Loading...
  • GVHD
  • To test this hypothesis in preclinical settings, we have previously developed several experimental models of GVHD using TK+ T-cells in mice. (bioportfolio.com)
  • Because of their immunomodulatory and anti-inflammatory effects, mesenchymal stem cells (MSCs) have been considered as potential therapeutic agents for treating immune-related or autoimmune diseases, such as graft-versus-host disease (GVHD). (frontiersin.org)
  • It may be an immune disorder involving immune complex deposition, B cells, regulatory T cells (Tregs), and Th1 cytokines and be a manifestation of chronic GVHD. (frontiersin.org)
  • Tregs suppress GVHD via early expansion of alloreactive T cell and cytokine dysregulation. (springer.com)
  • They are also the central mediators of graft-versus-host disease (GVHD), borne out in the reduction of this complication through use of T cell-depleted grafts ( 7 ). (jimmunol.org)
  • In addition, graft versus host disease (GVHD) will be virtually eliminated by CAMPATH that removes donor T cells from the graft. (clinicaltrials.gov)
  • Patients will also be monitored for secondary or immune-mediated graft rejection and or onset of grade II-IV acute GVHD following the administration of WT1-specific T-cell infusions. (clinicaltrials.gov)
  • Large pericardial effusion as a life-threatening complication after hematopoietic stem cell transplantation-association with chronic GVHD in late-onset adult patients," Annals of Hematology , vol. 91, no. 12, pp. 1953-1958, 2012. (hindawi.com)
  • opportunistic
  • Reconstitution of the T cell compartment is of importance, beyond their key role against opportunistic pathogens ( 5 ). (jimmunol.org)
  • patient and donor
  • With advances in DNA sequencing technology we now have the capacity to perform genome-wide analysis in a high throughput fashion, permitting a detailed genetic analysis of patient and donor prior to transplantation. (bloodjournal.org)
  • The favored hypothesis is a depletion of patient and donor B cells reducing the presentation of minor histocompatibility alloantigens. (knowcancer.com)
  • adult
  • Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated from various adult tissues including umbilical cord blood, adipose tissue, muscle, and dental pulp. (frontiersin.org)
  • antigens
  • HMA have shown to upregulate several antigens on leukemic cells and seem to enhance T cell mediated antitumor activity by increasing tumor-specific CD8 T cell responses against these upregulated antigens. (springer.com)
  • induce
  • While, several studies reported that HMA induce the expression of Foxp3 in activated T cells generating functional Tregs with suppressor properties. (springer.com)
  • mononuclear cells
  • The present invention provides a method of transplanting hematopoietic system reconstituting cells from a donor into an allogeneic recipient comprising administering to the recipient, prior to the administration of the hematopoietic system reconstituting cells, an amount of mononuclear cells which are. (google.com)
  • 2. The method of claim 1, wherein the mononuclear cells are T cells. (google.com)
  • 6. The method of claim 1, wherein the mononuclear cells are treated by exposure to a source of ionizing radiation. (google.com)
  • 12. The method of claim 1, wherein the treated mononuclear cells are administered to the recipient up to ten days prior to administration of the hematopoietic system reconstituting cells. (google.com)
  • 13. The method of claim 1, wherein the treated mononuclear cells are administered to the recipient between one and five days prior to the administration of the hematopoietic system reconstituting cells. (google.com)
  • 14. The method of claim 1, wherein the hematopoietic system reconstituting cells and the treated mononuclear cells are from the same donor source. (google.com)
  • 15. The method of claim 1, wherein the amount of treated mononuclear cells administered to the recipient is between 0.05 10 6 and 30 10 6 cells/kg of the recipient's body weight. (google.com)
  • malignant cells
  • Indeed, the anti-tumor effect of these cytoablative strategies is believed to be caused not only by direct effects on the malignant cells, but also in part by induction of new T cell responses, as T cells expand within the lymphopenic environment ( 9 ). (jimmunol.org)