Hematopoietic stem and progenitor cell self renewal. Medical search. Frequent questions

HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Hematopoietic stem cells are widely used in medical treatments, particularly in bone marrow transplantation for individuals with hematological disorders like leukemia or aplastic anemia. (thenoveldifference.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
However, this balance is altered during the hematopoietic recovery after Hematopoietic Stem and Progenitor Cell Transplantation . (bvsalud.org)
Transplantation efficacy can be limited by inadequate Hematopoietic Stem Cells number, poor homing, low level of engraftment, or limited self -renewal. (bvsalud.org)
and Ly6d+ bone tissue marrow progenitors by intrathymic transplantation. (lavoixdesrroms.org)
Mice lacking specific genes also showed deficits in the repopulating ability of hematopoietic cells in competitive transplantation experiments FK 3311 (10C13), although these phenotypes have been variable across studies (14). (biotech2012.org)
These outcomes identify potential essential regulators of HSC and present insights in to 8-Gingerol the medically important procedures of HSC mobilization for transplantation and leukemic advancement from cancers stem cells. (abic2004.org)
Elucidating the molecular pathways that keep HSC quiescence will hence enable aimed manipulation of HSC function endogenously and in the framework of hematopoietic cell transplantation. (abic2004.org)
Treatment typically includes combination chemotherapy to achieve remission, intrathecal and systemic chemotherapy and/or corticosteroids for CNS prophylaxis, and sometimes cerebral irradiation for intracerebral leukemic infiltration, consolidation chemotherapy with or without stem cell transplantation, and maintenance chemotherapy for up to 3 years to avoid relapse. (msdmanuals.com)

HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
We found that HSCs from Lnk-/- mice have an increased quiescent fraction, decelerated cell cycle kinetics, and enhanced resistance to repeat treatments with cytoablative 5-fluorouracil in vivo compared with WT HSCs. (jci.org)
Lnk -/- LSK HSCs show decelerated cell cycle kinetics. (jci.org)
The group are currently focused on the pivotal role that HOXA cluster genes play in the demarcation and possible emergence of haematopoietic stem cells (HSCs) and their role in cancer. (nottingham.ac.uk)
However, eradication of the leukaemia repopulating cell or stem cell whilst retaining normal HSCs remains a challenge with current experimental therapies. (nottingham.ac.uk)
Hematopoietic stem cells (HSCs) are a type of multipotent stem cell found primarily in the bone marrow and, to a lesser extent, in peripheral blood. (thenoveldifference.com)
HSCs have the remarkable ability to differentiate into a wide range of specialized blood cells. (thenoveldifference.com)
Hox genes modulate the properties of hematopoietic stem cells (HSCs) and reacquired Hox expression in progenitors contributes to leukemogenesis. (nih.gov)
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)
Aged LT-HSCs demonstrate a cell-intrinsic myeloid bias during inflammatory challenge. (biorxiv.org)
During fetal development, expansion of HSCs (self-renewal) and production of differentiated haematopoietic cells (differentiation) are both required to sustain the haematopoietic system for body growth 3,4 . (elsevierpure.com)
Here we used in vivo genetic tracing in mice to analyse the formation of HSCs and progenitors from intra-arterial haematopoietic clusters, which contain HSC precursors and express the transcription factor hepatic leukaemia factor (HLF). (elsevierpure.com)
Through kinetic study, we observed the simultaneous formation of HSCs and defined progenitors-previously regarded as descendants of HSCs 5 -from the HLF + precursor population, followed by prompt formation of the hierarchical haematopoietic population structure in the fetal liver in an HSC-independent manner. (elsevierpure.com)
The transcription factor EVI1 is heterogeneously expressed within the precursor population, with EVI1 hi cells being predominantly localized to intra-embryonic arteries and preferentially giving rise to HSCs. (elsevierpure.com)
These data suggest that fetal HSCs minimally contribute to the generation of progenitors and functional blood cells before birth. (elsevierpure.com)
Blood cells are produced from HSCs in a process called haematopoiesis. (whiterose-mechanisticbiology-dtp.ac.uk)
At each cell division HSCs give rise to daughter progenitor cells (non-HSCs) or create new HSCs through a process known as self-renewal. (whiterose-mechanisticbiology-dtp.ac.uk)
However, HSCs are a highly heterogenous population and the different molecular properties of individual HSCs, such as those controlling self-renewal capacity or cell cycle status, can affect their eventual fate. (whiterose-mechanisticbiology-dtp.ac.uk)
Hematopoietic Stem Cells (HSCs) are the most thoroughly characterized stem cell population in the body and their study has resulted in well established methods for their isolation, purification and reliable assays of HSC function. (bu.edu)
In textbook theory, HSCs branch early on into two progenitor cell types, one of which, known as the common lymphoid progenitor (CLP), later differentiates into T and B cells. (riken.jp)
In experiments with mouse HSCs cultured on immobilized delta-like 4 proteins, the researchers found that progenitors developing toward T cells were arrested in the absence of so-called feeder cells, which support survival and growth. (riken.jp)
Self renewal is the property that distinguishes stem cells and progenitors, and in the blood-forming system explains why haematopoietic stem cells (HSCs), not progenitors, are the only cells capable of providing rapid and sustained regeneration of the blood-forming system after ablation by cancer chemo- and radiotherapies. (edu.hk)
Cancer-free prospectively purified HSCs regenerate the haematopoietic system of patients as rapidly as a marrow or mobilized blood transplant, but without the risk of re-seeding the body with cancer cells. (edu.hk)
We have recently shown that myeloid leukaemias in mouse and human are often driven by rare leukaemia (cancer) stem cells which are at the progenitor stage of differentiation, but have activated the self-renewing cell division pathway normally used only by HSCs. (edu.hk)
Our research focuses on how hematopoietic stem cells (HSCs) and their immediate offspring are regulated in situations such as infections, stress, aging and leukemia. (lu.se)
Although HSCs are associated with a fairly clear functional definition regarding their developmental and self-renewal potential, all HSCs do not behave the same. (lu.se)
We have developed and applied FACS-based high-resolution cell fractionation procedures to map the differentiation processes from HSCs. (lu.se)
A broader interest of our laboratory is to understand the molecular regulation of HSCs both from the perspectives of self-renewal and differentiation, and how these features become altered upon disease-causing or disease-associated perturbations. (lu.se)
Our goal is to understand, at cellular and molecular levels, what controls HSCs and the fate of other immature blood cells. (lu.se)

Cysteines are an amino acid which are involved in pathways that feed cancer cells and provide building blocks for cancer cell growth. (uclahealth.org)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
Deletion of the DERARE reduced Hoxb expression, resulting in changes to many downstream signaling pathways (e.g., non-canonical Wnt signaling) and loss of HSC self-renewal and reconstitution capacity. (nih.gov)
1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
Stem cell-independent pathways during development thus offer a rational strategy for the rapid and simultaneous growth of tissues and stem cell pools. (elsevierpure.com)
Thus, uncovering and understanding new molecular and cellular pathways that govern HSPC cell fate is critical for basic biology and to develop new therapeutic strategies for hematologic disorders. (distefano-lab.com)
In my PhD project I will study the signalling pathways governing haematopoietic stem cell (HSC) fate. (whiterose-mechanisticbiology-dtp.ac.uk)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
One focus of our lab is differentiating mouse ESC into intestinal epithelial cells in order to understand the complex signaling pathways involved in intestinal commitment from endodermal progenitors and undifferentiated stem cells. (bu.edu)
Inhibition of JAK-STAT or NF-κB pathways did not result in rescue of PD-L1 up-regulation in RAD21 -deficient cells, suggesting more complex or combinatorial mechanisms at play. (dana-farber.org)
Introduction HOX gene expression is a common feature of acute myeloid leukemia (AML), and is thought to reflect dysregulation of HOX pathways that lead to abnormal self-renewal and the development of leukemia. (biotech2012.org)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)

Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
One important aspect of this is to define the role of co-activators of transcription in stem and progenitors cells during embryonic development and in adults. (edu.au)
We are currently investigating the function of the MYST family, particularly KAT6A and KAT6B, during embryonic development and in adult stem cell populations. (edu.au)
Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, et al: Polycomb complexes repress developmental regulators in murine embryonic stem cells. (karger.com)
Embryonic Stem Cells (ESC) are pluripotent undifferentiated cells capable of giving rise to cells from all three germ layers. (bu.edu)
We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. (ncl.ac.uk)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
Our current research aims to understand the post-transcriptional & epigenetic mechanisms that govern stem cell potency and cell fate decisions, and determine how to exploit these mechanisms to develop new therapeutic strategies. (distefano-lab.com)
These crucial regulators direct gene expression changes to establish cell-type specific transcriptional profiles. (distefano-lab.com)
The interplay between all these layers of epigenetic regulation finally controls the transcriptional output of the conversion process, thus determining the final cell fate. (distefano-lab.com)
His postdoctoral work focused on the role of post-transcriptional mechanisms in mammalian cell fate. (distefano-lab.com)
Comprehensive examination of the transcriptional effect of STAG2 deficiency in epithelial and myeloid cells revealed an activation of strong IFN and NF-κB expression signatures. (dana-farber.org)
Transcriptional profiles at the HOX loci were similar between normal cells and AML samples, and involved Rabbit Polyclonal to LRP10 bidirectional transcription FK 3311 at the center of each gene cluster. (biotech2012.org)

The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
he aim of the Thomas laboratory is to understand how the balance between proliferation and differentiation of stem cells is maintained. (edu.au)
This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)

Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
Hematopoietic stem and progenitor cells (HSPCs) have the capacity to self-renew and commit to fully mature specialized blood cell types. (distefano-lab.com)
However, the majority of samples expressed a canonical set of HOXA and HOXB genes that was nearly identical to the expression signature of normal hematopoietic stem/progenitor cells (HSPCs). (biotech2012.org)

Hematopoiesis is the process of blood cell formation. (thenoveldifference.com)
As recent evidences indicate that estrogens are involved in regulating the hematopoiesis , we sought to examine whether natural estrogens ( estrone or E1, estradiol or E2, estriol or E3 and estetrol or E4) modulate human Hematopoietic Stem and Progenitor Cells . (bvsalud.org)
During regular hematopoiesis, multipotent progenitors (myeloid-T-B progenitors) first lose the potential to generate B cells. (riken.jp)
We compared the HOX expression phenotypes in these AMLs to data from normal bone marrow cells to study the HOX regulatory programs in normal and malignant hematopoiesis. (biotech2012.org)
Prof Weissman is an expert in the fields of hematopoiesis, leukemia, and hematopoietic stem cells (HSC), and most recently, the clonal events leading from HSC to leukemia stem cells. (edu.hk)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

2 Protein interactions are critical to the stability, localization and activity of b-catenin, and we recently performed the first proteomic analyses of the b-catenin interactome in myeloid cells. (haematologica.org)
3 This study identified Wilms tumor protein (WT1) as a putative novel interaction partner in myeloid cells. (haematologica.org)
According to this model, T and B cells lose the potential to develop into non-lymphocytes (myeloid cells) once they pass the CLP branching point. (riken.jp)
In a model put forth nearly ten years ago, the researchers proposed a radically different picture in which progenitor cells retain the potential to generate myeloid cells across all branches of development. (riken.jp)
In the current research, the researchers sought to substantiate this theory by pinpointing the moment at which T cell progenitors lose the potential to develop into myeloid cells, a key step in determining cell fate. (riken.jp)
PD-L1 and MHC-I suppression by cohesin were shown to be conserved in mammary epithelial and myeloid cells. (dana-farber.org)

We examined hematopoietic stem cells at four stages of differentiation, lineage-committed progenitors, and mature myeloid and lymphoid cells. (nih.gov)
Targeted deletion of the Hoxa cluster affects B lymphopoiesis through depletion of early lymphoid progenitors. (nottingham.ac.uk)
These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Keywords: acute myeloid leukemia Beta Catenin Intro β-catenin functions as a co-activator for the T-cell Citalopram Hydrobromide element (TCF) 4/lymphoid enhancer element (LEF) 1 bipartite transcription element in the promoters of the WNT-β-catenin target genes and is implicated in malignancy transformation1. (researchassistantresume.com)
Consistent with this aberrant manifestation of LEF1 in hematopoietic stem cells has also been shown to induce AML with promiscuous manifestation of the myeloid and lymphoid factors5. (researchassistantresume.com)
The 2016 World Health Organization (WHO) classification of lymphoid neoplasms incorporates genetic data, clinical features, cell morphology, and immunophenotype, all of which have important implications for disease prognosis and management. (msdmanuals.com)

Our Team explores the biology of haematopoietic stem cells and focuses on the molecular mechanisms of stem cell self-renewal and differentiation. (whiterose-mechanisticbiology-dtp.ac.uk)
Cell chemical biology, 26 (6). (cshl.edu)
Discovery of the PD-L1 and IFN up-regulation in cohesin-mutant cells expands our understanding of the biology of cohesin-deficient cells as well as molecular regulation of the PD-L1 molecule. (dana-farber.org)
In 2002 he became Director of the Stanford Cancer/Stem Cell Institute, which was split into the Stanford Institute of Stem Cell Biology and Regenerative Medicine, and the Stanford Cancer Center in 2003. (edu.hk)
His research also encompasses the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems. (edu.hk)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics. (edu.au)
In addition, although some studies have shown that HOX genes are expressed in both AML samples and normal hematopoietic cells (25), the precise patterns of expression in normal versus malignant hematopoietic cells remains unclear. (biotech2012.org)

Wnt3A also regulates the Notch pathway to control the segmentation clock needed for normal torso development Wnt3a is in a signaling pathway that activates the gene Nodal which is left side signaling determinant The colon portion of the gastrointestinal tract is completely dependent on Wnt3a and Wnt3a selectively causes the growth of colon progenitors Wnt3a expands neural crest cells during early development Wnt3a promotes hematopoietic stem cell self-renewal. (wikipedia.org)
Combining gene signatures with bioinformatics databases (connectivity mapping) and drug repurposing to target leukaemic whilst sparing normal blood stem cells. (nottingham.ac.uk)
Ngoc Tung Tran, PhD, and colleagues published an article in the high-impact journal Science Advances for their work on gene editing in hematopoietic stem cells. (iu.edu)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
We centered on genes encoding cell surface area protein solely, as designated with the Gene Ontology (Move) database, with available antibodies ideal for movement cytometry commercially. (lavoixdesrroms.org)
We are combining novel engineered stromal cells with gene editing to explore a way to direct the differentiation of iPSC into hematopoietic progenitors and into a T cell/T reg lineage. (bu.edu)
A research team in Japan has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell lineages to the activity of a single gene encoding a transcription factor. (riken.jp)
Placing the final piece in the puzzle, the researchers discovered that T cell progenitors in the thymus from mice deficient in the gene Bcl11b exhibited the same halted development and self-renewal cycle, while further experiments connected up-regulation of the transcription factor encoded by this gene to IL-7 levels. (riken.jp)
Together, the findings identify Bcl11b as a "master gene" governing the final step toward differentiation into T cells, confirming the proposed model and heralding a paradigm shift in our understanding of blood cell lineages. (riken.jp)
These data provide an integrated epigenetic view of the HOX gene loci in primary AML samples, and suggest that HOX expression in most AML samples represents a normal stem cell program that is controlled by epigenetic mechanisms at specific regulatory elements. (biotech2012.org)
Initial studies of HOX gene expression in human hematopoietic cells showed that expression is largely restricted to hematopoietic stem/progenitor cells (1C4), which are uniquely capable of long-term self-renewal. (biotech2012.org)
As a result, a comprehensive view of HOX gene expression patterns in AML samplesand their relationships to normal hematopoietic cellshas not yet been established. (biotech2012.org)
Elucidation of stem cell regulatory systems in lots of systems continues to be advanced greatly lately by the use of genome-wide profiling methods to characterize gene regulatory systems in purified stem cell populations. (abic2004.org)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Research Objective We will use integrated gene editing techniques to develop a new CAR-T cell therapy for multiple myeloma treatment Impact Develop an improved CAR-T cell therapy for patients with refractory multiple myeloma and a new manufacturing strategy that circumvents the costs and inefficiencies of viral production. (ca.gov)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

Hematopoietic stem cells are pivotal in maintaining the body's blood cell supply, and their versatility makes them invaluable in both medical treatments and scientific research related to blood disorders and regenerative medicine. (thenoveldifference.com)
Progenitor cells are being explored for various therapeutic applications, including tissue engineering and regenerative medicine. (thenoveldifference.com)
We now aim at using iPS cells for disease modeling disease modeling and study their potential for regenerative medicine. (bu.edu)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. (lu.se)
They are committed to a specific cell lineage but retain the ability to generate a limited range of related cell types, making them essential for tissue repair, regeneration, and potential medical interventions. (thenoveldifference.com)
During development and lineage specification, pluripotent and adult stem cells generate the diverse arrays of specialized cells of the adult body. (distefano-lab.com)
To recognize markers that could different B-lineage-committed from uncommitted progenitors inside the CLP inhabitants possibly, we used the next seed circumstances for MiDReG (Fig. 2′-O-beta-L-Galactopyranosylorientin 1). (lavoixdesrroms.org)
For spleen cells, the lineage result is proven as a small fraction of total chimerism, with means indicated by horizontal pubs. (lavoixdesrroms.org)
Around 65% of donor cells produced from ALPs had been from the T-cell lineage (Fig. 3A), and in 10-fold better numbers compared to the T cells made by either MPPs or BLPs (Fig. 3B). (lavoixdesrroms.org)
ALPs do produce a minimal but detectable B-cell result (Fig. 3A,B), similar to the lineage potential of the initial Flk2+ thymic progenitor (Sambandam et al. (lavoixdesrroms.org)
2000). Hence, it seems Ly6d appearance marks a significant developmental changeover, when CLPs get rid of T-, DC-, and NK-cell commit and potential towards the B-cell lineage. (lavoixdesrroms.org)
Model of T cell lineage determination. (riken.jp)
Subsequently, myeloid potential is terminated and the progenitors become committed to the T cell lineage. (riken.jp)
Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells, are multi-potent stem cells from a variety of tissues with the capability of self-renewal, proliferation, differentiation into multi-lineage cell types, as well as anti-inflammatory and immunomodulatory. (thestemcellfoundation.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

Pathobiology: Cells and Genes;Cellular and Molecular Haematology. (nottingham.ac.uk)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Outcomes and Dialogue CLPs and the initial B-cell progenitors reside on the changeover from Kit-expressing progenitors to Compact disc19-expressing B-cell precursors, and therefore represent the perfect intermediates to check MiDReG using the set up seed genes. (lavoixdesrroms.org)
From this evaluation, MiDReG determined 26 genes encoding cell surface area proteins 2′-O-beta-L-Galactopyranosylorientin which were predicted to become differentially portrayed during B-cell advancement: 19 up-regulated (Fig. 1B) and seven down-regulated (Fig. 1C). (lavoixdesrroms.org)
Specifically, we have been focusing on Polycomb-group (PcG) genes, which play an important role in supporting self-renewal. (karger.com)
We aim at generating iPSC containing mutations in IRF5, Myd88, UNC93, TLRs and other relevant genes to test their role in mDC function compared to normal cells. (bu.edu)
Despite these efforts, few genes are known to play a role in the processes of stem cell self-renewal and differentiation. (bu.edu)
Therefore in the nucleus of AML stem/BPCs the β-catenin-TCF4/LEF1 complex increases manifestation of the pro-growth and pro-survival genes including cyclin D1 c-MYC and survivin while reducing Axin 2 levels1 3 15 In AML stem/BPCs Citalopram Hydrobromide multiple mechanisms are known to deregulate WNT signaling. (researchassistantresume.com)
To identify cancer drivers involved in immune evasion, we performed a CRISPR-Cas9 screen of tumor suppressor genes regulating the basal and interferon (IFN)-inducible cell surface levels of PD-L1. (dana-farber.org)
In addition, functional studies in mice demonstrated that expression of specific HOXA and HOXB genes can lead to expansion of long-term repopulating hematopoietic stem cells and a myeloproliferative phenotype (5C9). (biotech2012.org)
Many recently discovered genes that perturb HSC quiescence disrupt stem cell maintenance and homeostatic blood cell production also. (abic2004.org)
These ATG genes are highly conserved in mammalian cells, allowing to study their functions also in higher eukaryotes [ 1 - 4 ]. (hindawi.com)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)

Wnt-3a promotes the beta-catenin/Tcf pathway which is tumor inducing and can cause cancer when expressed in particular cell populations. (wikipedia.org)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
is portrayed just on T cells and for that reason this mixture would remove arrays of heterogeneous populations (e.g., whole-tissue arrays). (lavoixdesrroms.org)
We are particularly interested in the function of the MYST family of histone acetyltransferases in stem cell populations. (edu.au)
Research Objective LGR5-antibody drug conjugate to target LIC in B cell tumors that undergo self-renewal Impact LIC were only defined in myeloid leukemia, while LIC populations in B cell tumors remain elusive. (ca.gov)

Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). (lu.se)
Hematopoietic stem cells give rise to progenitor cells, which, in turn, differentiate into specific blood cell lineages. (thenoveldifference.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Reported in Science , the discovery lends support to a new model for the development of blood cells lineages. (riken.jp)
Objective: To establish cultures of cells from the pulp of permanent teeth by the explant method assessing parameters usually presented by stem cells, such as the expression of certain markers and the differentiation ability into osteogenic, adipogenic, and chondrogenic lineages. (bvsalud.org)
Similarly, the cells showed differentiation ability into all three lineages of cells tested. (bvsalud.org)

Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generation of specific cell types, especially RBC. (lu.se)

In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls HSC homeostasis and self-renewal. (jci.org)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell (HSC) homeostasis in the adult bone marrow 1,2 . (elsevierpure.com)
In the retina, a more complicated regulatory network among microglia, retinal neurons, retinal ganglial cells, retinal pigment epithelium, and other immune effector cells by exosomes are responsible for the elaborate modulation of tissue homeostasis under physical state and the widespread propagation of neuroinflammation and its consequent neurodegeneration in glaucoma pathogenesis. (bvsalud.org)
These Stem Cells are highly regulated to maintain homeostasis through a delicate balance between quiescence, self -renewal and differentiation. (bvsalud.org)
Cell fate decisions, including events that occur naturally (e.g., development, differentiation, regeneration, and homeostasis) and experimentally (e.g., reprogramming to induced pluripotent stem (iPS) cells, directed differentiation, transdifferentiation), are typically mediated by transcription factors in concert with epigenetic modifications. (distefano-lab.com)
Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. (hindawi.com)
Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)
While the importance of autophagy for cell homeostasis and survival has long been appreciated, its role in tumorigenesis and cancer progression is still developing [ 10 , 11 ]. (hindawi.com)

HSPC self-renewal and differentiation potential are tightly regulated and kept in balance. (distefano-lab.com)

Abstract: Stem cells are cells that at the single cell level both self-renew and give rise to differentiated progeny. (edu.hk)

Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Huang et al. (stemcell.com)
Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. (stemcell.com)
Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)

To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)

The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
Finally, the impact of E4 on promoting human hematopoietic engraftment in immunodeficient mice might be mediated through the regulation of mesenchymal stromal cells in the bone marrow niche. (bvsalud.org)
Plakoglobin is a component of both the adherens junctions and desmosomes, and therefore plays a vital role in the regulation of cell-cell adhesion. (oncotarget.com)
studies on cell cycle regulation and genome instability. (ncl.ac.uk)
From these data, we suggest that HoxB4 may play an important role in the regulation of pro-B cell survival under various apoptotic death environments. (kyobobook.co.kr)
Aberrant regulation of blood cell formation underlies a wide range of hematological disorders, including leukemia. (lu.se)

NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Under steady-state conditions, mice lacking the inhibitory adaptor protein Lnk harbor an expanded HSC pool with enhanced self-renewal. (jci.org)
Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice. (bvsalud.org)
Furthermore, we identified that E2 and, more significantly, E4 doubled human hematopoietic engraftment in immunodeficient mice without altering other Hematopoietic Stem and Progenitor Cells properties. (bvsalud.org)
Together, our data demonstrate that E4 is well tolerated and enhances human reconstitution in immunodeficient mice , directly by modulating human Hematopoietic Progenitor properties and indirectly by interacting with the bone marrow niche. (bvsalud.org)
Bruggeman SWM, Valk-Lingbeek ME, van der Stoop PPM, Jacobs JJL, Kieboom K, et al: Ink4A and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. (karger.com)

Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)
Focusing on novel positive regulators of primitive CML cells, the myostatin antagonist myostatin propeptide gave the largest increase in cell expansion and was chosen for further studies. (haematologica.org)
We also identified CTCF and the cohesin complex proteins, known regulators of chromatin architecture and transcription, among the most potent negative regulators of PD-L1 cell surface expression. (dana-farber.org)
Several encode transcription cell or elements routine regulators that directly modulate the proliferative activity of HSC. (abic2004.org)

Oct-4 (POU5F1) is a transcription factor that is critically involved in the self-renewal of pluripotent stem cells, and its expression is commonly used as a marker for pluripotency. (stemcell.com)
He developed the first rapid, ultra-efficient system to reprogram B cells into induced pluripotent stem cells. (distefano-lab.com)
Our lab has a major interest in the study of induced Pluripotent Stem cells or iPS cells and the development of tools for their generation and characterization. (bu.edu)
Pioneering work by the laboratory of Dr. Yamanaka showed that fibroblasts transduced with retroviral vectors expressing four transcription factors, Oct4, Klf4, Sox2 and cMyc can be reprogrammed to become pluripotent stem cells that appear almost indistinguishable from ESC. (bu.edu)
Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)

Considerably, while differentiation of HSC to multipotent progenitors (MPP) is normally associated with elevated proliferation and lack of self-renewal activity [4]C[6], change and mobilization of HSC induces proliferation without lack of self-renewal potential, demonstrating a proliferative condition will not preclude maintenance of long-term self-renewal highly. (abic2004.org)

Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells ONCOTARGET. (nottingham.ac.uk)
1 Wnt/b-catenin is also known to drive the emergence and maintenance of leukemia stem cells in AML. (haematologica.org)
A) Immunoblot of myeloid leukemia cell lines showing the relative level of b-catenin (~92 kDa) and WT1 (~50 kDa) protein, with b-actin (42 kDa) used to assess protein loading. (haematologica.org)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood. (frontiersin.org)
Akin to the normal hematopoietic system, leukemias are sustained by a small number of leukemia stem-like cells (LSC), which can be distinct from the normal hematopoietic stem cells (HSC) but also exhibit functional characteristics of self-renewal and (abnormal or hindered) differentiation, and are often quiescent ( 2 - 4 ). (frontiersin.org)
Emergence of LSC is dependent on individual or combined genetic mutations that broadly determine the cellular affiliation of the leukemia, and permit or impose ectopic self-renewal and a restricted differentiation potential into what constitutes the proliferative bulk of the leukemia ( 5 , 6 ). (frontiersin.org)
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
We have reported that the expression of BMI1 , a member of PcG, in hematopoietic stem cells or progenitor cells predicts the prognosis of patients with MDS and progression to acute leukemia. (karger.com)
β-catenin is also required for the HOXA9 and MEIS1-mediated transformation of the hematopoietic stem cells MLL-AF9-mediated transformation of the committed myeloid progenitor cells as well as necessary for the development and growth of MLL fusion protein-transformed leukemia stem cells2-5. (researchassistantresume.com)
Cell intrinsic WNT-β-catenin activation in human being AML stem cells makes them independent of the leukemia niche-derived WNT signals4. (researchassistantresume.com)
In FLT3-ITD-expressing AML stem/BPCs and in chronic myeloid leukemia blast problems myeloid progenitor (GMP) cells. (researchassistantresume.com)
We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)
Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
By studying murine transgenic leukemia models developed in our laboratory, we are currently exploring the relationships between hematopoietic progenitor cell identities and the development and progression of acute leukemia. (lu.se)

Although hematopoietic stem cells (HSC) are the best characterized and the most clinically used adult stem cells, efforts are still needed to understand how to best ex vivo expand these cells. (stemcell.com)
By genetically manipulating EVI1 expression, we were able to alter HSC and progenitor output from precursors in vivo. (elsevierpure.com)
In glaucoma, the crucial role of exosome-based crosstalk has been primarily revealed in animal models and ex vivo cell studies in the recent decade. (bvsalud.org)
On the other hand, BLPs, like pre-pro-B cells, created nearly B cells solely, comprising almost 90% of donor-derived cells (Fig. 3A), and in amounts much larger than ALPs (Fig. 3B), recommending that BLPs are nearly fully focused on the B-cell destiny even when positioned straight into a highly T-cell-inducing environment in vivo. (lavoixdesrroms.org)
In line with these observations, the allogeneic CAR T cells showed superior cytotoxicity in in vitro assays, and they efficiently targeted primary multiple myeloma cells in an ex vivo model. (liangyihui.net)
HoxB4, a homeodomain-containing transcription factor, is involved in the expansion of hematopoietic stem cells and progenitor cells in vivo and in vitro, and plays a key role in regulating the balance between hematopoietic stem cell renewal and cell differentiation. (kyobobook.co.kr)
Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)

Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
We previously showed that constitutive overexpression of the oncogenic transcription factor Spi1/PU.1 leads to pre-leukemic cells that have a shortened S phase duration with an increased replication fork speed and increased mutability in the absence of DNA breaks. (oncotarget.com)

3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
The production of distinct blood cell types can be selectively adapted to meet an individual's acute needs, such as for instance the rapid and enhanced generation of innate immune cells following infection. (lu.se)

By accessing primary human target cells we hope to establish a new paradigm in the use of iPSC-derived cells for infectious diseases. (bu.edu)
Our long standing interest in the immune system now focuses in the utilization of iPSC-derived immune cells, including myeloid dendritic cells (mDCs), T cells and others as the basis to study several inflammatory diseases such as lupus erythematosus and the signaling cascade responsible for immune dysregulation. (bu.edu)

Single-cell RNA-seq unmasked the existence of two subsets within the LT-HSC population that was apparent upon stimulation but not steady-state. (biorxiv.org)
Our results show that human Hematopoietic Stem and Progenitor Cell subsets express estrogen receptors , and whose signaling is activated by E2 and E4 on these cells . (bvsalud.org)

ADAR1 silencing in breast cancer cells leads to increased apoptosis, suggesting an anti-apoptotic function that promotes cancer progression. (cancerindex.org)
By exogenously modulating its activity, we demonstrate that PP1α is required to maintain CHK1 in a dephosphorylated state and, more importantly, that it is responsible for the accelerated replication fork progression in Spi1/PU.1-overexpressing cells. (oncotarget.com)
Moreover, the progression from early to late apoptotic stages was inhibited in Ba/F3 cells subjected to HoxB4 overexpression under removal of interleukin-3-mediated signal, leading to the induction of cell cycle arrest at the G2/M phase and attenuated cell death by Fas protein stimulation in vitro. (kyobobook.co.kr)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)

Wnt3a plays a role in these processes: Wnt3A patterns a multipotent stem cell population that form neurons, muscles, bones, and cartilage of the torso region. (wikipedia.org)

We assayed telomerase activity in single cells of the hematopoietic and immune systems. (nih.gov)
These remarkable cells play a crucial role in the production and maintenance of the body's blood and immune cell supply. (thenoveldifference.com)
Dendritic cells play a central role in the modulation of the immune response and several inflammatory diseases have been shown to have altered mDC function. (bu.edu)
CAR T cells generated from healthy donors showed a higher percentage of memory CD8+ T cells and lower expression of immune checkpoint proteins than those generated from patients with relapsed disease, suggesting that allogenic CAR T cells may be more cytotoxic. (liangyihui.net)
A key determinant of the immune system's efficacy against diseases and tumors is the diversity of B-cell and T-cell receptors, which is most pronounced in the complementarity determining region 3 (CDR3) of the receptors. (liangyihui.net)
When someone gets sick, they use their adaptive immune system as a pathogen fighter or defense against changed body cells. (jewelryon.com)
A team at Children's Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. (ca.gov)
The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)

bone tissue marrow had been stained to examine adjustments in the proportions of MPP, ALP, BLP, and pre-pro-B cells. (lavoixdesrroms.org)

Progenitor cells are often located within specific tissues, close to where they will ultimately function. (thenoveldifference.com)
They offer the potential to replace damaged or dysfunctional cells in specific tissues or organs. (thenoveldifference.com)
The structural integrity of these tissues requires extensive cell-cell adhesion and interactions mediated by the adhesive junctional complexes consisting of the adherens junctions and desmosomes [ 2 - 5 ]. (oncotarget.com)
Over the last years, dentistry has been exploring the potential application of stem cells from different origins in the regeneration of oral tissues that were lost or damaged by disease or trauma 1 . (bvsalud.org)

Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)
In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
However, both human and mouse stress erythropoiesis use signals and progenitor cells that are distinct from steady-state erythropoiesis. (psu.edu)
Additionally, these natural estrogens cause different effects on human Progenitors in vitro . (bvsalud.org)
We found that both E2 and E4 expand human Hematopoietic Stem and Progenitor Cells . (bvsalud.org)
However, E4 was the best tolerated estrogen and promoted cell cycle of human Hematopoietic Progenitors. (bvsalud.org)
We have also modified it to make it excisable and have used it to generate mouse and human iPS cells free of exogenous transgenes. (bu.edu)
Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots when dysregulated. (ca.gov)

However the tightly governed equilibrium between HSC quiescence and proliferation is actually very important to long-term maintenance of stem cell function, some physiologic features of HSC need short-term perturbation of the balance. (abic2004.org)

CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. (bmbreports.org)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)

3 Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. (nih.gov)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)

Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)

Immature stress erythroid progenitors (SEPs) are derived from short-term hematopoietic stem cells. (psu.edu)

WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
Once a cell type is specified, the mechanisms that restrict and maintain cell fate are important in ensuring tissue integrity, and their dysregulation often results in disease, particularly cancer. (distefano-lab.com)
The localization of RNAs in the cell can influence their folding, editing, splicing, translation, degradation, and even the fate of the proteins they encode. (distefano-lab.com)
Recently, RNAs have been shown to be selectively sequestered in cytoplasmic condensates, however, the functional role and composition of RNA condensates during cell fate specification remain unknown. (distefano-lab.com)
There his work focused on the mechanisms that control transcription factor-induced cell fate change. (distefano-lab.com)
This unique ability makes them ideal candidates to model early development allowing us to study the basic signaling mechanisms involved in stem cell fate determination. (bu.edu)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
In normal cells, the fate of pyruvate depends on many factors, one of which is oxygen availability. (hindawi.com)

These include red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes), all of which are vital for various functions in the body. (thenoveldifference.com)
Hematopoietic stem cells have the unique capacity to continuously self-renew and maintain a pool of stem cells for the lifelong production of blood cells. (thenoveldifference.com)
This regenerative ability ensures a constant supply of blood cells throughout an individual's lifetime. (thenoveldifference.com)
Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production of all blood cells . (bvsalud.org)
While varying widely in function, all blood cells share a common origin in progenitors known as hematopoietic stem cells (HSC). (riken.jp)

According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. (bmbreports.org)
The authors propose allogeneic healthy donor CAR T cells as a potential therapeutic option for patients with relapsed multiple myeloma. (liangyihui.net)
In recent years his work has included studying the potential of CD47 as a cancer therapeutic and identifying cancer stem cells from a variety of blood and solid cancers. (edu.hk)

Epigenetic analysis of a subset of AML samples also identified common regions of chromatin accessibility in AML samples and normal CD34+ cells that displayed differences in methylation depending on HOX expression patterns. (biotech2012.org)

In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

Developmental Cell. (wikipedia.org)
This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential. (nih.gov)
Bcl11b deficiency induces developmental arrest at the myeloid-T progenitor stage, and the arrested myeloid-T progenitors enter a self-renewal cycle. (riken.jp)

Progenitor cells, also known as precursor cells, are a type of cell that falls somewhere between stem cells and fully differentiated, specialized cells in terms of their differentiation potential. (thenoveldifference.com)
Launch Hematopoietic stem cells (HSC) are uncommon, multipotent, self-renewing precursor cells with the capacity of generating every single specialized cell from the bloodstream system. (abic2004.org)

Solid as well as blood cancers are associated with overexpression of HOX proteins in the nucleus, which is traditionally a difficult area of the cell to target with conventional drugs. (nottingham.ac.uk)
Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
The ability to self-renew is also potentially dangerous, as poorly regulated self renewal is, we believe, a central lesion in all cancers. (edu.hk)
Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)

The telomerase-expressing somatic cells observed in this study are not thought to be immortal, and expression was not correlated with cell cycle distribution or differentiation state. (nih.gov)
In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)

Anatomy57

Organisms16

Diseases15

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Psychiatry and Psychology2

Phenomena and Processes50

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Named Groups1

Health Care2

Transplantation12

HSCs32

Pathways15

Embryonic7

Transcriptional8

Proliferation and differentiation3

HSPCs5

Hematopoiesis6

Myeloid cells6

Lymphoid6

Biology6

Malignant hematopoietic2

Gene17

Regenerative medicine4

Lineage17

Genes17

20161

Populations5

Lineages6

Heterogeneity1

Homeostasis9

Self-renewal and differentiation1

Abstract1

Cord blood3

CD341

Regulation6

Mice6

Regulators4

Pluripotent5

Long-term self-renewal1

Leukemia15

Vivo7

Leukemic cells2

Acute3

IPSC2

Subsets2

Progression5

Multipotent stem cell1

Immune8

Bone tissue marrow1

Tissues4

Human12

Tightly1

Aberrant2

Apoptosis3

Expansion1

Immature1

Fate8

Blood cells5

Therapeutic3

Chromatin1

Transcription2

Developmental3

Precursor2

Cancers4

Somatic3