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  • severe
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets. (wikipedia.org)
  • An ultrasound examination shows accumulation of chalky material (calcification) in the adrenal gland in about half of infants with LAL-D. Complications of LAL-D progress over time, eventually leading to life-threatening problems such as extremely low levels of circulating red blood cells (severe anemia), liver dysfunction or failure, and physical wasting (cachexia). (wikipedia.org)
  • Heart transplantation is performed on patients with end-stage heart failure or severe coronary artery disease. (wikipedia.org)
  • immune
  • Aplastic anemia (AA) is an immune-mediated and life-threatening form of acquired bone marrow failure (BMF), characterized by development and expansion of self-reactive T cells. (springer.com)
  • In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing. (springer.com)
  • Zhao Q, Ren H, Han Z. Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. (springer.com)
  • Qi K, Li N, Zhang Z, Melino G. Tissue regeneration: the crosstalk between mesenchymal stem cells and immune response. (springer.com)
  • These antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells. (wikipedia.org)
  • The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
  • Although B cell receptors can also recognize MHCs, immune responses seem to only be elicited by T cells. (wikipedia.org)
  • The significance of MiHAs in an immune response was recognized following transplantation. (wikipedia.org)
  • Though early research on hematopoietic stem cell transplantation was equivocal, later research has shown it to improve immune function. (wikipedia.org)
  • acquired pure re
  • Response to cyclosporine A and corticosteroids in adult patients with acquired pure red cell aplasia: serial experience at a single center. (amedeo.com)
  • human bone
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • tissue
  • For this reason, the pathologist will examine the surgical specimen to determine if a margin of healthy tissue is present, thus decreasing the chance that microscopic cancer cells are left in the patient. (wikipedia.org)
  • Radiation therapy injures or destroys cells in the area being treated (the "target tissue") by damaging their genetic material, making it impossible for these cells to continue to grow and divide. (wikipedia.org)
  • chronic
  • In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. (wikipedia.org)
  • regimen
  • Frei and Peters developed the Solid Tumor Autologous Marrow Program (STAMP) regimen. (wikipedia.org)
  • In the FLAG-IDA regimen (also called FLAG-Ida, IDA-FLAG, or Ida-FLAG), idarubicin-an anthracycline antibiotic that is able to intercalate DNA and prevent cell division (mitosis)-is added to the standard FLAG regimen. (wikipedia.org)
  • radiation
  • Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure. (springer.com)
  • Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. (springer.com)
  • Radiation therapy (also called radiotherapy, X-ray therapy, or irradiation) is the use of ionizing radiation to kill cancer cells and shrink tumors. (wikipedia.org)
  • Although radiation damages both cancer cells and normal cells, most normal cells can recover from the effects of radiation and function properly. (wikipedia.org)
  • congenital
  • Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia. (amedeo.com)
  • Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia arising from ribosomal protein (RP) defects. (springer.com)
  • Genetic
  • Liver biopsy findings will generally show a bright yellow-orange color, enlarged, lipid-laden hepatocytes and Kupffer cells, microvesicular and macrovesicular steatosis, fibrosis, and cirrhosis.The only definitive tests are genetic, which may be conducted in any number of ways. (wikipedia.org)
  • gene therapy
  • The journal provides commentary and analysis to elucidate best clinical practice in hematology and to translate advances in research - in areas such as immunology, stem cell research, and cell and gene therapy - into the clinical context. (wikipedia.org)
  • hematopoiesis
  • Mammalian hematopoiesis is a unique developmental process in which stem cells continue to generate vast numbers of diverse cell types throughout adult life. (rochester.edu)
  • As in other systems, Notch appears to influence cell fate decisions at multiple steps during hematopoiesis, having effects that are determined by the presence of specific inductive signals and the precise maturational state of the cell. (rochester.edu)
  • tumor
  • A single cancer cell is invisible to the naked eye but can regrow into a new tumor, a process called recurrence. (wikipedia.org)
  • immunity
  • The low number of T cells (T cell lymphopenia) and other lymphocytes appears to be responsible for the susceptibility to infections, and the poor humoral immunity is responsible for low response to vaccines. (wikipedia.org)
  • malignancies
  • Research in her laboratory is guided by two fundamental questions: what are the molecular mechanisms responsible for the generation of diverse cell types from pluripotent stem cells, and how do aberrations in normal developmental pathways contribute to pediatric malignancies? (rochester.edu)