Loading...
  • disease
  • Metabolic/storage disorders e.g. leukodystrophies,mucopolysaccharidoses as Hurler disease;Stem cell defects e.g.reticular agenesis, among many other rare similar conditions. (clinicaltrials.gov)
  • sickle cell di
  • The major hemoglobinopathies are sickle cell disease and several forms of thalassemia. (encyclopedia.com)
  • This form of hemoglobin is called HbA (hemoglobin A). As discussed below, sickle cell disease is due to mutations in the beta chains in HbA. (encyclopedia.com)
  • The beta globin allele that leads to sickle cell disease is called the hemoglobin S (HbS) allele. (encyclopedia.com)
  • They are said to have the sickle cell trait, but not sickle cell disease. (encyclopedia.com)
  • Sickle cell disease is a recessive condition. (encyclopedia.com)
  • Sickle cell disease can occur when two individuals who have the sickle cell trait (they are called carriers) have children. (encyclopedia.com)
  • There is a one-in-four chance that a child conceived by two carriers will inherit a recessive , abnormal allele from each parent, and therefore be homozygous for the abnormal allele and develop sickle cell disease. (encyclopedia.com)
  • Sickle cell disease is the most prevalent genetically based disease in the United States . (encyclopedia.com)
  • In sickle cell disease, there is a change in only one nucleotide in the sequence that codes for the beta chain: A thymine is substituted for an adenine. (encyclopedia.com)
  • A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification-A Case Study on Sickle Cell Disease," Case Reports in Hematology , vol. 2017, Article ID 8394732, 5 pages, 2017. (hindawi.com)
  • potential donors
  • Buccal swabs are typically obtained at the time of bone marrow registry enrollment for all potential donors. (medscape.com)
  • Today the trust register has over 500,000 potential donors on it. (wikipedia.org)
  • A student organisation operating in universities throughout the UK known as 'Marrow' works with Anthony Nolan to recruit potential donors to the register and raise awareness of the charity and blood cancers within universities and their local communities. (wikipedia.org)
  • liver
  • Liver transplantation is the replacement of a diseased liver with a healthy liver allograft. (wikipedia.org)
  • Liver transplantation nowadays is a well accepted treatment option for end-stage liver disease and acute liver failure. (wikipedia.org)
  • In mammalian embryology, the first definitive HSCs are detected in the AGM (aorta-gonad-mesonephros), and then massively expanded in the fetal liver prior to colonising the bone marrow before birth. (wikipedia.org)
  • therapy
  • Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. (wikipedia.org)
  • Today two distinct categories of cell therapy are recognized. (wikipedia.org)
  • The first category is cell therapy in mainstream medicine. (wikipedia.org)
  • Cell therapy can be defined as therapy in which cellular material is injected into a patient. (wikipedia.org)
  • The origins of cell therapy can perhaps be traced to the nineteenth century, when Charles-Édouard Brown-Séquard (1817-1894) injected animal testicle extracts in an attempt to stop the effects of aging. (wikipedia.org)
  • In 1931 Paul Niehans (1882-1971) - who has been called the inventor of cell therapy - attempted to cure a patient by injecting material from calf embryos. (wikipedia.org)
  • In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (wikipedia.org)
  • The experimental field of Stem cell therapy has shown promise for new types of treatment. (wikipedia.org)
  • In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (wikipedia.org)
  • Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. (wikipedia.org)
  • biopsy
  • In addition, the diagnostic bone marrow biopsy must contain less than 25% of the normal cellularity). (clinicaltrials.gov)
  • The cells can be removed as liquid (to perform a smear to look at the cell morphology) or they can be removed via a core biopsy (to maintain the architecture or relationship of the cells to each other and to the bone). (wikipedia.org)