These mutations are not specific to myelofibrosis, but are observed in other myeloproliferative neoplasms, specifically polycythemia vera and essential thrombocythemia. (wikipedia.org)
Intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis. (unboundmedicine.com)
Momelotinib is indicated for intermediate or high-risk myelofibrosis (MF), including primary MF or secondary MF (post polycythemia vera [PV] and post essential thrombocythemia [ET]), in adults with anemia. (medscape.com)
Myelofibrosis (MF) is a hematopoietic stem cell malignancy classified as a myeloproliferative neoplasm (MPN). (cancernetwork.com)
The JAK1/JAK2 inhibitor also has an FDA-approved indication for the treatment of patients with intermediate or high-risk myelofibrosis. (targetedonc.com)
Post-transplant cyclophosphamide (PTCY) has been introduced as graft-versus-host disease (GvHD) prophylaxis in mismatched and matched unrelated hematopoietic cell transplant (HCT). (bvsalud.org)
Transplantation10
Results showed that adding quizartinib to standard chemotherapy with or without allogeneic hematopoietic stem cell transplantation, followed by continuation monotherapy for up to 3 years, resulted in improved overall survival. (medscape.com)
Motixafortide is indicated in combination with filgrastim to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma. (medscape.com)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the only curative treatment for MF. (antengene.com)
The open-label, single-cohort, multicenter phase II REACH1 study accrued patients aged ≥12 years old who had received allogeneic hematopoietic stem cell transplantation and developed grade 2 to 4 steroid-refractory aGVHD. (targetedonc.com)
There is a paucity of information to guide selection of the most suitable stem cell donor in haploidentical (Haplo) hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
The Japanese Society of Hematopoietic Cell Transplantation (JSHCT) has been conducting a nationwide survey on HCT since 1993, in which HCTs performed at participating centers are registered with the JSHCT every year. (apbmt.org)
The nature of the underlying disease process - For example, a patient who is given an immunosuppressive drug shortly after undergoing hematopoietic cell transplantation for malignancy may be at greater risk than a patient receiving the same drug for chronic, stable rheumatologic disease. (medilib.ir)
Stem cells7
JAK2 mutations play a significant role in the pathogenesis of all the MPNs because the recognized mutations all cause constitutive activation of the pathway controlling the production of blood cells arising from hematopoietic stem cells. (wikipedia.org)
Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrowhematopoietic stem cells, which can manifest as an increased number of functionally normal platelets, red blood cells (RBCs). (msdmanuals.com)
Extramedullary hematopoiesis (EMH) is likely the result of abnormal trafficking of hematopoietic stem cells (HSC) from the bone marrow to organs such as the spleen, liver, and lung, causing organomegaly and sometimes organ dysfunction. (cancernetwork.com)
Before chemotherapy medicines suppress the immune system, hematopoietic stem cells-which produce blood cells-that are generated from a person's bone marrow or blood are collected or kept. (bonemarrowtransplantations.com)
Myeloproliferative neoplasms (MPNs) are a group of disorders characterized by a proliferation of normally developed (nondysplastic) multipotent hematopoietic stem cells from the myeloid cell line . (amboss.com)
Abnormal2
Production of cytokines such as fibroblast growth factor by the abnormal hematopoietic cell clone (particularly by megakaryocytes) leads to replacement of the hematopoietic tissue of the bone marrow by connective tissue via collagen fibrosis. (wikipedia.org)
746 The underlying cause of PMF is almost always related to an acquired mutation in JAK2, CALR or MPL in a hematopoietic stem/progenitor cell in the bone marrow. (wikipedia.org)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Secondary2
In polycythemia vera, in contrast to secondary erythrocytosis, the red cell mass increase is often initially masked by an increase in the plasma volume that leaves the hematocrit in the normal range. (msdmanuals.com)
Therapeutic phlebotomy may be indicated for hemochromatosis, polycythemia vera, porphyria cutanea tarda, and polycythemia secondary to arterio-venous fistulae, cyanotic congenital heart disease or cor pulmonale. (aetna.com)
Myelodysplastic syndrome1
Myelodysplasia, or myelodysplastic syndrome (MDS), is a group of hematopoietic disorders characterized by dysmyelopoiesis and cytopenias [1]. (symptoma.com)
Essential2
12. Ruggeri M., Tosetto A., Frezzato M., Rodeghiero F. The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis // Ann. (medline.ru)
MF is a clonal bone narrow neoplasm which can emerge either as primary MF (PMF), polycythemia vera (PV) or essential thrombocythemia (ET). (antengene.com)
Neoplasm2
Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)
Polycythemia vera is a myeloproliferative neoplasm characterized by clonal hematopoiesis and an absolute increase in the red blood cell mass, with an associated leukocytosis and thrombocytosis. (targetedonc.com)
JAK22
The V617F subsustition also renders hematopoietic cells more sensitive to growth factors that use JAK2 for signal transduction, which include erythropoietin and thrombopoietin. (wikipedia.org)
Inhibits activated Janus Associated Kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3) which inhibits hematopoietic cell proliferation and causes apoptosis. (unboundmedicine.com)
Chronic1
See also " Polycythemia vera " and " Chronic myeloid leukemia " for further detail on these conditions. (amboss.com)
Acute1
Abatacept is now available for use in combination with certain immunosuppressants to prevent moderate to severe acute-graft-versus-host disease for select patients who have received unrelated donor hematopoietic stem cell transplant. (oncnursingnews.com)
Dr. Jay Mei, Founder, Chairman and CEO of Antengene , commented: "The NMPA's approval for this clinical trial of selinexor in patients with MF marks another major milestone in our effort in developing selinexor in a broad range of diseases, and a big step towards expanding potential indications for this candidate drug. (antengene.com)
Ruxolitinib is currently approved by the FDA as a treatment for patients with polycythemia vera who are intolerant of or have an inadequate response to hydroxyurea. (targetedonc.com)
Food and Drug Administration expanded the indication of pomalidomide (POMALYST, Celgene Corporation) to include treating adult patients with AIDS-related Kaposi sarcoma after failure of highly active antiretroviral therapy and Kaposi sarcoma in adult patients who are HIV-negative. (blogspot.com)
The long-term risks of polycythemia vera (PV) include leukemic and fibrotic transformation, which occur in fewer than 5% and 10% of patients, respectively, at 10 years. (medscape.com)
Although AML is the most common indication for allogeneic HCT, the relatively small number of patients and the highly complex nature of the procedure often render prospective studies on HCT unfeasible. (apbmt.org)
The decrease in hematopoietic tissue impairs the patient's ability to generate new blood cells, resulting in progressive pancytopenia, a shortage of all blood cell types. (wikipedia.org)
Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
Vor is a preclinical cell therapy company pioneering engineered hematopoietic stem cell (eHSC) therapies combined with targeted therapies for the treatment of hematological cancers. (globalgenes.org)
Clinical1
Furthermore, quanti- then the clinical indications have carcinogens, Cogliano et al. (who.int)
Phlebotomy1
Aetna considers therapeutic phlebotomy experimental and investigational for treatment of the following conditions because its effectiveness for these indications has not been established (not an all-inclusive list). (aetna.com)
Treatment2
Pharvaris develops small molecule bradykinin-B2-receptor antagonists for the treatment of hereditary angioedema (HAE) and other bradykinin-B2-receptor-mediated indications. (globalgenes.org)
The optimal management remains elusive despite the findings of the Polycythemia Vera Study Group (PVSG). (medscape.com)
Therapeutic1
Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area. (nihr.ac.uk)
Blood cells1
Polycythemia vera involves increased production of red blood cells (RBCs), white blood cells (WBCs), and platelets. (msdmanuals.com)
Coverage of CLONOSEQ ® for other cancer indications and episodes of care, and modifications to the definition of an episode of care will be evaluated as needed. (codemap.com)