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  • acute lymphobl
  • However, these models have struggled to recapitulate the defining features of JMML due to in utero lethality, nonhematopoietic expression, and the pervasive emergence of T cell acute lymphoblastic leukemia. (jci.org)
  • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. (springer.com)
  • bone marrow
  • Injury induces the recruitment of bone marrow-derived cells (BMDCs) that contribute to the repair and regeneration process. (bloodjournal.org)
  • Bone marrow contains a pool of stem cells that reconstitute the hematopoietic system throughout the life of the organism. (bloodjournal.org)
  • Bone marrow-derived cells (BMDCs) also migrate to and participate in homeostasis of tissues such as muscle, intestines, and skin (reviewed in 1 , 2 ). (bloodjournal.org)
  • Introduction] Recent reports demonstrating the ability of bone marrow (BM) cells to regenerate cardiomyocytes (CMs) have prompted clinical as well as basic studies for the treatment of ischemic and non-ischemic cardiomyopathies. (ahajournals.org)
  • The presence of disseminated tumor cells in breast cancer patient bone marrow aspirates predicts decreased recurrence-free survival. (aacrjournals.org)
  • After successful bone marrow transplantation, hematopoietically active stem cells repopulate the bone marrow in a predictable pattern which has been described by Stevens, et al.30. (amazonaws.com)
  • Marrow replacement disorders are exemplified by proliferation of abnormal (usually malignant) cells in the bone marrow. (amazonaws.com)
  • B) Flow cytometry analysis of C57BL/6 mouse bone marrow cells pre-labeled with Anti-Mouse Sca1 Antibody, Clone E13-161.7, Alexa Fluor® 488 and processed with the EasySep™ Mouse SCA1 Positive Selection Kit. (stemcell.com)
  • Histograms show labeling of bone marrow (Start) and isolated cells (Isolated). (stemcell.com)
  • Mesenchymal stem cells (MSC), the most important component of marrow microenvironment, have been defined as primitive, non-hematopoietic cells residing primarily in bone marrow, and capable of giving rise to different cell lineages, including fat, muscle, cartilage, bone, and fibroblasts ( 5 - 7 ). (pubmedcentralcanada.ca)
  • gene expression
  • iPSC clones from blood and other cell sources showed similar ultrastructural morphologies and genome-wide gene-expression profiles. (biomedcentral.com)
  • The myb family of transcription factors regulates tissue-specific gene expression in the hematopoietic system, as well as in the testis. (bloodjournal.org)
  • Biernaux C, Loos M, Sels A, Huez G, Stryckmans P (1995) Detection of major BCR-ABL gene expression at a very low level in blood cells of some healthy individuals. (springer.com)
  • C/EBPα induced a strong myeloid gene expression signature and down-regulated E2A-induced regulators of early lymphoid development. (bloodjournal.org)
  • In contrast several studies have shown a significant proportion (44-55%) of cytogenetic alterations in MDS-derived MSC ( 9 , 14 ), and more recent studies involving the use of genomic tools have demonstrated alterations at the gene expression level in these cells ( 15 ). (pubmedcentralcanada.ca)
  • phenotype
  • Here we show that sustained expression of Hoxa3 in diabetic-derived BMD Gr-1 + CD11b + cells reverses their diabetic phenotype. (bloodjournal.org)
  • This manifests in expansion of cells with the phenotype of MDSC. (nih.gov)
  • EC incubation with IL-6 did not improve cell expansion in comparison to non-stimulated EC supernatant, while the HPCs' phenotype and functional capacities were retained. (nih.gov)
  • granulocytes
  • CCAAT/enhancer binding protein α (C/EBPα) represents one of these factors and is involved in myeloid development and indispensable for formation of granulocytes. (bloodjournal.org)
  • Expanded progenitors from all interleukin conditions were further matured into functional granulocytes. (nih.gov)
  • HPCs
  • Because the use of blood cells allows minimally invasive tissue procurement under GMP conditions and rapid cellular reprogramming, mobilized HPCs and unmobilized PBMCs would be ideal somatic cell sources for clinical-grade iPSC derivation, especially from diabetes patients complicated by slow-healing wounds. (biomedcentral.com)