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  • apoptosis
  • Modulating PU.1 expression in acute myeloid leukemia cells, researchers found that PU.1 supports tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via two mechanisms: by repressing NF-κB activity via a novel direct PU.1-RelA/p65 protein-protein interaction, and by directly inducing TRAIL receptor DR5 expression. (hematopoiesisnews.com)
  • Over time, histological analysis revealed distinct cell morphologies, patterns of cell division and apoptosis, and cell arrangements with Pax-2 and Cytokeratin positivity. (ufl.edu)
  • endothelial
  • E-selectin mediated adhesion and migration of endothelial colony forming cells is enhanced by SDF-1α/CXCR4. (jove.com)
  • While it is known that endothelial and mural vascular cells are integral to the formation of stable blood vessels, the specific cell type and optimal conditions for engineered vascular networks have to be determined. (unipd.it)
  • A novel co-culture system was developed to study endothelial cell interactions with MSCs in a spatially controlled three-dimensional (3D) hydrogel model. (unipd.it)
  • Using a microfluidic based patterning technique it was possible to localize endothelial cells (HUVECs) and MSCs in parallel channels at varying relative distances (500, 1000 and 2000 µm) within a 3D fibrin hydrogel. (unipd.it)
  • CD34
  • Although separate IFNγ or imatinib mesylate treatment only slightly upregulated BCL6 expression, combined treatment induced remarkable BCL6 upregulation in CML lines and primary human CD34 + CML stem cells. (hematopoiesisnews.com)
  • neural
  • One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
  • MSCs
  • This study will assess the safety and efficacy of systemic (IV) administration of escalating doses of allogeneic MSCs in modulating immune cell phenotypes and suppressing aortic inflammati. (bioportfolio.com)
  • This is a prospective, multicenter, double-blind, placebo controlled interventional study to evaluate the safety and efficacy of allogeneic mesenchymal stem cells (MSCs) in 20 patients wit. (bioportfolio.com)
  • Teeth develop due to interactions between the oral ectodermal epithelial cells and MSCs, first forming the enamel organ and the second forming papilla and the dental follicle. (hindawi.com)
  • The cell angiogenic behavior and intracellular interactions were observed in terms of directed migration of MSCs toward HUVECs and the creation of stable vascular network. (unipd.it)
  • therapies
  • First of all, stem cells (SCs) present new perspectives in cell-based therapies and regenerative medicine, therefore bringing new hopes for patients with incurable conditions. (operamedphys.org)
  • vivo
  • However, in vitro culture conditions can alter the behavior of cells, making it unclear whether the cells shall behave in a similar manner in vivo. (euvolution.com)
  • Platelet derived growth factors have been shown to stimulate cell proliferation efficiently in vivo 1,2 and in vitro . (jove.com)
  • They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
  • Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
  • They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
  • gene
  • Resulting iPSCs were further characterized and deemed free of transfected DNA, integrated transgene DNA, and lack detectable gene rearrangements such as those within the immunoglobulin heavy chain and T cell receptor loci of more differentiated cell types. (jove.com)
  • Melanosomes were identified in these pigmented cells by electron microscopy, and global gene expression profiling of the pigmented cells showed a high similarity to that of human primary foreskin-derived melanocytes, suggesting the successful generation of melanocytes from iPS cells. (jove.com)
  • progeny
  • The ES/OP9 co-culture system was originally designed to produce hematopoietic progeny, without the over production of macrophages, as the OP9 stromal cell line is derived from the calvaria of osteopetrosis mutant mice that lack functional M-CSF. (jove.com)
  • However, with replating steps and the harvesting of only suspension cells one potentially misses a large portion of ES-derived progeny and developing hematopoietic cells. (jove.com)
  • organ
  • Ideally, the resulting extracellular matrices would retain the organ-specific architecture and chemical composition to guide implanted cells into functional structures and eventually working organs. (ufl.edu)
  • Examining the ability of these cells to proliferate and differentiate in a whole kidney extracellular matrix scaffold would serve as a valuable baseline for future studies in producing a functioning organ. (ufl.edu)
  • cancer
  • Multiple myeloma is a form of cancer where the plasma cells in the bon. (bio-medicine.org)
  • Multiple myeloma is a form of cancer where the plasma cells in the bone marrow grow out of control, causing damage to bones as well as predisposing patients to anemia, infection and kidney failure. (bio-medicine.org)
  • blastocyst
  • Human embryos reach the blastocyst stage 45 days post fertilization, at which time they consist of 50150 cells. (euvolution.com)
  • ESCs are derived from the inner cell mass (ICM) of the preimplantation blastocyst (Fig. SC hierarchy). (operamedphys.org)
  • embryo
  • The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)