acute myeloid leukemia type [AML-type] induction therapy). (nih.gov)
A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)
What is Stem Cell Transplant? (differencebetween.net)
This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
A bone marrow transplant is when stem cells are harvested directly from the bone marrow. (differencebetween.net)
In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
Instruments included the Functional Assessment of Cancer Therapy-Bone marrow transplant (FACT-BMT, version 4), the FACT-Cognition Function (FACT-Cog, version 3) and the Patient Health Questionaire-4 (PHQ-4). (biomedcentral.com)
In this study, we analyzed patient-reported CF and QoL focusing on long-term transplant survivors after 1st allo-HSCT applying a standardized TBI-technique as conditioning regimen. (biomedcentral.com)
Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
Measurable Residual IDH1 before Allogeneic Transplant for Acute Myeloid Leukemia. (mcw.edu)
Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients. (mcw.edu)
Real-World Data Showing Trends and Outcomes by Race and Ethnicity in Allogeneic Hematopoietic Cell Transplantation: A Report from the Center for International Blood and Marrow Transplant Research. (mcw.edu)
DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant. (mcw.edu)
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. (mcw.edu)
A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
The stem cells are frozen and stored until they are needed for a transplant. (medlineplus.gov)
Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)

Thus, the ability to identify high- risk patients in a manner that permits early intervention has the potential to improve survival outcomes. (bvsalud.org)
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o. (medscimonit.com)
Impact of conditioning intensity on outcomes of haploidentical stem cell transplantation for patients with acute myeloid leukemia over 45 years of age. (stembook.org)
High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. (oncotarget.com)
However, disease recurrence remains a major clinical challenge and identification of high-risk patients prior to HSCT is crucial to improve outcomes. (oncotarget.com)
This study analyzed the clinical outcomes of 119 pediatric acute leukemia patients who underwent haploidentical HSCT ( n =68) or human leukocyte antigen (HLA)-matched HSCT ( n =51). (blood-genomics.com)
The patients' clinical characteristics, treatment strategies and outcomes were retrospectively evaluated. (nih.gov)
Outcomes were similar in patients with resolved cGvHD and those who never had cGvHD. (biomedcentral.com)
The MRD status at the time of allo-SCT was an important prognostic factor for CIR and EFS in both patient cohorts, with MRD positivity linked to adverse outcomes. (oncpracticemanagement.com)
However, MRD-positive patients transplanted in CR1/CR1i had comparable CIR and EFS outcomes as MRD-negative patients transplanted in CR2/CR2i, thus highlighting the worse outcomes of transplantation in CR2/CR2i. (oncpracticemanagement.com)
In the European LeukemiaNet intermediate-risk patient cohort, both MRD-negative patients transplanted in first or second CR/CRi had favorable outcomes in terms of CIR and EFS, while MRD-positive patients transplanted in CR1/CR1i showed modest outcomes, and MRD-positive patients transplanted in CR2/CR2i experienced poor outcomes. (oncpracticemanagement.com)

We analyzed patient-reported QoL, CF, and symptoms of depression and anxiety in patients with primary or secondary AML who received their 1st allo-HSCT with TBI-based protocols at the Department of Hematology of the University Hospital Regensburg between 1999 and 2017. (biomedcentral.com)
All patients visited the Department of Hematology of the University Hospital Regensburg for routine follow-up visits. (biomedcentral.com)
Her industry career has spanned several therapeutic areas, including Hematology and Stem Cell Transplantation. (medexus.com)
Hematology, transfusion and cell therapy 2018 7 40 (2): 136-142. (cdc.gov)
The Institute of Hematology and Blood Transfusion is an expanding centre offering state‑of‑the art medicine and top-notch research, as well as a friendly and safe organization for both patients and personnel. (uhkt.cz)

Stem Cell Rev Rep. 2023. (stembook.org)
The American Cancer Society estimates that in the United States in 2023 there will be about 20,000 new cases of acute myeloid leukemia (AML) and about 11,300 deaths , almost all in adults. (msdmanuals.com)
PITTSBURGH, PA, February 6, 2023 - BlueSphere Bio , a T-cell receptor (TCR) T-cell therapy company developing a powerful TCR discovery platform and novel therapeutic candidates for patients with hematologic malignancies and solid tumors, today announced Keir Loiacono, Chief Executive Officer of BlueSphere Bio, will present a corporate overview at the 2023 BIO CEO & Investor Conference held in New York City, NY from February 6-9, 2023. (bluespherebio.com)

The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases. (stembook.org)
He has published significantly on this topic including recently in highly regarded journals including Leukemia and Haematologica and these work form the foundation of the clinical trials that he is bringing to patients in order to improve their quality of life and survival. (moffitt.org)
As an example, Dr. Sallman has focused research and clinical trial efforts on patients who have TP53 mutation (often associated with complex genes/cytogenetics) given their high risk of transformation to acute leukemia and poor survival. (moffitt.org)
Patients with high expressions of FHL2 and iASPP had significantly shorter event-free survival (EFS) and overall survival (OS) than patients with low expressions ( P = 0.005, P = 0.003, respectively). (nature.com)
A predictive model combining clinical characteristics and nutritional risk factors for overall survival after umbilical cord blood transplantation. (ucdavis.edu)
Poor survival and prediction of prolonged isolated thrombocytopenia post umbilical cord blood transplantation in patients with hematological malignancies. (ucdavis.edu)
One-year overall survival rate was 28% overall and 54% in patients with MDS. (aml-hub.com)
One-year progression-free survival rate was 8% and 6% in patients with AML and MDS, respectively. (aml-hub.com)
Patients with low-risk or intermediate-1-risk MDS typically have long-term survival and may receive multiple RBC transfusions. (medscape.com)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Efficacy of venetoclax combined with decitabine conditioning regimen for allogeneic hematopoietic stem cell transplantation in high-risk and elderly patients with myeloid neoplasms. (stembook.org)
Acute myeloid leukemia has a number of subtypes and precursor neoplasms that are distinguished from each other by morphology, immunophenotype, cytochemistry, and genetic abnormalities (see also The 2016 World Health Organization [WHO] Classification of myeloid neoplasms ) all of which have important implications for prognosis and treatment. (msdmanuals.com)
Acute myeloid leukemia (AML) and related neoplasms. (oncolink.org)
Therapy-related myeloid neoplasms. (oncolink.org)
Myeloid neoplasms with germline predisposition without a preexisting disorder or organ dysfunction. (oncolink.org)
Myeloid neoplasms with germline DDX41 mutation. (oncolink.org)
Myeloid neoplasms with germline predisposition and preexisting platelet disorders. (oncolink.org)
Myeloid neoplasms with germline predisposition and other organ dysfunction. (oncolink.org)

Dr. Sallman's research focuses on the development of novel, targeted therapeutic strategies for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). (moffitt.org)
Phase I and II clinical trials) for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) based on the underlying mutational drivers of each disease. (moffitt.org)
Combination of Azacitidine and Lenalidomide in Myelodysplastic Syndromes or acute Myeloid Leukemia-a wise Liaison? (aamds.org)
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)
Genetic predisposition to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) has been an emerging topic over recent years. (healthbooktimes.org)

The expression level of NCALD gene was associated with the prognosis of ovarian cancer and non-small cell lung cancer (NSCLC). (biomedcentral.com)
The expression level of NCALD gene is still unclear in the prognosis of patients with AML. (biomedcentral.com)
We integrated 5 independent datasets totally 665 AML patients (497 CN-AML patients) to analyzed relation between NCALD gene expression and the clinical FAB classification, gene mutation, therapy, prognosis of CN-AML. (biomedcentral.com)
We analyzed the NCALD gene expression with the prognosis and LSC of 165 AML patients from The Cancer Genome Atlas (TCGA) dataset and 78 AML patients from GEO dataset. (biomedcentral.com)
NCALD can be considered as independent predictors of CN-AML patients and can be used as a biomarker for the prognosis of CN-AML. (biomedcentral.com)
The prognosis can be further stratified according to different gene mutation combinations in CN-AML patients. (biomedcentral.com)
Although patients transplanted in CR2/CR2i had better disease risk at diagnosis, they had worse prognosis than those transplanted in CR1/CR1i. (oncpracticemanagement.com)
Induction therapy should not be modified based on the presence of leukemia cell characteristics that have variably been considered to predict a poorer prognosis (eg, secondary chromosomal abnormalities, FLT3 mutations, CD56 expression, BCR3 PML-RARA isoform). (medscape.com)

Acute promyelocytic leukemia (APL) is a subtype of AML with recurrent genetic abnormalities. (msdmanuals.com)
Patients with acute promyelocytic leukemia (APL) are treated according to a separate protocol (included in the care program) based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). (cancercentrum.se)
Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML). (medscape.com)

Biology of Blood and Marrow Transplantation. (wikipedia.org)
Acute myeloid leukemia (AML) is a malignant disorder of the hematopoietic stem cells characterized by abnormal proliferation of myeloid blast cells in the bone marrow and blood, preventing them from further differentiating into the specialized cells of the bone marrow and thus causing pancytopenia. (dovepress.com)
Bone Marrow Transplantation (2000) 25, 807-813. (nature.com)
These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
Further benefits are that the platelets and neutrophil cells (one of the white blood cells) are more easily able to recover if this method is used compared with the bone marrow procedure. (differencebetween.net)
There are some disadvantages to obtaining stem cells from blood rather than from bone marrow. (differencebetween.net)
This is necessary because it is a rather painful process in which a needle is inserted directly into the marrow cavity of the bone and stem cells withdrawn. (differencebetween.net)
The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
Source of stem cells were peripheral blood, bone marrow or cord blood. (biomedcentral.com)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018 8 25 (1): 100-106. (cdc.gov)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 6 25 (10): 1975-1983. (cdc.gov)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
A) Blood smear and B−F) bone marrow biopsy (BM) of Patient 4. (healthbooktimes.org)
Bone marrow transplantation plays a limited role. (medscape.com)
The goal is to replace cells that are prematurely undergoing apoptosis in the patient's bone marrow. (medscape.com)
Guidelines for transfusion in patients with MDS and bone marrow failure are as follows. (medscape.com)
In all patients that might become considered for intensive treatment, the AML diagnosis should be based on morphologic and immunophenotypic features of bone marrow aspirates as well as on genetic characteristics of the leukemic blasts. (cancercentrum.se)
Storage of bone marrow or blood leukemic cells in biobanks is strongly recommended. (cancercentrum.se)
Bone marrow aspiration is performed after hematopoietic recovery, or day 28 at the latest. (cancercentrum.se)
The bone marrow produces blood cells. (medlineplus.gov)
Stem cells in the bone marrow give rise to all of your different blood cells. (medlineplus.gov)
This also kills all healthy bone marrow that remains, and allows new stem cells to grow in the bone marrow. (medlineplus.gov)
The stem cells travel through the blood into the bone marrow. (medlineplus.gov)
Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)
An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)
Recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. (cdc.gov)

ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)

Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
Introduction: Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. (bvsalud.org)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment modality for selected patients with acute myeloid leukemia (AML). (biomedcentral.com)

The identification of cytogenetic, molecular, and clinical factors impacting on outcome at acute myeloid leukemia (AML) diagnosis improved risk stratification [ 1 , 2 ]. (oncotarget.com)
A more detailed knowledge about the immune systems of these patients is essential for an optimal design of future clinical immunotherapy studies in AML. (benthamopen.com)
Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, and is a malignant clonal disease of leukemia stem cells (LSCs). (biomedcentral.com)
We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
Acute myeloid leukemia, version 3.2017, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw , 2017, 15(7): 926−957. (blood-genomics.com)
Spatially resolved transcriptomics should be promoted from scientific research to clinical application as soon as possible in order to provide accurate diagnoses and individualized treatment for patients. (blood-genomics.com)
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (nature.com)
The clinical influence of preformed nonspecific anti-HLA antibodies on single-unit umbilical cord blood transplantation in patients with haematological malignancies. (ucdavis.edu)
This review provides a comprehensive overview of progress achieved to date in the treatment of pediatric patients with relapsed AML and highlights modern, state-of-the-art therapeutic approaches under active and emerging clinical investigation that have been facilitated by international collaboration among academic pediatric oncologists, laboratory scientists, regulatory agencies, pharmaceutical partners, cancer research sponsors, and patient advocates. (haematologica.org)
Dr. Fosdal began his clinical career working as a Physician Assistant at the Fred Hutchinson Cancer Research Center in Seattle while caring for patients undergoing both autologous and allogeneic stem cell transplants. (medexus.com)
Leukemia Society of America, Clinical Scholar Award. (rochester.edu)
At the same time, we often include patients in suitable clinical studies, if they are available. (uhkt.cz)
Clinical findings of A) Patient 2 and B) Patient 4. (healthbooktimes.org)
Leading clinical symptoms of GATA2 deficiency syndromes are immunodeficiency, infections (mainly nontuberculous mycobacteria and human papillomavirus), predisposition to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), pulmonary alveolar proteinosis (PAP) and primary lymphedema. (healthbooktimes.org)
This platform can be used in various clinical settings to discover TCRs for use in either TCR-based cell therapy or in antibody-like molecules, such as bi-specific T cell engagers. (bluespherebio.com)
His efforts are dedicated to collaboration with clinicians, researchers and patients groups to initiate clinical trials. (anticancerfund.org)
Encourage patients to participate in clinical trials to determine the optimal therapy for MDS. (medscape.com)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)
The content of the care program is based on published AML data, on the clinical experience of Swedish hematologists with special interest in AML, and on the Swedish AML registry, which has been collecting data on all Swedish AML-patients since 1997. (cancercentrum.se)
Although rapid confirmation of genetic diagnosis is mandatory, patients in whom APL is suspected (on the basis of clinical presentation and peripheral blood smear results) should be immediately hospitalized and their case managed as a medical emergency. (medscape.com)
System-wide Surveillance for Clinical Encounters by Patients Previously Identified with MRSA and VRE. (cdc.gov)

and (iii) the immune reconstitution following the initial period of hematopoietic reconstitution after autologous and allogeneic stem cell transplantation. (benthamopen.com)

Acute myeloid leukaemia. (stembook.org)

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)

Haploinsufficiency of GATA2 leads to impaired genesis and function of hematopoietic stem and progenitor cells, resulting in impairment of all subsequent blood cell lineages. (healthbooktimes.org)

The diagnoses were acute myeloid leukemia (AML, n=25) and chronic myeloid leukemia (CML, n=15). (medscimonit.com)
Twenty-three patients experienced acute GVHD and 17 developed chronic GVHD. (medscimonit.com)
Ophthalmic manifestations of leukemia are more frequent with acute than chronic leukemia and can affect all intraocular structures. (dovepress.com)
PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here? (haematologica.org)
When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
Recommendations for Preventing Transmission of Infections Among Chronic Hemodialysis Patients. (cdc.gov)

Two patient deaths were reported during the study period - one that was associated with a side effect not related to study treatment and one attributed to disease progression more than 30 days after study treatment completion. (curetoday.com)
Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia treatment. (oncotarget.com)
Background The positive rate of sputum bacteria in patients with pneumoconiosis complicated with pulmonary tuberculosis is lower than that in patients with simple tuberculosis, which makes the disease assessment more difficult. (bvsalud.org)
Myelodysplastic syndrome (MDS) is a rare disease in children and the treatment option before the allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rarely reported. (nih.gov)
With multiple JAK inhibitors now available to choose from, patient- and disease-specific factors are vital in determining the most appropriate therapy for patients with myelofibrosis. (targetedonc.com)
In total, 25 patients died, most commonly due to disease progression (n = 18) not related to bemcentinib. (aml-hub.com)
Treatment protocols for acute myeloid leukemia (AML) are provided below, including a general treatment approach and treatment recommendations for relapsed or refractory disease. (medscape.com)
A low CD4/CD8 T-cell ratio is also associated with the disease. (healthbooktimes.org)
Acute myeloid leukemia (AML) is a disease with diverse genetic features of the leukemic cells and with variable outcome. (cancercentrum.se)
This disease is characterized by the malfunctioning of the DNA repair mechanism, which present an increase in the rate of spontaneous damage, among these spontaneous chromosomal instability, and hypersensitivity of cells to the chromosomal breaking effect induced by clastogenic agents 2-3 . (bvsalud.org)

Also, there was an association between absence of radiographic signs of osseointegration of the structural graft and failure in this series of patients with large bone defects. (bvsalud.org)
The procedure is also a more painful one than simply removing stem cells from the blood since the needle has to go into bone. (differencebetween.net)

We retrospectively enrolled 414 younger patients ( aged 14-60 years) with AML who received allo-HSCT between January 2014 and May 2020. (bvsalud.org)
The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. (medscimonit.com)
EA and EDPc were increased in patients after HSCT. (medscimonit.com)
In the future, prospective studies should evaluate whether acute myeloid leukemia patients with high pre-HSCT BAALC / ABL1 copy numbers benefit from additional treatment before or early intervention after HSCT. (oncotarget.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for pediatric patients with high-risk or intermediate-acute myeloid leukemia. (blood-genomics.com)
There was no difference in transplantation-related toxicity (TRT) in terms of infection, hepatic dysfunction, oral mucositis, and engraftment syndrome between the haploidentical HSCT and HLA-matched HSCT groups. (blood-genomics.com)
The study suggests that haploidentical HSCT shows comparable OS, LFS, and GRFS to HLA-matched HSCT in pediatric patients with acceptable complications, and can therefore be recommended as an effective alternative for this population. (blood-genomics.com)
ABO blood group incompatibility is not a contraindication for allogeneic hematopoietic stem cell transplantation (allo-HSCT). (blood-genomics.com)
Isohemagglutinins (ISO) targeting red blood cell (RBC) antigens are associated with post-HSCT immunohematological complications, including hemolysis, passenger lymphocyte syndrome (PLS), and pure red cell aplasia (PRCA). (blood-genomics.com)
In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, EFS and OS were not significantly different between FHL2 or iASPP high- and low-expression groups. (nature.com)
Total body irradiation (TBI)-based-conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is standard of care in patients with acute myeloid leukemia (AML) but can cause long-term morbidity. (biomedcentral.com)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. (bvsalud.org)

The usual combination treatment is a cytarabine-anthracycline combination, which yields a response rate of 30-40% (high complication rate and morbidity in elderly patients). (medscape.com)
Deferoxamine (Desferal) is difficult to administer in elderly patients because it has to be given parenterally subcutaneously by pump over 12 hours daily to be effective. (medscape.com)
Elderly patients with secondary AML, high-risk genetics or significant co-morbidites should rather receive treatment with hypomethylating agents such as azacitidine, with or without venetoclax. (cancercentrum.se)
Elderly patients with intermediate- or high-risk genetics receive a maximum of 2 consolidations. (cancercentrum.se)

ONUREG ® is contraindicated in patients with known severe hypersensitivity to azacitidine or its components. (onuregpro.com)
Treatment of patients using intravenous or subcutaneous azacitidine at the recommended dosage of ONUREG ® may result in a fatal adverse reaction. (onuregpro.com)

In the FLAG-IDA regimen (also called FLAG-Ida, IDA-FLAG, or Ida-FLAG), idarubicin-an anthracycline antibiotic that is able to intercalate DNA and prevent cell division (mitosis)-is added to the standard FLAG regimen. (wikipedia.org)
Data points to the loss of predictive value of an interim PET2 scan for patients with Hodgkin lymphoma when treated with a regimen containing brentuximab vedotin. (targetedonc.com)

A high BMI is a risk factor in younger patients with de novo acute myelogenous leukemia. (stembook.org)
It is generally accepted that acute myelogenous leukemia (AML) patients are immunocompromized. (benthamopen.com)
Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
Acute myelogenous leukemia (AML) is a blood cancer that affects white blood cells, red blood cells, and/or platelets. (oncolink.org)

Patritumab deruxtecan showed clinically meaningful and durable efficacy in the phase 2 HERTHENA-Lung01 trial of patients with advanced EGFR-mutated non-small cell lung cancer. (targetedonc.com)
Guidance from the FDA has provided a clear pathway and requested no additional efficacy or safety trials for the resubmission of the biologics license application for denileukin diftitox in cutaneous T-cell lymphoma. (targetedonc.com)
Aoki J, Kimura K, Kakihana K, Ohashi K, Sakamaki H: Efficacy and tolerability of Entecavir for hepatitis B virus infection after hematopoietic stem cell transplantation. (ycuhri.com)

Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report. (stembook.org)
For patients lacking matched sibling donors, haploidentical donors are an option. (blood-genomics.com)
Impact of Donor Age in Haploidentical-Post-Transplantation Cyclophosphamide versus Matched Unrelated Donor Post-Transplantation Cyclophosphamide Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia. (mcw.edu)
Haploidentical vs matched unrelated donors for patients with ALL: donor age matters more than donor type. (mcw.edu)

Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region. (stembook.org)
a AML-RMG is a capture reagent consisting of all of the exons of the genes that are currently known to be recurrently mutated in acute myeloid leukemia, based on The Cancer Genome Atlas AML study. (jamanetwork.com)
Serial VAF measurements demonstrating the clearance patterns of several recurrently mutated acute myeloid leukemia genes in the set of 50 cases. (jamanetwork.com)

Differences in cellular composition of peripheral blood stem cell grafts from healthy stem cell donors mobilized with either G-CSF alone or G-CSF and Plerixafor. (stembook.org)
Similar expansions could also be obtained from the peripheral blood of patients with acute leukemia undergoing therapy ( n = 11). (aacrjournals.org)

Two patients had significant GVHD of the GI tract. (nature.com)

Aoki J, Tsubokura M, Kakihana K, Oshikawa G, Kobayashi T, Doki N, Sakamaki H, Ohashi K: The predictive value for pulmonary infection by area over the neutrophil curve (D-index) in patients who underwent reduced intensity hematopoietic stem cell transplantation. (ycuhri.com)

The outcome of acute leukemia patients with SET-NUP214 fusion after allogeneic stem cell transplantation. (stembook.org)
Comparable Long-Term Outcome after Allogeneic Stem-Cell Transplantation from Sibling and Matched Unrelated Donors in AML Patients Older than 50 years. (stembook.org)
Trends in patient outcome over the past two decades following allogeneic stem cell transplantation for acute myeloid leukemia. (stembook.org)
Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation. (stembook.org)
Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil. (cdc.gov)
The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation. (cdc.gov)

Application prospect of low-dose porcine anti-thymocyte globulin in HLA-matched sibling donor transplantation. (stembook.org)
Detection of HBV DNA in the blood of a stem cell donor after G-CSF treatment. (stembook.org)
The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades. (mcw.edu)
Stem cells are removed from another person, called a donor. (medlineplus.gov)
The red blood cells are returned to the donor. (medlineplus.gov)

Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. (zhaw.ch)

The number of newly diagnosed and intensively treated patients in the Inpatient Department is approximately 40 a year. (uhkt.cz)

Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)

Elgarten CW, Aplenc R. Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy[J]. Curr Opin Pediatr , 2020, 32(1): 57−66. (blood-genomics.com)

However, whether they have prognostic significance in acute myeloid leukemia (AML) is unknown. (nature.com)
Based on these results, it was concluded that MRD status at allo-SCT and the number of remissions prior to transplantation were important independent prognostic factors in patients with AML. (oncpracticemanagement.com)

Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. (stembook.org)
Recent study showed that iASPP could impact the proliferation and apoptosis of leukemia cells by interacting with FHL2 . (nature.com)
Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. (nature.com)

Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China. (bvsalud.org)
Application of prophylactic or pre-emptive therapy after allogeneic transplantation for high-risk patients with t(8;21) acute myeloid leukemia. (stembook.org)
Refractory patients with favorable/intermediate-risk acute myeloid leukemia benefit from azacytidine maintenance therapy following allogeneic hematopoietic stem cell transplantation. (stembook.org)
As a result, investigators aimed to see if maintenance therapy with eprenetapopt and Vidaza would induce similar results in this high-risk patient population. (curetoday.com)
Panels A through D show examples of different patterns of clearance of leukemia-associated mutations after induction therapy in 4 acute myeloid leukemia cases. (jamanetwork.com)
iASPP is a negative regulator of the apoptotic function of p53, and it can enhance the ability of hematopoietic stem cells to self-renew and resist chemo- and radiation therapy. (nature.com)
Allogeneic double-negative T cell therapy for relapsed acute myeloid leukemia patients post allogeneic hematopoietic stem cell transplantation: A first-in-human phase I study. (ucdavis.edu)
Bioengineered RNA Therapy in Patient-Derived Organoids and Xenograft Mouse Models. (ucdavis.edu)
The diffuse large B-cell lymphoma treatment landscape is evolving with Pola-R-CHP and CAR T-cell therapy moving into the frontline setting. (targetedonc.com)
60-65 years, select patients up to age 75 y) receive intensive therapy. (medscape.com)
Less-fit patients (70-75 years and older, or younger patients with significant comorbidities) receive low-intensity therapy. (medscape.com)
Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
Cell Therapy Informatics: Updates on the Integration of HCT/IEC Functionalities into an Electronic Medical Record System in the US to Promote Efficiency, Patient Safety, Research, and Data Interoperability. (mcw.edu)
BSB-1001, targeting the minor histocompatibility antigen-1 (HA-1) and part of BlueSphere's TCX-101 Program, is the first TCR-T cell therapy candidate generated using TCXpress and is in development for the treatment of acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and myeloid dysplastic syndrome (MDS) in conjunction with allogeneic hematopoietic stem cell transplantation (alloSCT). (bluespherebio.com)
Transplantation and cellular therapy. (lu.se)
Supportive therapy, including transfusions of the cells that are deficient (ie, red blood cells [RBCs], platelets), and treatment of infections are the main treatments. (medscape.com)

symptoms of extramedullary leukemic infiltration are present in only about 5% of patients (often as skin manifestations). (msdmanuals.com)

High-Dose Cytarabine Consolidation With or Without Additional Amsacrine and Mitoxantrone in Acute Myeloid Leukemia: Results of the Prospective Randomized AML2003 Trial. (stembook.org)
All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
In this phase 3 randomized trial, we assigned 657 patients between the ages of 17 and 60 years who had untreated AML to receive three once-daily doses of daunorubicin at either the standard dose (45 mg per square meter of body-surface area) or a high dose (90 mg per square meter), combined with seven daily doses of cytarabine (100 mg per square meter) by continuous intravenous infusion. (qxmd.com)

AML may also be called acute myelocytic leukemia, acute granulocytic leukemia, or acute non-lymphocytic leukemia. (oncolink.org)

11 The purpose of this review is to present and evaluate the medical literature on the early ophthalmological manifestations of acute myeloid leukemia, which physicians should be aware of for an earlier and more efficient diagnosis and treatment. (dovepress.com)
28% (66/236) of patients who received ONUREG ® and 30% (71/233) of patients who received placebo had an NPM1 mutation at diagnosis. (onuregpro.com)
Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. (bvsalud.org)

Natural killer (NK) cells can kill cancer cells in the absence of prior stimulation and hold considerable potential for cell-based therapies targeting human malignancies ( 1 - 4 ). (aacrjournals.org)
Cell based therapies: Academic or commercial? (ehaweb.org)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)

In an interview with Targeted Oncology, Amer Zeidan, MBBS, discussed the IMerge study and next steps for imetelstat for patients with lower-risk MDS. (targetedonc.com)

Dr. Sallman studies the genetic drivers of myeloid diseases in order to improve prognostication for patients and also to allow for more personalized treatment. (moffitt.org)
acute myeloid leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)
Mutations in the GATA2 gene were found to be the common genetic cause of four syndromes: Emberger syndrome, 1 mycobacterial infections (MonoMAC) syndrome, 2 dendritic cell/monocytopenia/natural killer (NK)-cell/B-cell lymphoid deficiency (DCML) 3 and familial MDS/AML. (healthbooktimes.org)
6 Patients may present with manifestations that overlap the clinically described syndromes 2,7,8 and are thus all considered part of a single autosomal dominant genetic disorder with varying presentations. (healthbooktimes.org)
It is classified based on genetic abnormalities (changes) in the cancer cells. (oncolink.org)
However, the aim of treatment may be dependent on the genetic risk and comorbidity, and some patients may need supportive care for infection before being eligible for treatment decision. (cancercentrum.se)

The NPM1 mutation, which is prognostically favorable, occurs in ~30% of patients with AML (based on an analysis of 1540 AML patients from 3 prospective multicenter trials). (onuregpro.com)

Anatomy33

Organisms12

Diseases52

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment75

Psychiatry and Psychology2

Phenomena and Processes37

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups6

Health Care20

Geographicals1

Chemotherapy22

Lymphoblastic leukemia6

Complete remission7

Remission3

Relapse30

Transplant33

Outcomes12

Hematology5

20233

Survival10

Neoplasms8

Myelodysplastic syndromes5

Prognosis8

Promyelocytic3

Marrow33

ABSTRACT1

Curative treatment3

Clinical23

Autologous and allogeneic1

Leukaemia1

Graft versus3

Progenitor cells1

Chronic6

Disease12

Bone2

HSCT14

Elderly patients4

Azacitidine2

Regimen2

Myelogenous5

Efficacy3

Haploidentical4

Genes3

Peripheral2

GVHD1

Reduced-intensity1

Outcome6

Donor6

Multiple myeloma1

Newly diagnosed1

Malignant2

Risk stratification1

Prognostic2

Proliferation3

Therapy16

Leukemic1

High-dose3

Myelocytic Leukemia1

Diagnosis3

Therapies3

Oncology1

Genetic6

Mutation1