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  • stem cell transplants
  • Other conditions treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's sarcoma , desmoplastic small round cell tumor , chronic granulomatous disease , Hodgkin's disease and Wiskott-Aldrich syndrome . (wikipedia.org)
  • In 2006 a total of 50,417 first hematopoietic stem cell transplants were reported as taking place worldwide, according to a global survey of 1327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
  • lineage
  • A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. (genome.jp)
  • apheresis
  • In most circumstances, adequate numbers of cells can be collected using granulocyte colony-stimulating factor (G-CSF, filgrastim [Neupogen]) to prime the patient prior to one to three apheresis procedures. (renalandurologynews.com)
  • gene
  • A current definition of gene therapy is the infusion of a therapeutic gene, or cells transduced with the gene, in order to cure or prevent illnesses. (go.jp)
  • Most hematopoietic cells, including hematopoietic stem cells (HSCs) and terminally differentiated cells (e.g., primary T cells and macrophages), are refractory to viral gene delivery. (clontech.com)
  • Inefficient transduction of HSCs is a significant obstacle to research into gene therapy strategies for hematopoietic diseases. (clontech.com)
  • These interactions increase the localized concentrations of cells and viral particles, an effect that enhances gene transduction. (clontech.com)
  • By facilitating close physical proximity of cells and viral particles, RetroNectin reagent can enhance viral-mediated gene transfer to a variety of hematopoietic cell types. (clontech.com)
  • Research using hematopoietic cells has been limited in part by low efficiency of gene transfer. (clontech.com)
  • immunosuppression
  • 1991) Kidney allograft tolerance in primates without chronic immunosuppression-the role of veto cells. (springer.com)
  • Mechanisms of immune evasion can involve abrogation of leukemia cell recognition due to the loss of HLA genes, immunosuppression by immune checkpoint ligand expression, production of anti-inflammatory factors, release of metabolically active enzymes, loss of pro-inflammatory cytokine production and acquisition of novel driver mutations that promote leukemia outgrowth. (bloodjournal.org)
  • patient's
  • Using the derived predictive formula, we illustrated bone marrow volume depending on the platelet count to obtain 2.3×10 8 nucleated cell count per patient's body weight. (go.jp)
  • In autologous transplantation, the reinfused stem cells are derived from the patient's own bone marrow and collected from the peripheral blood. (renalandurologynews.com)
  • She is currently running a clinical trial examining the effectiveness of administering a double or "tandem" dose of a patient's own healthy stem cells within a relatively short period of time. (cityofhope.org)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood cell production. (wikipedia.org)
  • neuroblastoma
  • 7. A process as claimed in claim 1 wherein the tumor cells are from breast carcinoma, lung carcinoma, or neuroblastoma, and the antibody composition contains antibodies specific for antigens expressed on the surface of cells from breast carcinoma, lung carcinoma, or neuroblastoma. (google.com)
  • procedure
  • Although this procedure can be accomplished in an individual with a baseline blood count, the number of cells and the efficiency of collection are increased if the cells are procured during white blood cell (WBC) recovery following chemotherapy or after the administration of hematopoietic growth factors. (renalandurologynews.com)
  • conventional
  • RetroNectin reagent provides better retroviral and lentiviral transduction efficiency for hard-to-infect cell types (e.g., hematopoietic cells) than conventional transduction protocols, including those that use Polybrene. (clontech.com)
  • severe
  • There are also occasional settings in which transplantation can be performed without any preparation, primarily in children with severe combined immunodeficiency who lack T cell function [ 1 ]. (uptodate.com)