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  • severe
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • Hematology
  • Allen C. Eaves (born 1941) was the founding Director of the Terry Fox Laboratory for Hematology/Oncology Research, which over a 25 year period (1981-2006) he grew into an internationally recognized[citation needed] centre for the study of leukemia and stem cell research. (wikipedia.org)
  • Mertelsmann is known for his scientific works in the fields of hematology, oncology, gene therapy and stem cell transplantation. (wikipedia.org)
  • At Freiburg University Medical Center he became the director of the Department for Medicine I, Oncology, Hematology and Stem Cell Transplantation. (wikipedia.org)
  • Dose
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
  • Blood
  • In CLL, high numbers of abnormal lymphocytes are found in the blood, lymph nodes, spleen, and bone marrow. (uptodate.com)
  • In recognition of his research accomplishments and leadership in moving basic science discoveries in stem cell biology into the clinic, he was elected President of the International Society of Cellular Therapy (1995-1997), Treasurer of the Foundation for the Accreditation of Cellular Therapy (1995-2002) and President of the American Society of Blood and Marrow Transplantation (1999-2000). (wikipedia.org)
  • Clonal hypereosinophilia, also termed Primary hypereosinophelia or clonal eosinophilia, is a grouping of hematological disorder characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell, in the bone marrow, blood, and/or other tissues. (wikipedia.org)
  • The expanding population of eosinophils, initially formed in the bone marrow may spread to the blood and then enter into and injure various tissues and organs. (wikipedia.org)
  • Some hematological malignancies exhibit increased numbers of circulating blood eosinophils, increased numbers of bone marrow eosinophils, and/or eosinophil infiltrations into otherwise normal tissues. (wikipedia.org)
  • Clinical
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • commonly
  • The most commonly observed adverse effect is mild bone pain after repeated administration and local skin reactions at the site of injection. (wikipedia.org)
  • lymphoid
  • BPDCN are characterized by co-expression of CD4 and CD56 antigens in the absence of any specific myeloid or lymphoid lineage or markers, primary skin infiltrations followed by bone marrow involvement, and aggressive clinical course. (czytelniamedyczna.pl)
  • malignant
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as (Erlenmeyer flask deformity) Alternating radiolucent femoral metaphyseal bands Pathologic fractures The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. (wikipedia.org)
  • clinical
  • Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes. (hunimed.eu)
  • On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential. (springer.com)
  • hematologic
  • Obliteration of bone marrow spaces and subsequent depression of the cellular function can result in serious hematologic complications. (wikipedia.org)
  • Hematologic manifestations related to bone marrow suppression and subsequent pancytopenia are a major source of morbidity and mortality. (wikipedia.org)