Hematopoietic stem cell transplant transplant blood stem cells. Medical search. Frequent questions

Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
Although outcomes after HSCT have improved markedly since transplants were first utilized, infection remains an important source of morbidity. (medscape.com)
But is there any reason to think that hematopoietic stem cell transplants (HSCT) could 'reset' the immune system in MS? (closerlookatstemcells.org)
His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
The CHMP recommended granting a conditional marketing authorisation for the ATMP Zalmoxis as an adjunctive, or add-on, treatment for adult patients receiving a haploidentical haematopoietic stem cell transplant (HSCT) for types of blood cancer to aid immune reconstitution and reduce the risk of graft-versus-host disease. (europa.eu)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Stem cells are removed from another person, called a donor. (medlineplus.gov)
Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
During leukapheresis, blood is removed from the donor through an IV line. (medlineplus.gov)
The red blood cells are returned to the donor. (medlineplus.gov)
The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
Stem cells from a donor, called a graft , are then infused to replace the destroyed cells, produce new marrow, and rebuild the recipient's immune system. (cancer.gov)
It also carries risks of potential harms, including infection, graft-versus-host disease (where certain immune cells from the donor attack the normal tissue of the transplant recipient), and death. (cancer.gov)
Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
Previously, he had been exploring ways to manipulate the immune system in leukemia patients to be able to give them highly mismatched donor stem cell transplants, and one of his colleagues wondered if the approach might also work for autoimmune diseases. (closerlookatstemcells.org)
Stem cell transplants remove blood-forming stem cells from a healthy donor, and then inject them into a patient, where they take hold and grow in the bone marrow. (stanford.edu)
Technicians process stem cells from the donor to elimi-nate alpha-beta T cells, immune cells that instigate graft-versus-host disease. (stanford.edu)
As a re-sult, patients can be safely transplanted us-ing stem cells from a donor with only 5 of 10 matching HLA antigens -- such as a parent. (stanford.edu)
Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
Patients who relapse after stem cell transplantation are typically treated with what is called donor lymphocyte infusion (DLI), but the response rates are typically low and often complicated by graft versus host disease (GVHD) causing significant morbidity and mortality. (lls.org)
Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (merckmanuals.com)
alternately, a small subset of patients with a matched sibling donor may currently pursue an allogenic hematopoietic stem cell transplant. (asgct.org)
Dr Cooper explained that donor pigs can be genetically engineered to be protected from the human immune response, with a requirement for only minimal immunosuppression after the transplant. (medscape.com)
The team's current research focus is to create "universal-donor" pluripotent stem-cell lines that are induced to grow into insulin-producing beta cells. (medscape.com)
The idea is that these will be analogous to the O-negative "universal-donor" blood type and could be employed for all cell-based transplantation therapies in patients with immune rejection, said Dr Cowan. (medscape.com)
If successful, this proposed work could have an enormous impact on regenerative medicine, leading the way to rigorously tested universal-donor stem cells that could be grown and differentiated into very large numbers of cells, made widely available to all medical institutions and used on demand to treat patients with type 1 diabetes and a variety of degenerative diseases, he concluded. (medscape.com)

Blood Adv. 2022. (stembook.org)

In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
If given in tandem with solid-organ transplants, they could also remove the need for immune-suppressing therapy in organ recipients. (stanford.edu)
The procedure, which was not available at any other U.S. hospital when the brothers received it last year, is now offered to most transplant recipients at Packard Children's. (stanford.edu)
Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)

BOSTON--( BUSINESS WIRE )-- Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, today reported financial results for the quarter ended March 31, 2021. (biospace.com)
In February 2021, the company presented details of the results of the omidubicel Phase 3 study at the Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy and Center for International Blood & Marrow Transplant Research. (biospace.com)
Transplant Cell Ther 2021. (harvard.edu)
Blood Adv 2021. (harvard.edu)

One potentially fatal complication, graft vs. host disease , occurs when the new, donated cells respond to the immune markers on a patient's own cells -- known as HLA antigens -- as if they are foreign, and mount an immune attack against the patient's body. (stanford.edu)
An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)

Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes. (stembook.org)
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)

According to the World Network for Blood and Marrow Transplantation (WBMN), about one million hematopoietic stem cell transplants were performed between 2006 and 2014. (medgadget.com)
Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic cell transplantation program (Part I): Minimum requirements and beyond. (stembook.org)

For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
In a new NCI-funded study, researchers found that, in people with blood cancers who had received an allogeneic hematopoietic stem cell transplant, the health of their gut bacteria was linked with their survival. (cancer.gov)
This process can potentially eliminate some cancers derived from cells in the bone marrow, such as leukemia and lymphoma. (cancer.gov)
The transplants were first developed for people with blood cancers, but have the potential to be used much more widely for a variety of genetic diseases. (stanford.edu)
Antibody-based hematopoietic stem cell transplants may transform the treatment of patients with blood and immune diseases including cancers. (stanford.edu)
A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
Search clinical trials for adult and pediatric cancers and blood disorders offered through Dana-Farber and our clinical partners. (dana-farber.org)
Dana-Farber Brigham Cancer Center has a long history utilizing cellular therapies to treat blood cancers and blood disorders. (dana-farber.org)
Acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and myeloproliferative neoplasms (MPN) are some of the most common blood cancers in adult patient population. (lls.org)
More recently, genetically modified T cells called CAR T cells have proven quite effective against various lymphoid cancers. (lls.org)
Stem cell treatments, which have been successfully applied to a range of cancers and blood and immune system disorders, are now being investigated for their potential against Alzheimer's. (scitechdaily.com)

Systemic transplantation of wild-type hematopoietic stem and progenitor cells (green) led to their differentiation into microglia-like cells (red), which reduced the amount of beta amyloid plaques (magenta) in the brain. (scitechdaily.com)
In the study, recently published in Cell Reports , the researchers demonstrate that transplanting hematopoietic stem and progenitor cells was effective in rescuing multiple signs and symptoms of Alzheimer's in a mouse model of the disease. (scitechdaily.com)
Mishra and her colleagues performed systemic transplantations of healthy wild-type hematopoietic stem and progenitor cells into Alzheimer's mice and found that the transplanted cells did differentiate into microglia-like cells in the brain. (scitechdaily.com)
Altogether, the transplantation of healthy hematopoietic stem and progenitor cells led to enhanced microglia health, which in turn protected against multiple levels of Alzheimer's pathology. (scitechdaily.com)

Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)

Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival. (ajbm.net)

A haploidentical transplant may be from a family member. (medlineplus.gov)

There are so many variables in play locally, including how we treat our patients, and environmental and genetic influences on the microbiome that vary across geographical regions," said Steven Pavletic, M.D., a stem-cell transplant specialist at NCI's Center for Cancer Research , who was not involved in the study. (cancer.gov)
Our Acute Care Oncology team is at the hospital every night, ensuring that patients with cancer, blood disorders, and hematopoietic stem cell transplants have continuous access to in-person subspecialty attending care. (seattlechildrens.org)
For years now, bone marrow transplants have been used to treat patients with leukemia and other blood disorders. (closerlookatstemcells.org)
For example, in their phase II trial with 24 patients who failed conventional therapy, Drs. Atkins and Freeman found that a very high dose of chemotherapy followed by purified autologous hematopoietic stem cell transplants appeared to have the most impact on preventing ongoing inflammatory activity and progression in these patients. (closerlookatstemcells.org)
Dr. Atkins highlights a few priorities for better understanding how to use hematopoietic stem cells transplants for MS. The first is finding the minimal dose of chemotherapy that will effectively destroy the immune system without being too toxic, and the second is to understand which patients could benefit most from this therapy and whether it would be better to start the therapy earlier during the treatment pathway. (closerlookatstemcells.org)
Haematologist Yvonne Loh shares her experience with treating patients with severe autoimmune diseases and blood stem cell transplants. (rafflesmedicalgroup.com)
But traditional stem cell transplants are so risky that they've usually been offered only to patients who would otherwise die. (stanford.edu)
We continue to offer patients the latest treatments, including CAR T-cell therapy, other genetically-modified T cells, and cancer vaccines. (dana-farber.org)
Although most clinicians would agree that hematopoietic progenitor cell transplantation after reinduction therapy is frontline therapy for these patients, there is no consensus as to what type of hematopoietic progenitor cell transplantation promises the best event-free and overall survival. (jnccn.org)
The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
In the first quarter of this year, we made significant progress on key initiatives across all functions of our business, starting with omidubicel, a potentially transformative treatment option for patients with hematological malignancies," said Julian Adams, Ph.D., chief executive officer of Gamida Cell. (biospace.com)
The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)
Long-term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial. (ajbm.net)
11. Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. (ajbm.net)
Hematopoietic stem cell transplant remains a curative option, however a significant number of patients relapse after the transplant and there are currently no effective and safe treatment options available for these patients. (lls.org)
However, CAR T cells have proven significantly less effective in patients with AML/MDS or MPN. (lls.org)
Use of memory-like NK cells was safe and associated with very promising results in our small clinical trial in patients with advanced AML. (lls.org)
Infusion of these cells was safe and induced complete remission (CR) in more than 50% of the patients. (lls.org)
We are now evaluating use of memory-like NK cells in patients with AML/MDS/MPN who have relapsed after stem cell transplantation. (lls.org)
With our current trial using memory-like NK cells in these patients we are expecting to demonstrate superior efficacy without causing GVHD. (lls.org)
LLS funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care. (lls.org)
Today the FDA approved betibeglogene autotemcel (beti-cel), a bespoke gene therapy to treat the underlying cause of beta thalassemia in adult and pediatric patients who require regular red blood cell transfusions. (asgct.org)
Results from phase III studies showed that 89% of evaluable patients across ages and genotypes achieved transfusion independence (no longer needing red blood cell transfusions for at least 12 months while maintaining a weighted average Hb of at least 9 g/dL). (asgct.org)
On the other hand, bulk RNA-sequence analyses reveal that gene expression profiles among patients are different according to the cytomegalovirus reactivation pattern, and are associated with cytokine production or cell division. (nature.com)
The Committee recommended that Adempas (riociguat) should not be used in patients with symptomatic pulmonary hypertension associated with idiopathic interstitial pneumonia or PH-IIP (high blood pressure in lung arteries caused by a lung disease called idiopathic interstitial pneumonia). (europa.eu)
Reduction in late mortality among patients with Multiple Myeloma treated with Autologous Peripheral Blood Stem Cell Transplantation - a BMTSS Report. (stembook.org)
CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets. (stembook.org)
Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)

Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)

This also kills all healthy bone marrow that remains, and allows new stem cells to grow in the bone marrow. (medlineplus.gov)

Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
Due to increased knowledge among prospective mothers about the benefits of preserving umbilical cord blood of their new-born children, regions such as Asia Pacific are projected to see substantial development. (medgadget.com)

BioGenes GmbH established a partnership with Eurofins Munich, a contract research organization for biopharmaceutical product testing, in June 2016 to improve host cell protein testing (HCP). (medgadget.com)

Dr. Katherine Warren, clinical director of Pediatric Neuro-Oncology at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. (childrenshospital.org)
Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
More work is also needed to understand how to protect the microbiome during intensive cancer treatments such as stem cell transplantation, he added. (cancer.gov)
http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
Dr. Villavicencio is an attending physician in the Cancer and Blood Disorders Center at Seattle Children's Hospital and a clinical associate professor at the University of Washington School of Medicine. (seattlechildrens.org)
We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
In recent years we have witnessed a revolution in developing novel treatments aimed at targeting cancer by immune cells like T cells. (lls.org)
The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
He is also a professor of medicine and pathology and director of the stem cell and gene therapy program at the University of Washington, and the Stephanus Family Endowed Chair for Cell and Gene Therapy at the Fred Hutchinson Cancer Center. (asgct.org)
However, the same immunosuppressive medications that are required to prevent the child's immune system from attacking and rejecting the transplanted organ can predispose these individuals to developing a very serious cancer that is linked to Epstein-Barr virus (EBV). (stanford.edu)
Cancer chemotherapy is based on an understanding of tumor cell growth and of how drugs affect this growth. (medscape.com)

My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)

Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
A method that broadens the pool of potential donors for stem cell transplants recently saved two young brothers from a severe genetic disease. (stanford.edu)
Before she came to Stanford, their doctor Alice Bertaina , MD, PhD, developed a technique that greatly reduces the risk of graft vs. host disease and broadens the potential pool of stem cell donors. (stanford.edu)
Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
If ultimately successful, both approaches would offer access to an unlimited number of implantable islets, representing a significant advance over the multiple human deceased donors that are currently required for islet-cell transplants to be undertaken in humans. (medscape.com)
You can put islet cells into someone with type 1 diabetes and they can leave the hospital 3 days later with no diabetes….But you're not going to get very far with human donors," press briefing moderator Gordon C Weir, MD, professor of medicine at Harvard Medical School, and cohead of the Joslin Diabetes Center's section on islet cell and regenerative biology, told Medscape Medical News . (medscape.com)

The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
In an allogeneic stem cell transplant, the blood-forming stem cells in a patient's bone marrow are destroyed using high doses of chemotherapy or radiation therapy. (cancer.gov)
This is the next step for Drs. Atkins and Freeman who are organizing a phase III randomized clinical trial to compare the hematopoietic stem cell transplant approach in people with MS who have highly active disease, and who have failed one or two conventional drugs, against individuals with MS who are treated with the best available, approved drug therapy. (closerlookatstemcells.org)
The main, huge difference is that with gene therapy we correct the patient's cells,' Bacchetta said. (stanford.edu)
Over more than 30 years, we have performed more than 9,200 hematopoietic stem cell transplants, the original form of cellular therapy. (dana-farber.org)
This review outlines the disparate types of stem cell therapy that have been used in this difficult-to-treat population as well as the role of maintenance and CAR T-cell therapy in conjunction with stem cell therapy. (jnccn.org)
1 - 3 However, those with relapsed and/or refractory (R/R) disease have had a historically dismal OS of ≤30% despite reinduction therapy and autologous hematopoietic progenitor cell transplantation (autoHCT) ( Figure 1 ). (jnccn.org)
and the role of CAR T-cell therapy as it relates to HCT as therapies for R/R B-NHL. (jnccn.org)
Kaplan-Meier curve showing probability of overall survival in children and adolescents with mature B-cell non‐Hodgkin's lymphoma with refractory or relapsed disease during or after therapy in the FAB/LMB96 international study. (jnccn.org)
We also continue to expand our clinical pipeline with plans to submit an IND for our GDA-201 natural killer cell therapy, initiate a multi-center Phase 1/2 clinical study in NHL and continue to advance our R&D activities to pursue the development of genetically modified NAM-enabled NK cells in solid tumors. (biospace.com)
During the quarter, Gamida Cell continued to advance omidubicel, the first cell therapy for bone marrow transplant to receive Breakthrough Therapy Designation from the U.S. Food and Drug Administration (FDA). (biospace.com)
The most prevalent application of cell banking is in stem cell research and therapy. (medgadget.com)
In addition, the country's growing number of active research and development initiatives in the fields of gene therapy, cell therapy, and biological products are fueling market expansion. (medgadget.com)
The success of the therapy stems from its effects on microglia, a type of immune cell in the brain. (scitechdaily.com)
Those that had received the stem cell therapy had less cortical expression of genes associated with diseased microglia, and less hippocampal expression of genes associated with diseased endothelial cells. (scitechdaily.com)
The spectrum of cutaneous T-cell lymphomas: new insights into biology and therapy. (medscape.com)
If it weren't for the hematopoietic stem cells, this transplant would only be a transient therapy meaning its effects would only last a short time. (lu.se)
It is because of these stem cells and their capacity to regenerate and rebuild the entire hematopoietic (blood) system that makes transplantation a promising therapy. (lu.se)

Blood Adv. 2020;4(12):2810-2820. (stembook.org)

Hematopoietic Stem Cells: a New Transplant Paradigm for Multiple Sclerosis? (closerlookatstemcells.org)
This same approach is now being tested in clinical trials for people with multiple sclerosis (MS) and other autoimmune diseases in the hope that providing brand new blood cells will reset the immune system to a healthy state. (closerlookatstemcells.org)

Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. (ajbm.net)
Genzyme's sweetened offer comes after it was given access to AnorMed's files on Mozobil (AMD3100), a drug designed to improve the success of stem cell transplantation procedures used to serious malignancies, in order to carry out proper due diligence. (pharmatimes.com)
This type of transplantation, also known as a bone marrow transplant, is one of the common treatments used to treat several blood malignancies. (lu.se)

The rapid increase in the number of stem cell therapies is likely to fuel the expansion of the cell banking outsourcing industry. (medgadget.com)
These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
Emerging new therapies for cutaneous T-cell lymphoma. (medscape.com)

However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
And antibiotic use after transplant, which can disrupt the microbiome, is associated with a higher risk of death from any cause and specifically from graft-versus-host disease. (cancer.gov)
1. Ozdemir ZN, Civriz Bozdağ S. Graft failure after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
4. Xue S, Liu F, Zhang Y, Tan Y, Wang J. Clinical study of cord blood mesenchymal stem cells combined with Eltrombopag when treating graft dysfunction after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
6. Gao J, Zhang Y, Su L. Advances in prevention of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)

Aplastic anemia is classified as severe according to blood counts. (rarediseases.org)

It comprises of two types of stem cells, that are hematopoietic and mesenchymal stem cells. (powershow.com)
To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
What are the types of stem cell transplants? (mdanderson.org)

Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)

Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)

Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
Keep in mind that these are the stem cells that power the blood and immune systems, churning out billions of blood cells every day. (closerlookatstemcells.org)
Scientists first tested the approach in animals with an MS-like disease and showed that radiation or chemotherapy followed by a bone marrow stem cell transplant could help to control the immune system. (closerlookatstemcells.org)
Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)
The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
In MS, the immune system cells that normally protect us from viruses, bacteria, and unhealthy cells mistakenly attack myelin in the central nervous system (brain, optic nerves, and spinal cord). (nih.gov)
Our work helped discover that another type of immune cell, memory-like Natural Killer (NK) cells, have enhanced activity against AML/MDS and MPN tumor cells. (lls.org)
Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)
First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
Immunogenicity is reduced by removing the major histocompatibility complex molecules from the stem cells with gene editing, and tolerance induced via "immune editing. (medscape.com)

The processing method allowed Ronnie and Levi to receive a stem cell transplant from their father, who does not have the autoimmune disease. (stanford.edu)

Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)

The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
Insurance businesses only compensate for cord blood banking when it is medically required. (medgadget.com)
In the U.S., cord blood banking is only reimbursed when it is medically required. (medgadget.com)
Successful cord blood transplantation for mycosis fungoides. (medscape.com)

DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. (seattlechildrens.org)
Stem cells can produce more stem cells (self-renewal) and also differentiate and proliferate, giving rise to red blood cells (erythrocytes), white blood cells (leukocytes), and platelets. (rarediseases.org)

Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)

Validation and refinement of the disease risk index for allogeneic stem cell transplantation: a study from the CIBMTR. (stembook.org)

Since then, people with certain forms of MS have received autologous hematopoietic stem cell transplants in clinical trials worldwide, and many lessons have been learned along the way. (closerlookatstemcells.org)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)

Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
The hematopoietic (blood-forming) stem cells present in bone marrow can restore a patient's blood system after it has been devastated by chemotherapy or radiation. (closerlookatstemcells.org)

An ideal transplant sce-nario is to use stem cells donated by a healthy sibling with a 10-for-10 antigen match. (stanford.edu)
In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)

Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)

Therefore, C9-M and C9-C (Rescued phenotype of wild-type growth by genetic complementation) parasites ( 26 ) showed the attenuation in PF13_0027 knock-out parasites (C9-M) growth, which in turn resulted in the irregular cell cycle. (frontiersin.org)

In dyskeratosis congenita and other telomere diseases, the protective caps on people's chromosomes shorten too quickly, causing cells and tissues to age prematurely. (childrenshospital.org)
Diseases treatable by transplants. (mayoclinic.org)

Novel treatment approaches for cutaneous T-cell lymphoma. (medscape.com)
NEW ORLEANS - Two innovative new approaches to replacing pancreatic beta cells offer hope for treating both type 1 and type 2 diabetes in the future, experts say. (medscape.com)

To look more closely at whether similar changes in the gut microbiome after transplant are observed in different sites around the world, Dr. van den Brink and his colleagues looked at changes in the gut microbiome among people undergoing the procedure at four centers in three countries: two in the United States (in New York and North Carolina), one in Germany, and one in Japan. (cancer.gov)

Weighing the Risks of Blinatumomab Prior to Hematopoietic Stem Cell Transplant in Acute Lymphoblastic Leukemia. (bvsalud.org)
A long-acting fluorinated corticosteroid, dexamethasone induces apoptosis of leukemia cells by means of glucocorticoid receptors. (medscape.com)

In June 2017, Alligator Bioscience announced a Cell Line Development Partnership with Sartorius Stedim Biotech Group (BioOutsource) in the development of immuno-oncology antibody drug candidates. (medgadget.com)

Anatomy37

Organisms16

Diseases44

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment67

Psychiatry and Psychology1

Phenomena and Processes39

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Named Groups6

Health Care13

HSCT9

Donor29

20221

Recipients6

20214

Patient's own cells2

Outcomes5

Network for Blood and Marrow Transplantation2

Cancers13

Progenitor cells4

Allogeneic bone marrow tra1

Chronic graft-versus-1

Haploidentical1

Patients30

Marrow Transplant Research1

Grow in the bone ma1

Umbilical cord4

20161

Cancer15

Disorders1

Donors7

Therapy18

20201

Multiple Sclerosis2

Malignancies3

Therapies4

Graft6

Severe1

Types of stem3

Type of transplant1

Mesenchymal1

Immune11

Autoimmune1

Doses of chemotherapy1

Cord Blood4

Differentiate2

Curative1

CIBMTR1

Clinical trials2

Chemotherapy or radiation4

Antigen2

High-dose1

Genetic1

Diseases2

Approaches2

Centers1

Leukemia2

20171