AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowTransplantation, HomologousHematopoietic Stem CellsBone Marrow CellsHematopoietic Stem Cell TransplantationGraft vs Host DiseaseTransplantation, AutologousWhole-Body IrradiationBone and BonesTransplantation ConditioningAnemia, AplasticLeukemiaTransplantation ChimeraHematopoiesisGraft SurvivalTissue DonorsLiver TransplantationBusulfanHistocompatibility TestingBone Marrow PurgingStem CellsHistocompatibilityMice, Inbred C57BLTransplantation, IsogeneicCyclophosphamideStem Cell TransplantationBone Marrow DiseasesRadiation ChimeraHematologic NeoplasmsKidney TransplantationColony-Forming Units AssayRecurrenceLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteCombined Modality TherapyTreatment OutcomeTime FactorsImmunosuppressive AgentsBone Marrow ExaminationRemission InductionHepatic Veno-Occlusive DiseaseAntigens, CD34Precursor Cell Lymphoblastic Leukemia-LymphomaCell DifferentiationGraft RejectionTransplantation ImmunologyLeukemia, MyeloidBone RemodelingHematopoietic Stem Cell MobilizationBone Marrow NeoplasmsLymphocyte DepletionSevere Combined ImmunodeficiencyGraft vs Host ReactionAcute DiseaseImmunosuppressionMyelodysplastic SyndromesLymphoma, Non-HodgkinT-LymphocytesFlow CytometryLeukocyte TransfusionHLA AntigensChimeraRetrospective StudiesHematologic DiseasesHeart TransplantationCell LineageSurvival AnalysisCells, CulturedGranulocyte Colony-Stimulating FactorLymphocyte TransfusionGraft vs Leukemia EffectCyclosporineLung TransplantationActuarial AnalysisBone DensityAntineoplastic Combined Chemotherapy ProtocolsCell SeparationCord Blood Stem Cell TransplantationGraft vs Tumor EffectPancytopeniaSpleenNuclear FamilySurvival RateCytomegalovirus InfectionsMice, KnockoutCarmustineOrgan TransplantationFollow-Up StudiesLeukocyte CountChimerismMice, Inbred BALB CCytarabineDisease-Free SurvivalMelphalanMultiple MyelomaGranulocytesPeripheral Blood Stem Cell TransplantationLymphomaEtoposide
TransplantHSCTProgenitor cellsTransplantsAutologousUmbilicalGraft versusCells residing in thAplastic AnemiaPeripheralEngraftmentDonorPediatricEmbryonic stemHSCsMalignanciesChemotherapyHematologyPatientsRemissionKidney transplantationLong-term survivorsAbstractSurvivalLymphomaEBMTTissueTreatmentsBlood stem cellsImmatureOrganProcedureClinicalTissuesDiseasesCordNicheMyelomaImmune systemRemoving stem cellsSource of stem cells2016
Transplant43
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • A new study published in the American Journal of Transplantation reports there is no evidence of children between 6 and 11 years of age being at a disadvantage if they are seeking deceased donor lung transplant in the current US lung allocation system. (medindia.net)
  • Graft-versus-host disease is a potentially serious complication in a recipient of an allograft (usually a haematopoietic stem cell transplant) that arises from the attack of recipient tissues (such as the skin, liver or gut) by donor-derived T cells. (nature.com)
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
  • See a list of publications about bone marrow transplant by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
  • Hematopoietic stem cell transplant. (mayoclinic.org)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • Are you considering a blood stem cell transplant? (nih.gov)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Have you received a stem cell transplant? (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • Autologous bone marrow transplant is when people donate their own bone marrow. (medlineplus.gov)
  • Allogenic bone marrow transplant is when another person donates bone marrow. (medlineplus.gov)
  • But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
  • Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
  • Various XSCID gene therapy clinical trials have been conducted over 20 years, both as an alternative to hematopoietic stem cell transplant (HSCT) or following a poor outcome. (stjude.org)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • Regret was measured using a FACT-BMT item not included in scoring: "I regret having the bone marrow transplant. (cdc.gov)
  • Akari's pipeline includes a Phase 3 clinical trial program investigating nomacopan for severe pediatric hematopoietic stem cell transplant-related thrombotic microangiopathy (HSCT-TMA). (wpri.com)
  • The registry follows the excitement surrounding Nigeria's first bone marrow transplant last October, in which. (the-scientist.com)
  • Bone Marrow Transplant is the procedure to replace bone marrow stem cells with a matched, healthier bone marrow stem cell. (bonemarrowtransplantations.com)
  • The bone marrow transplant procedure is highly safe for the donor and is used to treat various conditions, both cancerous and non-cancerous. (bonemarrowtransplantations.com)
  • Moreover, after a successful bone marrow transplant, the patient can return to everyday life within 6 to 12 months. (bonemarrowtransplantations.com)
  • Max hospital is one of the top bone marrow transplant hospitals in Asia. (bonemarrowtransplantations.com)
  • The Bone marrow transplant doctors in Max hospital are well experienced and treat using advanced technologies. (bonemarrowtransplantations.com)
  • As a result, the Max hospital bone marrow transplant cost is very affordable for high-quality surgeries and treatments . (bonemarrowtransplantations.com)
  • Results of Bone marrow transplant in Max hospital are very successful, as the surgeons pay close attention to even the smallest details and choose the best course of care, resulting in the best outcomes. (bonemarrowtransplantations.com)
  • Autologous and allogeneic bone marrow transplant procedures are most frequently used to treat blood disorders or cancers. (bonemarrowtransplantations.com)
  • By using an autologous bone marrow transplant, the immune system is attempted to be reset. (bonemarrowtransplantations.com)
  • Acute GVHD occurs in approximately 50% of patients who receive an allogeneic bone marrow transplant (BMT). (einpresswire.com)
  • The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care. (mayo.edu)
  • The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period. (mayo.edu)
  • One possible therapeutic approach for this disease is bone marrow transplant. (bvsalud.org)
  • Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
  • Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • This type of transplantation, also known as a bone marrow transplant, is one of the common treatments used to treat several blood malignancies. (lu.se)
  • If it weren't for the hematopoietic stem cells, this transplant would only be a transient therapy meaning its effects would only last a short time. (lu.se)
HSCT12
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • For pre-symptomatic infants and older individuals with mild symptoms, hematopoietic stem cell transplantation (HSCT) with cord blood is beneficial over symptomatic treatment only. (disabled-world.com)
  • The year 2020 marked the 30th anniversary of the Nobel Prize in Medicine awarded to E. Donnall Thomas for the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat hematologic malignancies and other blood disorders. (broadinstitute.org)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • Historically, the most effective treatment for XSCID has been bone marrow transplantation, [i.e. hematopoietic stem cell transplantation (HSCT)], where a patient receives healthy blood-forming cells from a matched sibling donor, or a half-matched parental donor. (stjude.org)
  • Akari has been granted Orphan Drug, Fast Track and Rare Pediatric Disease designations from the FDA for nomacopan for the treatment of pediatric HSCT-TMA and orphan drug designation from the European Commission for treatment in hematopoietic stem cell transplantation. (wpri.com)
  • Bone marrow transplants, or hematopoietic stem cell transplantations (HSCT), treat more than 70 different diseases, including some types of leukemia, lymphoma, and sickle cell anaemia. (the-scientist.com)
  • This study aimed to know the perceptions and experiences of family companions facing illness and transplantation of hematopoietic stem cells (HSCT) in light of the theory of anticipatory grief. (bvsalud.org)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Progenitor cells9
  • These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. (wikipedia.org)
  • In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. (nih.gov)
  • Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
Transplants7
  • Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. (wikipedia.org)
  • Blood-forming stem cell transplants. (mayoclinic.org)
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
  • Adebiyi also plans to establish another Nigerian source for stem cell transplants-an umbilical cord blood bank. (the-scientist.com)
  • Past patients of Max Healthcare are well impressed by the treatment results of Bone marrow transplants. (bonemarrowtransplantations.com)
Autologous4
Umbilical8
Graft versus3
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • establish a convolutional neural network-based model to predict acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation. (nature.com)
  • Currently, my work aims to establish strategies to reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease or interfering with donor stem cell engraftment. (stanford.edu)
Cells residing in th1
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
Aplastic Anemia1
Peripheral6
  • Peripheral blood stem cell collection. (medlineplus.gov)
  • 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • National Institutes of Health (NIH) Frequently Asked Questions (FAQs) Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers about these Adult/NONembryonic Stem Cells Key Points Hematopoietic or blood-forming stem cells are. (physiciansforlife.org)
Engraftment3
Donor10
Pediatric3
Embryonic stem5
  • Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
  • Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
  • They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)
  • An induced pluripotent stem cell (iPSC), is an adult stem cell which has been altered in a lab to behave more like embryonic stem cells. (centenary.org.au)
  • It is related to embryonic stem cells, but it is a distinct cell type, capable of developing into any type of blood cell but not other organs such as the brain or muscle. (primaryimmune.org)
HSCs2
Malignancies2
Chemotherapy7
  • Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. (wikipedia.org)
  • Unlike chemotherapy the effects may not be due to direct destruction of stem cells but the results may be equally serious. (wikipedia.org)
  • Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection. (wikipedia.org)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • Lymphoma is the most common haematopoietic malignancy in dogs, and is the most responsive to chemotherapy. (vin.com)
  • Before chemotherapy medicines suppress the immune system, hematopoietic stem cells-which produce blood cells-that are generated from a person's bone marrow or blood are collected or kept. (bonemarrowtransplantations.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Hematology2
  • Dr. Thomas, "father of bone marrow transplantation," first developed and reported this technique in 1957, and in the ensuing decades, this seminal study has impacted fundamental work in hematology and cancer research, including advances in hematopoiesis, stem cell biology, tumor immunology, and T-cell biology. (broadinstitute.org)
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Patients21
  • [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. (wikipedia.org)
  • All patients had increases in total body bone mineral content ranging from 21 to 29 grams (median, 28), compared with predicted values of 0 to 4 grams (median, 0) for healthy children with similar changes in weight. (nih.gov)
  • Hyperimmunoglobulin E syndrome (HIES) was first described as Job syndrome in 1966, when 2 patients were reported with eczematous dermatitis, recurrent staphylococcal boils, hyperextensible joints/recurrent bone fractures, and distinctive coarse faces. (medscape.com)
  • Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
  • Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
  • Because the chromosomal t(14;18) translocation is found in the majority of patients with follicular lymphoma, bone marrow aspiration and chromosome analysis can also help establish the diagnosis. (medscape.com)
  • Most patients with follicular lymphoma present at an advanced stage, and most patients have bone marrow involvement at diagnosis. (medscape.com)
  • In our image, induced pluripotent stem cells can be seen, derived from patients, that replicate unique heart cell behaviours in relation to genetic heart disease. (centenary.org.au)
  • The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
  • Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • Bio My research is focused on using preclinical models to develop novel therapies which improve outcomes for patients receiving allogeneic hematopoietic stem cell transplantation. (stanford.edu)
  • Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
  • The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5-29.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not. (cdc.gov)
  • Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (cdc.gov)
  • And while 70 percent of Caucasian patients are successfully matched, only 17 percent of black people in the United States are as lucky, according to The New York Stem Cell Foundation , likely because only 8 percent of donors in US registries are black. (the-scientist.com)
  • Intending to enhance the quality of life for patients and their families, the Center provides top-notch treatment facilities utilizing cutting-edge technology and cutting-edge medicines to treat the majority of complicated illnesses requiring allogeneic transplantation. (bonemarrowtransplantations.com)
  • Patients can be cured with bone marrow transplantations of haematopoietic stem cells. (lu.se)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
Remission1
Kidney transplantation1
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Long-term survivors1
Abstract1
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
Survival1
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
Lymphoma1
  • Although use of stem cell treatments in medicine is still in its early stages, they are currently being used to treat people with blood and immune system conditions, such as leukaemia and lymphoma. (centenary.org.au)
EBMT1
  • The ECIL-1 is a common initiative of the following groups or organisations: Infectious Diseases Working Party of the European Blood and Marrow Transplantation Group (EBMT-IDWP), Infectious Diseases Group of the European Organization for Research and Treatment of Cancer (EORTC-IDG), European Leukemia Net (ELN) (EU Grant No.: LSHC-CT-2004), and International Immunocompromised Host Society (ICHS). (edu.au)
Tissue5
  • Organ and tissue transplantation can give a second chance at life to thousands of people. (medindia.net)
  • Bone marrow is the soft, fatty tissue inside your bones. (medlineplus.gov)
  • With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged. (articlecity.com)
  • Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
  • But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
Treatments3
  • Some research indicates possible benefits associated with using bone marrow transplantation or cord blood transfusion as treatments for Krabbe disease. (disabled-world.com)
  • Today, it has become a distinct source of stem cells and, therefore, a critical element in advancing medical treatments for everything from hair loss, the treatment of wounds, and surgical procedures. (articlecity.com)
  • Stem cell research is important because it has the potential to both better understand and furthermore, cure diseases and injuries that currently have no effective treatments. (centenary.org.au)
Blood stem cells1
Immature2
Organ2
  • The Thoracic Transplantation Committee of the Organ Procurement and Transplantation Network (OPTN) will be re-evaluating lung allocation policy as it applies to children during late 2013 and early 2014. (medindia.net)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Procedure4
Clinical2
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • In addition to these already established stem cell therapies, there is ongoing research and development of new stem cell therapies, which are currently being investigated in clinical trials involving people. (centenary.org.au)
Tissues5
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • Stem cells can develop into any type of cell in the body, making them valuable for repairing damaged tissues and organs. (centenary.org.au)
  • The adult cells are found in small numbers in most tissues, such as bone marrow or fat. (centenary.org.au)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
Diseases4
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
  • For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
  • The research community is also actively engaged in expanding our understanding of stem cells and their potential applications in overcoming various diseases. (centenary.org.au)
Cord1
  • With as little as $75,000, we could build [a cord blood bank] in Nigeria by the end of this year instead of discarding this valuable source of stem cells," he said in a Lancet press release. (the-scientist.com)
Niche1
Myeloma2
  • Myeloma cells destroy bone , which releases calcium, a condition called hypercalcemia. (webmd.com)
  • Myeloma cells produce excess abnormal proteins, called paraproteins, in the bone marrow that can cause your blood to become so thick that it flows sluggishly in your body, a condition called hyperviscosity. (webmd.com)
Immune system3
Removing stem cells1
Source of stem cells1
20161
  • 2016 . DOI : 10.1016/j.stem.2015.09.019. (epfl.ch)