AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowHematopoietic Stem CellsBone Marrow CellsHematopoietic Stem Cell TransplantationTransplantation, HomologousGraft vs Host DiseaseBone and BonesWhole-Body IrradiationLeukemiaTransplantation, AutologousHematopoiesisAnemia, AplasticTissue DonorsStem CellsTransplantation ConditioningCytomegalovirus InfectionsGraft SurvivalHematologic NeoplasmsHistocompatibility TestingMice, Inbred C57BLColony-Forming Units AssayBone Marrow DiseasesHistocompatibilityImmunosuppressive AgentsBone RemodelingTransplantation ChimeraAntigens, CD34Leukemia, Myeloid, AcuteImmunocompromised HostBone Marrow ExaminationBone Marrow PurgingTime FactorsOpportunistic InfectionsCell DifferentiationBone Marrow NeoplasmsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveImmunosuppressionRadiation ChimeraPrecursor Cell Lymphoblastic Leukemia-LymphomaTreatment OutcomeBusulfanGraft RejectionRecurrenceHematopoietic Stem Cell MobilizationMycosesFlow CytometryCyclosporineRetrospective StudiesStem Cell TransplantationCell LineageHematologic DiseasesBone DensityCytomegalovirusCells, CulturedTransplantation, IsogeneicAcute DiseaseKidney TransplantationFatal OutcomeHLA AntigensMyelodysplastic SyndromesCyclophosphamideT-LymphocytesBone ResorptionLymphocyte DepletionCell SeparationSurvival AnalysisCombined Modality TherapyLeukemia, MyeloidPneumonia, ViralNuclear FamilyGanciclovirHepatic Veno-Occlusive DiseaseAspergillosisGraft vs Host ReactionPolymerase Chain ReactionCystitisMice, KnockoutStem Cell NicheBlood CellsSpleenBlood Group IncompatibilityGranulocyte Colony-Stimulating FactorGranulocytesLymphocyte TransfusionSevere Combined ImmunodeficiencyMice, TransgenicChimeraBone NeoplasmsLymphoma, Non-HodgkinAntilymphocyte SerumTransplantsStromal CellsRemission InductionLeukocyte CountMucormycosisSurvival RatePeripheral Blood Stem Cell TransplantationMice, Inbred BALB CAntigens, CD
TransplantationDonorsHSCTFound in the bone maProgenitor cellsMultiple myelomaMalignanciesTransplantationsRecipientsPatientsMaturing hematopoietic cellsAutologous stemEngraftmentCancersChemotherapyHSCsPediatricGrow in the bone ma2001Cells in theOccurs in the bone maAbstractReplace bone marrowClinicalPeripheral blood stemDonor'sUmbilical cordOutcomesPatient2002HematologyAllogeneic transplantGeneral anesthesiaOutpatientOrgansHaploidenticalLiverOrganAdultBlood-producingImmuneDonor registryCord bloodPatient'sUnipotentCancerAspirationRefractorySevereRecipientEmbryonic stem
Transplantation60
Donors11
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
  • Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • A method that broadens the pool of potential donors for stem cell transplants recently saved two young brothers from a severe genetic disease. (stanford.edu)
  • Before she came to Stanford, their doctor Alice Bertaina , MD, PhD, developed a technique that greatly reduces the risk of graft vs. host disease and broadens the potential pool of stem cell donors. (stanford.edu)
  • And while 70 percent of Caucasian patients are successfully matched, only 17 percent of black people in the United States are as lucky, according to The New York Stem Cell Foundation , likely because only 8 percent of donors in US registries are black. (the-scientist.com)
  • Currently, bone marrow transplants can cure sickle cell disease, but they are most effective in children who have well-matched donors. (nih.gov)
  • The researchers analyzed information from the Scientific Registry of Transplant Recipients, which includes data on all donors, wait-listed candidates, and transplant recipients in the United States. (medindia.net)
  • Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine. (sleepreviewmag.com)
  • The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)
HSCT5
  • Although outcomes after HSCT have improved markedly since transplants were first utilized, infection remains an important source of morbidity. (medscape.com)
  • Bone marrow transplants, or hematopoietic stem cell transplantations (HSCT), treat more than 70 different diseases, including some types of leukemia, lymphoma, and sickle cell anaemia. (the-scientist.com)
  • The drug candidate is also under development for bone marrow conditioning before a hematopoietic stem cell transplant (HSCT), in relapsed/refractory elderly AML patients. (pharmaceutical-technology.com)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Found in the bone ma1
Progenitor cells6
  • Stem and progenitor cells can be taken from the pelvis, at the iliac crest, using a needle and syringe. (wikipedia.org)
  • Human cord blood contains a large number of haematopoietic progenitor cells that can be used as a source of stem cells for treatment of blood disorders and cancers. (ndtv.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Multiple myeloma9
Malignancies2
  • The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
  • Cytomegalovirus Glycoprotein Polymorphisms and Increasing Viral Load in Non-Transplant Patients with Hematological Malignancies Undergoing Chemotherapy: A Prospective Observational Study. (cdc.gov)
Transplantations2
  • Low T Cell Numbers Resembling T-B+ SCID in a Patient with Wiskott-Aldrich Syndrome and the Outcome of Two Hematopoietic Stem Cell Transplantations. (medscape.com)
  • When it comes to hematopoietic stem cell transplantations, these are the important cells. (lu.se)
Recipients6
  • In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
  • If given in tandem with solid-organ transplants, they could also remove the need for immune-suppressing therapy in organ recipients. (stanford.edu)
  • The procedure, which was not available at any other U.S. hospital when the brothers received it last year, is now offered to most transplant recipients at Packard Children's. (stanford.edu)
  • Bertram Kasiske, MD, of the Scientific Registry of Transplant Recipients (SRTR) in Minneapolis, led a team that examined the validity of those data. (medindia.net)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
  • Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)
Patients21
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
  • But traditional stem cell transplants are so risky that they've usually been offered only to patients who would otherwise die. (stanford.edu)
  • As a re-sult, patients can be safely transplanted us-ing stem cells from a donor with only 5 of 10 matching HLA antigens -- such as a parent. (stanford.edu)
  • Antibody-based hematopoietic stem cell transplants may transform the treatment of patients with blood and immune diseases including cancers. (stanford.edu)
  • All patients achieved initial mixed hematopoietic chimerism with two patients rejecting their graft and recovering host hematopoiesis. (aacrjournals.org)
  • The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
  • A 28-year-old brain-dead man had his kidneys, lungs, and liver successfully transplanted into four critically ill patients at multiple hospitals in India. (medindia.net)
  • 05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
  • Continuous lenalidomide and low-dose dexamethasone in patients with transplant-ineligible newly diagnosed MM: FIRST trial subanalysis of Canadian/US patients. (vchri.ca)
  • Bendamustine and rituximab as induction therapy in both transplant-eligible and -ineligible patients with mantle cell lymphoma. (vchri.ca)
  • Tens of thousands of these procedures, often referred to as bone marrow transplants but more properly called hematopoietic stem cell transplants, are performed each year to rescue patients with immune system disorders or cancers. (sleepreviewmag.com)
  • Autologous Bone Marrow Treatment in India, is one of the most recent demands of many of our patients from Congo and the Middle east. (gomedii.com)
  • Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
  • In this context, patients experience the first psychological conflicts before this transplant. (bvsalud.org)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • Because the chromosomal t(14;18) translocation is found in the majority of patients with follicular lymphoma, bone marrow aspiration and chromosome analysis can also help establish the diagnosis. (medscape.com)
  • Most patients with follicular lymphoma present at an advanced stage, and most patients have bone marrow involvement at diagnosis. (medscape.com)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • Specialty care area for the care of patients who undergo bone marrow (stem cell) transplant for the treatment of various disorders. (cdc.gov)
Maturing hematopoietic cells1
  • Another CFU, the colony-forming unit-spleen (CFU-S), was the basis of an in vivo clonal colony formation, which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens of irradiated mice after 8 to 12 days. (wikipedia.org)
Autologous stem4
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • An autologous stem cell transplant is the process where healthy blood stem cells from your own body are used to replace your damaged bone marrow. (gomedii.com)
  • An autologous stem cell transplant is also called an autologous bone marrow transplant. (gomedii.com)
  • For example, there is no "rejection " factor for your own cells if you have an autologous stem cell transplant. (gomedii.com)
Engraftment3
  • A key milestone in a patient's recovery, neutrophil engraftment is a measure of how quickly the stem cells a patient receives in a bone marrow transplant are established and begin to make healthy new cells. (biospace.com)
  • Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
  • The research interests in my lab are on the development of new approaches to enhance hematopoietic stem cell engraftment and reconstitution following blood and bone marrow transplant. (dukehealth.org)
Cancers3
  • HSC transplants are used in the treatment of cancers and other immune system disorders. (wikipedia.org)
  • The transplants were first developed for people with blood cancers, but have the potential to be used much more widely for a variety of genetic diseases. (stanford.edu)
  • I focus my research and clinical work on treating blood and bone marrow cancers. (dukehealth.org)
Chemotherapy9
  • Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
  • Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • The normal preparation for this would be chemotherapy and several other medications to get his body ready for the transplant. (candlelighters.org.uk)
  • In a stem cell transplant, the patient gets high-dose of chemotherapy. (gomedii.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
HSCs7
  • Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. (wikipedia.org)
  • In vertebrates, the very first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition. (wikipedia.org)
  • The Cure Sickle Cell Initiative aims to develop curative strategies by initially focusing on gene therapies that modify hematopoietic stem cells (HSCs), which make red and other blood cells. (nih.gov)
  • Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously replenish all blood and immune cells during the lifetime of an individual. (ca.gov)
  • These difficulties have led to an interest in the conversion of embryonic stem cells or induced pluripotent stem cells into HSCs, which is not possible using current methodologies. (ca.gov)
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • 4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
Pediatric2
  • In an accompanying editorial, Stuart Sweet, MD, PhD, of Washington University in St. Louis, and Mark Barr, MD, of the University of Southern California in Los Angeles, noted that there are several other factors that should be considered as officials and the transplant community consider whether changes to pediatric lung allocation are warranted. (medindia.net)
  • Opportunities for improvement include bringing the lung donor yield in the 0-11 age group closer to the yield in adolescents, relaxing geographic allocation boundaries to ensure that pediatric lungs are offered first to children, and reserving deceased donor lobar transplant for circumstances where suitably sized donor organs are not available," they wrote. (medindia.net)
Grow in the bone ma2
20012
  • Bone Marrow Transplant 28, no. 6 (September 2001): 634-36. (duke.edu)
  • He trained in hematology and then as a leukemia/bone marrow transplant fellow in Vancouver from 1998 - 2001. (vchri.ca)
Cells in the2
Occurs in the bone ma2
Abstract2
  • Bone 2002(2): 436-9 [ PubMed abstract ]. (lu.se)
  • Bone Marrow Transplant 1998(10): 941-6 [ PubMed abstract ]. (lu.se)
Replace bone marrow2
Clinical5
  • We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. (cdc.gov)
  • These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
  • A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs) can reestablish the health-promoting bacteria that are often damaged by intense antibiotic treatment in people who have stem cell or bone marrow transplants for blood cancer. (mskcc.org)
  • Clinical efficacy is currently limited to bone marrow transplant, grafting new skin cells to treat burns, regenerating cornea in visually impaired, etc. (ndtv.com)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
Peripheral blood stem2
  • Now, stem cells are more often collected from blood (a peripheral blood stem cell transplant). (gomedii.com)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
Donor's3
Umbilical cord4
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
  • Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
  • Adebiyi also plans to establish another Nigerian source for stem cell transplants-an umbilical cord blood bank. (the-scientist.com)
Outcomes2
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • Earlier work from MSK physician-scientists Eric Pamer, MD, and Marcel van den Brink, MD, PhD , has shown that out-of-balance intestinal microbes can contribute to serious side effects that can affect outcomes after stem cell transplants. (mskcc.org)
Patient7
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
  • Patient has undergone prior solid organ and/or non-autologous hematopoietic stem cell or bone marrow transplant. (mayo.edu)
  • We are progressing well with our manufacturing readiness activities in response to the clear feedback from the FDA regarding registration of our commercial manufacturing facilities and are actively building our launch readiness capabilities, including market access and support services, to ensure a positive patient experience at transplant at the time of potential FDA approval. (biospace.com)
  • So-called bone-marrow transplants, which transfer tens of thousands of cells of many different kinds to a patient, most critically transfer hematopoietic (adult blood) stem cells. (harvard.edu)
  • Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
20021
  • He did further bone marrow transplant training in Toronto before joining the Leukemia/Bone Marrow Transplant Program attending staff in 2002. (vchri.ca)
Hematology1
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Allogeneic transplant1
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
General anesthesia2
Outpatient2
  • Lack of caregivers limits use of outpatient hematopoietic stem cell transplant program. (uchicago.edu)
  • This should start immediately after discharge from the transplant ward as in- or outpatient rehabilitation. (mdpi.com)
Organs3
  • These stem cells come from developed organs and tissues in the body. (healthline.com)
  • Of the 70 000 or so solid organs transplanted annually, 50 000 are kidney replacements, more than one-third of the latter operations are done in low- or medium-income countries. (who.int)
  • The supply of cadaveric organs is limited by an inadequately informed and educated public, inefficient or non-existent organizations for procuring transplant material, and cultural and religious barriers in some countries. (who.int)
Haploidentical1
Liver1
  • Recognizing MAS variants and the important anatomical considerations around macrophage perivascular topography in the marrow, liver and spleen allows for a novel evaluation of other states associated with hypercytokinaemia. (nature.com)
Organ2
  • This will help prevent the immune system from rejecting an organ transplant. (healthline.com)
  • A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
Adult7
Blood-producing1
Immune8
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Technicians process stem cells from the donor to elimi-nate alpha-beta T cells, immune cells that instigate graft-versus-host disease. (stanford.edu)
  • Hematopoietic stem cells are an important population of cells that continuously produce and replace red blood and immune system cells during life. (ca.gov)
  • Understanding how hematopoietic stem cells are made during embryonic development is important because it could teach us how to make such cells in the laboratory, and possibly allow circumvention of donor immune compatibility issues. (ca.gov)
  • Hematopoietic stem cells routinely save the lives of people with diseases such as leukemia, lymphoma, and immune deficiencies. (harvard.edu)
  • According to Medical Xpress, a sleep deficit of just 4 hours can effect stem cells of the blood and immune system and reduce the efficiency of transplants. (sleepreviewmag.com)
  • A sleep deficit of just four hours affects by as much as 50 percent the ability of stem cells of the blood and immune system to migrate to the proper spots in the bone marrow of recipient mice and churn out the cell types necessary to reconstitute a damaged immune system, the researchers found. (sleepreviewmag.com)
  • Primary HLH can only be cured by replacing the immune system by receiving a hematopoietic (blood or bone marrow) stem cell transplant. (candlelighters.org.uk)
Donor registry1
  • The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
Cord blood4
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • Cord blood stem cells are harvested from the umbilical cord after childbirth. (healthline.com)
  • With as little as $75,000, we could build [a cord blood bank] in Nigeria by the end of this year instead of discarding this valuable source of stem cells," he said in a Lancet press release. (the-scientist.com)
  • Stem cell work is still quite experimental but is very promising as many beneficial therapies are thought to exist with much scientific value being ascribed to cord blood and its cells. (ndtv.com)
Patient's1
  • Before the transplant, drug treatment is used to reduce the number of myeloma cells in the patient's body. (gomedii.com)
Unipotent1
  • The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
Cancer4
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
  • These rare cells are the important element of bone marrow transplants, which are used to treat a variety of conditions including many forms of blood cancer. (ca.gov)
Aspiration1
  • Workup may include a complete blood count (CBC), peripheral smear, iron studies (eg, ferritin and total iron-binding capacity [TIBC]), bone marrow aspiration and biopsy, and other studies as appropriate. (medscape.com)
Refractory1
  • [ 12 ] is a juvenile multisystem disorder caused by deletions in mitochondrial DNA (mtDNA) and manifested as severe, refractory sideroblastic anemia, neutropenia, vacuolated cells in bone-marrow precursors, exocrine pancreas insufficiency, malabsorption, and growth failure. (medscape.com)
Severe2
  • Unfortunately, two weeks after his stem cell transplant, Hughie developed a severe graft versus host reaction to his transplant. (candlelighters.org.uk)
  • Ramos CA " Striking the right balance: optimizing conditioning regimens for unrelated donor bone marrow transplant for severe aplastic anemia. . (bcm.edu)
Recipient9
  • In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
  • Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
  • In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
  • The harvested stem cells are processed before infusion into the recipient. (medscape.com)
  • The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
  • In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
  • However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
  • Five days before the scheduled transplant day, or day minus 5, the recipient tested positive for Klebsiella pneumoniae infection of the central venous catheter. (cdc.gov)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)
Embryonic stem3