Hematopoietic interleukin 11. Medical search. Frequent questions

IL-11 belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M, and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. (cellsignal.com)
Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. (abmole.cn)
Interleukins are a type of cytokine and cytokines regulate and control the messages sent by the body to the immune system and by the immune system to the body. (netriceuticals.com)
The Guna-IL-11 formula by GUNA Biotherapeutics provides low dose cytokines for supporting a healthy cytokine balance within the body. (netriceuticals.com)
gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. (ox.ac.uk)
11 Moreover, cytokines can interfere with erythropoietin/erythropoietin receptor-mediated signaling which involves the signal transducer and activator of transcription (STAT) family and mitogen and tyrosine kinase phosphorylation pathways. (haematologica.org)
The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. (rndsystems.com)
Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)

IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation IL-11 causes bone-resorption. (wikipedia.org)
Il 11 acts by Regulation of the growth and the differentiation of hematopoietic cells. (netriceuticals.com)
Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells. (ox.ac.uk)
Interleukin-21 (IL-21) enhances T helper 1 (Th1) and Th17 differentiation while inhibiting the conversion of inducible regulatory T cells (Tregs) from naive T cells. (biopaqc.com)
IL-11 can enhance the differentiation of pluripotent stem cells under the growth factor, and promote the differentiation of B cells that produce immunoglobulin under T cell dependence. (creative-proteomics.com)
IL-11 cooperates with IL-3 and IL-4 to stimulate the proliferation of hematopoietic stem cells at rest, and affects the generation and differentiation of red blood cells. (creative-proteomics.com)
The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)

In this study we investigated for the first time the potential role of IL-13 in the regulation of the growth of hematopoietic progenitor cells. (ox.ac.uk)
Immature haematopoietic precursors can be identified and quantified by fluorescence flow cytometry employed by the XN-Series and partly XN-L Series analysers and are expressed in the following parameters: nucleated red blood cells (NRBC), immature granulocytes (IG), reticulocytes, immature platelets (IPF) and haematopoietic progenitor cells (HPC). (sysmex.es)
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
MyeloCult™ media have been developed for the long-term culture of hematopoietic progenitor cells in association with adherent stromal cells. (stemcell.com)

IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. (wikipedia.org)
IL-11 through its binding to its transmembrane IL-11Rα receptor and resultant activation of downstream signaling pathways has been thought to regulate adipogenesis, osteoclastogenesis, neurogenesis and platelet maturation. (wikipedia.org)
First, effects of calphostin C, a specific inhibitor for protein Kinase C(PKC), and genistein and herbimycin A, specific tyrosine kinase (TK) inhibitors on colony formation of 5-FU resistant, dormant, primitive hematopoietic progenitors supported by IL-6 which receptor has the same signal transducer gp 130 of IL-11 receptor and 12-o-tetradecanoyl phorbol-13-acetate(TPA). (nii.ac.jp)
IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. (cellsignal.com)
The domains in the CHR are the structural hallmarks of the hematopoietic cytokine receptor family (2). (rndsystems.com)
The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. (ox.ac.uk)
[ 10 ] Other factors studied include T-cell immunoglobulin, mucin-domain-containing-3, interleukin (IL)-6, and soluble tumor necrosis factor receptor-1. (medscape.com)
IL-11 exerts its biological function by binding to IL-11 receptor (IL-11R). (creative-proteomics.com)
A novel pathogenic mutation on the interleukin-7 receptor has been described in a newborn. (medscape.com)

The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. (wikipedia.org)
The human IL-11 gene encodes a precursor protein containing 199 amino acids. (creative-proteomics.com)

Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). (brainimmune.com)

In this study, we tried to elucidate signal transduction pathway in primitive hematopoietic progenitors of mice stimulated with interleukin-11(IL-11). (nii.ac.jp)
These findings suggested that signal of IL-11 in colony formation of primitive hematopoietic progenitors was transduced through an activation of PKC and TK.Confirmation of these findings by immunocytochemical examination on activation of PKC and TK by IL-11 is on going. (nii.ac.jp)
In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)

Although long-term repopulating hematopoietic stem cells (HSC) can self-renew and expand extensively in vivo, most efforts at expanding HSC in vitro have proved unsuccessful and have frequently resulted in compromised rather than improved HSC grafts. (lu.se)
article{ff9b980d-2e89-453c-b22b-428d2e903c6f, abstract = {{Although long-term repopulating hematopoietic stem cells (HSC) can self-renew and expand extensively in vivo, most efforts at expanding HSC in vitro have proved unsuccessful and have frequently resulted in compromised rather than improved HSC grafts. (lu.se)

Interleukin-11: A cytokine signaling through gp130 with pleiotropic effects and potential clinical utility within and outside the hematopoietic system. (ox.ac.uk)
Signal transduction is initiated upon binding of IL-11 to IL-11Ralpha and gp130, facilitating the formation of higher order structures involving dimers of gp130:Il-11:Il11RA complexes. (wikipedia.org)
The complex of IL-11 and IL-11R triggers the activation of gp130 most likely by enforcing gp130 homodimerization (2). (cellsignal.com)
Eleven potential N-linked glycosylation sites are found within the rat gp130 ECD (1). (rndsystems.com)
IL-11 mediates downstream signal transduction by a common signal transduction molecule glycoprotein 130 (gp130). (creative-proteomics.com)
Targeting IL-11, IL-11R and gp130 and other IL-11 Drugs that treat the target and its downstream signaling pathways (such as JAK / STAT3, RAS / ERK, and PI3K / mTOR) can provide new options for the treatment of IL-11-related tumors. (creative-proteomics.com)

The leading cause of GVHD is hematopoietic stem cell transplantation (HSCT), most commonly allogeneic (between two individuals) rather than autologous (from the same individual). (medscape.com)
Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
Whereas IL-17 and Th17 cells reduce GVHD mediated by CD4+ and CD8+ donor T cells, 11 Th17 cells accelerated GVHD mediated exclusively by CD4+ T cells.12 Naive CD4+ T cells skewed toward a Th17 phenotype in vitro have been used to demonstrate that Th17 cells contribute to GVHD pathogenesis, especially involving the skin and lung. (biopaqc.com)

Leukemia 2021 3 35 (11): 3223-3231. (cdc.gov)

IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. (wikipedia.org)
In other instances, in stromal cells, IL-11 activates non-canonical MAPK/ERK-dependent signalling to initiate the post-transcriptional upregulation of specific subsets of transcripts in the absence of an effect on transcription. (wikipedia.org)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Interleukin (IL) -11 is an IL-6 family cytokine found in primate bone marrow stromal cells with a molecular weight of 23KD. (creative-proteomics.com)
IL-11 is a cytokine produced by hematopoietic microenvironmental stromal cells with multiple functions. (creative-proteomics.com)
11. Sungaran R., Chisholm O.T., Markovic B. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells // Blood. (medline.ru)

An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)

We study ILCs development from hematopoietic precursors using mouse models. (pasteur.fr)
While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)

SHED-Cryo amended improved interleukin 17-secreting helper T cells in MRL/mice systemically and locally. (bio-cavagnou.info)
including hyper-autoantibody levels renal dysfunction and hyperactivity of interleukin 17 (IL-17)-generating helper T (Th17) cells in MRL/mice [13]. (bio-cavagnou.info)

In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)

In fibroblasts, IL-11 drives an ERK-dependent autocrine loop of fibrogenic protein synthesis that is at a nexus of fibrotic signalling and required for the pro-fibrotic activity of TGFB1, PDGF, endothelin1, angiotensin and many other pro-fibrotic factors. (wikipedia.org)
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. (cytekbio.com)
The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)

Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
For the reconstruction of bone marrow hematopoietic function after bone marrow transplantation and radiotherapy Sexual blood cell deficiency is of great value. (creative-proteomics.com)

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. (rndsystems.com)
The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. (rndsystems.com)

In allogeneic HSCT, donor T cells target malignant hematopoietic cell populations, creating a graft-versus-tumor effect. (medscape.com)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)

Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
IL-11 used in vivo can effectively shorten the period of bone marrow suppression, accelerate the recovery of white blood cells and platelets. (creative-proteomics.com)

Through such studies, c-kit ligand (KL), flt3 ligand (FL), thrombopoietin, and IL-11 have emerged as likely positive regulators of HSC self-renewal. (lu.se)
Growth factors include for example erythropoietin (EPO), thrombopoietin (TPO), interleukins (e.g. (sysmex.es)
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis // Blood. (medline.ru)

It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. (wikipedia.org)
Interleukin 11 is manufactured using recombinant DNA technology. (wikipedia.org)
Serial dilutions of Mouse IL-11 Recombinant Protein were added to B9 cells. (cellsignal.com)
The purity of Mouse IL-11 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant mIL-11 and staining with Coomassie Blue. (cellsignal.com)
Mouse IL-11 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. (cellsignal.com)
The bioactivity of recombinant mIL-11 was determined in a B9 cell proliferation assay. (cellsignal.com)
Recombinant mouse IL-11 was expressed in E. coli and is supplied in a lyophilized form. (cellsignal.com)

The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)

IL-3, IL-6, IL-7, IL-11) and colony-stimulating factors (e.g. (sysmex.es)
Recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. (nwbio.com)

Transforming growth factor β1 (TGFβ1) through up-regulation of IL-11, stimulates collagen production and is important in wound healing. (wikipedia.org)

These may be classified into those that result in pancytopenia and those limited to failure of 1 or 2 hematopoietic lineages. (medscape.com)

Previous studies have indicated that organic chemicals extracted from DEP result in induction of apoptosis 11 , increase oxidative stress 12 , and induce the production of inflammatory cells 13 - 15 through the release of pro-inflammatory molecules in vitro 15 , 16 . (ersjournals.com)
Accelerated hematopoietic cell apoptosis has been demonstrated in virtually all IBMFS. (medscape.com)

Preincubation of bone marrow cells with IL-11 in combination with calphostin C or herbimycin A canceled the augmentation of IL-3-dependent colony formation by IL-11. (nii.ac.jp)
Interleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). (cellsignal.com)
Here, in the presence of KL+FL+megakaryocyte growth and development factor (MGDF), which recruits virtually all Lin(-)Sca-1(+)kit(+) bone marrow cells into proliferation and promotes their self-renewal under serum-free conditions, IL-3 and IL-11 revealed an indistinguishable ability to further enhance proliferation. (lu.se)
Interleukin-11 (IL-11) is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. (abmole.cn)
Interleukins are specific types of proteins that play essential roles in relaying messages between the cells of the body. (netriceuticals.com)
In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
Haematopoiesis is the process by which uncommitted haematopoietic stem cells proliferate and differentiate into all the cellular components of the blood. (sysmex.es)
Haematopoietic stem cells, unlike embryonic stem cells, can be collected from the peripheral blood by apheresis after mobilisation. (sysmex.es)
Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
Leukocytic, hematopoietic cells are important in maintaining the body's defense against disease. (justia.com)
The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
The current authors have recently shown that PQ induces recruitment of inflammatory cells, such as eosinophils and neutrophils, into the lung with the lung expression of pro-inflammatory molecules such as interleukin (IL)-5 and eotaxin in vivo 24 . (ersjournals.com)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Interleukin-21 (IL-21) is certainly produced by Compact disc4+ T cells (specifically T helper 17 [Th17]Cproducing cells) and organic killer T (NKT) cells1 and indicators through the IL-2c and IL-21R complicated. (biopaqc.com)
Erythropoietin levels in ACD have been found to be inadequate for the degree of anemia in many but not all conditions including IBD 9 , 10 which may be partly due to interleukin-1- and TNF-α-mediated inhibition of erythropoietin promoter activity and a cytokine-driven formation of toxic radicals, thereby damaging erythropoietin-producing cells and inhibiting erythropoietin formation in the kidney. (haematologica.org)
Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. (nature.com)
Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
IL-11 is an anti-inflammatory factor that can inhibit inflammation by directly acting on macrophages and NK cells. (creative-proteomics.com)
IL-11 has effects on hematopoietic stem cells, megakaryocytes, lymphocytes and fat cells. (creative-proteomics.com)
Besides, IL-11 can increase the production of proteins in the liver during acute inflammation, and inhibit the formation of fat cells. (creative-proteomics.com)
Hematopoietic cells are almost totally absent. (medscape.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
Chemotherapy (CT) + radiotherapy (RT) compared to CT alone (P = .007), and hematopoietic stem cell transplantation (HSCT) compared to non-HSCT (P (bvsalud.org)
These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
Treatment is usually with chemotherapy and, in refractory cases or in cases with a genetic cause, hematopoietic stem cell transplantation. (msdmanuals.com)

153(9): 1643-1657, 2023 11 01. (bvsalud.org)

Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy. (nwbio.com)

As IL-11 over expression is associated with a number of cancers, inhibition of its signaling pathway may have utility in treating cancer. (wikipedia.org)
Next, we studied the effect of IL-11 on IL-3-dependent colony formation and its inhibition by these protein kinase inhibitors. (nii.ac.jp)

The recently cloned interleukin 13 (IL-13) shares most investigated biological activities on B lymphocytes and monocytes with IL-4. (ox.ac.uk)

More recently it has been discovered that over-expression of IL-11 is associated with a variety of cancers and may provide a link between inflammation and cancer. (wikipedia.org)
Combined exposure to NQ and antigen enhanced the local expression of interleukin (IL)-4, IL-5, eotaxin, macrophage chemoattractant protein-1 and keratinocyte chemoattractant, compared with exposure to antigen or NQ alone. (ersjournals.com)
IL-11 can regulate the expression of plasma protein genes in hepatocytes and induce acute phase protein production. (creative-proteomics.com)

Here, activation of STAT3 by IL-11 is mandatory to allow regeneration and to prevent injury-induced fibrotic remodeling and scar formation. (wikipedia.org)
Initiation of the Jak/Stat pathway in response to IL-11 requires Jak1 and leads predominantly to the activation of Stat3 (3,4). (cellsignal.com)

Interleukin 11 can help to regulate overactive immune activity, which ca n be one of the underlying causes of skin inflammation and psoriasis. (netriceuticals.com)

Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. (wikipedia.org)

Anatomy46

Organisms10

Diseases10

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes33

Disciplines and Occupations1

Information Science3

Health Care2

Cytokines9

Differentiation7

Progenitor8

Receptor9

Human IL-11 gene2

Known as hematopoietic stem1

Progenitors4

Repopulating hematopoietic stem2

Gp1306

GVHD3

20211

Stromal6

Acute graft-versus-2

Precursors2

Mice2

Normal hematopoietic1

Fibroblasts3

Bone Marrow Transpla2

Subunit2

Allogeneic2

Platelets2

Thrombopoietin3

Recombinant7

Reconstitution1

Colony-stimula2

Regulation1

Lineages1

Apoptosis2

Cells24

Cell10

20231

Malignancy1

Inhibition2

Lymphocytes1

Expression3

STAT32

Regulate1

Protein1