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  • clinical
  • Introduction] Recent reports demonstrating the ability of bone marrow (BM) cells to regenerate cardiomyocytes (CMs) have prompted clinical as well as basic studies for the treatment of ischemic and non-ischemic cardiomyopathies. (ahajournals.org)
  • The availability of human samples (e.g., cells and tissues), although supporting successful translation from bench research to clinical medicine, is limited by both logistic and ethical concerns. (jimmunol.org)
  • Using a high-throughput sequencing platform, we sought to analyze the TCR γ-chain (TRG) repertoire of γδ T cells within donor stem cell grafts and address its potential impact on clinical response in the corresponding patients. (jimmunol.org)
  • In multivariate analysis of clinical variables, including age, gender, race, cytogenetic risk category, and CD34 + cell dose, only autograft multigene MRD as assessed by RQ-PCR was statistically significantly associated with relapse. (nih.gov)
  • Clinical efficacy of allogeneic hematopoietic cell transplantation (HCT) using reduced-intensity conditioning (RIC) for younger patients remains unclear. (ovid.com)
  • One of the key issues for clinical-grade iPSC derivation is the accessibility of donor cells used for reprogramming. (biomedcentral.com)
  • Because the use of blood cells allows minimally invasive tissue procurement under GMP conditions and rapid cellular reprogramming, mobilized HPCs and unmobilized PBMCs would be ideal somatic cell sources for clinical-grade iPSC derivation, especially from diabetes patients complicated by slow-healing wounds. (biomedcentral.com)
  • In early 2009, the US Food and Drug Administration (FDA) approved the first clinical trial using ES cells in patients with spinal cord injuries. (biomedcentral.com)
  • Despite these advances in clinical applications, the use of ES cells is associated with ethical issues and immunologic mismatch, which could affect their widespread use in the clinic. (biomedcentral.com)
  • For clinical applications, it would be ideal if iPSCs could be generated from somatic cells through a minimally invasive tissue-procurement procedure under GMP-compliant process. (biomedcentral.com)
  • recipients
  • In some experiments cells were cultured in vitro, in other experiments cells were injected into lethally irradiated recipients, along with non-transduced bone marrow cells. (springer.com)
  • NK alloreactive donors possessed HLA class I, killer-cell immunoglobulin-like receptor (KIR) ligand(s) which were missing in the recipients, KIR gene(s) for missing self recognition on recipient targets, and alloreactive NK clones against recipient targets. (bloodjournal.org)
  • transcriptional
  • To generate great numbers of very different cells-ranging from erythrocytes to highly specialized lymphocytes-a delicate balance of activity of transcriptional programs and hematopoietic growth factors is required ( 1 ). (pnas.org)
  • chronic
  • Thus the study population included 426 patients older than 18 years with chronic myeloid leukaemia (CML), transplanted in first chronic phase and receiving a total body irradiation and cyclophosphamide preparative regimen. (pubmedcentralcanada.ca)
  • Aberrant recruitment/retention of these cells in wounds of diabetic patients and animal models is associated with chronic inflammation and impaired healing. (bloodjournal.org)
  • genes
  • Furthermore, gene expression profiling of hematopoietic cells demonstrated that PBX3/MEIS1 overexpression, but not HOXA9/MEIS1 , HOXA9/PBX3 , or HOXA9 overexpression, recapitulated the MLL -fusion-mediated core transcriptome, particularly upregulation of the endogenous Hoxa genes. (aacrjournals.org)
  • engraftment
  • Competitive repopulation of lethally irradiated murine hosts with EAR-2-transduced BM cells resulted in increased engraftment and increased colony formation in serial replating experiments. (springer.com)