AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed GroupsHealth Care
Cord Blood Stem Cell TransplantationHematopoietic Stem CellsHematopoietic Stem Cell TransplantationFetal BloodTransplantation, HomologousStem CellsSpinal CordGraft vs Host DiseaseAntigens, CD34HematopoiesisBone Marrow TransplantationTransplantation ConditioningStem Cell TransplantationSpinal Cord InjuriesBone Marrow CellsHematopoietic Stem Cell MobilizationHematologic NeoplasmsCell LineageColony-Forming Units AssayCell DifferentiationTransplantation ChimeraUmbilical CordMice, Inbred C57BLFlow CytometryGraft SurvivalCells, CulturedBlood BanksCell SeparationStem Cell NicheBone MarrowHistocompatibility TestingTransplantation, AutologousLeukemiaWhole-Body IrradiationTissue DonorsMice, SCIDInfant, NewbornT-LymphocytesStem Cell FactorAdult Stem CellsMice, Inbred NODHistocompatibilityAntigens, CDCell ProliferationNeoplastic Stem CellsGraft vs Leukemia EffectPlant StemsChimerismTime Factors
TransplantationHSCTTransplantsPeripheralProgenitor cellHuman allogeneic stem cellsType of allogeneic transplantTherapiesUmbilical cordTransplantationsHematologic malignanciesMyeloablativeClinicalGraftHigh-dose chemotherapy or radiationMorbidity and mortaCancersHSCsAcute2018AdultMalignanciesTaken from a donorRecipientsCell transplant patientsOmidubicelDonor source for patientsPediatric2023GVHDMultipotentImmune SystemCells in the bone maEngraftmentEmbryonicRegenerative medicineChemotherapyInfusion
Transplantation77
HSCT13
  • Worldwide, 50,000 hematopoietic stem cell transplant (HSCT) procedures are undertaken annually to replace a person's blood-forming cells - hematopoietic stem cells (HSCs) - to treat blood disorders and cancers, yet two-thirds of patients who need HSCT lack matched donor tissue. (utoronto.ca)
  • If more donors where available and the efficacy and safety of HSCT improved, HSCT could benefit more patients with blood diseases. (utoronto.ca)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • Many of these patients needed an allogeneic hematopoietic stem cell transplant (HSCT)-also known as a blood stem cell transplant-to treat their disease. (cellculturedish.com)
  • The FDA approved the blood forming stem cells derived from cord blood for use in patients who need unrelated HSCT for a disorder of the hematopoietic system. (cellculturedish.com)
  • HSCT may be autologous (the patient's stem cells are used) or allogeneic (the stem cells come from a donor). (smart-immune.com)
  • Allogeneic HSCT carries significant risks such as rejection of the graft, infection, graft versus host disease (GVHD), and potential long-term side effects, translating into a 50% morbidity and mortality rate at 3 years post HSCT. (smart-immune.com)
  • Smart Immune's ProTcell platform is designed to reconstitute a T-cell compartment in around three months , compared with 12-18 months through the standard HSCT approach, significantly reducing the time to full immune recovery and possibly opening access to allogeneic medicine to more patients. (smart-immune.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (yashfiin.com)
  • The overall and sustained clinical benefit of omidubicel makes it an important addition to the options for allogeneic HSCT. (gamida-cell.com)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Transplants14
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
  • Early reports indicated cell engraftment from bone marrow transplants into non- hematopoietic tissues in mouse to mouse and in human allogeneic bone marrow transplants. (ucl.ac.uk)
  • Most of these therapies require allogeneic transplants, where the patient must use a genetically-matched cord blood donor. (bioinformant.com)
  • Our providers specialize in pediatric blood and marrow transplants and cellular therapy, so you can trust that your child is in good hands. (childrenscolorado.org)
  • Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
  • Cord blood transplants are an alternative to using stem cells from a matched adult donor. (vanyahealth.com)
  • Dr. Nagler established the first public cord blood bank in Israel and performed the first cord blood transplants from related and unrelated donors in genetic and malignant hematological diseases in Israel. (labiotech.eu)
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
  • The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
Peripheral10
Progenitor cell2
  • Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood. (wikipedia.org)
  • Smart Immune announced in October 2022 that SMART102, a human T-cell progenitor cell injection derived from cord blood using the ProTcell platform, has entered clinical testing with the first adult patient treated. (smart-immune.com)
Human allogeneic stem cells2
Type of allogeneic transplant4
  • Haploidentical transplant, also known as half-matched transplant, is a type of allogeneic transplant where the donor and the recipient are not a perfect match but share one haplotype (half of the genetic material) in common. (vanyahealth.com)
  • Cord blood transplant is a type of allogeneic transplant that uses stem cells from the umbilical cord of a newborn baby. (vanyahealth.com)
  • Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
Therapies11
  • Regardless of when contamination occurred, this investigation highlights the serious potential risks to patients of stem cell therapies administered for unapproved and unproven uses other than hematopoietic or immunologic reconstitution ( 5 ). (cdc.gov)
  • An assessment of over 20 commonly targeted therapeutic areas and details of stem cell-based therapies being developed to treat the same conditions. (blavida.com)
  • The methods proposed are cutting-edge and no other team in the world has this combination of technologies, approaches and expertise to make advances in hematopoietic cell therapies. (utoronto.ca)
  • T-cell therapies can be manufactured from different materials (mature T-cells, stem cells, possibly induced pluripotent stem cells) and from different sources (the patient or a donor). (smart-immune.com)
  • Smart Immune is the first company to develop thymus-empowered allogeneic T-cell therapies and advance them into clinical testing through its T-cell progenitor platform, ProTcell. (smart-immune.com)
  • ProTcell is Smart Immune's thymus-empowered T-cell therapy platform to fully and rapidly re-arm the immune system, aimed at enabling next-generation allogeneic T-cell therapies for all. (smart-immune.com)
  • The ProTcell platform has the potential for enabling a broad range of future applications including CAR ProTcell for allogeneic, long-lasting, targeted immuno-oncology therapies. (smart-immune.com)
  • Gamida Cell is pioneering a proprietary NAM-enabled immunotherapy pipeline of diverse potentially curative cell therapies for patients with solid tumor and blood cancers and other serious blood diseases. (gamida-cell.com)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)
Umbilical cord13
  • Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
  • The only Food and Drug Administration (FDA)-approved stem cell products are derived from umbilical cord blood, and their only approved use is hematopoietic and immunologic reconstitution ( 1 ). (cdc.gov)
  • On September 17, 2018, the Texas Department of State Health Services received notification of Enterobacter cloacae and Citrobacter freundii bloodstream infections in three patients who had received injections or infusions of non-FDA-approved umbilical cord blood-derived stem cell products processed by Genetech, Inc., and distributed by Liveyon, LLC, for other than hematopoietic or immunologic reconstitution at an outpatient clinic on September 12. (cdc.gov)
  • Umbilical cord blood cannot be decontaminated after collection because there are currently no validated processes for sterilization, so manufacture of derived products must be highly controlled to prevent distribution of contaminated products ( 4 ). (cdc.gov)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • Despite advances in using umbilical cord blood, donor material remains restricted by limited stem cells and the lack of ethnic diversity to provide sufficiently matched material. (utoronto.ca)
  • Many people look at umbilical cord blood as medical waste after a baby's birth. (cellculturedish.com)
  • Researchers are using umbilical cord blood to develop NK cells, NK-CAR and other types of T cells. (cellculturedish.com)
  • Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
  • Umbilical cord blood (UCB) was once considered a waste product and was discarded with the placenta after delivery. (reportsanddata.com)
  • For umbilical cord blood harvest, the cord is clamped after delivery of the baby, and blood is drawn from the cord with a needle and collected in a sterile bag. (msdmanuals.com)
  • Stem cells are removed from a newborn baby's umbilical cord right after birth. (medlineplus.gov)
  • Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
Transplantations2
  • In the last decade, the number of transplantations of HPCs derived from cord blood has increased, particularly for children. (nationalacademies.org)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Hematologic malignancies2
  • Omidubicel is an advanced cell therapy under development as a potential life-saving allogeneic hematopoietic stem cell transplant for patients with hematologic malignancies (blood cancers), for which it has been granted Breakthrough Status and orphan drug designation by the FDA. (gamida-cell.com)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
Myeloablative1
  • Based on our findings, we suggest that 131 I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible. (biomedcentral.com)
Clinical3
  • Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. (elsevierhealth.com)
  • My core clinical focus is autologous, allogeneic and cord blood hematopoietic stem cell transplant patients with blood cancers. (dukehealth.org)
  • Recently presented data continue to support the clinical benefits and safety of omidubicel, which, if approved, may be a valuable new donor source for patients in need of allogeneic stem cell transplant. (advfn.com)
Graft7
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
  • I used cord blood almost exclusively as the graft source for transplant unless a patient had an HLA-matched sibling. (cellculturedish.com)
  • There are medical benefits to using cord-such as less graft-versus-host disease (GvHD) and less relapse-that made it my preferred graft source. (cellculturedish.com)
  • The donor's cells are not as well matched to the patient's cells as in a standard allogeneic transplant, which increases the risk of complications such as graft-versus-host disease (GVHD) and graft rejection. (vanyahealth.com)
  • My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
High-dose chemotherapy or radiation2
  • Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
Morbidity and morta1
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
Cancers12
  • Omidubicel, sold under the brand name Omisirge, is a blood-based cell therapy used for the treatment of blood cancers. (wikipedia.org)
  • All participants in the study had confirmed blood cancers. (wikipedia.org)
  • The FDA has approved Gamida Cell 's omidubicel-onlv, now to be marketed as Omisirge , in patients over 12 years of age with blood cancers, the company announced Monday. (pharmalive.com)
  • A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • Our top-ranked hematology, oncology, blood and marrow transplant and cellular therapy programs are national leaders in new and advanced treatments for pediatric cancers and blood diseases. (childrenscolorado.org)
  • This procedure is typically used to treat blood cancers such as leukemia, lymphoma, and multiple myeloma, as well as other disorders such as sickle cell anemia and thalassemia. (vanyahealth.com)
  • The failure of the immune system to function as it should, can result from immune deficiencies present at birth, acquired diseases such as blood cancers, medications that suppress or damage the immune system, unnecessary or over-the-top immune responses such as allergies, or immune responses to one's self, called autoimmunity. (smart-immune.com)
  • It is a therapeutic option for treating several serious blood cancers and some other conditions. (smart-immune.com)
  • Smart Immune is working to improve the prognosis of immune-compromised patients with life-threatening diseases such as high-risk blood cancers and primary immunodeficiencies. (smart-immune.com)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
  • For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
HSCs6
  • Hematopoietic stem cells (HSCs) are defined as stem cells that have a preference for becoming cells of the blood and immune system, such as white blood cells, red blood cells, and platelets. (bioinformant.com)
  • Hematopoietic stem cells (HSCs) are the stem cells that repopulate the blood and immune system within humans, via a process known as haematopoiesis. (bioinformant.com)
  • Thus, alternative sources of patient-specific hematopoietic stem cells (HSCs) are required. (utoronto.ca)
  • The generation of HSCs has been a long-standing goal of stem cell biologists working in the field of developmental hematopoiesis. (utoronto.ca)
  • HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
  • CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
Acute1
  • [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
20182
  • On September 22, the Florida Department of Health received notification of Escherichia coli , Enterococcus faecalis, and Proteus mirabilis joint infections in four patients who had received injections of these same products at an orthopedic clinic during February 15-August 30, 2018, also for other than hematopoietic or immunologic reconstitution. (cdc.gov)
  • As of 2018, Cord blood segment is the dominating cord blood banking services market which holds 32.5% of the global market and generates highest revenue. (reportsanddata.com)
Adult6
  • For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
  • This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)
  • Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
  • Mesenchymal adult stem cells ( MSCs ) with their anti-inflammatory, immunomodulatory, self-renewal, cell-division, signaling, and multilineage differentiation properties are the perfect choice for reducing the severity of systemic immune-mediated (autoimmune) diseases like psoriasis. (plexusnc.com)
  • The main advantage is that cord blood cells are less mature than adult stem cells, which makes it less likely for the patient's immune system to reject the transplant. (vanyahealth.com)
  • Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
Malignancies1
  • There is also a small risk of infections and malignancies from donor blood. (medscape.com)
Taken from a donor2
  • However, if the patient has a family history of the condition, then doctors may recommend using allogeneic cord blood stem cells (taken from a donor). (plexusnc.com)
  • In this type of transplant, stem cells are taken from a donor (usually a close relative or sibling) and given to the patient. (vanyahealth.com)
Recipients3
  • Avoiding and monitoring transfusion-transmissible diseases (TTDs) is crucial to ensure the safety of blood transfusions and protect both donors and recipients. (researchgate.net)
  • The recipients who will be using the cord blood units for their treatment will be charged. (reportsanddata.com)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
Cell transplant patients1
  • The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)
Omidubicel3
  • In total, 125 participants were randomized--62 participants to receive omidubicel-onlv and 63 to the unmanipulated cord blood group. (wikipedia.org)
  • The company highlighted positive data, productive regulatory interactions and progress on commercial readiness activities supporting its lead product candidate, omidubicel, an advanced cell therapy candidate for allogeneic stem cell transplant, as it advances toward its May 1, 2023 target Prescription Drug User Fee Act (PDUFA) action date. (advfn.com)
  • The translational data from our Phase 3 study of omidubicel, our lead product candidate, show faster, multi-faceted immune response - as quickly as seven days-in omidubicel-treated patients compared to standard cord blood. (oilnow.gy)
Donor source for patients1
  • These data add to the substantial body of knowledge that supports omidubicel's potential, if approved, as a new advanced cell therapy donor source for patients in need of an allogeneic stem cell transplant. (oilnow.gy)
Pediatric3
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • That's why our Pediatric Blood and Marrow Transplant and Cellular Therapy Program team is committed to the highest standards of quality, the latest and most proven treatments, and the overall care and well-being of your child and family. (childrenscolorado.org)
  • Our team is the region's most experienced pediatric blood and marrow transplant and cellular therapy (BMT) program. (childrenscolorado.org)
20232
  • Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase, Blood Advances, Vol.7, No.6, 1019-1032, 2023. (matci.jp)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
GVHD2
  • The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
  • GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
Multipotent2
  • B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
  • These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
Immune System4
  • Five years later in 1988, the first successful cord blood transplant to restore a patient's blood and immune system cells took place in France. (bioinformant.com)
  • For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
  • For this type of cellular therapy, we draw blood from a patient to collect circulating T cells, which are an important part of the body's immune system. (childrenscolorado.org)
  • Cord blood, the blood left in the placenta after a baby is born, has been proved to be as effective as bone marrow in saving children who suffer from leukemia or people whose immune system has been damaged. (china.org.cn)
Cells in the bone ma2
Engraftment4
  • NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
  • Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
  • However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
Embryonic4
  • Embryonic stem cells were first identified in mice (Martin, 1981). (bmrat.org)
  • Embryonic stem cells are pluripotent, meaning they are able to produce all cell types in the body. (bmrat.org)
  • Recently, scientists have discovered how to reprogram normal cells to behave like embryonic stem cells. (bmrat.org)
  • The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)
Regenerative medicine3
  • In addition to a long history of use within transplant medicine, human cord blood cells are playing a growing role within regenerative medicine. (bioinformant.com)
  • Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
  • This book also has a dedicated section on Regenerative Medicine with chapters on platelet rich plasma, stem cell therapy, and intradiscal regenerative therapy. (nshealth.ca)
Chemotherapy6
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • In this type of transplant, the patient's own stem cells are collected before the high-dose chemotherapy and/or radiation therapy is given. (vanyahealth.com)
  • After the chemotherapy and radiation therapy, the stored stem cells are thawed and returned to the patient's body. (vanyahealth.com)
  • In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
Infusion2
  • Cord blood is also readily available and I could have the cord blood unit in my hands for patient infusion in two weeks. (cellculturedish.com)
  • She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)