Loading...
  • efficacy
  • Whether treatment with AHST could still achieve adequate glycemic control and preserve the β-cell function and what the factors are associated with the therapeutic efficacy have not been explored. (clinicaltrials.gov)
  • CD34
  • After enrichment for CD34 + cells, two-thirds of the cells were stored without further manipulation. (biomedcentral.com)
  • The mean number of CD34 + cells was (7.3±3.8)×10 6 /kg. (asnjournals.org)
  • Shpall EJ, Jones RB, Bearman SI, Franklin WA, Archer PG, Curiel T et al (1994) Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment. (springer.com)
  • Results of some clinical trials indicate that plerixafor in addition to granulocyte colony-stimulating factors (G-CSF) compared to G-CSF only could lead to an increased mobilisation and release of CD34-positive cells, facilitating effective apheresis. (uzh.ch)
  • autoimmune
  • Pro-inflammatory helper T (Th) cells contribute to disease activity in several autoimmune inflammatory conditions including multiple sclerosis (MS). In MS, Th1 and Th17 subsets have been considered pathogenic, while Th2 and regulatory T cell subsets may limit disease activity ( 1 ). (frontiersin.org)
  • toxicity
  • HCT also is used in the support of patients undergoing high-dose chemotherapy for the treatment of certain solid tumors for whom hematologic toxicity would otherwise limit drug administration (germ cell, soft-tissue sarcomas, and neuroblastoma). (renalandurologynews.com)
  • If a patient's hematopoetic system was reconstituted using cells containing this gene, then there is the potential to further treat the patient with drugs such as paclitaxel without causing significant hematopoietic toxicity. (biomedcentral.com)
  • NK cells were also found to be cytotoxic to memory Th17 cells, and this toxicity is mediated through NKG2D-dependent necrosis. (frontiersin.org)
  • To minimize hematologic toxicity, stem cells were reinfused at days 7 and 14 after 90Y-ibritumomab tiuxetan. (unimi.it)
  • HSCs
  • Nevertheless, high dose therapy with reinfusion of HSCs is commonly used in the hematopoietic malignancies, and if the transduction efficiency can be improved then the therapeutic possibilities are great, limited only by the number of useful genes available. (biomedcentral.com)
  • Six patients were enrolled in the study, four of whom received infusion of genetically altered cells (one patient mobilized insufficient HSCs, and the other developed early progressive disease). (biomedcentral.com)
  • flow cytometric
  • At that time point, flow cytometric analyses revealed a drastic increase in B cell numbers, expansion of circulating plasmablasts and a predominance of CD45RO memory CD4 T cells with oligoclonal T cell receptor Vβ expression (table 1), but clinical and laboratory tests showed no evidence of lupus activity. (bmj.com)
  • study
  • Nevertheless, the study raises many interesting questions, and provides a tantalizing hint that this technique can result in the engraftment of cells with added beneficial biological properties. (biomedcentral.com)