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  • minor histocom
  • The biology of GvT response still isn't fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. (wikipedia.org)
  • Treg
  • CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
  • GVHD
  • However, it has been shown that genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle are differentially expressed in patients with fatal GvHD versus "indolent" GvHD. (wikipedia.org)
  • CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
  • undergo
  • The recombination-activating genes (RAGs) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules, however there is no evidence to suggest the developing T cells can undergo receptor editing in the same way that B cells do. (wikipedia.org)
  • IgM is the form of antibody that all B cells produce initially, before they undergo class switching due to exposure to a recognized antigen. (wikipedia.org)
  • lymphoma
  • To identify relevant publications, PubMed and Medline (the Web sites developed by the National Center of Biotechnology Information at the National Library of Medicine of the NIH), were searched using the search terms "follicular lymphoma" and "transplantation" limited to "English language," and a publication date of 1992 or later. (hindawi.com)
  • To study the highest tolerable dose of VNP40101M that can be given to patients with a form of leukemia, MDS, lymphoma, or myeloma in preparation for an autologous stem cell transplant. (clinicaltrials.gov)
  • Other conditions treated with stem cell transplants include sickle-cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease and Hodgkin's disease. (wikipedia.org)
  • He led the initial clinical trials of the drug that resulted from the team's research, later known as rituximab, which demonstrated its safety and activity against CD20-positive B cells in patients with lymphoma. (wikipedia.org)
  • In 1997, rituximab became the first monoclonal antibody drug for cancer on the market, revolutionizing treatment for B-cell non-Hodgkin lymphoma. (wikipedia.org)
  • Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. (wikipedia.org)
  • immune
  • To enable the study of hematopoietic stem cell (HSC) biology, immune cell function, and leukemogenesis in zebrafish, we have developed hematopoietic cell transplantation (HCT) into adult recipient animals conditioned by gamma irradiation. (nih.gov)
  • These receptors are located on the surface of host immune cells whereby they provide a method of entry for the HIV-1 virus to infect the cell. (wikipedia.org)
  • The transplanted immune cells then attack the host's body cells. (wikipedia.org)
  • Early efforts to use CBT in adults led to mortality rates of about 50%, due somewhat to the procedure being done in very sick people, but perhaps also due to slow development of immune cells from the transplant. (wikipedia.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • Patients with RD have a genetic defect that affects the T cells and at least one other type of immune cell. (wikipedia.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • Patients who suffer from RD will now have more stem cells that can differentiate into immune cells. (wikipedia.org)
  • genetically
  • In genetically engineered mice, certain CCHCR1 polymorphisms cause upregulation of the expression of cytokeratins 6 (KRT6A), 16 (KRT16) and 17 (KRT17) and change in expression in other genes associated with terminal differentiation and formation of the cornified cell envelope. (wikipedia.org)
  • acute
  • In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. (wikipedia.org)
  • lack
  • There are also occasional settings in which transplantation can be performed without any preparation, primarily in children with severe combined immunodeficiency who lack T cell function [ 1 ]. (uptodate.com)
  • HLA-C was recognized as a classical transplantation determinant long after HLA-A and HLA-B. Its low level of expression and lack of robust serologic typing reagents impeded investigation of this locus. (frontiersin.org)