AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowHematopoietic Stem CellsTransplantation, HomologousBone Marrow CellsHematologic NeoplasmsHematopoietic Stem Cell TransplantationGraft vs Host DiseaseLeukemiaTransplantation, AutologousWhole-Body IrradiationBone and BonesTransplantation ConditioningHematopoiesisAnemia, AplasticTransplantation ChimeraGraft SurvivalTissue DonorsLiver TransplantationBusulfanLeukemia, Myeloid, AcuteLymphomaHistocompatibility TestingBone Marrow PurgingStem CellsPrecursor Cell Lymphoblastic Leukemia-LymphomaHistocompatibilityMice, Inbred C57BLLeukemia, MyeloidCyclophosphamideTransplantation, IsogeneicLymphoma, Non-HodgkinStem Cell TransplantationMyelodysplastic SyndromesCell DifferentiationBone Marrow DiseasesRadiation ChimeraRecurrenceKidney TransplantationColony-Forming Units AssayCombined Modality TherapyMultiple MyelomaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveTreatment OutcomeMyeloproliferative DisordersTime FactorsFlow CytometryImmunosuppressive AgentsRemission InductionBone Marrow ExaminationAntigens, CD34Hepatic Veno-Occlusive DiseaseGraft RejectionTransplantation ImmunologyBone RemodelingHematopoietic Stem Cell MobilizationBone Marrow NeoplasmsLymphocyte DepletionRetrospective StudiesAcute DiseaseSevere Combined ImmunodeficiencyImmunosuppressionGraft vs Host ReactionGene Expression Regulation, LeukemicT-LymphocytesLeukocyte TransfusionHLA AntigensHematologic DiseasesSurvival AnalysisChimeraCell LineageHeart TransplantationCell ProliferationNeoplasmsCells, CulturedGranulocyte Colony-Stimulating FactorLymphocyte TransfusionGraft vs Leukemia EffectCyclosporineAntineoplastic Combined Chemotherapy ProtocolsLung TransplantationSurvival RateActuarial AnalysisCord Blood Stem Cell TransplantationFollow-Up StudiesGraft vs Tumor EffectCell SeparationBone DensityPancytopeniaSpleenNuclear FamilyMice, KnockoutCytomegalovirus InfectionsOrgan TransplantationCarmustineLeukocyte CountMice, Inbred BALB CChimerismCytarabineDisease-Free Survival
HSCTCurativeDonorHematological malignChemotherapyProgenitorTherapy and autologous bone marrow traImpaired hematopoietic stemTransplantsPrevention of relapse followingDisordersGraft versusBloodClinicalHematologyAllogeneic haematopoieticKidney transplantationRevealing a hypocellularRelapsePost-transplantationStromal cellPediatricCell Transplant Recipients2000BiologyTreatmentCytopeniasOrganMesenchymalCharacterized by peripheralLymphomaEngraftmentSurvivalSupportive careGVHDAccess to transplantationMorbidity and mortaBiopsyReconstitutionMyeloproliferativeDiseasesMalignantHematopoiesisCancersTissuesLiverHSCs
HSCT15
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • The year 2020 marked the 30th anniversary of the Nobel Prize in Medicine awarded to E. Donnall Thomas for the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat hematologic malignancies and other blood disorders. (broadinstitute.org)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. (lidsen.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • The purpose of this study is to evaluate the effectiveness of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal aGvHD-free survival by Day +180 in participants who receive allo-HSCT as treatment for a hematologic malignancy or myeloproliferative disorder. (mayo.edu)
  • The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
  • Allogeneic hemopoietic stem cell transplantation (HSCT) is the only curative option for many patients with hematological malignancies. (nih.gov)
  • Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Curative6
Donor17
  • Slavin pioneered the use of immunotherapy mediated by allogeneic donor lymphocytes and innovative methods for stem cell transplantation for the cure of hematological malignancies and solid tumors, and using hematopoietic stem cells for induction of transplantation tolerance to bone marrow and donor allografts. (wikipedia.org)
  • In early 1987 Slavin introduced the concept of cancer immunotherapy using donor lymphocytes infusion (DLI) for the treatment and prevention of recurrent disease and pioneered the use of adaptive allogeneic cell-mediated immunotherapy and cytokine-activated lymphocytes for both treatment and prevention of relapse following allogeneic and autologous stem cell transplantation for hematologic malignancies and solid tumors. (wikipedia.org)
  • Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • If you receive stem cells from a donor, the transplanted stem cells may attack your body. (cdc.gov)
  • We treated 18 patients with acute leukemia for marrow ± extramedullary relapse after a previous alloHSCT with a myeloablative cytoreductive regimen including clofarabine, melphalan, and thiotepa followed by a second or third transplantation from the same or a different donor. (bvsalud.org)
  • Experimental methods have principally centered on strategies that make use of ex vivo remedies to increase the figures or raise the effectiveness of donor hematopoietic stem cells ahead of transplantation (2C4). (thetechnoant.info)
  • The collaboration supports NiCord ® , Gamida Cell's investigational cell therapy, which has the potential to serve as a universal bone marrow donor source for patients with hematologic malignancies, or blood cancers, and bone marrow failure disorders requiring bone marrow transplantation. (bethematchbiotherapies.com)
  • 1 NiCord is designed to potentially serve as a universal alternative to existing donor sources for bone marrow transplant. (bethematchbiotherapies.com)
  • Our two organizations share the belief that new cell therapies are needed not only to improve outcomes for patients undergoing stem cell transplants but also to offer patients unable to find a matched donor the chance for a successful transplant," stated Julian Adams, Ph.D., chief executive officer of Gamida Cell. (bethematchbiotherapies.com)
  • Backed by the industry-leading experience of the National Marrow Donor Program/Be The Match , and a research partnership with the CIBMTR ® (Center for International Blood and Marrow Transplant Research ® ), the organization designs solutions that advance cell and gene therapies in any stage of development. (bethematchbiotherapies.com)
  • PURPOSE OF REVIEW: 2008 marks the 20th anniversary of the first use of umbilical cord blood (UCB) as a source of donor cells for hematopoietic stem cell transplantation. (duke.edu)
  • UCB increases access to transplantation therapy for many patients unable to identify a fully matched adult donor. (duke.edu)
  • Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. (sagepub.com)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
  • The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
Hematological malign1
Chemotherapy18
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • These observations that confirmed the therapeutic benefits of cell therapy led to the development of new concepts for the treatment of hematologic malignancies and solid tumors focusing on utilizing well-tolerated non-myeloablative stem cell transplantation as a platform for cell therapy of cancer targeting killer cells against chemotherapy-resistant malignant cells. (wikipedia.org)
  • Using procedures developed by Slavin and his team, treatment of cancer is based on bright rather than aggressive treatment with conventional chemotherapy, which is associated with immediate and late procedure-related toxicity and mortality, aiming at selective elimination of all malignant cells including cancer stem cells. (wikipedia.org)
  • Lymphoma is the most common haematopoietic malignancy in dogs, and is the most responsive to chemotherapy. (vin.com)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • I am scheduled to undergo stem cell transplantation and chemotherapy in the next month due to recurrence of lymphoma in the lymph nodes surrounding my spleen. (pocketdentistry.com)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants. (medlineplus.gov)
Progenitor5
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • This reduced differentiation of CD34+ hematopoietic progenitor stem cells could occur due to both infectious and non-communicable diseases and also due to their drug induced treatments. (hoajonline.com)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Therapy and autologous bone marrow tra1
Impaired hematopoietic stem1
Transplants9
  • Stem cell transplants have many benefits, but they also have risks. (cdc.gov)
  • Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
  • Several studies have reported the impact of organ transplants on bone metabolism, electrolytes and blood profile. (lidsen.com)
  • The condition is among the leading causes of death and long-term adverse health consequences associated with bone marrow transplants. (genengnews.com)
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
  • dmPGE2 treatment of human being cord bloodstream stem cells ahead of their administration in human being HSC transplants happens to be being examined in clinical tests (4). (thetechnoant.info)
  • Data from the United Network of Organ Sharing ( UNOS ) and the Organ Procurement and Transplantation Network ( OPTN ) catalog over 175,000 transplants between the years 2000 and 2015 (Optn.transplant.hrsa.gov 2016 ). (pocketdentistry.com)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
Prevention of relapse following1
  • NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. (sagepub.com)
Disorders9
  • More recently, he's been working on the use of multi-potent mesenchymal stem cells (MSCs) in regenerative medicine for the treatment of neurological, systemic, and orthopedic disorders. (wikipedia.org)
  • As such, innovative reduced intensity conditioning (RIC) or non-myeloablative stem cell transplantation (NST) was pioneered by Slavin for safer stem cell transplantation for the treatment of malignant and life-threatening non-malignant disorders correctable by using stem cells and post-transplant immunotherapy if indicated for all patients in need. (wikipedia.org)
  • Transplantation of hematopoietic stem cells is a medical procedure used in hematology and oncology for blood and bone marrow disorders and other malignancies. (tengrinews.kz)
  • Maillard, together with co-senior and co-corresponding author Leslie S. Kean, MD, PhD, a professor of pediatrics at Harvard Medical School and director of pediatric stem cell transplant at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, and lead author Victor Tkachev PhD, an assistant professor of surgery at Mass General Brigham, have long sought to prevent this fatal complication. (genengnews.com)
  • Thus homeostasis of T regulatory cells is an overbearing requirement for prevention of autoimmune disorders arising from uncontrolled self-tolerance which also permits malignancies to occur. (hoajonline.com)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • He has been working in the field of bone marrow transplantation for hematological malignancies for the last 25 years and is one of the pioneers of the non-myeloablative and reduced intensity/toxicity allogeneic transplantations for both malignant and non-malignant disorders. (labiotech.eu)
  • Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots when dysregulated. (ca.gov)
  • This honour recognizes how his work has impacted our understanding of normal and dysregulated stem cell biology and lineage specification, with a direct clinical impact on the management of blood disorders. (ox.ac.uk)
Graft versus5
  • In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
  • Gene delivery through stem cells using specific viral vectors are also utilised to confer lineage specificity of transducedautologous or allogeneic stem cell gene expressionin the recipient while addressing graft versus host disease. (hoajonline.com)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
  • Doubts about whether UCB, containing 10-20x fewer cells than bone marrow, had sufficient cells to durably engraft a myeloablated patient and, after demonstration that engraftment occurred with less graft-versus-host disease, whether it would confer graft-versus-leukemia activity were raised. (duke.edu)
  • Transplantation without full human leukocyte antigen matching is possible and, despite a lower incidence of graft-versus-host disease, graft-versus-leukemia is preserved. (duke.edu)
Blood29
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
  • Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
  • Nevertheless, pursuing HSC transplantation, folks are at risky of possibly lethal attacks while awaiting regeneration of peripheral bloodstream neutrophils, and so are also vulnerable to internal blood loss while awaiting regeneration of platelets (1). (thetechnoant.info)
  • Nonrelapse-related mortality was increased after carmustine (RR = 2.3) and with use of peripheral blood stem cells (RR = 2.4). (qxmd.com)
  • Arnon Nagler is director of the Division of Hematology and the Bone Marrow Transplantation and Cord Blood Bank at the Chaim Sheba Medical Center, Tel-Hashomer, Israel and Professor of Medicine at The Tel Aviv University, Tel-Aviv, Israel . (labiotech.eu)
  • His main contributions and scientific interests are hematopoietic stem cell transplantation, hematological malignancies, cord blood biology and, transplantation, and adoptive cell-mediated immunotherapy including NK cell biology. (labiotech.eu)
  • Anna's scientific curiosity has led her to explore the regenerative dynamics of hematopoietic stem cells, also known as blood stem cells. (lu.se)
  • Hematopoietic stem cells are the stem cells that give rise to all other blood cells in the body. (lu.se)
  • This type of transplantation, also known as a bone marrow transplant, is one of the common treatments used to treat several blood malignancies. (lu.se)
  • It is because of these stem cells and their capacity to regenerate and rebuild the entire hematopoietic (blood) system that makes transplantation a promising therapy. (lu.se)
  • The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
  • The purpose of this study is to evaluate the effects that psychological and health behavior factors have on quality of life, level if sickness, and death after blood and bone marrow transplantation. (mayo.edu)
  • BMASCT increases blood levels of intestinal growth factors and induces regeneration of the irradiated host ISC niche, thus providing a platform to discover potential radiation mitigators and protectors for acute radiation syndromes and chemo-radiation therapy of abdominal malignancies. (elsevierpure.com)
  • Research Objective Our goal is to develop and optimize novel drugs that can attack blood cancer stem cells. (ca.gov)
  • Impact By targeting blood cancer stem cells, these compounds can be used to treat and prevent recurrence of cancer in patients. (ca.gov)
  • Myeloma cells produce excess abnormal proteins, called paraproteins, in the bone marrow that can cause your blood to become so thick that it flows sluggishly in your body, a condition called hyperviscosity. (webmd.com)
  • 2 The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 study showed that patients receiving an autologous SCT (ASCT) followed by an allo-SCT had significantly higher CR rates that patients receiving double ASCTs. (medicalupdateonline.com)
  • 10 Data from the European Society for Blood and Marrow Transplantation (EBMT) megafile database indicates that the graft-versus-tumour effect achieved with allo-SCT is weaker and PFS rates lower in MM than in other types of haematological cancers. (medicalupdateonline.com)
  • Scholars@Duke publication: Update on umbilical cord blood transplantation. (duke.edu)
  • SUMMARY: Cord blood transplantation is now an established field with enormous potential. (duke.edu)
  • Prof Jacobsen pioneered research examining how mature blood cells are produced from haematopoietic stem cells (HSCs), in particular by unravelling new pathways of lineage commitment, in work that has redrawn the "textbook" roadmap of normal hematopoiesis. (ox.ac.uk)
  • While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. (biomedcentral.com)
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
  • Current Knowledge and Priorities for Future Research in Late Effects after Hematopoietic Cell Transplantation for Inherited Bone Marrow Failure Syndromes: Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation. (cdc.gov)
  • The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. (medlineplus.gov)
  • If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. (medlineplus.gov)
Clinical11
  • In 1975-1978, Slavin trained in clinical immunology/rheumatology at the Division of Immunology, Stanford University School of Medicine and later on in 1978, trained in clinical bone marrow transplantation under the late E.D. Thomas at the Fred Hutchinson Cancer Research Center in Seattle, Washington. (wikipedia.org)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • The emerging therapeutic approach of CAR-T cell therapy has sparked great interests, extensive studies in preclinical and clinical trials have revealed encouraging therapeutic efficacy in treating a variety of cancers, particularly in treating B-cell hematologic malignancies with CD19 CAR-T cells [ 3 ]. (ijbs.com)
  • Pancreatic islet transplantation (ITx) has moved from the experimental phase of development to a position of an accepted and appropriate procedure to apply in clinical medicine. (lidsen.com)
  • NiCord, Gamida Cell's lead clinical program, is under development as a universal bone marrow transplant solution for patients with high-risk hematologic malignancies. (bethematchbiotherapies.com)
  • They also showed the clinical significance of MDS stem cells, by demonstrating how they selectively escape treatment in patients in seemingly complete remission. (ox.ac.uk)
  • The group also played a key role in halting clinical bone marrow transplantation towards regeneration in non-hematopoietic tissues. (ox.ac.uk)
  • The clinical course of individuals with MF is heterogeneous and characterized by constitutional symptoms, bone marrow myeloproliferation and fibrosis, progressive cytopenias, and symptomatic splenomegaly. (cancernetwork.com)
  • The clinical course of individuals with MF is characterized by constitutional symptoms (fevers, night sweats, and weight loss), bone marrow myeloproliferation and reticulin/collagen fibrosis, worsening cytopenias, thrombosis, and progressive symptomatic splenomegaly. (cancernetwork.com)
  • The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)
  • Acquired and germline predisposition to bone marrow failure: Diagnostic features and clinical implications. (cdc.gov)
Hematology3
  • Dr. Thomas, "father of bone marrow transplantation," first developed and reported this technique in 1957, and in the ensuing decades, this seminal study has impacted fundamental work in hematology and cancer research, including advances in hematopoiesis, stem cell biology, tumor immunology, and T-cell biology. (broadinstitute.org)
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
  • To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
Allogeneic haematopoietic1
  • After undergoing an allogeneic haematopoietic stem cell transplantation (alloHCT), patients need intensive physiological and psychological rehabilitation. (mdpi.com)
Kidney transplantation3
Revealing a hypocellular1
Relapse3
  • Cancer stem cellsand their susceptibility over their expected to be "downstream or progeny" cancer cells represent a target for therapeutic interventions to prevent latency and consequently relapse or metastasis of the malignant disease. (hoajonline.com)
  • Relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT) remains one of the leading causes of mortality in patients with leukemia. (bvsalud.org)
  • Relapse of primary disease (56%) and subsequent malignancies (25%) were leading causes of late death. (qxmd.com)
Post-transplantation2
  • 7 In the recently completed LenaRIC study patients undergoing allo-SCT with reduced-intensity conditioning received lenalidomide for 12 months from day 35 post-transplantation, with DLI for mixed chimerism or persistent disease. (medicalupdateonline.com)
  • At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
Stromal cell2
  • We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. (elsevierpure.com)
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Pediatric6
Cell Transplant Recipients1
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
20002
Biology2
  • We are delighted to announce that Sten Eirik Jacobsen , Bass Professor of Developmental and Stem Cell Biology at the MRC Molecular Haematology Unit and Radcliffe Department of Medicine , has been elected as EMBO member. (ox.ac.uk)
  • Prof Jacobsen is also a Professor of Stem Cell Biology and Regenerative Medicine at the Karolinska Institutet in Stockholm, Sweden. (ox.ac.uk)
Treatment11
  • Baxter International recognized the potential of cell therapy and signed an agreement which resulted in significant investment with Slavin at Hadassah Medical Center for further development of new approaches based on cell therapy for the treatment of cancer, autoimmune diseases, and organ transplantation based on new methods for regulation rather than non-specific suppression of the immune system. (wikipedia.org)
  • Retrospective 340 patients with hematological malignancy in Turkey, showing higher mortality with HCQ treatment. (c19hcq.org)
  • Treatment usually involves immunosuppression with equine antithymocyte globulin and cyclosporine , or bone marrow transplantation. (merckmanuals.com)
  • The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
  • Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
  • RECENT FINDINGS: Transplantation with UCB is effective in the treatment of children with hematological malignancies, marrow failure, immunodeficiencies, hemoglobinopathies and inherited metabolic diseases. (duke.edu)
  • Thrombocyte transfusions, hemodialysis, peritoneal dialysis, and hematopoietic stem cell transplantation are treatment methods which were used. (dergipark.org.tr)
  • Although it is proving to be a heterogeneous disease process, the only treatment with proven survival benefit for poor risk AML remains allogeneic hematopoietic cell transplant. (sagepub.com)
  • Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. (sagepub.com)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
Cytopenias1
  • The term aplastic anemia commonly implies a panhypoplasia of the bone marrow with cytopenias in at least two hematopoietic lineages. (merckmanuals.com)
Organ6
  • This has had a negative impact on organ donation and transplantation rates. (lidsen.com)
  • Finally, cells regeneration is definitely a restorative requirement in liver organ surgery for malignancy, where survival needs individuals regaining sufficient body PD98059 organ function after going through incomplete hepatic PD98059 resection (6C8). (thetechnoant.info)
  • Outcomes Hereditary Deletion or PD98059 Pharmacologic Inhibition of 15-PGDH Boosts Tissue PGE2 Amounts To verify that 15-PGDH broadly regulates PGE2 in vivo, we likened PGE2 amounts in 15-PGDH knockout (21) and wild-type mice, retesting lung (21) and digestive tract (22), and recently interrogating bone tissue marrow and liver organ. (thetechnoant.info)
  • Since the first successful organ transplant in 1954, advancements in medical technology, immunology, and pharmacology have increased the success rate of solid organ transplantation. (pocketdentistry.com)
  • Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Mesenchymal4
  • mesenchymal stem cells - placenta) differentiate into multipotency as precursors to formation of the cellular components. (hoajonline.com)
  • These CD4+ CD25+ T regulatory cells can be isolated from mesenchymal stem cells and CD34+ hematopoietic stem cells. (hoajonline.com)
  • Methodology/Principal Findings: Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy) or abdominal irradiation (16-20 Gy) in a single fraction. (elsevierpure.com)
  • Conclusion/Significance: Mitigation of lethal intestinal injury, following high doses of irradiation, can be achieved by intravenous transplantation of marrow-derived stromal cells, including mesenchymal, endothelial and macrophage cell population. (elsevierpure.com)
Characterized by peripheral1
Lymphoma2
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • 20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
Engraftment2
Survival4
  • The team confirmed that the Notch pathway involvement in GVHD was conserved across species, and demonstrated in their animal models that just a single dose of the DLL4-blocking antibody given immediately before stem cell transplantation greatly increased survival and prevented signs of GVHD in the intestines, but without causing global immunosuppression. (genengnews.com)
  • Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
  • Transplantation of enriched myeloid and non-myeloid fractions failed to improve survival. (elsevierpure.com)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
Supportive care2
GVHD1
  • In experiments with mouse models of GVHD, the researchers showed that blocking a particular Notch activator known as DLL4 effectively prevented GVHD when administered within the first days after transplantation. (genengnews.com)
Access to transplantation1
  • Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
Morbidity and morta1
Biopsy2
  • In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
  • Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
Reconstitution2
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • Autologous hematopoietic stem cell transplantation and reconstitution: Different species and including primates and humans for studies are being used for development, localization, and therapeutic strategies. (hoajonline.com)
Myeloproliferative2
  • Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
  • The myeloproliferative neoplasms (MPNs) are a heterogeneous group of chronic hematological malignancies that are generally divided into the Philadelphia chromosome-positive (Ph-positive) MPNs, which refers to chronic myelogenous leukemia (CML) and the Philadelphia chromosome-negative (Ph-negative) MPNs. (cancernetwork.com)
Diseases5
  • However, the cure can only be achieved at the price of morbidity and long-term complications such as bone diseases leading to fractures and osteopenia. (lidsen.com)
  • Therapeutic regeneration of molecularly engineered and transplanted autologous stem cells in neurological and cardiovascular diseases due to inability of self-regeneration or repair of endogenous stem cells at sites of inflammation or disease at various stages of progress for regeneration of the damaged tissue depending upon the sites and nature of degeneration. (hoajonline.com)
  • CAR against malignancies, and even against nonmalignant diseases like autoimmunity. (labiotech.eu)
  • Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)
  • Immune-related gastrointestinal diseases can be classified as those that develop primarily via autoimmunity, infection, an inflammatory response, or malignancy. (medscape.com)
Malignant2
Hematopoiesis2
Cancers1
  • Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)
Tissues4
  • Tissues regeneration is a medical problem faced in damage from disease and during procedures such as bone tissue marrow transplantation. (thetechnoant.info)
  • The age-associated progressive degeneration of many tissues is thought to be driven by the functional decline and gradual attrition of adult stem cells. (helmholtz-muenchen.de)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
Liver3
HSCs1
  • 4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)